University of Houston lab reports breakthrough in cancer-detecting technology

making moves

This uniquely Houston technology is an AI program that allows scientists to understand the functions of cells by evaluating cell activation, killing, and movement. Photo via Getty Images

T-cell immunotherapy is all the rage in the world of fighting cancer. A Houston company’s researchers have discovered a new subset of T cells that could be a game changer for patients.

CellChorus is a spinoff of Navin Varadarajan’s Single Cell Lab, part of the University of Houston’s Technology Bridge. The lab is the creator of TIMING, or Time-lapse Imaging Microscopy In Nanowell Grids. It’s a visual AI program that allows scientists to understand the functions of cells by evaluating cell activation, killing, and movement.

Last month, Nature Cancer published a paper co-authored by Varadarajan entitled, “Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling.”

“Our results showed that a subset of T cells, labeled as CD8-fit T cells, are capable of high motility and serial killing, found uniquely in patients with clinical response,” says first author and recent UH graduate Ali Rezvan in Nature Cancer.

Besides him and Varadarajan, contributors hail from Baylor College of Medicine/Texas Children’s Hospital, MD Anderson Cancer Center, Kite Pharma, and CellChorus itself.

The team identified the CD80-fit T cells using TIMING to examine interactions between T cells and tumor cells across thousands of individual cells. They were able to integrate the results using single-cell RNA sequencing data.

T-cell therapy activates a patient’s own immune system to fight cancer cells, but not every patient responds favorably to it. Identifying CD8-fit cells could be the key to manufacturing clinical response even in those for whom immunotherapy hasn’t been effective.

“This work illustrates the excellence of graduate students Ali Rezvan and Melisa Montalvo; and post-doctoral researchers Melisa Martinez-Paniagua and Irfan Bandey among others,” says Varadarajan in a statement.

Earlier last month, CellChorus recently received a $2.5 million SBIR grant. The money allows the company to share TIMING more widely, facilitating even more landmark discoveries like CD8-fit cells.

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CellChorus, a biotech startup operating out of the University of Houston Technology Bridge, has secured fresh funding. Photo via Getty Images

Houston biotech startup secures $2.3M grant

cha-ching

They say it’s all in the timing. For CellChorus, it’s all in the TIMING. That’s Time-lapse Imaging Microscopy In Nanowell Grids. TIMING is a visual AI program that evaluates cell activation, killing and movement, which allows scientists to better understand how cells function.

The technology is important to the development of novel therapies in the realms of oncology, infectious diseases, and countless other disorders and diseases. By allowing scientists to observe those maladies at their roots, it will enable them to create, and ultimately deliver new medications and other therapies faster, at lower cost, and with a higher success rate.

CellChorus is a spinoff of the Single Cell Lab at the University of Houston. Part of UH’s Technology Bridge, CEO Daniel Meyer connected with co-founder and leader of Single Cell Lab, Navin Varadarajan, through co-founder Laurence Cooper.

“The company had been established, but there were limited operations,” recalls Meyer during a phone call with InnovationMap.

That was the fall of 2020. Now, the team has just announced a $2.3 million SBIR (Small Business Innovation Research) Fast-Track grant from the National Institute of General Medical Sciences.

“This funding will support development of a product offering that builds on the success of our early access laboratory,” Cooper said in a press release. “As the next frontier of cellular analysis, dynamic single-cell analysis will increase the impact that immunotherapies have in improving the lives of patients.”

Meyer is based in the Bay Area, but the rest of the team is in Houston. Meyer has a proven track record as an investor and early stage entrepreneur in life sciences companies, including work as COO of Genospace, which was acquired by HCA Healthcare.

Meyer says that what attracted him to CellChorus was a combination of a clear need for the technology and the fact that it was “very well validated.“

“Developers of immunotherapies need better functional data earlier so that they can develop and deliver better therapies,” he explains.

Another aspect of its appeal was the fact that more than 10 publications featured data from the TIMING platform.

“We’ve had both large and small biopharmas publish data,” says Meyer. “That’s important as well because it shows there’s applicability in both nonprofit and for-profit research.”

Though Meyer himself doesn’t currently live in Houston, he recognizes its importance to CellChorus. He says that it can be difficult for an early stage company to find appropriate lab space, so Technology Bridge was of exceptional importance for CellChorus. Since opening the lab a year and a half ago, Varadarajan and his team have been busy.

