Report: E-commerce soars in 2020 — in Houston and beyond

online shopping spree

Retail trends are affecting Houston's real estate growth, a report from Avison Young finds. Photo via Getty Images

This year's holiday shopping season is keeping online retailers hopping. Commercial real estate services provider CBRE predicts holiday e-commerce sales in 2020 will exceed last year's by a whopping 40 percent.

But even before Americans were focusing intently on buying holiday gifts, e-commerce had taken off amid pandemic-generated shopping constraints. In the second quarter of this year, online sales skyrocketed by 44.5 percent compared with the same period in 2019, according to the U.S. Census Bureau. E-commerce accounted for a record-high 15.1 percent of total retail sales from April through June.

A forecast from commercial real estate services provider Avison Young indicates the U.S. upswing in e-commerce sales will benefit one segment of Houston's real estate sector more than any other in 2021 — industrial. Riding this year's e-commerce wave, Houston's industrial market will "remain solid" next year, the forecast says.

"Industrial continues to outperform all other asset types," Avison Young's report reads, "but higher vacancies and larger rent concessions will continue in 2021 as the new supply outpaces immediate demand. Online shopping is strong, and national retailers are building large distribution centers and last-mile facilities throughout the metro."

The forecast cites several industrial projects underway or recently leased in the Houston area:

  • A 1 million-square-foot spec warehouse under construction in Baytown, near the Port of Houston. It's said to be one of the largest spec industrial facilities underway in the U.S. The developer is Hunt Southwest Industrial Real Estate. The warehouse is set to open in March.
  • A 1.5 million-square-foot distribution center under construction in New Caney for home improvement retailer Lowe's. The $65 million project, which will be the largest industrial facility in Montgomery County, is supposed to be ready for occupancy in July.
  • A newly completed 402,648-square-foot facility that online retailer Costway is occupying in Pasadena, near the Port of Houston.
  • Dunavant Distribution's expansion into a 784,000-square-foot leased property in Deer Park, near the Port of Houston.

Various e-commerce players are relying more and more on regional distribution centers, last-mile distribution facilities, and micro-fulfillment centers throughout the Houston area, according to Avison Young. E-commerce behemoth Amazon is driving a lot of this activity. For instance, the retailer is planning a 1 million-square-foot fulfillment center in Missouri City. That space is scheduled to open sometime in 2021. Meanwhile, an 850,000-square-foot Amazon fulfillment center is on tap for nearby Richmond.

In a third-quarter report, Avison Young noted that 15.1 million square feet of industrial space was under construction in the Houston area and 4.1 million square feet of industrial space had been completed, with net absorption of 1.1 million square feet.

The Port of Houston is helping propel many of the moves in Houston's industrial market. In October, the port notched its busiest month on record, with cargo activity sailing 15 percent above the same period in 2019. Operators of the port hope to begin work on widening of the Houston Ship Channel in 2021.

Nationally, this year's spike in online shopping rocked the retail boat. This surge has produced new generations of retailers and consumers, Avison Young says, and has put pressure on the entire supply chain. Furthermore, it has accelerated chatter about the road ahead for last-mile delivery and brick-and-mortar retail.

"Existing retail space, which was either redundant or surplus to requirements, is being repurposed to facilitate 'click and collect' models," per the report. "Retailers are adjusting the 'front end' consumer-facing component of the store for showroom or experiential space to complement traditional browse-and-buy activity. In-store staff, coupled with technology investments, are being channeled into order picking and back-of-house fulfillment activities."

"Traditional stores were always a combination of the retail and logistics functions; recent trends suggest a renewed recognition of this dual role," the firm adds. "As surplus retail space becomes cheaper and more available, innovations around hyperlocal delivery will be a key part of reimagining the future of retail."

Florida startup Fit:Match chose Houston for its first location of its AI-enabled retail store. Photo via shopfitmatch.com

New Houston-area store pops up to optimize artificial intelligence for retail shopping

fashion forward

In November, on the first floor of Friendswood's Baybrook Mall, wedged between the Abercrombie & Fitch and the Apple Store, a small studio popped up. At the window, a bubblegum assortment of balloons replaced the usual spruced-up manakin, and the shop is sparse for racks of clothing.

That's because the Fit:Match studio isn't really trying to sell clothes — it's trying to help you buy them online. By fusing artificial intelligence with retail shopping, Fit:Match makes ordering clothes online more trustworthy. The writing on the walls promised to revolutionize the way that people could: "Shop what fits. Not what doesn't," reads a neon sign. The tech might not only reduce long waits for the dressing room — it could abolish it altogether.

