Houston-based organization tasked by NASA to take risks and innovate solutions in space health

HOUSTON INNOVATORS PODCAST EPISODE 14

The NASA-backed Translational Research Institute for Space Health is innovating the future of life in space. Libby Neder Photography

For Dorit Donoviel, innovation means risk — and there's not a lot that's riskier than traveling to and living in outer space. As director of Houston-based TRISH — the Translational Research Institute for Space Health — Donoviel is tasked by NASA to take some risks in order to innovate.

"Everyone tosses the word 'innovation' around, but that means, to us, taking risks in science. Health care, in particular, is very risk averse, but the space industry is taking risks every single day when they put people in a rocket and hurl them into space," Donoviel says on this week's episode of the Houston Innovators Podcast. "If we're going to mars, for example, we are going to put people at risk.

"For us to take risks in order to reduce risk is a really amazing opportunity."

TRISH works hand in hand with NASA's Human Research Program to identify the program's biggest concerns, and then tap into professors, researchers, and scientists from Baylor College of Medicine, California Institute of Technology, the Massachusetts Institute for Technology, and other partners in order to innovate solutions.

Some of the issues TRISH is working to provide solutions for range from protecting from radiation exposure on the moon and mars to personal health care — astronauts have to be a doctor to themselves when they are on the space station.

"That's a totally new model for health care, so we have to solve all those problems and invest in them," Donoviel says.

In a lot of ways, TRISH connects the dots of modern space research, explains Donoviel. The organization taps into its researcher network, as well as into startups and companies with innovative technologies, in order to deliver the best space innovations to NASA.

Donoviel goes into more details on how TRISH interacts with entrepreneurs as well as what new technologies the organization has seen success with in the episode. Stream the podcast below, and subscribe wherever you get your podcasts.


Australia-based Moonshot has opened a Houston chapter. Miriam Espacio / Pexels

Global space startup and innovation connector opens Houston branch

Space city win

It's almost an understatement to say that Houston's space economy is taking off like a rocket.

On May 28, four companies in the Houston area — Axiom Space Inc., Boeing Co., KBRwyle, and NanoRacks LLC — were tasked with helping chart NASA's course in the space economy, whose global value is projected to climb as high as $3 trillion by 2040. Three days later, Houston-based Intuitive Machines LLC was awarded a $77.2 million contract to send as many as five NASA payloads to the moon.

And a month later, on June 26, officials broke ground on the first phase of Houston Spaceport, a 450-acre project at Ellington Airport that will serve as a sort of control center for aerospace research and manufacturing, and commercial space operations.

Then, on July 19 — a day ahead of the 50th anniversary of Apollo 11 man-on-the-moon mission — Australia-based startup Moonshot Space Co. launched a chapter in Houston to help foster the region's multibillion-dollar space economy. Through its programming, which will kick off this fall, Moonshot seeks to corral entrepreneurs, students, job seekers, business executives, investors, university researchers, government officials, and others in an effort to nurture and promote Houston's space economy.

Troy McCann, founder and CEO of Moonshot, believes Houston — home to NASA's Johnson Space Center — can emerge as the epicenter of the global space economy.

"You'd have to have been living under a rock for the past 50 years not to be aware of Houston's stellar aerospace ecosystem," McCann says. "It's got both the historical credibility and a suite of … successful commercial space ventures based there."

"We want to help fine-tune Houston's space economy by providing a proven framework to elevate people and their ideas into successful teams and scalable businesses," McCann adds, "and to create the industries of the future and solve humanity's greatest challenges."

The Houston chapter, a nonprofit venture, is Moonshot's first in the U.S. and second outside Australia. Nathan Johnson, a Houston attorney who specializes in space law and business development, has been tapped to direct it.

"We're in the process of starting chapters across the globe because we believe that the next Nikola Tesla or Marie Curie is out there somewhere, but they don't have access to the resources they need to change the world for the better," McCann says. "Today, the average person has the ability to start a commercial space program for less than the cost of a fast-food franchise."

Johnson says Houston's prominence as NASA's hub for human spaceflight, its status as the "Energy Capital of the World," and the presence of the Texas Medical Center combine to make Space City a potent force in the space economy.

