Houston ranked in the top emerging North American startup ecosystems

We're No. 4!

Houston fell on the international list of emerging startup hubs, but — when it comes to North America — Houston still ranks favorably. Photo via Getty Images

The evolution of Houston’s startup scene continues: A new report awards the region a No. 1 ranking for the robustness of early-stage funding among North America’s emerging startup ecosystems.

Policy advisory and research firm Startup Genome reports that startups in the Houston area attracted $884 billion in early-stage funding from the second half of 2020 to the end of 2022. Early-stage funding generally refers to a startup’s seed and series A rounds.

The $884 million figure puts Houston at No. 1 for early-stage funding among emerging startup ecosystems in North America and at No. 9 globally. Istanbul, Turkey, grabs the top global spot. Startup Genome characterizes the funding meccas in this ranking category as “Strong Starters.”

Startup Genome’s 2023 report on startup ecosystems emphasizes that early-stage funding “is an important indicator of potential success,” since most startups that receive series A rounds have demonstrated their potential by generating revenue, creating a minimal viable product, or being close to launching a product.

In Startup Genome’s global ranking of emerging startup ecosystems as a whole, Houston falls to No. 11 this year from No. 5 in 2022. The report doesn’t cite a reason for the drop. Copenhagen, Denmark, takes the No. 1 ranking in this category.

While its global ranking slipped, Houston still makes this year’s list of the top five emerging ecosystems in North America:

Detroit (same position as last year)
North Carolina’s Research Triangle (up two spots from last year)
Minneapolis (down one spot from last year)
Houston (down one spot from last year)
Phoenix (up two spots from last year)

Startup Genome pegs the value of Houston’s startup ecosystem at $22 billion, based on startup exits and valuations from the second half of 2020 to the end of 2022.

A 2022 report from the Greater Houston Partnership noted that the Houston area is home to more than 60 organizations that foster startup growth. These include incubators, accelerators, coworking spaces, makerspaces, college and university programs, and nonprofit initiatives.

“These organizations have formed a growing web of resources assisting tech entrepreneurs across the Houston region,” says the report.

Silicon Valley once again tops Startup Genome’s list of the world’s leading startup ecosystems, followed by New York City and London (tied at No. 2), Los Angeles (No. 4), and Tel Aviv, Israel (No. 5).

Startup Genome defines a startup ecosystem as a shared pool of resources generally within a 60-mile radius of a central point, such as the city of Houston. These resources include accelerators, incubators, funding groups, coworking spaces, schools, and policymakers.

Startup Genome’s six ranking factors for ecosystems are performance, funding, talent and experience, market reach, knowledge, and “connectedness.”

“Despite current economic challenges, we are confident that, equipped with the right knowledge, entrepreneurs, policymakers, and community leaders everywhere can leverage opportunities to come together and show how innovative technologies can not only continue to drive growth and job creation, but simultaneously help save the planet and ensure a better future for everyone,” JF Gauthier, founder and CEO of Startup Genome, says in a news release. “This essential mission cannot be put on hold while we wait out rocky economic times.”

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Houston's ranking on this global report improved 14 spots between now and last year. Photo via Getty Images

Houston tech ecosystem ranks as No. 5 in the world for emerging startup hubs

tech in texas

As a startup hub, Houston is movin’ on up.

In a new report from Startup Genome and the Global Entrepreneurship Network, Houston ranks fifth among the world’s top 100 emerging ecosystems for startups. Last year, the groups’ report put Houston at No. 19 in the same category.

Ahead of Houston on the list of the top emerging ecosystems for startups are first-ranked Detroit; second-ranked Hong Kong; third-ranked Dublin, Ireland; and fourth-ranked Minneapolis.

Further bolstering Houston’s status as a rising startup hub, Bayou City ranks third among the top North American challengers to traditional startup anchors like Silicon Valley, Boston, and Seattle. Joining Houston on the challengers’ list are first-ranked Detroit; second-ranked Minneapolis; third-ranked Research Triangle, North Carolina; and fifth-ranked Pittsburgh.