“Example projects we have completed include understanding mechanism of action for cell therapy products, selecting lead candidates for T cell engagers, identifying biomarkers of response to cell therapies, and quantifying potency and viability for cell therapy manufacturing technologies,” says Meyer.

And now, CellChorus is collaborating with leaders in the industry.

“These include top-25 biopharmaceutical companies and promising venture-backed biotechnology companies, as well as leading not-for-profit research institutions,” says Meyer in a press release. It’s clear that the TIMING is right for CellChorus to excel.

The UH Tech Bridge just received fresh federal funding to expand its space for innovation. Photo via UH.edu

University of Houston receives nearly $3M grant for Tech Bridge upgrades

funds granted

The University of Houston's Technology Bridge, which focuses on providing research and development space to UH-affiliated startups and entrepreneurs, has received funding to work on some upgrades.

UH received $2.875 million from the U.S. Department of Housing and Urban Development through a Community Project Funding award was included in an appropriations bill by U.S. Rep. Sylvia Garcia, who represents the region where the Tech Bridge resides.

“Congresswoman Garcia was instrumental in making this funding a reality and we are incredibly grateful for her support and for promoting the innovation ecosystem in the Houston region,” says University of Houston President Renu Khator in a news release. “The Technology Bridge is a growing community of innovators that supports the overall economic health of Houston while creating new opportunities in academia and industry."

Most of the grant will be put toward the UH Industry & International Innovation Hub, or UHI3, a rising center that will provide space for industry partner engagement, an investor and mentoring studio, startup space, training rooms, and innovation event space. The center will also have satellite office for UH’s Small Business Development Center.

The rest of the funding — $475,000 of the grant — will establish The Deck Innovation & Coworking Center, which will include eight new private offices and mail lockers for startups. According to UH, the project is expected to increase capacity by more than 20 companies.

“I am proud to have secured these funds for the University of Houston Technology Bridge. Through this investment, our community will grow stronger, and our economy will be bolstered,” says Rep. Garcia in the release. “Engagement between universities and industry is a priority as we prepare our students to be the workforce of tomorrow in a rapidly evolving world.

"The University of Houston is a world-class institution deserving of our full support, and these federal dollars are proof of that," she continues. "I am proud to represent so many UH students and faculty in Congress and will always fight to get them the resources they need to be on the cutting edge of innovation.”

Currently, the 15-building Tech Bridge and its 31,000 square feet of incubator space houses more than 20 small companies and startups that provide internship and learning opportunities for UH students, along with several federally funded research centers and institutes. The new funding will allow for the Tech Bridge to expand its impact.

“This funding will result in stronger academic and external partnerships, promote key, nationally relevant research and strengthen industry connections for our students,” says Ramanan Krishnamoorti, vice president of energy and innovation at UH. “But most importantly, it will provide an economic catalyst for startups and small businesses in the underserved communities located near the University of Houston.”

UH has launched its Tech Map, which visualizes startup and innovation activity across the city. Photo via Getty Images

University of Houston launches interactive map of the city's innovation ecosystem

introducing tech map

The greater Houston area spans 9,444 square miles — an area larger than the entire state of New Jersey — and the question was never if Houston's sprawl was going to affect interaction between startups, resources, and opportunities, but how to overcome these physical challenges with digital solutions. The latest of which has launched out of the University of Houston's Technology Bridge.

The Tech Map — an interactive, embeddable visualization that takes data about startups and other innovation players and compiles it into a map of entrepreneurial activity in the Houston area — has officially launched with hundreds of startups represented already.

"This kind of tool — it really tells you where innovation is happening, it's not just in the startup development organizations," says Lindsay Lewis, executive director of communications for the UH Division of Research. "It's amazing to see that it's happening all over the city."

The tool, which is free to embed and available to anyone, is already live on Houston Exponential's homepage and the city of Houston's Innovation Portal. It's comprised of data submitted by startup development organizations, self-submitted information, and research by the Tech Bridge's team.

To be represented on the map, click here.


Lewis stresses the importance of creating the tool in a collaborative way, which is why bringing on partners and their databases was so key. The tool isn't designed in Cougar Red or predominantly feature UH-based startups or anything. The Tech Map isn't meant to rock the boat of what any other organization is doing, rather just visually represent the goings on.