"My hope is to see Houston continue to lead in space and become a hub for the next wave of space commercialization," Johnson says. "We have a wide breadth of industries, and I would like to see that terrestrial expertise extend to new market applications in space."

If Houston does evolve into a nucleus for the global space economy, it stands to reap sky-high financial rewards. Various analysts forecast the global space economy will soar to between $1 trillion and $3 trillion by 2040, up from an estimated $415 billion in 2018.

"Space is and will be a global endeavor, depending on a strong economy, smart industries, and a talented workforce," Johnson says. "Houston already has all of those things, continues to actively develop them at all levels of the community, and does so in a way that reflects the world's population."

The new exhibit is the first of its kind and will be open later this summer. Courtesy of Space Center Houston

New SpaceX exhibit expected to land at Space Center Houston this summer

Mission control

Space Center Houston has a new exhibit launching this summer. The nonprofit will have a Falcon 9 first stage booster on display starting later this summer.

The booster was used in two missions, which marked the first time a refurbished booster was used on a NASA mission. It first launched in June 2017 with a commercial resupply mission (CRS-11) and returned successfully to Earth. Then, the booster was flown a second time in December 2017 (CRS-13).

"We're excited to welcome Falcon 9 to our growing center," says William T. Harris, president and CEO of Space Center Houston, in a release. "It's part of an historic achievement designing a reusable rocket to further space exploration and America's commercial space industry. The new exhibit is one way we're interpreting the future of human spaceflight. We are deeply grateful to SpaceX for their contribution."

The booster, B1035, is one of only two of its kind on display, and the exhibit is the first commercial space exhibit for the museum. The booster will be displayed near Independence Plaza and will be presented on its side and raised 14 feet so that visitors can walk underneath it and learn about reusable technology in space and how it's making space travel more accessible.

NASA's Space Shuttle Program was the first to bring reusable spacecraft into existence, which lead to more accessibility and the creation of important advances in space technology, such as the International Space Station. SpaceX is continuing this technology within the commercial realm of space travel.

The exhibit was announced at Space Center Houston's Galaxy Gala presented by Chevron on Thursday, May 9. The event was led by co-chairs Peggy Kostial with Shanell and Walker Moody. Guests at the event enjoyed special presentations and sneak peeks, while raising nearly $700,000 for the Manned Space Flight Education Foundation. The proceeds will support the nonprofit's extensive education programs that benefits serving youth and educators from around the world.

"We strive to inspire youth to be part of the NASA mission," says Harris in the release. "From launching a rocket to designing a future spacecraft, we want everyone to have exceptional learning opportunities and to think outside the box like a scientist, engineer or astronaut. Thank you to our generous sponsors and donors whose contributions help us provide authentic learning experiences to people of all ages."

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Houston medical robotics startup announces $42M series C

cha-ching

A Houston medical device company that's tapping into robotics technology for the operating room has just announced a major chunk of fresh funding.

EndoQuest Robotics Inc. announced that it has closed a $42 million series C to advance its robot technology that's targeting endoluminal and gastrointestinal minimally invasive procedures. Returning investors, CE Ventures Limited and McNair Interests, and new investor, Puma Venture Capital, led the round of funding.

"Our investors share our vision of leveraging robotics to redefine the possibilities in minimally invasive procedures," Kurt Azarbarzin, CEO of EndoQuest Robotics, says in a press release. "This financing enables us to continue innovating and refining our technology, ultimately improving patient care and transforming the future of endoluminal interventions."

The funding will go toward continued research and development, regulatory initiatives, commercialization, and other key initiatives. Dr. Vipul Patel, the co-founder and senior venture partner of Puma Venture Capital, is a robotic urologic surgeon and sees potential in EndoQuest's technology.

"I've had the privilege of seeing just about every robotic surgical system either in development or on the market today and can honestly say that EndoQuest's system is a true game changer for both physicians and patients," Patel says in the release.

Founded in 2017, EndoQuest's robotics technology has not yet been cleared by the FDA and is not for commercial sale in the United States.

"The EndoQuest team is trailblazing novel solutions in minimally invasive surgery," Neeraj Agrawal, executive director of Crescent Enterprises, the parent organization to CE Ventures Limited. "We welcome our new partners, and remain fully supportive of the Company and the prospects to transform healthcare with our innovative endoluminal surgical platform."

