Houston jumped four spots to No. 34 this year. Photo via Getty Images

Houston's reputation for being an entrepreneurial and business powerhouse was confirmed in WalletHub's new list of the "Best Large Cities to Start a Business" in 2025. The Energy Capital of the World moved up four spots this year and ranked No. 34 nationwide.

The annual report ranked 100 U.S. cities based on 19 metrics across three main categories: business environment, access to resources, and costs. Factors considered in the report include five-year business survival rates, job growth comparisons from 2019 and 2023, office space affordability, and more.

The sunny Florida city of Orlando (No. 1) topped the list as the best large city for starting a business this year.

Houston's business climate has improved slightly since 2024, when the city previously ranked No. 38.

Houston performed the best in the national business environment category, ranking No. 33 out of all 100 cities in the report. It fell behind in the categories for "business costs" and "access to resources" ranking No. 50 and No. 65, respectively.

"Starting a business can be very scary, considering one in every five startups doesn’t make it past the first year," said WalletHub analyst Chip Lupo. "That’s why it’s especially important to live in a city that provides an environment where new businesses can thrive, with enough capital, workers and customers to keep it going long-term."

Elsewhere in Texas
Austin was the only Texas city to rank among the top 10 best big cities to start a business in 2025, climbing up into the No. 3 spot.

"Businesses that are currently in Austin are thriving, as the city has a very high growth rate in the number of small businesses," the report said. "It also has the best employment growth in the country, which makes it more likely that new businesses will be able to find employees."

Dallas-Fort Worth had the greatest concentration of cities on the list, contributing six out of 13 total Texas cities, and all of them among the top 50: Fort Worth (No. 11), Arlington (No. 15), Dallas (No. 16), Irving (No. 22), Garland (No. 29), and Plano (No. 43).

Other large Texas cities that were named among the best places to start a business in 2025 include Lubbock (No. 33), Laredo (No. 44), San Antonio (No. 64), El Paso (No. 67), and Corpus Christi (No. 70).

The top 10 best large cities to start a business in 2025 are:

  • No. 1 – Orlando, Florida
  • No. 2 – Tampa, Florida
  • No. 3 – Austin, Texas
  • No. 4 – Jacksonville, Florida
  • No. 5 – Miami, Florida
  • No. 6 – St. Petersburg, Florida
  • No. 7 – Boise, Idaho
  • No. 8 – Atlanta, Georgia
  • No. 9 – Raleigh, North Carolina
  • No. 10 – Hialeah, Florida
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A version of this story originally appeared on our sister site, CultureMap.com.

HCC's HOU Made is a free initiative that provides programming — workshops, resources and networking — to local businesses. Photo via HCC

Houston college system provides support, resources for local entrepreneurs

hou made

Launching and growing small businesses and startups can take a village, and Houston Community College has a program that can help be that village for entrepreneurs.

HCC's HOU Made, which launched in 2021 and is run from HCC's West Houston Institute, is a free initiative that provides programming — workshops, resources and networking — to local businesses.

"It is designed to open up HCC's Makerspace to the public with access to tools and resources that were previously reserved for staff, faculty and students,” Connie Leon, the program’s coordinator, says in a news release. “The initiative gives small business owners access to use the Makerspace after their representatives attend a series of workshops.”

In addition to the workshops, which range from business 101 and branding to scaling operations, participants have access to equipment like laser cutters, 3D printers and heat press machines. One program within HOU Made is the Maker to Market initiative that provides entrepreneurs with materials including tents, tables, and marketing collateral to help set up pop-up stores for markets.

The program also provides opportunities with key financial advisers and partners like Chase Bank. LaShan Arceneaux, owner of Three Lumps of Sugar that creates mixes for cocktails, secured a $12,000 startup loan from participating in the program.

"I plan to use the loan to have a website built, and to purchase equipment and business supplies such as mixers, aprons, and supplies needed for business. This will allow me to grow the business successfully," Arceneaux says in the news release.

In the last few years, the National Oceanic and Atmospheric Administration has devoted $10 million to $15 million annually to small businesses in the form of SBIR grants. Photo via Getty Images

Expert advice: Should your Houston startup apply for this lesser known SBIR grant?

guest column

Inside the Department of Commerce is a relatively small federal agency, compared to the others, call the National Oceanic and Atmospheric Administration. They too have a small business innovation research (or SBIR) program in which technology startups can have access to funds to de-risk their innovation.