"For us, it was a balance between trying to show the story of Houston and where innovation is happening and aggregating, but what we didn't want to do was be a replacement. We wanted this to be a resource for an individual starting point," says Chris Taylor, executive director for the Tech Bridge. "The biggest challenge for most people is you really don't know where to start."

This year has been one for digital tools focused on better portraying Houston's innovation ecosystem. This summer, Houston Exponential launched the HTX TechList to virtually connect startups, mentors, investors, and other movers and shakers in Houston. The two entities are collaborative — HTX TechList's data is even involved in the Tech Map.

"There was a need for connection," Taylor says. "Since 2013 when I got here, that's always been a challenge and a hurdle. How do we connect all these different stakeholders in a way that's meaningful."

While the map is launched and ready to be used, it's only the beginning for it as it grows its data and adds new features.

"We're not done with this map — this is just the 1.0 version," Lewis says. "We're meeting to talk about next-step functionalities and where we are going to take it."

UH has been ranked among the top schools for new patents. Photo courtesy of University of Houston

University of Houston scores spot on top schools in the world for new patents

put a patent on it

A Houston school has ranked on a global list that recognizes new utility patents issued. University of Houston tied for No. 75 on the list with 39 utility patents issued in 2019.

The list is created by the National Academy of Inventors and the Intellectual Property Owners Association based on data from the U.S. Patent and Trademark Office. UH has made the list every year for the past five years.

"The rankings show that UH continues to make a major contribution to the innovation enterprise on the U.S. and global stage," says Amr Elnashai, vice president/vice chancellor for research and technology transfer at UH.

"To be in the top 100 universities worldwide for U.S. patents emphasizes that the UH research enterprise has been successfully steered towards impactful research with the potential to address societal challenges."

A utility patent, known as a patent for invention, is the most commonly referred to type of patent and regards the creation of a new or improved product, process, or machine.

Two Texas schools ranked above UH on this year's list. The University of Texas ranked at No. 3 with 276 utility patents and Texas A&M University came in a few spots ahead of UH at No. 65 with 44 utility patents issued.

UH tied with Drexel University in Philadelphia, and the University of California scored the top spot by far with 631 utility patents filed last year. All in all, the ranking finds that 7,873 U.S. utility patents were issued in 2019, which is up from 1,046 patents in 2018.

UH's Technology Bridge was revamped in 2018 to focus on cultivating innovation and new technologies as they develop from the lab and into the marketplace.

The Chancellor's Technology Bridging Fund will provide grants to UH faculty to help them bring their research and ideas into reality. Natalie Harms/InnovationMap

UH launches $2 million fund for faculty innovators to help them bring their ideas to the market

Funding the faculty

The University of Houston Technology Bridge exists to help transition university research and ideas into the marketplace, and now the UH System has gone one step further to aid in that transition process.

UH has announced a $2 million fund for faculty inventors who then could use the grants — estimated to range between $25,000 to $75,000 — to bring their invention to the commercialization stage. The fund, called the Chancellor's Technology Bridging Fund, was revealed on July 18.

"University faculty are working to solve some of the most critical problems of the day, from energy and the environment to medicine," says Renu Khator, chancellor of the UH System and president of UH, in a release. "It often requires an additional boost to get technologies from the lab to the commercial arena, and this fund is designed to help our faculty take that leap."

According to the release, UH officials plan to give out anywhere from four to 10 grants each year for the next five years.

The grants are intended to aid in the prototyping or product testing process, says Tom Campbell, executive director of the Office of Technology Transfer and Innovation in the UH Division of Research. He adds that usually that ideas in that stage of growth aren't usually granted basic research funding.

"The Technology Bridging Fund will fill a gap. It's really difficult to find funding at this early stage of development, and as a consequence, a lot of innovative concepts sit on the shelf," Campbell says in the release.

The fund directly aligns with the institution's goal of taking these UH-originated ideas, companies, and technologies and introducing them to the world, where they can be used by other companies.

"It's a way to de-risk these technologies and attract external interest," Campbell says in the release. "We want to move people and ideas closer to the market. Having access to this type of funding to do that can be extremely valuable."

Last year, UH transitioned its Energy Research Park into the Technology Bridge to better facilitate the growth for its innovators and research. The organization also works to bring in corporations that are looking to expand in Houston, and, earlier this year, two organizations set up shop in the Tech Bridge.