EndoQuest Robotics is targeting endoluminal and gastrointestinal minimally invasive procedures. Image via endoquestrobotics.com

Houston expert: How to build startup runway in a choppy venture funding market

guest column

The venture funding market in 2023 has been very tough.

The number of rounds closing is significantly down from the 2022, and a record number of companies are raising. Overall VC fundraising is down, but great deals are getting funded well and at good valuations, while many are struggling. Fewer new investors are writing lead checks and being more cautious when they do, later stage investors are shifting earlier stage to manage risk, bad cap tables, operating plans, and reluctant insiders are killing otherwise good deals, and everyone is working on ensuring their portfolio is in good shape.

This is just another venture cycle. The sky is not falling, the playbook for this cycle was written long ago. But if you are a founder, you may need to take action. If you are less than 15 months of runway, it’s time to go to your investors with a plan. You need to either be well on your way to closing a round, starting your fundraise if the company is ready, know your investor group’s plan to bridge or do an inside round if necessary and what you need to achieve to unlock that, or bring them a realistic plan yourself to get to 18 to 30 months of runway. But whatever you need to do, you need to do it now.

The runway plan

The core of a good runway plan is building a cash wedge by taking a little from everywhere, and drop margin and cash. A little revenues, a little in pricing, a little headcount reduction, a little insider capital, a little new capital, and a little balance sheet help. How much a little is, depends on your own dynamic. The secret to a good cash wedge runway plan is starting early, and doing it now. Every day of delay increases the depth of the changes needed for the same runway – until you reach a point where the brutal burn math just doesn’t work, and the changes become costly or even untenable.

Focus on your customers. Nothing cures runway or fundraising ills like revenue. You’ve built these relationships for a reason. They are taking your calls because they care. If you and your team aren’t spending most of your time with customers right now, you are doing it wrong. Good customers get it. Focus their attention on how your product makes them money, and how much. Support their internal efforts to grow the account. Open book it, raise prices if it makes sense, and ask for more volume or contract extensions at good prices if you can’t. With new customers, focus on getting more phase ones that fit in the budget your champions have available quickly. Bet you and your customer can find more budget later when you’ve demonstrated value to them. Bid every grant and non-dilutive source that makes sense, which builds leverage for yourself and your investors.

Burnmatters. In a tight market, no one likes to buy burn, and demonstrating efficiency of revenue and backlog relative to capitalization and burn level matters. If you’re going to cut (and you probably should), cut much deeper than you think, and do it now. You ran this company when it was four people and no money, you can do it again if you really had to. Start making quick decisions about what you can defer and cut in the near term, there is always an easy 5 to 10 percent of costs you can cut and push to next year, and often a few points that can be pulled from supply chain deals. Overplan for growth, but don’t release to spend until your capital markets plan is clear.

Rebalance your spend. Shift your cost structure and organization chart forward towards the customer. Aggressively expand customer facing lead generation, guerilla marketing, applications engineering and direct sales efforts, at the expense of internally facing ones like R&D, manufacturing, and overhead. Repurpose people, change comp structures, job descriptions, or adjust costs and headcount. Get your team on board with the focus and where your runway is. A 12-person startup has about 2,000 labor hours a month to throw at its problems, 3,000 hours on overdrive, when your runway shortens, it’s time to hurl those at customers. Keep in mind, none of this is permanent, good startup organizations are elastic and in six months you can shift back or add again. You’re only really making 180-day changes here. That’s what the nimble startup means. It’s about runway and quick product and operational shifts.

Hit the balance sheet for cash. Depending on company stage and type, sell any underutilized assets and inventory, defer some capex, put someone on collecting AR and adjust your contract terms and pricing to pull forward cash flow, term out and negotiate payment terms on AP, leases and debt. One huge caveat. Do not take venture debt. Until you are profitable, venture debt does not actually create the runway in the real world that you see on paper, and has killed more good startups on the cusp of greatness. Venture debt is Lucy, runway is the football, and you are Charlie Brown.