"You never have to try on clothes again," says Haniff Brown, founder of the Florida-native startup.

The store does have a fitting room, but Brown says it's not really for trying on clothes — it's for preparing to "get fitched," the process through which the imaging tech measures a customer's body.

It's fitting that the pop-up sits next to the iPhone giant. Fit:Match uses the same 3D imaging tech as Apple's FaceID, Brown says, which blasts infrared light at thousands of dots at a user's face. Where the light bounces off, the AI technology images the person's face. The sensors at the Fit:Match studio in Baybrook Mall expand this to the rest of the body. In 10 seconds, the AI sensor lets people sketches a customer's shape through 150 measurements.

Those measurements become indicators of how well a piece of clothing will fit the wearer. In the initial phase of the project, Brown's team fitched thousands of women — wanting to keep things neat, the company hasn't ventured into men's fashion yet — and compared the scores of the AI's algorithm with how the women scored their own clothes.

Now, once a customer has been fitched at the Baybrook studio, she can log online through an app or the company site and sift through thousands of clothes that will likely fit her. Each clothing item — mostly smaller brands that range from eclectic pieces and dresses to athleisure right now, Brown says, although he's already working to partner with better-known labels — is rated with a percentage of how well it's likely to fit the individual customer, based on her measurements and on how snug or loose she likes her wear. From the array of brands, she'll get specific matches — clothes that have a 90 percent chance or higher of fitting — that might look completely different from a friend's. Over time, the app will also update her on the latest matches.

"You're going to have this personalized wallet," Brown says, adding that this will also decrease a store's rate of return. "You will see a completely truncated assortment of clothes that are meant to fit you."

The Baybrook Mall hosts Fit:Match's first location. Brown says he chose the Houston area for its size and demographics, calling it a "hotbed to test new ideas, to get traction, to get customer feedback," and is even considering expanding to the Woodlands Mall and other places around Texas, too. It's also not far from the Austin-based Capital Factory, which brought Fit:Match under its wing late last year to help the startup raise $5 million.

In the meantime, the five-member management team at Fit:Match is focused on getting more Houstonians fitched. In the first month of operations, the studio measured more than 1,200 mallgoers, and Brown says the company could fitch a quarter million in the next two or three years.

"We think that the opportunity here is immense," Brown says.

The Nap Bar offers "pay-by-snooze" rest. Photo by Dominique Monday

New Rice Village nap bar refreshes sleep-deprived Houstonians

Stay woke

Khaliah Guillory wants to put you to sleep. To clarify: She wants you to nap. And the power nap is all the rage right now. Busy workers, executives and entrepreneurs in New York, Europe, and Japan are all napping during the day — taking a short snooze that not only helps them be more productive in their daily tasks, but allows them to be healthier.

"Americans lose 1.2 million work days because of sleep deprivation," Guillory tells CultureMap. "That costs the economy $411 billion. And the Centers for Disease Control estimate that driving while you're sleep deprived is the equivalent of driving under the influence."

To counter the trends, Guillory will open Nap Bar in Rice Village. Slated for a late April unveiling, a pay-by-the-snooze napping facility will be at the back of New Living. Guillory has partnered with the company, already known for its commitment to sustainability. Nap Bar's custom-patented napping pods are designed with sound-proof materials and contain organic, nontoxic Bungaloom mattresses and bedding.

A Comfort Concierge will greet visitors and lead them to a private suite surrounded with T.L.C. There are also two shared nap pods with twin mattresses available. Naps are scheduled 20 to 26 minutes for short-term alertness, or longer, if needed. A 20-minute snooze will set you back $25, while 26 minutes run $32. (If you're looking for a full hour, that's available for $69). Sleeping pods have blackout curtains and are soundproof.

Guillory has also made the napping experience into a luxury one so Nap Bar nappers receive complimentary aromatherapy and custom brain wave therapy with every siesta. Other add-ons include, lymphatic massages, hot showers, espressos, and EarthCraft Juicery blends that are crafted from raw, healing ingredients. The all-organic experience all designed to provide gentle healing and peaceful rest.

"Our culture tells us that if you're napping during the day, you're either a kid or you're lazy," says Guillory. "But that's not true. If you take as little as 20 minutes to nap, you'll feel revitalized."