Earlier this year, a new ranking, new ranking, published by the National Academy of Inventors and the Intellectual Property Owners Association, puts UH at No. 88 among the world's top 100 universities for patent activity in 2018. And, according to Campbell, UH will continue this patent growth.

"As the UH research portfolio grows and the medical school starts up, we would continue to anticipate a strong IP portfolio going forward for UH," Campbell tells InnovationMap in a previous article.

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Shipley Donuts launches AI-powered ordering assistant

fresh tech

Popular Houston-born doughnut chain Shipley Donuts has added a first-of-its-kind AI-powered assistant to its online ordering platform.

The new assistant can create personalized order recommendations based on individual or group preferences, according to a news release from the company. Unlike standard chatbox features, the new assistant makes custom recommendations based on multiple customer factors, including budgetary habits, individual flavor preferences and order size.

"We're not just adding AI for the sake of innovation — we're solving real customer pain points by making ordering more intuitive, personalized and efficient," Kerry Leo, Shipley Vice President of Technology, said in the release.

The system also works for larger events, as it can make individual orders and catering recommendations for corporate events and meetings by suggesting quantities and assortments based on group size, event type and budget.

According to Shipley, nearly 1 in 4 guests have completed orders with the new AI technology since it launched on its website.

“The integration of the AI ordering assistant into our refreshed website represents a significant leap forward in how restaurant brands can leverage technology to enhance the customer experience,” Leo added in the release.

Houston company wins AHA competition for pediatric heart valve design

winner, winner

Houston-based PolyVascular, which develops minimally invasive solutions for children with congenital heart disease, was named the overall winner of the American Heart Association’s annual Health Tech Competition earlier this month.

The company was founded in 2014 by Dr. Henri Justino and Daniel Harrington and was part of TMCi's 2017 medical device cohort. It is developing the first polymer-based transcatheter pulmonary valve designed specifically for young children, allowing for precise sizing and redilation as the child grows while also avoiding degradation. PolyVascular has completed preclinical studies and is working toward regulatory submissions, an early feasibility study and its first-in-human clinical trial thanks to a recent SBIR grant from the National Heart, Lung, and Blood Institute.

With the new AHA honor, PolyVascular will be invited to join the association’s Center for Health Technology & Innovation Innovators’ Network, which connects entrepreneurs, providers and researchers to share and advance innovation in cardiovascular and brain health.

“This is a tremendous honor for PolyVascular—we’re especially proud to bring hope to families and children living with congenital heart defects,” Justino said in a news release. “Our technology—a minimally invasive valve that can be expanded over time to grow with the child—has the potential to dramatically reduce the need for repeated open-heart surgeries.”

The Health Tech Competition is a live forum for health care innovators to present their digital solutions for treating or preventing cardiovascular diseases and stroke.

Finalists from around the world addressed heart failure, hypertension, congenital heart defects and other issues that exist in cardiovascular, brain and metabolic health. Solutions were evaluated on the criteria of validity, scientific rigor and impact.

The judges included Texas-based Dr. Eric D. Peterson, professor of medicine in the division of cardiology at UT Southwestern Medical Center, and Dr. Asif Ali, clinical associate professor of cardiovascular medicine at the University of Texas Medical School in Houston and director at Cena Research Institute.

According to the American Heart Association, nearly half of U.S. adults live with some form of cardiovascular disease or stroke.

“The American Heart Association plays a pivotal role in advancing innovative care pathways, and we’re excited that our solution aligns with its guidelines and mission,” Justino said in a news release. “It’s time these life-changing technologies reach the youngest patients, just as they already do for adults.”

EO Houston is where ambitious founders go to scale smarter

Don't Go It Alone

Scaling a business from early traction into true growth is one of the most exciting — and punishing — chapters of entrepreneurship. Houston founders know this better than most. Our city is built on ambition: fast-moving industries, talent from around the world, and opportunities that expand as large as the Texas sky.

But as many entrepreneurs eventually learn, scaling isn’t simply “more of what worked.” It requires new systems, new thinking, and often, a new version of the founder. Even the most capable founders eventually face decisions, pressures, and turning points that only other entrepreneurs can truly understand.

Entrepreneurs’ Organization, a global peer-to-peer network of more than 18,000 business owners across 220 chapters in 75+ countries, exists for exactly this stage. One of the largest chapters in the organization, EO Houston brings that global community to life locally, offering founders the connection, learning, and accountability needed to grow sustainably and to grow up as leaders.