Adjust your capital markets strategy. The classic rule is raise all you can when you can, because capital is available most when you need it least. But that’s not the whole story. And founders need to realize it is really dangerous to take a deal to market that is not ready, and doesn’t have the right level of insider support, is priced or structured wrong. While the market sets the price and terms, once you’ve a cap table full of investors, both new and existing investor appetite, and valuation, becomes a partial function of existing and new investor appetite and support. Take out a deal that’s not ready, or with too much burn, too little insider support, too high a last valuation, too large a convert or safe overhang or prior capitalization, too little team ownership, or too much valuation or cash need relative to its team, technology, TAM and traction (and cap table), and a founder and board can turn a good opportunity into a death spiral headed straight off a cliff, fast.

The "Magical 25" percent ratio. This is an art not a science, but the Magical 25 percent ratio on a prototypical startup will give you an idea of how powerful a Runaway Plan can be to get a deal done and reset a founder’s opportunity.

Imagine a middle of the road seed funded SaaS startup, burning $350,000 gross, with $100,000 in MRR, which has raised $3 million in cash from three investors and spent half of it. On its current trajectory it has six months of cash left, and is bankrupt by March. Market turned down, and the initial investor calls don’t result in a lead VC leaning in. The logic of burn rate math is brutal. In 90 days the company is on fumes, and it has no term sheet in hand, with the odds of getting one generally falling. And in today’s market the $1 million in ARR has become the new minimum not sufficient condition for fundraising, and the company will need to get farther on it’s A to be attractive to a B round investor. If the founder does nothing and waits 90 days they’ll be begging their investors for a bridge, and begging new investors for a flat round, and will likely end up with downround or an ugly insider bridge. At $250,000-a-month burn and no term sheet, within 150 days the founder will then need an inside round of between $4.5 and $6 million to get to the prototypical 24 month runway, or a $1.5 to $2 million bridge to buy enough more months to fundraise and build value. That’s 1.5x to 2x the capital raised, or over half the existing capital in a bridge, and puts intense pressure on strength of your cap table, growth rate, broad insider support, and quality of revenues in a tight venture funding market.

If the founder instead cuts costs 25 percent immediately, and then throws all hands on deck to find 25 percent more revenue — at this level of burn the startup probably has a team of at least 12 to 15 people, meaning the founder can throw at least 2,000-3,000 man hours in an all hands customer push in just the next 30 days if they had to. At the same time, the founder goes to his largest investors, walks through the cash and cost plan, and asks them to give him a term sheet for a seed extension with existing investors all kicking in 25 percent of their contribution to date, with the extension equal to 25 percent of the total capital at close. It can be papered fast and cheap. That adds $750,000, leaving the founder to find one new investor to join the insiders at the last price for 25 percent of the extension – a much easier ask of a new investor in a tough market, and probably one the founder has a couple of interested parties that have been watching, or certainly one of the founder’s investors can make a quick call to a friend to close. Brutal burn rate math has now become magical burn rate math and the company has 18 months of runway, has halved its net burn, and can additionally get away with half the A round equal to 1x the capital it has raised to date at the end of it if need be.

The "magical" part is the founder has now changed the odds for everyone – his team only has to find 25 percent revenues and costs. His insiders are only asked for 25 cents on the dollar support at a price they should love, leaving the typical fund with plenty of follow-on reserves after that, a new investor does not have to carry the lion share of the burn, set price, do as much dd, or worry about investor fatigue, and the insiders don’t have to go it alone and have external validation, and the founder has minimized their dilution, and their fundraising time. If the founder then is able to keep costs flat for just 6 months in a sprint and pick up another 25 percent in revenues, the runway at the current cashout date is still 16 months, and the company is set up well for its next round, with on $4 million in capitalization on nearly $2 million in ARR, a new investor with dry powder in the deal, and plenty of reserves left on the cap table to support the A, with a lot more traction – leaving the size of A round the company has to have at less than half the level of before, the effective revenue multiple insiders and new investors are facing halved, the burn the new investor had to buy halved and lots of time and options for the founder to drive value, dilution, and scale.

Founders, it’s your company. Your decision. Just be aware, how and how fast you play the tough decisions when the market shifts, changes the calculus for your investors, and their level of confidence and ammunition to back your future decisions. When you feel the market starting to tighten up, consider giving yourself, and your investors, some breathing space, then use that breathing space to drive value.

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Neal Dikeman is a venture capitalist and seven-time startup co-founder investing out of Energy Transition Ventures.