A recent report from Houston Exponential, which was recently acquired, emphasizes Houston’s position as the third fastest-growing tech ecosystem in the U.S. for early-stage startups. Houston sits behind Miami (No. 2) and Bridgeport-Stamford-Norwalk, Connecticut (No. 1).

Houston startups at all stages raised $2.34 billion in 2021, setting a record for the region’s annual VC haul, the HX report says. Of that total, early-stage startups collected $618.9 million in 46 deals.

Health and information technology startups dominate the VC landscape in Houston, with each accounting for 30 percent of VC deals in 2021, according to the HX report.

Elsewhere in Texas, Austin ranks 25th among the world’s top 100 ecosystems for startups, while Dallas ties for 31st place, according to the Startup Genome and Global Entrepreneurship Network report. San Antonio is wedged into the 91-to-100 range in the ranking of the world’s top 100 ecosystems.

“The importance and dispersal of tech startups have amplified the influence — for both good and ill — of geopolitics,” the report notes. “Where once the sector was sufficiently small to avoid the kind of pressures experienced by large industries such as energy and travel, those garage-spawned entrepreneurs have grown into a major economic force. Keeping their heads down is no longer an option.”

According to a new report, Houston is among the top emerging ecosystems. Photo by Zview/Getty Images

Houston rise in the ranks of the top emerging ecosystems in the world

stacking up

If you need evidence that Houston's startup ecosystem is flourishing, look no further than a new report from Startup Genome and the Global Entrepreneurship Network.

This year's Global Startup Ecosystem Report, released September 22, places Houston at No. 19 among the world's top 100 emerging startup ecosystems. Furthermore, it puts Houston at No. 4 among the top regional challengers in North America. Last year's report lumped Houston with other emerging startup ecosystems in the 31-to-40 ranking range.

Mumbai, India, appears at No. 1 among the world's top 100 emerging startup ecosystems this year, while Miami lands at No. 1 among the top regional challengers in North America.

According to Houston Exponential, the city's startup ecosystem "is experiencing a growth spurt that appears to show no signs of abating."

Case in point: Houston startups raised more than $1 billion in the first six months of 2021, surpassing all annual totals from previous years. In 2020, Houston startups reaped a record-high $753 million in venture capital.

"Venture capital invested in Houston startups has nearly quadrupled since 2016," according to a recent Houston Exponential report. "The sustained level of progress we've seen in startup formation and growth over the past four years shows that Houston has what it takes to build a vibrant, healthy innovation economy with an emphasis on equity."

Collectively, the health care and information technology sectors accounted for nearly 60 percent of Houston's VC deals in the first half of 2021, the report says.

Another sign of the expansion of Houston's startup ecosystem: the rising number of workspaces, incubators, and accelerators designed to foster startups.

"These key institutions create density and drive collisions among founders, investors, and talent, significantly increasing the rate of startup formation and growth," according to the Greater Houston Partnership.

Those institutions include The Ion entrepreneurial hub, the Greentown Labs climate-tech incubator, and the DivInc startup accelerator. All are new arrivals on the Houston startup scene.

"DivInc is about broadening the startup ecosystem by making it more authentically diverse, equitable, and inclusive of underrepresented entrepreneurs," Preston James II, CEO of DivInc, said in April. "When we, as a community, do this successfully, we optimize our opportunities for economic GDP growth, we can help reduce racial/gender wealth divide, and drive greater innovation."

Elsewhere in Texas, Austin ranks 20th among the leading startup ecosystems in the Global Startup Ecosystem Report, down from No. 19 last year, and Dallas repeats its 31st-place tie. Silicon Valley tops the global list.

The report says North America represents half of the top 30 ecosystems in the world.

"Entrepreneurs, policymakers, and community leaders in North America have been working hard to build inclusive innovation ecosystems that are engines of economic growth and job creation for all," JF Gauthier, founder and CEO of Startup Genome, says in a news release.

