Two Houston companies will be pitching at SXSW in March hoping to win their categories and take home "Best of Show." Marie Ketring/via sxsw.org

In two months, a couple Houston companies will be packing their bags and headed for Austin, where they will pitch their startups at the 11th annual SXSW Pitch event. SXSW announced the 50 finalists on Wednesday.

A total of six Texas companies — two from Houston and four from Austin — will be presenting to a live audience and panel of judges at the March 9 to 10 competition. There are 10 categories, each with one winner, as well as an overall "Best of Show" winner.

Houston-based Fluidity Technologies will be presenting as its drone controller, FT Aviator, has been named a finalist in the Hyper-Connected Communities category. Fluidity is lead by CEO Scott Parazynski, a former NASA astronaut, pilot, and physician. The FT Aviator has the potential to revolutionize drone technology. The joystick-like controller is based off movement in space, Parazynski says, and is less prone to user error by someone not as well trained in drone operation.

"I've flown aircraft and spacecraft," Parazynski says in an InnovationMap article about the company. "But none allowed for the precision of motion I was looking for. None prevented unintended motion."

The other Houston company selected as a finalist is Zibrio SmartScale, which is in the Health and Wearable category. The company is all about balance. Its product, a smart scale that tracks balance, aims to reduce dangers that come with poor balance — injuries, deaths, and costs from falls. Katharine Forth leads the company as CEO and founder. The company was a member of TMCx's 2015 medical devices cohort.

SXSW's competition this year has expanded to include new categories and has seen an increase in startups.

"We have seen a 42 percent rise in applicants coming out of last year's event, and we couldn't be more thrilled to see such an impressive increase in the value of SXSW Pitch among the tech industry's most innovative startups," says SXSW Pitch Event Producer Chris Valentine in the release. "In addition to the creation of the new AI and blockchain categories, we've also expanded our advisory board to highlight geographic, gender, and racial inclusion – accelerating our desire to represent the world's most innovative and successful leaders in all areas of technology."

It's not just in the finalists that Houston is represented — two advisers are from the Bayou City. Mariam Jacob, of Allergy and Asthma Clinics of Houston, will be a pre-event coach, and Gabriella Rowe, CEO of Station Houston, will be an on-site coach.

These three entrepreneurs have a lot up their sleeves for 2019. Courtesy images

3 Houston innovators to know this week

Who's Who

This week starts in one year and ends in the next, and InnovationMap has three inspiring entrepreneurs to lead you into 2019. All three are behind Houston startups that are planning for big growth in the upcoming year. So, read their stories and get familiar with their names and faces — they aren't going anywhere.

Ben Johnson, founder and CEO of Apartment Butler

Ben Johnson's business idea turned into a growing company making the lives of apartment dwellers easier. Courtesy of Apartment Butler

Ben Johnson has his own master plan. He'd work as an oil and gas banker for a bit, establish himself, get his MBA, and then, when he was in his 40s, would start his own company. He wasn't wrong about his future as an entrepreneur, but he was off by the timeline.

Johnson started Apartment Butler a few years ago when he saw how apartment communities had the potential to provide streamlined access to resident elected services — such as cleaning or pet care. At the same time, apartment communities across the U.S. were looking to beef up their amenities. Now, Apartment Butler is expanding to its third and fourth markets early next year and is looking to provide more services to its users.

Scott Parazynski, CEO of Fluidity Technologies

Scott Parazynski is a accomplished astronaut and surgeon, but he has a new career focus on drone operation. Courtesy of Fluidity

There are Renaissance men and then there's Scott Parazynski. He's has spent 57 days in space, trained as a trauma surgeon, and climbed Mount Everest as a team physician for the Discovery Channel. His latest conquest is designing a drone controller based on movement in space. The device, called the FT Aviator, allows for one-handed piloting of drones and has the potential to affect the way unmanned vehicles are piloted across industries. As the CEO of Fluidity Technologies, he has big plans for what one-handed drone operation can do.

David Grimes, CEO and co-founder of Snap Diligence

David Grimes thought he was creating a useful tool to vet colleagues. Turns out, he made a way for warm connections better than LinkedIn. Courtesy of Snap Diligence

Hell hath no fury like a businessman scorned. When a business partner ended up being a shady miscreant, David Grimes realized there wasn't a digital vetting tool where you can evaluate a potential associate. After thinking on the idea for a while, Grimes found a co-founder and a way to create an algorithm that can take public information and run it against a person. The company he created is called Snap Diligence.