Here’s what you need to know about this non-dilutive funding opportunity:

Overview of NOAA’s SBIR Program

Although the SBIR program has been around for over forty years, NOAA entered the scene in 2010 when their research and development budget reached over $100 million. Per the federal statue, they joined a host of federal agencies that were to devote 3.2 percent of that budget to small businesses.

In the last few years, NOAA has devoted $10 to $15 million annually to small businesses in the form of SBIR grants. These Phase I awards have reached $175,000 in funding for a six-month feasibility study. Follow-on Phase II awards can reach up to $650,000 for 24 months of R&D. Each year’s solicitation is generally announced near the end of the calendar year with deadlines ranging from December to March. While not exactly cyclical, anticipating these deadlines allows a company to set aside enough to prepare a proper application.

What is NOAA Looking For?

According to the NOAA’s website, “NOAA is an agency that enriches life through science. Our reach goes from the surface of the sun to the depths of the ocean floor as we work to keep the public informed of the changing environment around them.“ Their SBIR research topics have stayed consistent since 2011 with minor general topic changes. These six topics have been the same for the last two funding cycles:

  • 9.1 Extreme Events and Cascading Hazards
  • 9.2 Coastal Resilience
  • 9.3 The Changing Ocean
  • 9.4 Water Availability, Quality, and Risk
  • 9.5 Effects of Space Weather
  • 9.6 Monitoring and Modeling for Climate Change Mitigation

When analyzing past winners, which you can find online, a clear emphasis is placed on developing advanced tools for data collection, analysis, and prediction, particularly in the areas of weather forecasting, oceanic observation, and ecosystem health. Many projects involve AI and machine learning for processing large datasets to improve decision-making in disaster response, fishery management, and habitat conservation.

The recurring theme of scalability, real-time data applications, and cost-effective, sustainable solutions shows NOAA's interest in technologies that not only address immediate environmental challenges but also have broader implications for global climate and ecosystem management. Additionally, NOAA seems to value partnerships that leverage cross-disciplinary expertise, integrating cutting-edge science with practical applications.

Their grading criteria also give you some early insight into what they are interested in receiving:

  1. The scientific merit and technical approach of the proposed research (40 points)
  2. The level of innovation the proposed effort offers to the research topic area (20 points)
  3. Consideration of an application’s commercial and societal impacts and potential applications (20 points)
  4. Qualifications of the proposed principal/key investigators, supporting staff, and consultants and availability of instrumentation and physical facilities necessary to complete the proposed work (20 points)

How to Apply

Because of the previous trends, we anticipate NOAA will publish a similar list of research topics along the same lines as the last few years within the next several months. With a deadline being between December and March, it’s in your best interest to begin preparing your application now. Here are the first three early steps I’d recommend for you to get a headstart:

  • Check your eligibility
    • You must be a for-profit organization.
    • You must have fewer than 500 employees
    • You must be primarily owned by a U.S. citizen or permanent resident
    • You must not be majority owned by venture capital or private equity
  • Complete your registrations
    • System for Award Management (SAM) — registration can take over a month and must be renewed on an annual basis.
    • Small Business Association SBA — registration can take up to 90 days.
    • Grants.gov — registration typically takes between three to 10 business days.
  • Start writing your first sections
    • Develop your abstract and specific aims. If possible, schedule a meeting with a program manager from NOAA to review and provide early feedback on these early sections.

Don’t Forget About Asking for Help

Practice regular and open communication with NOAA and their SBIR program managers. Ask questions early and often to make sure you have the best chance of receiving positive feedback when you finally submit your application. I’d encourage you to find previous NOAA SBIR reviewers to do a preliminary review before your submission. Since these solicitations only come around once a year, it’s worth the time and effort to polish your application to the highest degree. If you’re worried about the time commitment of writing a 15 page application for funding, find a local grant writer (or grant writing firm) to help with application and submission process.

Finally, good luck to all you NOAA applications as you innovate in such a way to make the world a better place.

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Robert Wegner is the director of business development for Baginski Wegner and Company (BW&CO).

In partnership with top organizations — like Progressive, Antares Capital, Wells Fargo, and FedEx — Hello Alice has added new offerings for its 2024 Boost Camp programs. Photo via Pexels

Houston-based equitable entrepreneurship tech platform expands programs

coming soon

Fresh off of celebrating the dismissal of a lawsuit from former Trump Administration officials, Hello Alice is expanding some of its offerings for entrepreneurs.

In partnership with top organizations — like Progressive, Antares Capital, Wells Fargo, and FedEx — Hello Alice has added new offerings for its 2024 Boost Camp programs, a mix of skill-building support and grant opportunities.