San Francisco-based Startup Genome is a research and advisory firm specializing in startup ecosystems.

A new hub on Rice University campus, Houston receives national rankings, and more local innovation news. Photo courtesy of Rice University

Shell commits to $10M carbon initiative with Rice University, Houston startup acquired by Honeywell, and more innovation news

Short Stories

Even toward the end of the year and amid the holiday season, Houston's innovation news can be a lot to keep up with. Here are seven short stories of Houston innovation — from an exit for a Houston startup and a multimillion-dollar clean energy commitment from Shell to new national recognitions for Houston and 2020 plans unveiled for MassChallenge in Houston.

Shell commits $10 million to new Carbon Hub at Rice University

Matteo Pasquali will lead the new hub at Rice University. Courtesy of Rice University

Rice University has introduced its Shell-backed Carbon Hub — a research initiative to innovate zero-emissions technologies. According to a news release, Shell has committed to a $10 million arrangement for the hub.

"Trying to address climate change is like playing whack-a-mole; you think you're making something better, and you realize that made something else get worse," says Carbon Hub director, Matteo Pasquali, in the release. "For example, you make cars more fuel efficient by removing weight, and then realize you've increased CO2 emissions by using more aluminum and carbon fibers. Or you try to fix CO2 into a useful product, and you realize you now need much more energy than you had gotten by making the CO2 in the first place."

The plan is to "fundamentally change how the world uses hydrocarbons," reads the release. Rather than burning hydrocarbons for fuel, creating carbon dioxide, the hydrocarbons "will be split to make clean-burning hydrogen fuel and solid carbon materials that can be used to make buildings, cars, clothing and more."

Through the partnership with Shell — and other potential partners — the hub will help fund and lead $100 million of science and engineering initiatives. The inaugural meeting for the hub is expected to be early next year and will be hosted by The Center for Energy Studies at Rice's Baker Institute for Public Policy.

"Providing energy to the world's population in an economically and environmentally sustainable manner is the global energy challenge," says Ken Medlock, senior director of the Center for Energy Studies, in the release. "In part, this will require new technologies and forward-looking, creative thinking, which is exactly what Carbon Hub offers."

Houston-based Rebellion Photonics acquired by Honeywell

Photo via rebellionphotonics.com

Innovative gas monitoring technology company, Rebellion Photonics, founded by Allison Sawyer and Robert Kester in Houston in 2009, has been acquired by Honeywell for an undisclosed amount.

The business will be rolled into Honeywell's Safety and Productivity Solutions business, as well as through Honeywell's Performance Materials and Technologies business, according to a press release.

"Honeywell is an amazing company and a recognized leader in our industry. We are excited to be part of their world-class family," Kester, who serves as CEO of Rebellion Photonics, says in the release. "Automated visual monitoring is the future of gas leak detection. Combining our products with Honeywell's platform will make this the new industry standard for safety and environmental monitoring globally."

MassChallenge to announce details of its second Houston cohort

Photo courtesy of MassChallenge

MassChallenge Texas has released new details of its second cohort in Houston. The zero equity startup accelerator based in downtown will run its second cohort from June to September of next year. Up to 100 startups will be selected for the Houston program, and another cohort of up to 100 startups will run along the same timeline in Austin.

On the line for prizes this year is six months of free office space, experts and mentors, the MassChallenge curriculum, access to top corporate leaders, as well as cash prizes and in-kind support — valued at over $500,000.

Both Austin and Houston will celebrate the launch of the two programs on January 29 — Houston's event will take place at the Four Seasons Hotel (1300 Lamar St.) from 5:30 to 7:30 pm.

MassChallenge recently announced its new home in The Cannon's Downtown Launch Pad in partnership with Amegy Bank.