Now, the tool has morphed into something else that's been unexpectedly in demand. Snap Diligence can find business connections through your already-established network of associates. It's this new feature the company is looking to expand in 2019.

Fluidity Technologies' joystick-like device is designed based on movement in space. Courtesy of Fluidity

Houston-based company's device is revolutionizing drone technology across industries

Unmanned with one hand

It's not enough that Scott Parazynski has spent 57 days, 15 hours and 34 minutes in space. Nor is the fact that he's trained as a trauma surgeon. Not even climbing Mount Everest as a team physician for the Discovery Channel could satisfy one of Earth's most talent-blessed residents. Now Parazynski is on course to change multiple industries with his latest invention.

Not surprisingly, the member of the US Astronaut Hall of Fame based his design on movement in space. He wanted to approximate the movement of simultaneously shifting from one place to another, but also changing the body's orientation. In zero gravity, it takes precision and planning, Parazynski says, to do that in the most efficient way possible.

As a member of the Houston Methodist Research Institute, his goal was to create a joystick-like device "that would revolutionize surgical robotics." That is still a target for the technology, but with his own Houston-based company, Fluidity Technologies, Parazynski is first releasing the device as a drone controller known as FT Aviator.

"Mostly because it's an enormously growing marketplace and the barriers are a lot less," he admits.

That's not to say Parazynski is anything less than a world-class expert on the subject of flight.

"I've flown aircraft and spacecraft," says Parazynski. "But none allowed for the precision of motion I was looking for. None prevented unintended motion."

Lifelong passion
He himself has had toy drones for as long as they've been available and purchased his first "serious drones" three or four years ago, around the same time he conceived of FT Aviator.

When he started to research other drone controllers, he realized that most current models aren't too different from relics from the 1930s on display at the Smithsonian.

"There has been zero innovation in flight control," he says.

As opposed to the two-handed controllers that recall 1990s video game systems, FT Aviator only requires the attention of the pilot's dominant hand. This is especially useful to those using drone cameras. Instead of complex machinations that often require multiple launches, the user can simply make adjustments to the camera with his or her other hand.

"It does this incredibly intuitive motion with a drone or computer game or virtual augmented reality," Parazynski says, listing other potential uses for the technology.

It's FT Aviator's natural movement that will one day make Fluidity's core technology a groundbreaker in surgical robotics. Since the da Vinci surgical robot's 2000 FDA approval, the machine has created controversy. In the hands of a well-trained surgeon, it substantially reduces healing time. But there is no approval process for doctors to use it, so disasters in the hands of untrained practitioners have made the news.

By using the simpler mechanism of Parazynski's technology, the learning curve for robotic surgery is far less steep.

"What we want to do is make it so someone with less training can enjoy the same outcomes," Parazynski explains.

Cross-industry innovation
Ideally, one day a doctor in Houston will be able to operate remotely on a patient across the globe. Thanks to the device's tactile feedback, it's a realistic goal.

But Parazynski foresees "dozens of applications" for his invention, which will begin shipping in February. Sandia National Laboratories in New Mexico has already engaged Fluidity, just one on a list of about 50 businesses and government institutions interested to work with the company when it comes onto the marketplace.

"But any good startup will tell you it's about focus," the entrepreneur admits.

That means that for now, he and his team have his eye specifically on controlling drones. Within two weeks of launching a Kickstarter this fall for the business, Fluidity doubled its goal. The FT Aviator has been named a 2019 Innovation Award Honoree at the 2019 Consumer Electronics Show. But Parazynski says he owes much of his success to Houston, his home of a quarter century.

Fluidity is based out of a WeWork coworking space.

"I think it's a really exciting place to have a tech startup" Parazynski says. "It's not yet to the scale of Silicon Valley or even Austin but certainly the innovation that's taking place here warrants a major tech hub."

And thanks to Parazynski's work, that day may be coming sooner rather than later.

Drone on

Courtesy of Fluidity

From surgeries to flying drones, Fluidity's technology will affect several industries.

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CultureMap Emails are Awesome

Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”