UH's C. T. Bauer College of Business will house the newly launched Healthcare Business Institute. Photo via Getty Images

The University of Houston announced this month that it has now launched its new Healthcare Business Institute, which will work with medical and business leaders as well as students to find solutions to pressing issues in the health care industry, such as high costs, access to care and new innovative technologies.

The institute will be part of the university's C. T. Bauer College of Business and led by Ravi Aron, research director and professor of health care strategy and technology in the Bauer College Department of Decision & Information Sciences, and Dr. Edward Kroger, the administrative director of the center.

“Providers are facing increasingly limited reimbursement from the U.S. government, insurers and employers. The industry is, therefore, struggling with finding new ways to increase value by improving quality and decreasing cost,” Aron says in a statement. “This is complicated by the fact that the industry is the most heavily regulated in the country. While policy, regulations and the government all have roles to play, efficient care delivery also requires businesses–small, medium, large and startups-to play a significant role in delivering effective and efficient care.”

The institute plans to bring together stakeholders from device makers and pharmaceutical companies to angel investors and educators to address many of these issues. Faculty and partners will release impactful research on topics such as hospital operations, new health care technologies, AI and machine learning in hospital contexts, emerging financial models in health care and a number of other topics.

Research will be shared in a new practitioner-facing Knowledge Portal that will feature a journal, editorials, and other media components like blogs, videos and audio.

The HBI will also have an educational component, with formal degree-based and shorter non-degree tracts, as well as a masters program related to health care leadership. Multiple executive education programs are also in the works.

“This unique combination of researchers, educationists and students will also benefit by connecting to perhaps the world’s most diversified health care ecosystem,” Aron says in the statement.

And Houston is the right place to house such an institute, says Bauer College Dean and Cullen Distinguished Chair Professor Paul A. Pavlou.

“Technology, data, and AI are enabling unprecedented advances in medicine, and Houston’s impressive health care network presents an exciting opportunity for a Healthcare Business Institute,” Pavlou says in the release. “Not only is Houston home to the Texas Medical Center, UH is the only university in Houston that includes a large number of health care researchers at the Bauer College of Business, a world-ranked health law program at the UH Law Center, a computer science department with many distinguished research faculty, and a new College of Medicine."

“The opportunity for meaningful collaboration among health care researchers, industry leaders, and students through HBI will be a tremendous asset for Houston with the potential for local, national and global impact,” he continues.

Earlier this summer, UH announced plans to open a 70,000-square-foot innovation hub next to the M.D. Anderson Library on UH's main campus in 2025. It's slated to house a makerspace, the Cyvia and Melvyn Wolff Center for Entrepreneurship, the Energy Transition Institute, innovation programs, and Presidential Frontier Faculty labs and offices.
UH's business school has a new program focused on artificial intelligence thanks to a partnership with Intel. Photo via uh.edu

University of Houston, Intel team up to prepare workforce for AI revolution

back to school

The University of Houston’s C.T. Bauer College of Business has teamed up with semiconductor chip manufacturer Intel Corp. to provide training in artificial intelligence.

The new artificial intelligence program features a standalone business certificate with two specialized courses; the first course launched in January. Bauer also plans to offer non-degree certificate programs in AI, such as the AI Certificate for Entrepreneurship and AI Certificate for Executive Education.

In a news release, Elizabeth McGee, chief strategy and innovation adviser at Santa Clara, California-based Intel, says the UH initiative will help bridge the AI knowledge gap. An online search indicates hundreds of AI-related jobs are open in the Houston area.

“Digital upskilling, or digital readiness, needs to be a catapult for economic prosperity for everyone and not a dividing point,” McGee says. “I commend the University of Houston for being the first higher education institution to take our award-winning curriculum and lend your expertise in entrepreneurship, your access to the broader Houston community, and supporting this digital upskilling for everyone.”

AI education has taken on a greater sense of urgency as the healthcare and energy sectors, among others, incorporate AI into their operations.

Paul Pavlou, dean of the Bauer College and Cullen Distinguished Chair Professor, says the collaboration between UH and Intel will help propel growth and innovation in Houston’s tech sector. Intel, whose only Texas location is in Austin, is a key player in the expanding AI market.