Houston named in Inc.'s top 50 cities to start a business

Getty Images

Houston just made it onto the list of the top 50 cities to start a business, according to Surge Cities index, Inc., and Startup Genome. Coming in at No. 45, the Bayou City ranked behind Austin (No. 1) and Dallas (No. 29).

"Houston wants to be known as the Third Coast, a place that is both a business and cultural hub," the blurb on Inc. reads. "A place where people want to be. And this city, one of the most diverse in the country, is well on its way."

The report highlights Houston's historic hold on the oil and gas industry, the Texas Medical Center's established presence, and the space innovation happening at NASA. Roger Griesmeyer, a partner at Hunton Andrews Kurth, says in the article that Houston has low regulations and taxes coupled with "a highly educated populace, great weather, and a bunch of money."

"There's such diversity and a confluence of talent and opportunity in one place," says Griesmeyer in the article. "Houston is selling a lifestyle brand with all the resources to bear."

Houston was ranked highly on three factors:

No. 23 for job creation
No. 20 for wage growth
No. 25 for population growth

Accenture announces finalists for Houston-based competition

Courtesy of Accenture

In February, Accenture's Houston innovation hub will host the fourth annual Accenture HealthTech Innovation Challenge. Eleven companies have been named finalists and are headed to Houston in the new year.

"This annual HealthTech challenges creates an exciting opportunity to connect healthcare incumbents with emerging businesses to drive health system evolution focused on improving the lives of consumers and clinicians by enhancing access, affordability, quality and experience," says Brian Kalis, managing director of digital health and innovation services at Accenture, in the news release. "We are all looking forward to the final round and awards ceremony on February 6, 2020 in Houston when the finalists will present to an exclusive panel of healthcare executive judges."

No Texas companies were selected as finalists. The 11 selected startups are: New York-based Capital Rx, Minneapolis-based Carrot Health, San Francisco-based Cleo, Boston-based DynamiCare Health, San Francisco-based InsightRX, United Kingdom-based Lantum, Washington, D.C.-based Mira, Denver-based Orderly Health, New York City-based Paloma Health, St. Louis-based TCARE, and Seattle-based Xealth.

Houston area ranked the 18th best-paying city for software developers

Chart via heytutor.com

According to a new report from HeyTutor.com, the Houston-The Woodlands-Sugar Land metroplex is the 18th best-paying city for software developers. The report factored in salary and employment statistics for Houston and other U.S. metropolitan areas using data from the U.S. Bureau of Labor Statistics Occupational Employment Statistics.

Houston's mean adjusted software developer salary is $107,672 annually, according to the report. Here are some other interesting statistics regarding the Houston area from the data:

Mean software developer salary (adjusted): $107,672
Mean software developer salary (unadjusted): $109,503 — compared to $109,914 nationally
Mean salary across all occupations (unadjusted): $54,290 — compared to $51,960 nationally
Number of software developer jobs: 20,400 — compared to $51,960 nationally
Median home price: $205,600 — compared to $226,800 nationally

Business idea competition calls for applications

Photo courtesy of LILIE

The Liu Idea Lab for Innovation and Entrepreneurship has announced the applications for the 2020 H. Albert Napier Rice Launch Challenge business idea competition, which will take place on March 25. On the line is $60,000 in prize money to the teams, and the applications are open to Rice-affiliated teams until 11:59 pm on January 20.

To apply, click here.

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Baylor College of Medicine names Minnesota med school dean as new president, CEO

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Dr. Jakub Tolar, dean of the University of Minnesota Medical School, is taking over as president, CEO and executive dean of Houston’s Baylor College of Medicine on July 1.

Tolar—who’s also vice president for clinical affairs at the University of Minnesota and a university professor—will succeed Dr. Paul Klotman as head of BCM. Klotman is retiring June 30 after leading Texas’ top-ranked medical school since 2010.

In tandem with medical facilities such as Baylor St. Luke’s Medical Center and Texas Children’s Hospital, Baylor trains nearly half of the doctors who work at Texas Medical Center. In addition, Baylor is home to the Dan L Duncan Comprehensive Cancer Center and the Texas Heart Institute.