A snooze story
Guillory didn't intend to become a nap guru. Like many things in life, however, necessity became the mother of invention. While working as an executive for a Fortune 500 company, Guillory was traveling heavily, catching brief bits of shut-eye in airport lounges or her car. At one point she found herself in Richmond, with an hour and a half to kill before her next meeting in Houston. Driving straight into town would make her far too early for her appointment. There wasn't time to go home. And checking into a hotel seemed silly.

"That's when my wife said to me, Google nap spaces in Houston," she recalls. She did. There were none. And that's why she created her own. "I wanted a safe haven for people to unplug," Guillory says. "It doesn't have to be full-on sleep. It can be relaxation, meditation, whatever you need."

And far from resting on her own laurels with her business on the cusp of opening, Guillory is pursuing other nap-centric opportunities. She's looking to partner with area businesses to incorporate nap pods into their space for employees, and is planning a Nap Bar Snooze Unit, a mobile tour bus that will "roll through downtown and let people take power naps," she explains.

She generated a great deal of interest when she took her concept on the road to Bush Intercontinental Airport earlier this week, displaying the nap pod and sharing the feedback she'd received from Nap Bar's beta testers. That input is something she takes seriously; when Nap Bar debuts, it'll be with products that her testers recommended — and they had opinions on everything from the bedding to the materials used in the pod.

"I want to turn sustainable rest into sustained productivity," says Guillory. "And I think this is just what Houston needs."

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This article originally ran on CultureMap.

Oils and scents help you relax. Photo by Dominique Monday

SeeHerWork launched its line of female-gear in September. Courtesy of SeeHerWork

Houston company aims to equally equip female workers

If the glove doesn't fit

When Jane Henry was working on her home right after Hurricane Harvey — her house got three feet of mud in it — she went to throw a board into the dumpster, and her glove went with it.

Henry says the industry standard is to recommend small and extra-small sizes for women's workwear, but as a ladies large in athletic gloves, Henry still had a good inch or so of glove at her fingertips in her workwear gloves.

"I went upstairs to my sewing room, and I ripped that glove apart and I resewed it to fit my hand," Henry says.

Other women stopped her in hardware stores to ask her about her shoddily sewn glove, and she realized this was the idea for next company. She incorporated SeeHerWork a few months later in January of 2018, and she launched her line of clothing in September, just a year after she had the idea. Based in Houston, SeeHerWork rents warehouse space in Kingwood and has its corporate office in Midtown.

Doing the legwork
Henry is no stranger to the startup game. She created her own consulting company, Xcution Inc., over 16 years ago, but she downsized the company in 2016 when oil prices took a turn. Instead, she went into Rice University's MBA program, where, ultimately, she created a network of associates that would eventually help SeeHerWork grow.

"I've been a serial entrepreneur — been trying to avoid calling myself that," says Henry. "I have two entrepreneurial parents, and I told myself I'd never be an entrepreneur, yet that's what I keep doing."

Through her business expertise and education, she knew she had to start with a one-page business plan for the company. She then took her idea to over 50 focus groups made up of 10 to 20 female workers, safety managers, and procurement managers across industries — transportation, military oil and gas, engineering, and more.

"The response was eerily similar despite the industry," Henry says.

The focus group participants were tired of the "pink it and shrink it" approach to women's workwear and equipment. They felt like if their supplies don't fit, they don't fit. Mentorship opportunities and performance are then subsequently hindered, creating a spiral effect of deterring women from entering the skilled labor workforce. This is a huge problem, considering there's the recent labor shortage with these types of jobs.

She took this information and her first prototypes to a national pitch competition to great success — and a standing ovation. Henry also connected with the Rice Angel Network, Station Houston, The Cannon, and other local innovation-focused entities.

Roadwork ahead
Henry has big plans for SeeHerWork, and is in talks with a few large entities — like the Houston Airport System, Fluor Corp., and Toyota — that have expressed interest in using her gear for their workforce. Henry also wants to expand her products and reach female workers through retail — online and in store.

"Ultimately, SeeHerWork is the Lululemon of workwear," Henry says.

SeeHerWork is focused on keeping women safe, firstly, but also encouraging more women to enter the skilled labor workforce and then work their way up the ladder.

"I don't want people to think of us as a workwear company," Henry says. "I want them to think of us as an inclusion company. Mostly because just like professional sports team, the first step is the right clothing and equipment and the second step is working to be a team and working together."