“Intel has been very generous with their resources, and with our expertise in analytics and faculty research and students’ initiative in bringing new products to life, the opportunities for this collaboration to be transformative are endless,” Pavlou says.

AI is growing at an incredibly rapid pace. According to Precedence Research, the size of the global AI market was estimated at $119.78 billion in 2022 and is expected to reach nearly $1.6 trillion by 2030.

“While some markets, sectors and individual businesses are more advanced than others, AI is still at a very early stage of development overall,” says professional services firm PwC. “From a macroeconomic point of view, there are … opportunities for emerging markets to leapfrog more developed counterparts.”

AI is viewed as both positive and negative in terms of today’s workforce.

“AI is a fast-evolving technology with great potential to make workers more productive, to make firms more efficient, and to spur innovations in new products and services. At the same time, AI can also be used to automate existing jobs and exacerbate inequality, and it can lead to discrimination against workers,” says a report published by the White House in 2022.

Houston Mayor Sylvester Turner and Houston City Council celebrated “AI Innovation and Entrepreneurship Day” at City Hall on Feb. 7. Photo via Facebook

Here's some local Houston startup news you may have missed. Photo by Zview/Getty Images

Houston startups raise funds, enter into new partnerships, and more local innovation news

short stories

Houston startups across industries have been moving and shaking these past few weeks, and there's a chance you may have missed some of these Houston innovation stories.

In this roundup of short stories within Houston innovation, two Houston-based e-commerce startups announce big news, a tech company pitches abroad, and more.

Houston industrial e-commerce startup expands into the construction industry

Houston-based GoExpedi has expanded its business. Photo by Colt Melrose for GoExpedi

GoExpedi, an end-to-end digital supply chain and data analytics company with solutions within procurement and delivery of maintenance, repair, and operations products for heavy industries, announced it has expanded into the commercial construction space.

Builders partnering with GoExpedi now have access to more than 200,000 critical parts and supplies, according to a news release from the company.

"Access to needed tools and materials in construction is already a challenge in today's supply chain environment," says GoExpedi CEO Tim Neal in the release. "Expanding into commercial construction is a natural extension of our capabilities as we already provide significant operational and cost value with our digital platform across similar heavy sectors. We're quickly ramping up the number of construction groups we're working with, giving them a better way to plan for and order materials to help avoid costly building delays."

GoExpedi raised a $25 million series C round in 2020 and is deploying these funds as the company grows. Earlier this year, the startup opened a new industrial and energy MRO warehouse in Pittsburgh, Pennsylvania

UH business college snags prestigious grant

Dean​ Paul Pavlou leads the University of Houston's Bauer College of Business.

The University of Houston's C. T. Bauer College of Business is partnering with Texas A&M University and Temple University to develop and implement an energy risk tracking and alert system in Houston and San Antonio. The research project recently received $1.5 million in grant funding from the National Science Foundation. The grant is part of the Smart and Connected Communities program.

"Advanced Learning for Energy Risk Tracking" (ALERT) is designed to prevent and mitigate costly and potentially devastating electricity outages — such as the 2021 winter storm — according to a news release from UH. Bauer College Dean and Cullen Distinguished Chair Professor Paul A. Pavlou is one of co-investigators.

"If there is one positive outcome of the winter storm, it certainly created an awareness for many people that we need to invest more in intelligent systems that can minimize the huge costs and negative impacts that electricity outages can have on people and local communities," he says in the release. "The idea of this research is to create a data-driven system to reduce, predict, and mitigate costly power outages, especially in traditionally disadvantaged communities that usually suffer the most from power outages."

The ALERT system depends on data generated by utilities, city and county governments, school districts and others, enabling preemptive repairs and allowing officials to react more quickly in the event of unforeseen outages, per the release, and a test version of the resource may begin operating in San Antonio as soon as 2022, followed by a trial in Houston.

"It's a technologically very advanced solution, but the beauty of it is that we are working with local communities to acquire the data, to enhance the system and also feed the data back to the community to actually minimize the impact on the people who suffer most from power outages," Pavlou says in the release.