“We are fortunate to continue working with great enterprise partners who share our commitment to supporting Main Street through crucial grants and mentorship programs,” Carolyn Rodz, CEO and co-founder of Hello Alice, says in a news release. “Small businesses drive our economy, yet often lack the necessary financing and resources. By partnering with major companies, Hello Alice is ensuring that small businesses have access to the tools and opportunities they need to thrive and create jobs in their local communities. Together, we are building a robust support system that fosters innovation and growth for small businesses across the country.”

This year's programs, according to Hello Alice, are as follows:

  • Antares Capital REACH Cohort: The Antares REACH Grant Program provides $20,000 grants to small businesses. Grant recipients will also take part in Antares’ Growth Track Boost Camp program, a digital community which will be home to monthly business coaching workshops, mentorship, networking, and more. Applications are open until June 28, and the program begins August 8.
  • Progressive Driving Small Business Forward Grant & Booster Camp Program: Progressive is dedicating $1 million to award 20 deserving businesses with a $50,000 grant each. Grant recipients will be invited to attend an exclusive 12-week virtual Boost Camp coaching program. Applications have closed for the program beginning September 10.
  • Wells Fargo: Wells Fargo is supporting four virtual accelerator programs over the next 18 months, designed to support up to 500 participants for each program, with a focus on business health and credit-building practices. Applications will be announced this summer for the program, which will begin in early fall.
  • FedEx: The FedEx Entrepreneur Fund supports entrepreneurs in the United States by providing them with the necessary funding, resources, and networks to enhance the success of their businesses, including the Boost Camp coaching program.
  • Applications will be announced this fall for the program, which will begin in the winter.

More information and application access is available online.

Last year's Boost programs benefitted 100 small businesses, according to Hello Alice, which reported that the 2023 Antares REACH Cohort resulted in 60 percent of participants seeing an increase in their Business Health Score and 93 percent felt better equipped to confront challenges and capitalize on opportunities. In the end, 85 percent of participants feeling more optimistic about their business growth prospects.

"Hello Alice is proud to partner with high-level enterprise companies to empower small businesses and foster their success," Natalie Diamond, vice president of business development at Hello Alice, adds. "Together, we are creating unparalleled opportunities for entrepreneurs to achieve brand success, drive financial fitness, and thrive in today's competitive market. Our joint endeavors not only offer access to capital and resources but also provide tailored guidance and mentorship, arming small business owners with the insights and support necessary to navigate challenges and seize growth opportunities.”

Here are some tips to help startups and small businesses break through to candidates who are content in their current position or afraid to jump to a smaller business in today’s market. Photo by Tima Miroshnichenko from Pexels

How Houston startups can hire top talent amid 'The Big Stay' trend of 2024

Guest column

Attracting “A-plus” talent when job candidates are favoring "The Big Stay” is a challenge for small businesses today. This is especially true when small businesses are competing with larger corporations for the same top talent.

To help startups and small businesses break through to candidates who are content in their current position or afraid to jump to a smaller business in today’s market, small businesses need to strategically position themselves as an attractive, viable alternative.

The following tips can help small businesses increase their appeal and attract top job candidates.

Employer branding

The employer brand or managing your reputation among job seekers and internal employees, plays a crucial part in attracting talent. Your internal workplace culture influences current employees and potential job candidates, but it also includes your digital presence. You want to ensure your digital footprint – website to social media – reflects your values, culture and successes. Your career page is a first impression for the job candidate. Including testimonials, day-in-the-life videos and clear job descriptions enhances the appeal of your organization.

Online reviews are another area that needs attention from an employer branding standpoint. Managing your reputation on review platforms like Glassdoor, Indeed and LinkedIn, exhibits how you address concerns and take any corrective action. It is also a barometer for many job candidates regarding employee satisfaction and potential areas for improvement.

Unique selling points

Your product or service has a unique selling point (USP) for customers and your company has a USP for talent. Small businesses usually trump larger corporations in flexibility and innovation. Small businesses can make quick decisions and employees can make a big impact on the company’s direction and success. When job candidates desire to make a substantial impact and have a more dynamic work environment, this is a definitive USP.

Learning and development programs that offer greater opportunity for leadership, cross-functional work and rapid advancement than your larger competitors can be appealing to top talent. Many high performers desire to move up the ranks and make a notable impact as quickly as possible, which is quickly attainable with startups and small businesses. The pathways to career advancement are many times less rigid in small business.

