A Texas organization has doled out millions to Houston cancer-fighting professionals

granted

Texas doctors and researchers received millions for their transformational work in cancer prevention and treatment. Getty Images

Researchers at medical institutions across the state have something to celebrate. The Cancer Prevention and Research Institute of Texas has made 71 grants this week to cancer-fighting organizations that total a near $136 million.

"CPRIT's priorities of pediatric cancer research and cancers of significance to Texans highlight this large slate of awards," says Wayne Roberts, CPRIT CEO, in a release. "Investments are made across the cancer research and prevention continuum in Texas unlike any other state in the country."

New to the awards this time around is the Collaborative Action Program for Liver Cancer, which has been claimed by Baylor College of Medicine's Hashem B. El-Serag.

"Texas has the highest incidence rates of hepatocellular cancer in the nation," El-Serag says in a release from BCM. "Our CPRIT funded Center will house infrastructure to support and enhance research collaborations among liver cancer researchers; to educate providers, researchers and the general public on best practices and opportunities to reduce the burden of liver cancer; and to engage private and public entities in policy initiatives."

Houston organizations also received recruitment awards, which reward Texas organizations for bringing in great minds from across the world. According to the release, CPRIT has brought in a total of 181 scholars and 13 companies to the Lone Star State.

Of the 71 grants, 58 represent academic research, 10 prevention, and three product development research. Here are the ones awarded to Houston organizations.

The University of Texas MD Anderson Cancer Center

$900,000 granted for Shao-Cung Sun's research in regulation of CD8 T cell responses in antitumor immunity (Individual Investigator Research Award)
$897,483 granted for Alemayehu A. Gorfe's research in characterization and optimization of novel allosteric KRAS inhibitors (Individual Investigator Research Award)
$3 million granted for Hashem B. El-Serag's research at The Texas Collaborative Center for Hepatocellular Cancer (Collaborative Action Program to Reduce Liver Cancer Mortality in Texas: Collaborative Action Center Award)
$2.46 million to Jessica Hwang for patient-centered liver cancer prevention in the Houston community (Collaborative Action Program to Reduce Liver Cancer Mortality in Texas: Investigator-Initiated Research Awards)
$3.51 million for Kevin McBride's Recombinant Antibody Production Core at Science Park
$199,804 granted for Andrea Viale's epithelial memory of resolved inflammation as a driver of pancreatic cancer progression (High Impact High Risk Award)
$6 million for the recruitment of Christopher Flowers, M.D. (Recruitment of Established Investigator Awards)
$2 million for the recruitment of Kevin Nead, MD, MPhil (Recruitment of First-Time, Tenure-Track Faculty Members Awards)
$2 million for the recruitment of Alison Taylor, PhD (Recruitment of First-Time, Tenure-Track Faculty Members Awards)
$2 million for the recruitment of Mackenzie Wehner, MD, MPhil (Recruitment of First-Time, Tenure-Track Faculty Members Awards)

Baylor College of Medicine

$5.38 million granted for Steven J. Ludtke's new capabilities for cancer research in the TMC CryoEM Cores (Core Facility Support Awards)
$1.35 million granted for Bryan M. Burt's novel endoscope-cleaning port for minimally invasive cancer surgery (Early Translational Research Awards)
$199,500 granted for Yohannes T. Ghebre's Topical Esomeprazole for Radiation-induced Dermatitis (High Impact High Risk Award)
$199,920 granted for Robin Parihar's targeting of cancer associated fibroblasts with anti-IL-11-secreting CAR T cells (High Impact High Risk Award)
$2 million for the recruitment of Umesh Jadhav, PhD (Recruitment of First-Time, Tenure-Track Faculty Members Awards)
$2 million for the recruitment of Stanley Lee, PhD (Recruitment of First-Time, Tenure-Track Faculty Members Awards)
$2 million for the recruitment of Ang Li, MD (Recruitment of First-Time, Tenure-Track Faculty Members Awards)
$1.29 million for Jane R. Montealegre's expansion of "a Community Network for Cancer Prevention to Increase HPV Vaccine Uptake and Tobacco Prevention in a Medically Underserved Pediatric Population"

Texas Medical Center

$5.44 million granted for William McKeon's Business-Driven Accelerator for Cancer Therapeutics (Core Facility Support Awards)

The University of Texas Health Science Center at Houston

$5.95 million granted for Zhiqiang An's Advanced Cancer Antibody Drug Modalities Core Facility (Core Facility Support Awards)
$2 million granted for Qingyun Liu's discovery and development of novel peptibody-drug conjugate for treating cancers of the digestive system (Early Translational Research Awards)
$199,998 granted for Leng Han's expression landscape and biomedical significance of transfer RNAs in cancer (High Impact High Risk Award)
$2 million for Lara S. Savas' Salud en Mis Manos that delivers "Evidence-Based Breast & Cervical Cancer Prevention Services to Latinas in Underserved Texas South and Gulf Coast Communities"