The hunt for a new leader at Baylor yielded 179 candidates. The medical school’s search firm interviewed 44 candidates, and the pool was narrowed to 10 contenders who were interviewed by the Board of Trustees’ search committee. The full board then interviewed the four finalists, including Tolar.

Greg Brenneman, chair of Baylor’s board and the search committee, says Tolar is “highly accomplished” in the core elements of the medical school’s mission: research, patient care, education and community service.

“Baylor is phenomenal. Baylor is a superpower in academic medicine,” Tolar, a native of the Czech Republic, says in a YouTube video filmed at the medical school. “And everything comes together here because science saves lives. That is the superpower.”

Tolar’s medical specialties include pediatric blood and bone marrow transplants. His research, which he’ll continue at Baylor, focuses on developing cellular therapies for rare genetic disorders. In the research arena, he’s known for his care of patients with recessive dystrophic epidermolysis bullosa, a severe genetic skin disorder.

In a news release, Tolar praises Baylor’s “achievements and foundation,” as well as the school’s potential to advance medicine and health care in “new and impactful ways.”

The Baylor College of Medicine employs more than 9,300 full-time faculty and staff. For the 2025-26 academic year, nearly 1,800 students are enrolled in the School of Medicine, Graduate School of Biomedical Sciences and School of Health Professions. Its M.D. program operates campuses in Houston and Temple.

In the fiscal year that ended June 30, 2024, Baylor recorded $2.72 billion in operating revenue and $2.76 billion in operating expenses.

The college was founded in 1900 in Dallas and relocated to Houston in 1943. It was affiliated with Baylor University in Waco from 1903 to 1969.

$50 million for Houston ibogaine research tops innovation news to know

News to know

Editor's note: The Houston innovation scene is entering 2026 with fresh funding for startups and major grants for innovative health treatments and neurological research. Here are the five most-read InnovationMap stories to start the new year, published Jan. 1-15, 2026:

1. Houston hospitals win $50M grant for ibogaine addiction treatment research

UTHealth Houston and UTMB will lead IMPACT, an initiative working toward ibogaine-based treatments for addiction and neurological issues. Photo via Pexels.

The Texas Health and Human Services Commission has awarded $50 million to UTHealth Houston in collaboration with The University of Texas Medical Branch at Galveston (UTMB Health) to co-lead a multicenter research trial to evaluate the effect of ibogaine, a powerful psychoactive compound, on patients suffering from addiction, traumatic brain injury and other behavioral health conditions. The funding will establish a two-year initiative—known as Ibogaine Medicine for PTSD, Addiction, and Cognitive Trauma (IMPACT)—and a consortium of Texas health institutions focused on clinical trials and working toward potential FDA-approved treatments. Continue reading.

2. Rice scientist earns $600K NSF award to study distractions in digital age

Kirsten Adam, a Rice psychologist, is studying how the brain refocuses in the age of screens, instant gratification and other lingering distractions. Photo via Pexels.

Rice University psychologist Kirsten Adam has received a $600,000 National Science Foundation CAREER Award to research how visual distractions like phone notifications, flashing alerts, crowded screens and busy workspaces can negatively impact focus—and how the brain works to try to regain it. Adam’s work will aim to clarify how the brain refocuses in the age of screens, instant gratification and other lingering distractions. The funding will also be used to train graduate students in advanced cognitive neuroscience methods, expand access to electroencephalography (EEG) and for public data sharing. Continue reading.

3. TMC launches new biotech partnership with Republic of Korea

The Texas Medical Center and KBIOHealth have launched the TMC Republic of Korea BioBridge. Photo via LinkedIn.

Houston's Texas Medical Center has launched its new TMC Republic of Korea BioBridge. The new partnership brings together the TMC with the Osong Medical Innovation Foundation, or KBIOHealth. The Biobridge aims to support the commercialization of Korean biotech and life science startups in the U.S., foster clinical research, and boost collaboration in the public, private and academic sectors. Continue reading.

