The NASA-backed Translational Research Institute for Space Health is innovating the future of life in space. Libby Neder Photography

For Dorit Donoviel, innovation means risk — and there's not a lot that's riskier than traveling to and living in outer space. As director of Houston-based TRISH — the Translational Research Institute for Space Health — Donoviel is tasked by NASA to take some risks in order to innovate.

"Everyone tosses the word 'innovation' around, but that means, to us, taking risks in science. Health care, in particular, is very risk averse, but the space industry is taking risks every single day when they put people in a rocket and hurl them into space," Donoviel says on this week's episode of the Houston Innovators Podcast. "If we're going to mars, for example, we are going to put people at risk.

"For us to take risks in order to reduce risk is a really amazing opportunity."

TRISH works hand in hand with NASA's Human Research Program to identify the program's biggest concerns, and then tap into professors, researchers, and scientists from Baylor College of Medicine, California Institute of Technology, the Massachusetts Institute for Technology, and other partners in order to innovate solutions.

Some of the issues TRISH is working to provide solutions for range from protecting from radiation exposure on the moon and mars to personal health care — astronauts have to be a doctor to themselves when they are on the space station.

"That's a totally new model for health care, so we have to solve all those problems and invest in them," Donoviel says.

In a lot of ways, TRISH connects the dots of modern space research, explains Donoviel. The organization taps into its researcher network, as well as into startups and companies with innovative technologies, in order to deliver the best space innovations to NASA.

Donoviel goes into more details on how TRISH interacts with entrepreneurs as well as what new technologies the organization has seen success with in the episode. Stream the podcast below, and subscribe wherever you get your podcasts.


Australia-based Moonshot has opened a Houston chapter. Miriam Espacio / Pexels

Global space startup and innovation connector opens Houston branch

Space city win

It's almost an understatement to say that Houston's space economy is taking off like a rocket.

On May 28, four companies in the Houston area — Axiom Space Inc., Boeing Co., KBRwyle, and NanoRacks LLC — were tasked with helping chart NASA's course in the space economy, whose global value is projected to climb as high as $3 trillion by 2040. Three days later, Houston-based Intuitive Machines LLC was awarded a $77.2 million contract to send as many as five NASA payloads to the moon.

And a month later, on June 26, officials broke ground on the first phase of Houston Spaceport, a 450-acre project at Ellington Airport that will serve as a sort of control center for aerospace research and manufacturing, and commercial space operations.

Then, on July 19 — a day ahead of the 50th anniversary of Apollo 11 man-on-the-moon mission — Australia-based startup Moonshot Space Co. launched a chapter in Houston to help foster the region's multibillion-dollar space economy. Through its programming, which will kick off this fall, Moonshot seeks to corral entrepreneurs, students, job seekers, business executives, investors, university researchers, government officials, and others in an effort to nurture and promote Houston's space economy.

Troy McCann, founder and CEO of Moonshot, believes Houston — home to NASA's Johnson Space Center — can emerge as the epicenter of the global space economy.

"You'd have to have been living under a rock for the past 50 years not to be aware of Houston's stellar aerospace ecosystem," McCann says. "It's got both the historical credibility and a suite of … successful commercial space ventures based there."

"We want to help fine-tune Houston's space economy by providing a proven framework to elevate people and their ideas into successful teams and scalable businesses," McCann adds, "and to create the industries of the future and solve humanity's greatest challenges."

The Houston chapter, a nonprofit venture, is Moonshot's first in the U.S. and second outside Australia. Nathan Johnson, a Houston attorney who specializes in space law and business development, has been tapped to direct it.

"We're in the process of starting chapters across the globe because we believe that the next Nikola Tesla or Marie Curie is out there somewhere, but they don't have access to the resources they need to change the world for the better," McCann says. "Today, the average person has the ability to start a commercial space program for less than the cost of a fast-food franchise."

Johnson says Houston's prominence as NASA's hub for human spaceflight, its status as the "Energy Capital of the World," and the presence of the Texas Medical Center combine to make Space City a potent force in the space economy.

"My hope is to see Houston continue to lead in space and become a hub for the next wave of space commercialization," Johnson says. "We have a wide breadth of industries, and I would like to see that terrestrial expertise extend to new market applications in space."