The University of Texas Medical Branch at Galveston

$3.55 million granted for William K. Russell's A Targeted Proteomics and Metabolomics Mass Spectrometry Core Facility at the University of Texas Medical Branch at Galveston (Core Facility Support Awards)
$199,996 granted for Brendan Prideaux's novel cellular-level imaging approach to assess payload drug distribution in tumors following administration of targeted drug delivery systems (High Impact High Risk Award)
$200,000 granted for Casey W. Wright's targeting ARNT and RBFOX2 alternative splicing as a novel treatment modality in lymphoid malignancies (High Impact High Risk Award)

The Methodist Hospital Research Institute

$200,000 granted for Robert Rostomily's development of a mini-pig glioma model and validation of human clinical relevance (High Impact High Risk Award)

Texas Southern University

$200,000 for Song Gao's alleviating SN-38-induced late-onset diarrhea by preserving local UGTs in the colon (High Impact High Risk Award)

University of Houston

$200,000 granted for Sergey S. Shevkoplyas' Novel High-Throughput Microfluidic Device for Isolating T-cells Directly from Whole Blood to Simplify Manufacturing of Cellular Therapies (High Impact High Risk Award)

Rice University

$2 million for the recruitment of Jiaozhi (George) Lu, PhD (Recruitment of First-Time, Tenure-Track Faculty Members Awards)
$1.67 million for the recruitment of Vicky Yao, PhD (Recruitment of First-Time, Tenure-Track Faculty Members Awards)

The Rose

$2 million for Bernice Joseph's Empower Her To Care Expansion

Legacy Community Health Services

$999,276 for Charlene Flash's "Increasing Breast and Colorectal Cancer Screening Rates for the Medically Underserved using Population Health Strategies at a Multi-County FQHC"

The design and construction team has been announced for TMC3. Courtesy of Elkus Manfredi Architects

Texas Medical Center reveals new details and renderings for its TMC3 campus

Coming to hou in 2022

The Texas Medical Center just announced the dream team of architects and designers that are making TMC3 into a reality.

Elkus Manfredi Architects, Transwestern, and Vaughn Construction are the three companies that will serve as the architectural and development team for the 37-acre research campus. TMC3's founding institutions — TMC, Baylor College of Medicine, Texas A&M University Health Science Center, The University of Texas Health Science Center at Houston, and The University of Texas MD Anderson Cancer Center — decided on the three entities.

"Texas Medical Center is eager to move forward with a bold, imaginative and dynamic new design vision for the TMC3 Master Plan," says TMC CEO and president, Bill McKeon, in a press release. "With the combined talents of Elkus Manfredi Architects, Transwestern, and Vaughn Construction on-board, I couldn't be more confident that this dream team will flawlessly execute the totality of the project's vision and fulfill its mission to bring together leading researchers and top-tiered expertise from the private sector to create the number one biotechnology and bioscience innovation center in the entire world."

TMC3 was first announced just over a year ago and is planned to open in 2022. The campus will incorporate research facilities, retail space, residential plans, a hotel and conference center, and green space. Parking will be underground to optimize surface area.

Design in mind

The 37-acre research campus will be interconnected by a DNA helix outdoor promenade.

Courtesy of Elkus Manfredi Architects

From a design perspective, the key element will be a DNA helix-shape that looks like a necklace chain that connects the campus.

"Our idea was to expand on the DNA design concept and create a series of spaces that would elongate the strand all the way north to the historic core of the Texas Medical Center and south to the new development by UTHealth and MD Anderson in order to create more opportunity for connections and collisions," says Elkus Manfredi Architects CEO and founding principal, David Manfredi, in the release. "We're implementing the connective tissue between all these places and establishing opportunities for unplanned interactions. Science, technology, medicine, discovery and innovation are all about making connections, and we are building a space for institutions, industry and startups to interact."

Manfredi's firm is responsible for a few other iconic medical facilities, such as the original Broad Institute of MIT and Harvard and The Stanley Building at the Broad Institute in Cambridge, Massachusetts, and the New York Genome Center.

"We want to create spaces that attract talent," Manfredi says in the release. "You can attract talent with great colleagues, research and facilities, but if you don't have a great social environment for people to live, learn, and play, people move on. We are creating a place where people will want to be because they're constantly stimulated – whether it's breakfast at the local coffee shop, or a volleyball league in the afternoon, or working in a central lab and the person next to them is doing something intersects with their own research."