Houston health tech company receives new investment

Dan Purvis, CEO of Velentium

A Houston company has fresh funding. Photo courtesy of Velentium

Velentium has announced a growth recapitalization in partnership with Connecticut-based Great Point Partners. Houston-based Velentium is an engineering firm specializing in the design and manufacturing of therapeutic and diagnostic active medical devices, and GPP is a leading health care investment firm. The new investment allows Velentium to scale national operations.

"When Great Point reached out to us earlier this year, we were immediately impressed with their deep knowledge of our market and track record building businesses," says Dan Purvis, CEO of Velentium, in a news release. "We continue to build an organization that improves the lives of people and families by helping to bring transformative medical devices to market, and Great Point is uniquely positioned to enable us to do that at an even larger scale. Today, we are starting a new chapter and taking a crucial step in realizing our dream of having 1,000 families as part of our organization."

Velentium was created to advance the next breakthrough medical device technology — all within the same company. Innovators and inventors don't have to go through the processes — from cybersecurity to manufacturing — by themselves.

"Our dream from day one was to create a one-stop shop here in Houston where new startups with IP can come to us and know that start to finish they would have their commercial device ready for approval with the FDA and that we were going to handle everything," Purvis previously told InnovationMap.

With GPP's investment, Velentium is equipped to augment its end-to-end solutions and its nearshore and offshore manufacturing capabilities, per the release.

"Velentium has played a pivotal role in the development of groundbreaking neuromodulation devices that have led to important medical technology advancements," says GPP Managing Director Adam Dolder in the release. "We look forward to being partners with Dan, Tim and the entire team and helping them to achieve their goals for the company."

Houston startup tapped for European pitch competition

Jessica Reitmeier, is the co-founder of Pandata Tech. Photo courtesy of Pandata Tech

Houston-based Pandata Tech is one of 29 companies from around the globe competing in Scotland's Net Zero Technology Centre's Clean Energy Start-up Pitch Battle finals. Each featured company has a technology solution that can help accelerate the transition to a net zero energy industry, and 10 finalists will be selected to pitch at COP 26 UN Climate Change Conference in Glasgow, Scotland, on November 2, 2021.

"These start-ups are truly inspiring. Offering extraordinary innovation and ambition, all these teams are developing technologies that have significant potential to reduce greenhouse gas emissions," says Mark Anderson, TechX Director of Net Zero Technology Centre.

The Ion Houston nominated Pandata Tech to be part of the competition because of the startup's previous work in offshore energy and geothermal utility distribution.

"When we think about reducing C02 emissions by 50 percent or more by 2030 and the data required to meet that mark, it's simple — humans and algorithms need data they can trust," says Jessica Reitmeier, co-founder of Pandata.

Houston e-commerce services provider announces strategic partnership

Houston-based e-commerce software startup and Amazon competitor raises $25M in its series A

Cart.com has a new partner, which has increased access to tools for its clients. Photo via cart.com

Houston-based Cart.com, an end-to-end ecommerce services provider and Amazon competitor, announced a strategic partnership with Clearco, the world's largest ecommerce investor. With the new partnership, Cart.com's clients will receive access to Clearco's capital financing and Clearco's portfolio of over 5,500 companies will have access to Cart.com's end-to-end e-commerce platform.

"We're committed to making all aspects of running an ecommerce business streamlined and hassle-free — and that includes getting access to the capital needed to fuel growth," says Omair Tariq, Cart.com CEO, in a news release. "Through this partnership we're giving online sellers frictionless access to the resources they need to scale up, while allowing founders to stay laser-focused on serving their customers and building their brand."

The two companies share the mission to democratize ecommerce by delivering easier, more streamlined access to critical resources — including capital, services, and domain-specific information — which have previously only been available to companies like Amazon.

"Like Cart.com, we envision a world where founding a business is accessible to everyone, and where founders can access essential capital without having to jump through endless hoops," says Andrew D'Souza, Clearco CEO, in the release. "By partnering with Cart.com, Clearco companies will be able to access the platform's end-to-end ecommerce engine — including online store technology, integrated fulfillment services, and customer service support — to scale their ecommerce growth."

The University of Houston has announced new and evolved online business programs. Photo courtesy of University of Houston

UH launches online MBA, plus six new digital degree programs

online ed

The University of Houston's C. T. Bauer College of Business announced this month that it will begin offering fully online Master of Business Administration and Bachelor of Business Administration programs in the upcoming fall semester.

