These three entrepreneurs saw a need in their industries and created their own solutions. Photos courtesy

A true innovator is someone who's able to look past how something has been done for years — decades even — and be creative enough to find a better way to do it.

From redesigning conventional lab space to seeing a niche opportunity for luxury home rentals, these three innovators to know this week have made strides in changing the game.

Caleb Bashor, professor at Rice University

Photo courtesy of Caleb Bashor

Not all labs are created equal — or affordably. Caleb Bashor, a professor at Rice University, along with seven colleagues, created a DIY lab to further research efforts based at the university.

The DIY lab, eVOLVER, comprises three modules: a customizable "smart sleeve" housing and interface for each culture vessel, a fluidic module that controls movement of liquid in and out of each culture vessel, and a modular hardware infrastructure that simplifies high-volume bi-directional data flow by decoupling each parameter into individual microcontrollers.

"The prototype 16-chamber version of eVOLVER described in the new paper cost less than $2,000, cheaper than what a lab might pay for a single continuous culture bioreactor," Bashor says. Read more about the eVOLVER here.

Sébastien Long, founder and CEO of Lodgeur

Photo courtesy of Lodgeur

Sébastien Long ended up in Houston by chance, and the city ended up being a great place to take his luxe apartment rental business plan and turn it into a reality. Houston-based Lodgeur is a rental company that takes the convenience of Airbnb and adds in the luxury experience of a hotel.

Long identified stylish apartment complexes and built his business which now has a couple properties downtown that are attractive to a niche market of clientele.

"We're roughly split between leisure guests and business travelers," Long says. "They want to feel like they're staying in a home away from home." Read more about Lodgeur here.

Gustavo Sanchez, co-founder and CEO of Pandata Tech

Photo courtesy of Pandata Tech

In oil and gas, proper data management can be the difference of millions of dollars in savings. Pandata Tech can run a data quality check for its oil and gas clients — and even engages automation and machine learning for quicker, more thorough results.

Gustavo Sanchez, co-founder and CEO of the company, is looking to bring his data systems into new industries, like health care, where data management can be hectic, overwhelming, and crucial to life-saving opportunities.

"There's so much data, and it's so noisy, that it's hard to know whether the data can be trusted or not," Sanchez says. Read more about Pandata Tech here.

Lodgeur provides its guests with hotel luxury with room to breathe. Courtesy of Lodgeur

Hospitality startup adds a new luxe approach to Houston's apartment rental market

City living

In 2018, Houston set a new tourism record with 22.3 million visitors to the city. That same year, Sébastien Long was finishing his Cambridge thesis on home-sharing companies like Airbnb and falling in love with a classmate. When the couple moved to Houston after graduation, Long brought his ideas with him, and that's how Lodgeur was born.

Lodgeur works as an upscale home-sharing startup that offers luxury apartments in midtown and downtown Houston for nightly rent. It doesn't replace Airbnb; customers can browse through and book the properties through the familiar website. Guests can also book short or extended stays directly with Lodgeur's website.

In short, Long's research found that most Airbnb's have high guest experience ratings, but those user reviews don't work to inspire the 90 percent of Americans who haven't used a homestay service. Those people have worries — mostly about what to expect, about safety, and about having to interact with homeowners. Long believes he can calm those fears by building a trusted brand that customers recognize on Airbnb, and Houston turned out to be the perfect place to do that: his main inspiration, Conrad Hilton, did the same with hotels over the last century.

"Houston has been a city that's been overlooked. Most companies didn't come here first," Long says. "Actually, people are coming to Houston every week of the year, prices don't fluctuate too much, and you're probably going to be running at a high occupancy every week of the year."

So Long drove around the city, looking for apartment buildings he liked and hoped his guests would, too. Having grown up working at the campground-turned-resort started by his parents in the French Mediterranean, he had an eye for what tourists found attractive — buildings with character, high-end aesthetics and clean designs like a hotel, but with modern kitchen appliances and more space.

"We're roughly split between leisure guests and business travelers," Long says. "They want to feel like they're staying in a home away from home."

Getting that experience is about the same price as a hotel. The properties range from $90 per night to a $200 apartment with 50 feet of floor-to-ceiling windows overlooking downtown. The apartments have not just attracted outside visitors; people have come from around Houston to stay during home renovations or when their houses have flooded, Long says.

The first guests arrived in mid-April. Long wanted to open by managing just a few properties, to make sure the company could ensure great guest experiences.

Last week, he hired his first full-time employee — an ex-marine who graduated from the University of Houston's Conrad Hilton College of Hospitality — and has contracted a marketing agency to turn up Lodgeur's social media presence. For now, Lodgeur relies on a freelance interior designer to fashion the apartments and a local housekeeping company to keep them clean.

Long — who is a Station Houston and WeWork Labs member — says he is looking to expand, but he wants to do so organically: Many of the owners of properties he's already renting own other apartment complexes, and he plans to work with them to move Lodgeur out of inner Houston, and then to other cities. Lodgeur isn't raising funds yet, but Long says he'll be looking for investors this summer.

Recently, Long stayed at Hilton in Austin — his first time at a hotel since launching Lodgeur. He booked a room with a king-sized bed, but it felt small. Business requires him to carry a tape measure, so he measured the mattress: it was six inches smaller than the mattresses Lodgeur uses. He laughed, thinking of how much more comfortable guests would be in an apartment with bigger beds and more space.