Growing partner institutions

TMC3 Collaborative will be a centrally located building on the campus that is designed to host gatherings and share space with industry leaders.

Courtesy of Elkus Manfredi Architects

While a big portion of the attraction in the new campus is this multi-purposeful and connective space, the project opens doors for the five partner institutions. For Baylor College of Medicine, TMC3 means an expansion of its facilities and an increased footprint for Baylor St. Luke's Medical Center's McNair Campus. The second tower of the hospital will be right at TMC3's eastern edge.

"The selection of a development team is an important milestone for the TMC3 project," says Paul Klotman, president, CEO and executive dean of Baylor College of Medicine, in the release. "The project itself is a huge step in developing the biotech industry in Houston. At Baylor, we look forward to working closely with TMC leaders, as well as those of the other anchor institutions, in making this project a reality."

Additionally, the Texas A&M Health Science Center research building — led by Carrie L. Byington, M.D — on the north end adjacent to BCM's building and the hotel and conference center. On the south side of the campus, MD Anderson and UTHealth will each develop new research facilities that will connect to the existing University of Texas Research Park that is directly to the south of the campus. UT Research Park will be connected to TMC3 via a new skybridge.

The release also describes a central building dubbed TMC3 Collaborative that will create collaborative research space for industry partners. The first level of the building will be an open atrium for gatherings and have food and beverage concepts.

"When TMC3 opens in 2022, Texas Medical Center will officially plant a tangible flag that signals its arrival as the Third Coast for life sciences for the foreseeable future," McKeon says in the release.

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Houston logistics software startup secures $8.4M series A from international investors

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A Houston-based software company that's reducing cost and risk in the marine supply chain has closed its latest round of funding.

Voyager Portal, a software-as-a-service platform closed an $8.4 million series A investment round this week. The round was led by Phaze Ventures, a VC fund based in the Middle East, and included new investors — ScOp Venture Capital, Waybury Capital and Flexport. Additionally, all of Voyager's existing investors contributed to this round.

Voyager has reported significant growth over the past two years since its $1.5 million seed round. Between Q3 2020 to Q3 2021, the company's revenue has increased 13 times and was up 40 percent from Q2 2021. Voyager now manages over $1 billion in freight on the platform, according to a news release.

“Voyager Portal was created to significantly reduce cost, risk, and complexity when transporting bulk materials around the world,” says Matthew Costello, CEO and co-founder of Voyager, in the release. “The last two years have demonstrated just how critical shipping bulk commodities is to global markets – freight rates have increased and port congestion is at an all-time high – accelerating the demand for Voyager’s solution.”

Costello says the fresh funds will be used to support Voyager's continued growth.

“With our Series A funding, we’ll be able to expedite our product roadmap to support an international client base whilst expanding our engineering, development, marketing and sales teams internationally," he adds.

Matthew Costello Voyager Matthew Costello is the CEO and co-founder of Voyager.

Built from the ground up, Voyager's software was created to replace the antiquated and complex legacy systems the market has seen for decades. The platform allows companies to seamlessly collaborate in real time over a single shipment.

“Voyager's implementation has been hugely impressive,” says Adam Panni, operations manager at OMV, a multinational energy company based in Austria, in the release. “The low-code functionality allows almost real-time modifications to the developing workflows and reporting capabilities with no lengthy development and minimal testing prior to implementation. By digitizing data capture across all our physical movements, we are able to analyze our business much better, enabling faster and smarter decisions driven by data. This, in turn, will provide significant, quantifiable cost reductions for our business.”

Abdullah Al-Shaksy, co-founder and CEO of Phaze Ventures says the platform is evolving the industry as a whole at an important moment.

“Voyager is changing the way companies are thinking of their global shipping operations,” he says. “Global supply chains are becoming increasingly complex and strained, and there is an incredible treasure trove of data that organizations are underutilizing in their decision-making process. We believe what Voyager has created for their customers across the globe will revolutionize this space forever.”

H-E-B leader gifts $5 million to historic Houston-area university for future students

HEB and PVAMU

The leader of the Lone Star State’s beloved H-E-B has bestowed a monumental gift upon a historic Houston-area university.

On November 17, Prairie View A&M University announced that H-E-B chairman Charles Butt — one of America’s favorite CEOs and member of one of Texas’ richest families — has donated $5 million to create Founders Scholarships for incoming PVAMU students.

“The $5 million gift will provide a permanent endowment to support students today and in the coming years,” a release notes. “Initially generating approximately $200,000 a year for scholarships, the fund will grow significantly in coming years, making even more available to support students.”