Compensation and benefits

Startups and small businesses usually cannot compete head-to-head with salaries, but there are a number of other ways to make your business more attractive to top talent. Starting off, you need to do your market research to ensure your compensation package is competitive, but other desirable benefits to consider include work-from-home or flex work options, health and wellness programs, financial wellness programs and robust retirement plans. Offering flexible benefits packages that can be tailored to meet the needs of employees at different life stages can be a considerable draw as well.

Candidate experience

When you are trying to recruit candidates who may be content with their current positions, it is important to make the application process as straightforward and clear as possible. This shows attention to detail, tells the candidate that you know what you want in an employee and it is respectful of their time. Once they apply, being responsive to their communication, establishing clear timelines and providing constructive feedback further elevates the candidate experience.

Referrals

Employees are your best recruiting tool. A personal referral speaks volumes since very few recommend candidates who would not fit the culture or the jobs available. Additionally, encouraging current employees to share their positive experiences with the company on social media can help cast a wider recruiting net.

Even though many employees are choosing to stay in their current roles, startups and small businesses can position themselves as attractive employers of choice. When you intentionally position yourself in an authentic manner, top-tier talent looking for career-growth opportunities, influence and meaningful work can be lured away from large competitors that may offer more traditional stability and name recognition.

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Jaune Little is a director of recruiting services with Insperity.

Rushi Patel, co-founder and COO of Homebase, joins the Houston Innovators Podcast in honor of National Small Business Week. Photo courtesy of Homebase

Houston tech founder shines spotlight on small businesses with new awards initiative

houston innovators podcast episode 234

For decades, small businesses have operated in essentially the same manner — handwritten notes to request time off, manual punch cards to clock in, and verbal agreements to swap shifts. And 10 years ago, Houstonian Rushi Patel thought it was time to upgrade these local shops, eateries, and other businesses.

Homebase, which was founded in San Francisco in 2014 and has its largest office in Houston, provides a suite of software tools for employee scheduling, time tracking, communication, and task management for its users, most of which are small businesses.

After a decade of growing its technology and clientbase, Patel, co-founder and COO of the company, explains the unique challenges these small businesses face on the Houston Innovators Podcast — as well as how Homebase helps.

"It's a bit of an orchestra in terms of what entrepreneurs have to do. Your job is to compose a little, but conduct as well," Patel says on the show. "You've built the song of what you want to have happen, but you're conducting lots of different things to make it a reality as a small business owner."



Patel explains how optimizing these personnel aspects of the business frees up founders and managers and improves the employee experience too. Currently, the job market is competitive for these types of businesses, and retention and hiring are major focus points for entrepreneurs.

With 10 years of data and experience of working with small businesses, Homebase introduced a new awards program this week in honor of National Small Business Week. The inaugural Top Local Workplace Awards honored over 50,000 businesses across the country for a range of positive workplace factors — like pay transparency and employee engagement.

"There are over 2 million employee-centric, main street type of businesses in the United States," Patel says, "these are the restaurants, the retailers, and the service providers. They employ north of 70 million people, so there's a lot of impact that these businesses can have. But what we found was they deserve recognition, and there wasn't recognition for the good practices that these employers were doing."

Using its data, which includes over 2.5 million hourly worker data points, Homebase's team implemented the awards to highlight the companies providing their employees — who are in most cases considered a work family, as Patel says — with a great experience.

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Houston biotech co. raises $11M to advance ALS drug development

drug money

Houston-based clinical-stage biotechnology company Coya Therapeutics (NASDAQ: COYA) has raised $11.1 million in a private investment round.

India-based pharmaceuticals company Dr. Reddy’s Laboratories Inc. led the round with a $10 million investment, according to a news release. New York-based investment firm Greenlight Capital, Coya’s largest institutional shareholder, contributed $1.1 million.

The funding was raised through a definitive securities purchase agreement for the purchase and sale of more than 2.5 million shares of Coya's common stock in a private placement at $4.40 per share.

Coya reports that it plans to use the proceeds to scale up manufacturing of low-dose interleukin-2 (IL-2), which is a component of its COYA 302 and will support the commercial readiness of the drug. COYA 302 enhances anti-inflammatory T cell function and suppresses harmful immune activity for treatment of Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD), Parkinson’s disease and Alzheimer’s disease.

The company received FDA acceptance for its investigational new drug application for COYA 302 for treating ALS and FTD this summer. Its ALSTARS Phase 2 clinical trial for ALS treatment launched this fall in the U.S. and Canada and has begun enrolling and dosing patients. Coya CEO Arun Swaminathan said in a letter to investors that the company also plans to advance its clinical programs for the drug for FTD therapy in 2026.