4. CPRIT CEO: Houston’s $2B in funding is transforming cancer research and prevention

Kristen Doyle, CEO of the Cancer Prevention and Research Institute of Texas (CPRIT). Photo courtesy CPRIT.

With its plethora of prestigious health care organizations like the University of Texas MD Anderson Cancer Center, UTHealth Houston, and the Baylor College of Medicine, Houston sits at the heart of cancer research and prevention in Texas. Of course, it takes piles of cash to support Houston’s status as the state’s hub for cancer research and prevention. Much of that money comes from the Cancer Prevention and Research Institute of Texas (CPRIT). Data supplied by CPRIT shows organizations in Harris County gained $2.3 billion in institute funding from 2009 through 2025, or nearly $145 million per year. That represents almost 60 percent of the roughly $4 billion that CPRIT has granted to Texas institutions over a 16-year period. Continue reading.

5. 14 Houston startups starting 2026 with fresh funding

From groundbreaking energy leaders to growing space startups, here's who secured funding in the last six months of 2025. Photo via Getty Images

Houston startups closed out the last half of 2025 with major funding news. Here are 14 Houston companies—from groundbreaking energy leaders to growing space startups—that secured funding in the last six months of the year, according to reporting by InnovationMap and our sister site EnergyCapitalHTX.com. Continue reading.

Planned UT Austin med center, anchored by MD Anderson, gets $100M gift

med funding

The University of Texas at Austin’s planned multibillion-dollar medical center, which will include a hospital run by Houston’s University of Texas MD Anderson Cancer Center, just received a $100 million boost from a billionaire husband-and-wife duo.

Tench Coxe, a former venture capitalist who’s a major shareholder in chipmaking giant Nvidia, and Simone Coxe, co-founder and former CEO of the Blanc & Otus PR firm, contributed the $100 million—one of the largest gifts in UT history. The Coxes live in Austin.

“Great medical care changes lives,” says Simone Coxe, “and we want more people to have access to it.”

The University of Texas System announced the medical center project in 2023 and cited an estimated price tag of $2.5 billion. UT initially said the medical center would be built on the site of the Frank Erwin Center, a sports and entertainment venue on the UT Austin campus that was demolished in 2024. The 20-acre site, north of downtown and the state Capitol, is near Dell Seton Medical Center, UT Dell Medical School and UT Health Austin.

Now, UT officials are considering a bigger, still-unidentified site near the Domain mixed-use district in North Austin, although they haven’t ruled out the Erwin Center site. The Domain development is near St. David’s North Medical Center.

As originally planned, the medical center would house a cancer center built and operated by MD Anderson and a specialty hospital built and operated by UT Austin. Construction on the two hospitals is scheduled to start this year and be completed in 2030. According to a 2025 bid notice for contractors, each hospital is expected to encompass about 1.5 million square feet, meaning the medical center would span about 3 million square feet.

Features of the MD Anderson hospital will include:

Inpatient care
Outpatient clinics
Surgery suites
Radiation, chemotherapy, cell, and proton treatments
Diagnostic imaging
Clinical drug trials

UT says the new medical center will fuse the university’s academic and research capabilities with the medical and research capabilities of MD Anderson and Dell Medical School.

UT officials say priorities for spending the Coxes’ gift include:

Recruiting world-class medical professionals and scientists
Supporting construction
Investing in technology
Expanding community programs that promote healthy living and access to care

Tench says the opportunity to contribute to building an institution from the ground up helped prompt the donation. He and others say that thanks to MD Anderson’s participation, the medical center will bring world-renowned cancer care to the Austin area.

“We have a close friend who had to travel to Houston for care she should have been able to get here at home. … Supporting the vision for the UT medical center is exactly the opportunity Austin needed,” he says.

The rate of patients who leave the Austin area to seek care for serious medical issues runs as high as 25 percent, according to UT.

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