A community where founders learn at the highest level
The real value of EO emerges in the lived experiences of other entrepreneurs. When Houston-area founders talk about the moments growth nearly broke their companies, a universal theme appears: you can’t do it alone.

EO Houston member Robert De Los Santos of Sky High Party Rentals learned this the hard way when rapid post-COVID growth made expansion feel limitless — until it wasn’t.

“After COVID, we doubled every year and assumed inventory was the limit. In 2023 we overbought, only to realize demand had peaked. That taught us a hard truth: growth in one city has ceilings. Expanding into Austin and Dallas — the Texas Triangle — gave us new markets to put our inventory to work while we figured out how to penetrate Houston better. The challenge shifted from a strategy of ‘buy more units for demand’ to learning how to tackle the challenges of ‘leading across cities.’”

Founders often enter EO exhausted from trying to maintain control as things grow more complex. Many discover, like Jarred King of Summit Firms, that scaling requires the difficult shift from doing everything to building the team that can.

“We grew quickly because of my network, relationships, and hustle… but I was doing all the work,” King says. “I realized at that point you have to delegate — not just busy work, but important decisions to your key team, as well as set up really effective SOPs.”

“The uncomfortable truth is that you are no longer the best person for most jobs in your company," agrees Darren Randle of Houston Tents & Events. "Your inability to delegate or hire people smarter than you in key leadership and management level roles will become the single biggest drag on the entire business. You have to accept that your original 'hustle' is now a scalability risk."

Making hard decisions, such as walking away from customers or contracts, can feel like less of a sting when you know others have also been faced with tough choices. Aaron Gillaspie of West U's My Salon Suite recalls, “You can’t be everything to everyone, it’s ok to say no, and just understand some customers aren’t the right fit. It’s a two way street and both must win.”

Perspective is perhaps the most important reality check that members find at EO.

“Bigger volume will not make problems go away — you just got to get used to walking the tightrope," says Roger Pombrol of Emerald Standard. "Develop a system for good balance and do not freak out. Scared is no way to live your life. It’s ok if you fall. Your family will still love you. Money is just money. Love is love. The world tries to make you conflate them, but don’t."

Actionable insights from entrepreneurs who’ve already scaled
Conversations like these are happening every month inside EO Forum Meeting. Each EO chapter is divided into several small Forums. These confidential, committed group of 7–10 entrepreneurs who meet to share the real five percent of what they’re experiencing. It’s not advice, but experience — shared candidly, respectfully, and with the kind of vulnerability that leads to breakthroughs.

What makes Forum so impactful is the honesty it draws out. Entrepreneurs are often surrounded by employees, partners, and even family members who rely on them for answers, but seldom do they have a group where vulnerability is not only welcomed, but expected.

Learning experiences that match your ambition
EO supports that growth far beyond peer groups. Through the organization’s global partnerships with institutions like Harvard, Oxford, and INSEAD, Houston members gain access to executive-level learning experiences designed specifically for entrepreneurs.

These programs help founders step out of the day-to-day and think strategically about competitive advantage, innovation, and organizational leadership. Paired with ongoing learning through EO Jumpstart, Nano Learning, and its global library of member-created content, founders stay informed, challenged, and ahead of emerging trends.

And through global communities — ranging from EO Women and EO Under 35 to industry-specific groups — Houston members tap into expertise that spans continents and sectors. Whether someone is navigating M&A, exploring international expansion, or integrating new technologies, the right perspectives are always within reach.

What truly distinguishes EO Houston, however, is its culture. Houston’s entrepreneurial landscape is uniquely diverse and resilient, filled with founders who are hungry to build, innovate, and elevate the city’s business community. EO Houston amplifies that spirit, creating relationships that are as supportive as they are strategic. Many members describe the chapter not simply as a network, but as a catalyst for becoming better leaders, better thinkers, and — just as importantly — better human beings.

Your next level starts here
For entrepreneurs who are ready to scale—beyond their first million, beyond their current comfort zone, and toward a future that requires sharper leadership and stronger community—EO Houston offers an unmatched platform. It is a place where ambitious founders grow faster, think bigger, and gain the confidence to take bold next steps.

If you’re ready to elevate your business and your leadership alongside people who understand the journey, EO Houston is ready to welcome you. Your next level starts with the peers who can help you reach it. Learn more and become a member here.

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