"I don't know how people would go back (to hotels)," he says.

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Houston researchers report promising first in-human trial for implantable cancer therapy

cancer breakthrough

When it comes to cancer remedies, the treatment can be as challenging for the body as its cause. But what if immunotherapy could be localized? That’s precisely what a Houston team may soon make a reality.

Rice University researchers, in partnership with MD Anderson Cancer Center, recently published their findings from the first in-human trial of an implantable cancer-fighting treatment in the journal Clinical Cancer Research. The paper details testing of AVB-001, encapsulated cells engineered to release interleukin-2 (IL-2)—a naturally occurring signaling protein that boosts immunity—in the peritoneal cavities of 14 patients. The goal is to avoid the toxicity usually experienced with less targeted treatments, as well as find a solution to IL-2s’ abbreviated half-lives.

“Traditional IL-2 therapy has shown potent antitumor activity, but its clinical use has been limited by severe side effects and delivery challenges,” Omid Veiseh, director of the Rice Biotech Launch Pad, professor of bioengineering at Rice and a senior author on the study, said in a press release. “This platform allows us to localize and sustain cytokine exposure directly where tumors reside while minimizing systemic toxicity.”

Serous ovarian carcinoma is especially well-suited to the use of AVB-001 because it tends to spread throughout the abdomen. After a minimally invasive laparoscopic procedure, patients implanted with the cells were noted to tolerate the treatment well. Half of the enrolled patients’ cancer was stabilized, with several among them reporting extended signs of benefit. No maximum tolerated dose was reached and there were no life-threatening events tied to the study.

If that sounds like less-than-earth-shaking results, this is only the beginning. The capsules were implanted for about one week because IL-2 activity drops off after that. The researchers now know that further testing should include either higher levels, repeated doses, or a combination thereof, in order to create stronger advances.

The team has already made early headway on this next step. Preclinical studies in nonhuman primates were not only tolerated well, but without added toxicity, the apes had consistent pharmacological effects.

“This is a foundational step,” Veiseh explained. “We now have evidence that the platform is safe, biologically active and potentially scalable. The next phase is optimizing dosing and exploring combination therapies to unlock its full clinical potential.”

The combination would also include a checkpoint inhibitor, which might improve AVB-001’s tumor-fighting power. “What is exciting is that we are not just delivering a drug, we are programming a microenvironment,” added Dr. Amir Jazaeri, professor of gynecologic oncology at MD Anderson, member of the Rice Biotech Launch Pad’s clinical advisory board and a senior author on the study. “This opens the door to combination strategies that could amplify immune responses in ways that have not been feasible before.”

Houston startup raises $6M to scale home-based healthcare platform

fresh funding

As healthcare systems race to expand care beyond hospitals and into the home, investors are placing bigger bets on the infrastructure needed to make that shift possible.

This month, Rosarium Health announced it has raised $6 million in seed funding led by Kalos Ventures, with participation from ResilienceVC, Rock Health Capital, Symphonic Capital, Black Tech Nations Ventures and others.

The investment will help the Houston-based startup continue to build its platform, which features a national network of 800-plus clinicians and 3,000-plus contractors to coordinate home accessibility upgrades and modifications for seniors and people living with disabilities.

For founder and CEO Cameron Carter, the company’s mission grew out of firsthand caregiving experiences.

“From my own personal caregiving experiences, I realized that the benefits exist on paper, but not in reality,” Carter said in a news release. “Families are being left to figure out the paperwork and installations all on their own, which shouldn’t be how this works.”

While Medicare Advantage and Medicaid plans have expanded coverage for home-based services and accessibility modifications, the logistics behind delivering those services often remain fragmented.

Rosarium’s platform coordinates the entire process, from clinical assessments and referrals to contractor management, documentation, reimbursement and installation.

“A clinician can document that a home isn’t safe and a plan can approve a benefit, but there’s no one that’s responsible for making sure the work actually gets done,” Carter says. “We built the missing piece.”

The company was founded in 2021 as Rose Health and was a 2023 participant in the Texas Medical Center’s Accelerator for HealthTech program. It has scaled quickly, building a network of more than 800 clinicians and 3,000 contractors across 34 states.

Rosarium is currently in-network for 1.2 million Medicare and Medicaid lives, with projected coverage expected to reach nearly 4 million by the end of the year, according to the release.

“We’re excited to back Cameron because he and the team at Rosarium are building the infrastructure healthcare needs right now to make the home a safe and comfortable place of care,” Kate Ballinger, investor at Kalos Ventures, added in the release.

As part of the recent investment, Ballinger will join Rosarium’s board of directors.

With eyes on the future, Rosarium plans to grow its partnerships with Medicaid and Medicare Advantage plans, including CalViva and Community Health Plan of Imperial Valley, strengthening its presence in California while expanding access to underserved communities.

Additionally, Carter predicts that home-based healthcare will be part of a broader transformation happening across the industry.

“There’s a growing recognition that health outcomes are shaped by what happens in the home,” he said in the release. “The future of healthcare isn’t just treating people after something goes wrong. It’s creating environments that help prevent those problems in the first place.”