At your fingertips

  

Courtesy of SeeHerWork

SeeHerWork has a full line of products, from gloves and bags to safety vests and long-sleeves shirts. She's launching more products — like coveralls, pants, and footwear — soon.

Suitcase company, Tiko, raised $100,000 in its first crowdfunding campaign. Courtesy photo

Texas-based travel brand unpacks stylish and affordable luggage

Wheels up

If Marcus Segui's successful 2016 Kickstarter is any indication, people are looking for innovative ways to make traveling a little easier. With that intention in mind, Segui launched Tiko, a Texas-based travel brand shaking up the industry by providing affordable, beautifully designed, quality luggage to passengers across the world.

On November 1, Tiko rolled into the world with its signature carry-on, priced at $195, and designed to fit in overhead bins (a must for those of us who find baggage fees insulting). Available only online, the company's first bag comes with 360-degree spinning wheels, and is offered in charcoal and gray.

For the Texas-born Segui, the idea for his company was born out of one thing: he travels — a lot. After a career in finance in New York, Segui traveled to Colombia, a trip that ended up lasting three years. "I got a Spanish tutor, found an apartment, and started looking for a way to do business," Segui says. "Before long I linked up with a local investment fund who asked me to launch a real estate company for them."

"Running a business in Spanish was really hard," he jokes, and by the time Segui decided to leave Colombia, he had logged countless flights across South and Central America. The University of Texas grad eventually made his way back to Austin with a busted carry-on in tow.

"After my time in New York and South America, I decided to return to Austin for two reasons: friends and family. Every entrepreneur needs to lean on their network to get a new company off the ground," he says.

And oh how that network helped. Unable to find a carry-on replacement that was both durable and affordable, Segui got the idea for a direct-to-consumer luggage company designed to bypass retailers and thus cut the price point for the luggage in half.

Segui began development on a series of prototypes, eventually landed on Tiko's current carry-on model, and decided to launch a Kickstarter to gauge interest (and funds, of course). The campaign raised over $100,000, allowing Segui to take off with the new company.

In order to move the company into its next phase, Segui assembled a who's who team of tech talent, including former execs from YETI and Airbnb. Earlier this month, the company officially launched its first product from its coworking space headquarters in South Austin.

A few weeks into the new endeavor, it remains to be seen if the public will embrace Tiko, but its launch points to a growing trend: consumers are demanding a different travel experience. Suddenly, people are beginning to question the inconvenient, expensive, and yes, unstylish things that must be endured in order to get from one point to another.

Perhaps one day we'll return to that glamorous apex of airline travel, the time where no one wore pajamas and passengers didn't have to line up like cattle to board the aircraft. Until then, at least we can have nice luggage.

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This story originally appeared on CultureMap.

B8ta has all the perks of a digital marketplace — but customers are able to physically test all the products. Photo by Natalie Harms

10 futuristic products you can buy today in this Galleria store that's flipping the script on retail

You b8ta believe it

Retail is in a transformative phase, as more and more consumers are shopping online. According to United States Census data, over 9 percent of this year's first-quarter retail sales were e-commerce transactions — that's more than doubled in less than 10 years. But one brick-and-mortar retailer has a new approach to sales for new, innovative products entering the marketplace.

San Francisco-based b8ta opened its first store in 2015, and now has 13 flagship stores nationwide — in addition to having setups in Lowe's stores across the country. Houston's first and only location opened in October of 2017 in the Galleria.

The store acts as a general marketplace, where companies can rent shelf space at the store to feature their products — everything from home accessories to tech gadgets and even items like electric skateboards. Consumers can come into the store and test products, and the developers can see — in real time — how customers are interacting with their products.

"If you look at our store, nothing's in a box. Everything is out on display," says Jalal Bsaiso, b8ta Houston's general manager. "Everything has a tablet with information on the product, and that data is controlled by the maker — they can swap photos, change pricing, all on the fly. They also can see analytics in real time. They can see how many people walk by their product and how long they are engaging. Sales associates log demos we do with the customer, so the partner can see that too."

Bsaiso says that innovators have trouble entering brick-and-mortar sales because consumers need to take the products out of the box to experience them and have a sales associate educate and demonstrate how to use the product. The company's three founders — Phillip Raub, Vibhu Norby, and William Mintun — worked at Nest, a smart home technology product, prior to launching b8ta. They saw Nest struggle to get into brick-and-mortar stores and started envisioning a concept that would be right for products like Nest.