The scholarships will be available to students from public high schools in Texas graduating in the top quartile of their class, the release says. They must be incoming first-year students, enrolled in a full-time course load, and as scholarship recipients, they will benefit from “enrichment opportunities unique to their [Founders Scholarships] cohort.”

Scholarship disbursements will begin in fall 2022, a spokesperson confirms; the number of initial scholarships available has not been revealed.

“Charles Butt has been amazingly generous to our university. He has shown time and time again that he genuinely cares about the opportunities afforded to students at PV. We are indebted to him for his grace and his humanity,” says Ruth Simmons, president of PVAMU, in the release.

Prairie View A&M University is the second-oldest public institution of higher learning in the state and is one of Texas’ historically Black universities. It is located approximately 50 miles northwest of Houston and has a current enrollment of more than 8,000 undergraduate and graduate students.

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This article originally ran on CultureMap.

Rice research: Revisiting the merits of nondigital data collecting

houston voices

Academics are learning quickly that investigations based on data from online research agencies have their drawbacks. Thousands of such studies are released every year – and if the data is compromised, so too are the studies themselves.

So it’s natural for researchers, and the managers who rely on their findings, to be concerned about potential problems with the samples they’re studying. Among them: participants who aren’t in the lab and researchers who can’t see who is taking their survey, what they are doing while answering questions or even if they are who they claim to be online. In the wake of a 2018 media piece about Amazon’s Mechanical Turks Service, “Bots on Amazon’s MTurk Are Ruining Psychology Studies,” one psychology professor even mused, “I wonder if this is the end of MTurk research?” (It wasn’t).

To tackle this problem, Rice Business professor Mikki Hebl joined colleagues Carlos Moreno and Christy Nittrouer of Rice University along with several other colleagues to highlight the value of other research methods. Four alternatives – field experiments, archival data, observations and big data – represent smart alternatives to overreliance on online surveys. These methods also have the advantage of challenging academics to venture outside of their laboratories and examine real people and real data in the real world.

Field experiments have been around for decades. But their value is hard to overestimate. Unlike online studies, field experiments enhance the role of context, especially in settings that are largely uncontrolled. It’s hard to fake a field experiment in order to create positive results since each one costs a considerable time and money.

And field experiments can yield real-life results with remarkable implications for society at large. Consider one experiment among 56 middle schools in New Jersey, which found that spreading anti-conflict norms was hugely successful in reducing the need for disciplinary action. Such studies have an impact well beyond what could be achieved with a simple online survey.

The best way to get started with a good field experiment, Hebl and her colleagues wrote, is for researchers to think about natural field settings to which they have access, either personally or by leveraging their networks. Then, researchers should think about starting with the variables critical for any given setting and which they would most like to manipulate to observe the outcome. When choosing variables, it’s helpful to start by thinking about what variable might have conditions leading to the greatest degree of behavior change if introduced into the setting.

Archival data is another excellent way to work around the limitations of online surveys, the researchers argue. These data get around some of the critical drawbacks of field research, including problems around how findings apply in a more general way. Archival data, especially in the form of state or national level data sets, provide information and insight into a large, diverse set of samples that are more representative of the general population than online studies.

Archival data can also help answer questions that are either longitudinal or multilevel in nature, which can be particularly tricky or even impossible to capture with data collected by any single research team. As people spend increasing amounts of time on social media, the internet also serves as a source of newer forms of archival data that can lend unique insights into individuals’ thoughts, attitudes, and behaviors over time.

With every passing year, technology becomes increasingly robust and adept at collecting massive amounts of data on an endless variety of human behavior. For the scientists who research social and personality psychology, the term “big data” refers not only to very large sets of data but also to the tools and techniques that are used to analyze it. The three defining properties of Big Data in this context include the speed of data processing and collection, the vast amount of data being analyzed and the sheer variety of data available.

By using big data, social scientists can generate research based on various conditions, as well as collect data in natural settings. Big data also offers the opportunity to consolidate information from huge and highly diverse stores of data. This technology has many applications, including psychological assessments and improving security in airports and other transportation hubs. In future research, Hebl and her team noted, researchers will likely leverage big data and its applications to detect our unconscious emotions.

Big data, archival information and field studies can all be used in conjunction with each other to maximize the fidelity of research. But researchers shouldn’t forget even more old-fashioned techniques, including the oldest: keen observation. With observation, there are often very few, if any, manipulations and the goal is simply to systematically record the way people behave.

Researchers – and the managers who make decisions based on their findings – should consider the advantages of old-style, often underused methodologies, Hebl and her colleagues argue. Moving beyond the college laboratory and digital data survey-collection platforms and into the real world offers some unparalleled advantages to science. For the managers whose stock prices may hinge on this science, it’s worth knowing – and understanding – how your all-important data was gathered.