If Houston does evolve into a nucleus for the global space economy, it stands to reap sky-high financial rewards. Various analysts forecast the global space economy will soar to between $1 trillion and $3 trillion by 2040, up from an estimated $415 billion in 2018.

"Space is and will be a global endeavor, depending on a strong economy, smart industries, and a talented workforce," Johnson says. "Houston already has all of those things, continues to actively develop them at all levels of the community, and does so in a way that reflects the world's population."

The new exhibit is the first of its kind and will be open later this summer. Courtesy of Space Center Houston

New SpaceX exhibit expected to land at Space Center Houston this summer

Mission control

Space Center Houston has a new exhibit launching this summer. The nonprofit will have a Falcon 9 first stage booster on display starting later this summer.

The booster was used in two missions, which marked the first time a refurbished booster was used on a NASA mission. It first launched in June 2017 with a commercial resupply mission (CRS-11) and returned successfully to Earth. Then, the booster was flown a second time in December 2017 (CRS-13).

"We're excited to welcome Falcon 9 to our growing center," says William T. Harris, president and CEO of Space Center Houston, in a release. "It's part of an historic achievement designing a reusable rocket to further space exploration and America's commercial space industry. The new exhibit is one way we're interpreting the future of human spaceflight. We are deeply grateful to SpaceX for their contribution."

The booster, B1035, is one of only two of its kind on display, and the exhibit is the first commercial space exhibit for the museum. The booster will be displayed near Independence Plaza and will be presented on its side and raised 14 feet so that visitors can walk underneath it and learn about reusable technology in space and how it's making space travel more accessible.

NASA's Space Shuttle Program was the first to bring reusable spacecraft into existence, which lead to more accessibility and the creation of important advances in space technology, such as the International Space Station. SpaceX is continuing this technology within the commercial realm of space travel.

The exhibit was announced at Space Center Houston's Galaxy Gala presented by Chevron on Thursday, May 9. The event was led by co-chairs Peggy Kostial with Shanell and Walker Moody. Guests at the event enjoyed special presentations and sneak peeks, while raising nearly $700,000 for the Manned Space Flight Education Foundation. The proceeds will support the nonprofit's extensive education programs that benefits serving youth and educators from around the world.

"We strive to inspire youth to be part of the NASA mission," says Harris in the release. "From launching a rocket to designing a future spacecraft, we want everyone to have exceptional learning opportunities and to think outside the box like a scientist, engineer or astronaut. Thank you to our generous sponsors and donors whose contributions help us provide authentic learning experiences to people of all ages."

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Axiom Space-tested cancer drug advances to clinical trials

mission critical

A cancer-fighting drug tested aboard several Axiom Space missions is moving forward to clinical trials.

Rebecsinib, which targets a cancer cloning and immune evasion gene, ADAR1, has received FDA approval to enter clinical trials under active Investigational New Drug (IND) status, according to a news release. The drug was tested aboard Axiom Mission 2 (Ax-2) and Axiom Mission 3 (Ax-3). It was developed by Aspera Biomedicine, led by Dr. Catriona Jamieson, director of the UC San Diego Sanford Stem Cell Institute (SSCI).

The San Diego-based Aspera team and Houston-based Axiom partnered to allow Rebecsinib to be tested in microgravity. Tumors have been shown to grow more rapidly in microgravity and even mimic how aggressive cancers can develop in patients.

“In terms of tumor growth, we see a doubling in growth of these little mini-tumors in just 10 days,” Jamieson explained in the release.

Rebecsinib took part in the patient-derived tumor organoid testing aboard the International Space Station. Similar testing is planned to continue on Axiom Station, the company's commercial space station that's currently under development.

Additionally, the drug will be tested aboard Ax-4 under its active IND status, which was targeted to launch June 25.

“We anticipate that this monumental mission will inform the expanded development of the first ADAR1 inhibitory cancer stem cell targeting drug for a broad array of cancers," Jamieson added.

According to Axiom, the milestone represents the potential for commercial space collaborations.

“We’re proud to work with Aspera Biomedicines and the UC San Diego Sanford Stem Cell Institute, as together we have achieved a historic milestone, and we’re even more excited for what’s to come,” Tejpaul Bhatia, the new CEO of Axiom Space, said in the release. “This is how we crack the code of the space economy – uniting public and private partners to turn microgravity into a launchpad for breakthroughs.”