The new offerings are part of the college's 2020-2025 Strategic Plan that focuses on becoming a leader in digital learning and affordable education options.

In addition to the online BBA and MBA degrees, Bauer is launching five other fully online business-minded graduate programs:

  • Online Master of Science in Business Analytics
  • Online Master of Science in Finance
  • Online Master of Science in Management & Leadership
  • Online Master of Science in Management Information Systems
  • Online Master of Science in Supply Chain Management

Over the summer, Paul Pavlou, dean of the Bauer School and Cullen Distinguished Chair Professor, told InnovationMap that enrollment in the Bauer College had increased by about 70 percent, as the school focused on accessibility and affordability amid the pandemic and record job losses.

According to Pavlou, these new degree programs will be an extension of that effort.

"Given the recent developments due to COVID-19, and the broader challenges for higher education, it has become imperative to enhance our ability to leverage technology to offer courses remotely," he says in a statement.

The seven programs will cost between 15 to 20 percent less than traditional degree programs at the university, according to UH. The new programs will charge in-state tuition for all students, regardless of residency, and online students will not pay additional fees.

"These new offerings demonstrate our dedication to providing students financially accessible programs that emphasize innovation, technology, and experiential learning," says Paula Myrick Short, senior vice president for academic affairs and provost at UH. "Student success is our top priority, and as the need for flexible instruction and course delivery increases, we will meet that need."

The Bauer School has long been touted as one of the top schools for entrepreneurship in the country. In late 2020, UH announced that it received a $13 million donation from the Cyvia and Melvyn Wolff Family Foundation to go toward Bauer's well-known programs, as part of the school's $1.2 billion "Here We Go" initiative.
Rice University and the University of Houston each ranked No. 1 on lists on entrepreneurship programs. Photo courtesy of Rice University

Houston schools reign supreme on lists of best universities for entrepreneurship

we're No. 1

Perhaps Houston warrants a new nickname in addition to Space City and Bayou City. How about Entrepreneurship City?

Rice University tops a new list of the top 25 graduate entrepreneurship programs in the U.S., and the University of Houston lands atop a new list of the top 50 undergraduate entrepreneurship programs. Rice and UH repeated their No. 1 rankings from last year. The Princeton Review and Entrepreneur magazine published both lists November 17.

The Princeton Review ranked graduate and undergraduate entrepreneurship programs based on a survey of administrators at more than 300 graduate and undergraduate schools that offer entrepreneurship programs. Schools were rated according to more than 40 metrics, including the percentage of students taking entrepreneurship courses, the number of startups founded by recent alumni, and the cash prizes offered at school-sponsored business plan competitions.

The Princeton Review, a provider of tutoring, test prep, and college admission services, noted that businesses launched by graduates of Rice's program have launched have raised more than $5.5 billion in capital over the past 10 years. Meanwhile, graduates of UH's program have started over 1,300 businesses in the past 10 years.

Entrepreneurship initiatives at Rice's Jones Graduate School of Business include the Rice Alliance for Technology and Entrepreneurship, which launched in 2000, and its annual Rice Business Plan Competition; the OwlSpark Accelerator, which began in 2012; and the Liu Idea Lab for Innovation and Entrepreneurship (Lilie), which started in 2015. In addition, Rice is developing the Midtown innovation district anchored by The Ion, set to open next spring.

"Entrepreneurship and the creation of new businesses and industries are critical to Houston and Texas' future prosperity and quality of life," Rice Business Dean Peter Rodriguez says in a release.

Here are two highlights of Rice's offerings:

  • Lilie equips students, faculty and alumni with entrepreneurial prowess through courses, co-curricular opportunities, and resources for founders such as coworking space, mentorship, and equity-free funding. Lilie hosts the university's new venture competition, the H. Albert Napier Rice Launch Challenge, in which Rice-founded teams compete for $65,000 in equity-free prizes.
  • The Rice Alliance's flagship event is the Rice Business Plan Competition, billed as world's richest and largest student startup competition. Startups from across the globe — including one team from Rice — compete in front of over 300 investor and industry judges. The competition awarded more than $1.3 million in prizes in 2020.