Coya was founded in 2021. The company merged with Nicoya Health Inc. in 2020 and raised $10 million in its series A the same year. It closed its IPO in January 2023 for more than $15 million. Its therapeutics uses innovative work from Houston Methodist's Dr. Stanley H. Appel.

New accelerator for AI startups to launch at Houston's Ion this spring

The Collectiv Foundation and Rice University have established a sports, health and wellness startup accelerator at the Ion District’s Collectiv, a sports-focused venture capital platform.

The AI Native Dual-Use Sports, Health & Wellness Accelerator, scheduled to formally launch in March, will back early-stage startups developing AI for the sports, health and wellness markets. Accelerator participants will gain access to a host of opportunities with:

  • Mentors
  • Advisers
  • Pro sports teams and leagues
  • University athletics programs
  • Health care systems
  • Corporate partners
  • VC firms
  • Pilot projects
  • University-based entrepreneurship and business initiatives

Accelerator participants will focus on sports tech verticals inlcuding performance and health, fan experience and media platforms, data and analytics, and infrastructure.

“Houston is quickly becoming one of the most important innovation hubs at the intersection of sports, health, and AI,” Ashley DeWalt, co-founder and managing partner of The Collectiv and founder of The Collectiv Foundation, said in a news release.

“By launching this platform with Rice University in the Ion District,” he added, “we are building a category-defining acceleration engine that gives founders access to world-class research, global sports properties, hospital systems, and venture capital. This is about turning sports-validated technology into globally scalable companies at a moment when the world’s attention is converging on Houston ahead of the 2026 World Cup.”

The Collectiv accelerator will draw on expertise from organizations such as the Rice-Houston Methodist Center for Human Performance, Rice Brain Institute, Rice Gateway Project and the Texas Medical Center.

“The combination of Rice University’s research leadership, Houston’s unmatched health ecosystem, and The Collectiv’s operator-driven investment platform creates a powerful acceleration engine,” Blair Garrou, co-founder and managing partner of the Mercury Fund VC firm and a senior adviser for The Collectiv, added in the release.

Additional details on programming, partners and application timelines are expected to be announced in the coming weeks.

4 Houston-area schools excel with best online degree programs in U.S.

Top of the Class

Four Houston-area universities have earned well-deserved recognition in U.S. News & World Report's just-released rankings of the Best Online Programs for 2026.

The annual rankings offer insight into the best American universities for students seeking a flexible and affordable way to attain a higher education. In the 2026 edition, U.S. News analyzed nearly 1,850 online programs for bachelor's degrees and seven master's degree disciplines: MBA, business (non-MBA), criminal justice, education, engineering, information technology, and nursing.

Many of these local schools are also high achievers in U.S. News' separate rankings of the best grad schools.

Rice University tied with Texas A&M University in College Station for the No. 3 best online master's in information technology program in the U.S., and its online MBA program ranked No. 21 nationally.

The online master's in nursing program at The University of Texas Medical Branch in Galveston was the highest performing master's nursing degree in Texas, and it ranked No. 19 nationally.

Three different programs at The University of Houston were ranked among the top 100 nationwide:
  • No. 18 – Best online master's in education
  • No. 59 – Best online master's in business (non-MBA)
  • No. 89 – Best online bachelor's program
The University of Houston's Clear Lake campus ranked No. 65 nationally for its online master's in education program.

"Online education continues to be a vital path for professionals, parents, and service members seeking to advance their careers and broaden their knowledge with necessary flexibility," said U.S. News education managing editor LaMont Jones in a press release. "The 2026 Best Online Programs rankings are an essential tool for prospective students, providing rigorous, independent analysis to help them choose a high-quality program that aligns with their personal and professional goals."

A little farther outside Houston, two more universities – Sam Houston State University in Huntsville and Texas A&M University in College Station – stood out for their online degree programs.

Sam Houston State University

  • No. 5 – Best online master's in criminal justice
  • No. 30 – Best online master's in information technology
  • No. 36 – Best online master's in education
  • No. 77 – Best online bachelor's program
  • No. 96 – Best online master's in business (non-MBA)
Texas A&M University
  • No. 3 – Best online master's in information technology (tied with Rice)
  • No. 3 – Best online master's in business (non-MBA)
  • No. 8 – Best online master's in education
  • No. 9 – Best online master's in engineering
  • No. 11 – Best online bachelor's program
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This article originally appeared on CultureMap.com.