Houston entrepreneur launches platform for on-demand ordering with biz support for restaurateurs

it's chewtyme

While Ashley Loveless Cunningham has advised clients how to fix bad credit and build a healthy financial life for years, a look at her family’s own spending on food delivery came as a wake-up call.

Like a lot of busy households, they loved to order food through delivery apps, so much so that Cunningham realized it was time for a change. With the delivery charge and other fees that apps like DoorDash and GrubHub tack on, a food order can easily double in price. A $15 bowl from Chipotle that her son liked to order cost almost $40 by the time it got to the house — and that doesn’t even include a tip for the delivery driver.

“I thought, wait a minute. This is ridiculous,” she says.

She says she brainstormed, and began to look into ways to offer an alternative, not only for consumers, but for minority-owned restaurants that were struggling to keep their doors open.

So, Cunningham, whose business ventures include her financial literacy business New Credit Inc. and a perfume line, created her own app, ChewTyme.

The app launched in Houston and Atlanta last Friday, and has drawn over 3,000 consumer downloads, which Cunningham says is a “pretty good” start.

Cunningham, 40, a native of Mobile, Alabama, says she moved to Houston with her family ten months ago, drawn by the opportunity to grow their various businesses. And, the city’s vibrant food scene offered another avenue.

“Everybody moves here to open a restaurant,” she says of Houston.

Extra support on the side

Through restaurant owner clients of her credit counseling business, she learned that many were struggling to remain open. A lot of the business owners aren’t aware of the many options available to them, in business lines of credit, assuming their own personal financial credit is in good shape.

That’s where the business education side of the app comes in, where restaurateurs will gain access to “Business University,” financial guidance for their journey in the industry.

“I tell people, it’s not only about cash funding. There are other resources out there, things we need to thrive in the business space,” she says, adding that this includes mentorship and publicity services.

Many restaurant owners told her they partner with at least two or three food delivery apps already. But she thinks ChewTyme will stand out.

“A lot of people I’ve talked to, they just don’t know where to start,” she says. Her partnership with the restaurants would solve that issue, helping restaurateurs create a “full, state-of-the-art profile” that guides them every step of the way.

While she's yet to onboard her inaugural Houston restaurants, the app has begun to draw interest, Ashley says, especially from entrepreneurs who need a cheaper way to scale their business growth.

Cunningham says ChewTyme offers a competitive alternative to many third-party apps, which she says charge anywhere from a 20-22 percent commission on a restaurant’s delivery orders. The app will charge a 17 percent commission, with no monthly fee, and a flat $4.95 delivery rate to consumers, whom she plans to attract with discounts and promotions.

She hopes to initially sign up 25 restaurants in Houston and the same number in Atlanta, during the beta run of the app. As they work out the kinks, she feels confident in expansion.

Her biggest challenge moving forward is hiring quality drivers, she says.

“That really scares me. People who want to work, who have integrity. I’ve heard horror stories because people literally pick up their food and don’t deliver it,” she says.

ChewTyme is working with contracting partners who are conducting screening and background checks for potential drivers, and onboarding restaurant owners with follow-up. Interested restaurateurs or drivers can request more information on ChewTyme's website.

Tapping into a high-growth market

Third-party food delivery exploded in popularity during the pandemic, and a 2021 McKinsey report found that food delivery more than tripled since 2017. Post-pandemic, the on-demand services industry growth hasn't waned.

The Texas Restaurant Association fought for a law passed in 2021 to prevent third-party apps from adding restaurants to a delivery platform without a financial agreement or partnership, according to Christine Robbins, executive director of the association. But now that relationship seems to have settled into a profitable venture on both sides.

Taj Walker, of H-Town Restaurant Group, which owns Hugo’s, Xochi, and six other local restaurants, says the apps don’t typically charge a fee unless the restaurant takes part in an app’s ad promotion of their restaurant.

An app’s commission can range from 10 to 25 percent, he says, which their restaurants compensate for by charging 10 percent more on app orders than in-house food. The apps have become an important revenue stream for some H-Town’s more casual eateries, especially Urbe and Prego, which are popular among younger clientele, Walker says.

While Cunningham’s main goal is to uplift minority entrepreneurs and communities, the app will be available to any restaurateur who wants it.

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