"Online it's easy to sell something," Bsaiso says. "You post it on your website, you have analytics, and you can see how people got to your website and what they purchased. There's nothing like that in physical retail."

Product makers can apply online to become b8ta partners. Usually, each partner has products in at least half of the 13 stores, and every product has an inventory of six to 10 products in the store.

"Retail is evolving," Bsaiso says. "I think everything is moving toward experience. You don't want to spend $200 online on a product that might not even work for you from a company you're not really familiar with."

The store will stock any types of products in its stores, as long as it fits the bill as an innovative product. Here are 10 that seem like are from the future.

A self-caring herb garden

Photo by Natalie Harms

The Véritable Indoor Garden has lights that mimics the sun and a tank of water that together lets your plants be all set for up to 3 weeks.

A camera with 16 lenses

Photo by Natalie Harms

The Light L16 camera would make a spider jealous. With 16 lenses, the camera captures all the different types of lighting and focus to ensure you capture the best picture.

A gadget to make you fluent in every language

Photo by Natalie Harms

Here's one for the world traveler. Pocketalk Two-Way Voice Translator allows you to translate what someone is trying to tell you, and vice versa.

A collar that tells you everything you need to know about Fido

Photo by Natalie Harms

The LINK AKC™ Smart Dog Classic Collar tells you everything from location and body temperature to even recording activity.

A device that swims for you

Photo by Natalie Harms

Going on an underwater adventure? The WHITESHARK MIX Underwater Scooter is the smallest underwater scooter and takes you 3.35 miles per hour with its two propellers.

A shark-preventing ankle band

Photo by Natalie Harms

The Sharbanz technology prevents any nefarious sharks from coming anywhere close to you.

A robot to talk to your child

Photo by Natalie Harms

Tyche AI Learning Robot for Kids learns your child's facial expression, name, and voice to communicate, educate, and interact with him or her.

A next-gen speaker that features the song's lyrics

Photo by Natalie Harms

Ever wonder what that one lyric is in your favorite song? COTODAMA Lyric Speaker will tell you. In addition to featuring the lyrics of most popular songs, the speaker will visualize any tune you queue.

A deep tissue massager the size of headphones

Photo by Natalie Harms

The UGYM mini Deep Tissue Massager vows to relieve back pain and help you sleep better. And, it's on sale.

A handheld smart safety device

Photo by Natalie Harms

Much like your actual father, D.A.D.® 2 (Defense Alert Device), is here to keep you safe. It tracks your location and can send an emergency alert on your behalf. Plus, there's also the military-grade pepper spray to also keep an attacker at bay.

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Greentown Labs names Lawson Gow as its new Houston leader

head of hou

Greentown Labs has named Lawson Gow as its Head of Houston.

Gow is the founder of The Cannon, a coworking space with seven locations in the Houston area, with additional partner spaces. He also recently served as managing partner at Houston-based investment and advisory firm Helium Capital. Gow is the son of David Gow, founder of Energy Capital's parent company, Gow Media.

According to Greentown, Gow will "enhance the founder experience, cultivate strategic partnerships, and accelerate climatetech solutions" in his new role.

“I couldn’t be more excited to join Greentown at this critical moment for the energy transition,” Gow said in a news release. “Greentown has a fantastic track record of supporting entrepreneurs in Houston, Boston, and beyond, and I am eager to keep advancing our mission in the energy transition capital of the world.”

Gow has also held analyst, strategy and advising roles since graduating from Rice University.

“We are thrilled to welcome Lawson to our leadership team,” Georgina Campbell Flatter, CEO of Greentown Labs, added in the release. “Lawson has spent his career building community and championing entrepreneurs, and we look forward to him deepening Greentown’s support of climate and energy startups as our Head of Houston.”

Gow is the latest addition to a series of new hires at Greentown Labs following a leadership shakeup.

Flatter was named as the organization's new CEO in February, replacing Kevin Dutt, Greentown’s interim CEO, who replaced Kevin Knobloch after he announced that he would step down in July 2024 after less than a year in the role.

Greentown also named Naheed Malik its new CFO in January.

Timmeko Moore Love was named the first Houston general manager and senior vice president of Greentown Labs. According to LinkedIn, she left the role in January.

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This article originally appeared on our sister site, EnergyCapitalHTX.com.

Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

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