At UH, Paul Pavlou, dean of the C.T. Bauer College of Business, says the spirit of entrepreneurship is woven into the DNA of the Wolff Center for Entrepreneurship and the Bauer College.

"Entrepreneurship is at the heart of American business life," Pavlou says in a release. "The culture and values of the Wolff Center allow our students to found successful new companies and bring new and innovative ideas to established organizations. We believe these skills will be even more crucial in the coming years as we seek to rebuild our economy post-COVID-19."

Between 35 and 40 students are accepted each year into the Wolff Center's entrepreneurship program. However, more than 3,000 UH students from 85 different majors took at least one entrepreneurship course last year.

"The students at the Wolff Center are not just passionate about entrepreneurship. They are eager to take the lessons learned in the classroom and enhance their lives," Dave Cook, executive director of the Wolff Center, says in a release. "Purpose isn't just a class in [the center]. It is a challenge to create the best life possible, with a focus on the student's values and on doing good in the world."

Other than UH, these Texas schools appeared on the list of the top 50 undergraduate entrepreneurship programs:

  • Baylor University, No. 7
  • University of Texas at Dallas, No. 18
  • University of Texas at Austin, No. 24
  • Texas Christian University, No. 27
  • Texas A&M University-College Station, No. 35

Aside from Rice, these Texas schools made the list of the top 25 graduate entrepreneurship programs:

  • University of Texas at Austin, McCombs School of Business, No. 6
  • University of Texas at Dallas, Naveen Jindal School of Management, No. 10
  • Texas A&M University-College Station, Mays School of Business, No. 26

"The schools that made our ranking lists for 2021 all offer exceptional entrepreneurship programs," Rob Franek, The Princeton Review's editor in chief, says in a release. "Their faculties are outstanding. Their courses have robust experiential components, and their students receive outstanding mentoring and networking support."

This week's innovators to know include University of Houston business school Dean Paul Pavlou, the PR Boutique's Karen Henry, and SecurityGate Founder Ted Gutierrez. Photos courtesy

3 Houston innovators to know this week

Who's who

As another week begins, there's a few people you should know within the business and innovation world of Houston.

This week's Houston innovators to know includes a quick-thinking business school dean leading a college virtually, a public relations expert with the reasons you need to focus on social media for your business, and an entrepreneur who's providing key resources for business owners looking to safely get workers back in the office.

Paul Pavlou, dean of the C.T. Bauer College of Business at the University of Houston

Courtesy of The University of Houston

The University of Houston's C.T. Bauer College of Business is going to remain completely online only through the summer. And, while that might present some challenges for students and staff, Dean Paul Pavlou says he's actually seeing an increase in enrollment. Plus, the virtual platforms allow faculty to support more classes.

"One advantage of online learning is it's very flexible — we aren't confined to the classroom," Pavlou says on this week's episode of the Houston Innovators Podcast. "We've opened up more sections and seats to make it easier for students to sign up." Read more and stream the episode.

Karen Henry, founding partner of The PR Boutique

Photo courtesy of the PR Boutique

Public relations expert Karen Henry, who founded the PR Boutique based in Houston, shared in a guest column for InnovationMap how key — especially in times like these — your company's online pressence is.

"We cannot work in silos; instead, we need to have a comprehensive approach, including tactics such as media relations, community partnerships, unique events, influencer collaborations, digital and traditional advertising, email marketing and social media," Henry writes.

Social media, she argues, can be a powerful, cost-effective tool. Read more.

Ted Gutierrez, CEO and founder of SecurityGate

Courtesy of Security Gate

Houston-based software startup SecurityGate Inc. specializes in cyber-risk management for companies, but this spring, SecurityGate shifted to a different type of risk management — keeping workplaces healthy in the wake of the coronavirus pandemic. The company launched a cloud-based wellness technology, available through an online platform and a mobile app.

"The biggest thing that I want people to know is you don't have to come up with your own workflow and you don't have to spend tons of money to get your people back to work," says Ted Gutierrez, co-founder and CEO of the three-year-old startup. "There's a company out there that is already doing this for a living, so this is the least we could do to help out." Read more.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."