From research and venture capital funding to startup growth and accelerator applications opened, here's what you need to know in Houston innovation news. Photo via Getty Images

The month of May has started strong with Houston innovation news, and there might be some headlines you might have missed.

In this roundup of short stories within Houston startups and tech, local universities share big moves in cybersecurity and plant research, a Houston entrepreneur raises extra seed funding, and more.

Houston medical technology accelerator opens applications

This medtech startup accelerator has applications open. Graphic via proximacro.com

M1 MedTech, Proxima Clinical Research's medical technology accelerator is accepting applications for its fall cohort. The program is seeking five to seven early-stage medical device companies for the three-month program. The cohort companies will have investment opportunities up to $100,000 as a combination of both cash and in-kind services.

“Our program is unique in that it combines acceleration capital, company building expertise, and the regulatory and clinical services of a top CRO,” says Larry Lawson, a venture partner and investor with M1, in the news release. “Access to the M1 founders’ network, both within and outside of the Texas Medical Center, sets these companies up for success. There’s no better group to build a MedTech company with, period.”

M1 MedTech, which was announced last year, was created to support early-stage medical device companies with a unique coaching process that will include a curated educational program, interactive workshops where participants can continually build out specific company deliverables, and tailored one-on-one mentoring.

“Many MedTech companies are launched by innovative first-time founders with strong scientific and medical expertise, but who have never taken a regulated product to market or built a business. After working with so many companies at various stages of this journey to market, both with Proxima CRO and with accelerators from across the country, we realized there was a gap that needed to be filled for these rising founders. They not only need regulatory and clinical assistance from experts with hundreds of success stories in this field, we found they also need assistance with design, manufacturing, business, IP, and so much more,” says Isabella Schmitt, RAC, Director of Regulatory Affairs for Proxima CRO and Principle at M1. “These rising founders need to know what they don’t know; so, we put a lot of thought into what emerging companies and rising executives really need, and from that, we built the M1 curriculum.”

Applications will remain open until May 31. To apply for the Fall 2022 cohort or to learn more about M1 MedTech, visit m1medtech.com.

Houston entrepreneur adds $1M to seed round

Houston-based Upgrade has raised additional seed funding. Photo via LinkedIn

Houston-based Upgrade Boutique — which uses technology to connect women with high-quality wigs and hair extensions — extended its seed round by $1 million, Fast Company reported. The round's initial seed leaders included Houston-based venture capital firms Artemis Fund and Mercury Fund, as well as Logitech president and CEO Bracken P. Darrell and ANIM.

“This [investment] will enable us to scale even faster and continue to invest in tools and resources that will improve the consumer experience, and help stylists operate more efficiently,” Winters tells Fast Company. “Based on feedback from the stylists on our platform, we see this as a natural development in the company’s evolution.”

University of Houston joins cybersecurity initiative

UH joins group that's advancing cybersecurity. Image via Getty Images

The University of Houston has joined a consortium that's funded by the U.S. Department of Defense (DoD) to launch a virtual institute that will recruit and train the next cybersecurity generation that will protect entities from cyber warfare, cyber espionage, and attacks on the electromagnetic spectrum.

The virtual institute is called VICEROY — Virtual Institutes for Cyber and Electromagnetic Spectrum Research and Employ — DECREE and will be led by Northeastern University and offered across five universities, including UH, Northern Arizona University, the University of Texas at Austin, and the University of South Carolina.

“The VICEROY DECREE virtual institute consortium model is transformational. It brings together the best offerings from multiple institutions to meet the workforce training needs in these domains," says Hanadi Rifai, Moores Professor of civil and environmental engineering and UH team lead on the project, in the news release.

One major focus for the program is the electromagnetic spectrum, which includes radio waves, and is a critical enabler for communications, navigation, radar, training and other military operations. The DoD has been seeking to hire more than 8,000 cyber workers to help defend the virtual space.

"We recognize the importance and need for workforce training in cybersecurity, electromagnetism, cryptography and data science. These are areas of specific focus and expertise on our campus,” says Paula Myrick Short, UH senior vice president for academic affairs and provost, in the release.

The two-year program starts in fall 2022 and is funded by a $1.5 million award from the Griffiss Institute, a nonprofit talent and technology accelerator for DoD and its academic, government, and industry partners around the world.

Local composting company moves into new Houston space and expands to Austin

Moonshot has expanded locally and statewide. Photo courtesy of Moonshot

Houston-based Moonshot Composting has announced its relocation to a 8,225-square-foot space in Northside Village at 1410 Bigelow St. The former Yellow Cab outpost is over five times the size of the originally location.

Additionally, this month Moonshot will open its doors in the greater Austin area with a facility in Creedmoor, just south of Austin. Moonshot's first commercial customer was Austin-headquartered Tacodeli.

The company has grown its business to nearly 500 subscribers, including 40 commercials accounts, as well as seven full-time and four part-time employees. Moonshot is diverting 30,000 pounds of food waste a week, with a total of nearly 1,000,000 pounds diverted since July 2020, per a news release.

“We are excited about our growth and all the individuals and companies getting on board to get food waste out of landfills and onto composting sites,” says Chris Wood, Moonshot principal and co-founder, in the release. “Our new space will make for more efficient operations all around.”

Moonshot Composting's commercial subscribers include Rice University, Houston Baptist University, The Awty International School, ConocoPhillips, Snooze Eatery, Ostia, and Amli Residential.

Rice University biologist wins NIH award

This Rice University scientist has received national recognition for her work plant cell analysis. Photo courtesy of Rice

A Rice University postdoctoral fellow and molecular and cell biologist has received a prestigious National Institutes of Health award.

Durre Muhammad of Rice Academy won the MOSAIC (Maximizing Opportunities for Scientific and Academic Independent Careers) K99/R00 award, which is intended to help postdoctoral researchers transition into careers while enhancing diversity within the academic biomedical research workforce, according to a news release from Rice. She's only the fourth individual from Rice to receive this recognition.

The first two years of the award will support the biologist's work in Bonnie Bartel's lab. She is working on defining the mechanisms by which cells in plants identify and eliminate damaged or obsolete organelles known as peroxisomes, which also play important roles in human aging.

“Our lab in general works on all things peroxisome, and I mainly focus on the latter stage when it’s ready for degradation,” Muhammad says in the release. “We identify the signals and different mechanisms involved in the process of decay.”

Muhammad joined Rice in 2018. She earned her Ph.D. in plant and microbial biology at North Carolina State University and her bachelor’s degree in biological sciences from the University of Illinois Chicago. She also has her MBA from Benedictine University. She received an NSF Postdoctoral Fellowship in Biology in 2019.

“Durre is a fantastic scientist who has brought new perspectives and approaches to my lab,” says Bartel, the Ralph and Dorothy Looney Professor of BioSciences. “We are delighted that NIH has recognized her accomplishments and potential with this award.”

Since Moonshot Composting's inception, its subscribing businesses and residents have diverted more than 209 thousand pounds of food waste from landfills. Photo courtesy of Moonshot

Houston-based composting startup grows commercial and residential subscribers amid pandemic

green initiatives

From landfills leaking into the water supply to reports of recycling being dropped in landfills, Houston's sustainable future has been mired by waste management faux-pas. According to a fact sheet from the City of Houston, 81 percent of trash in Houston ends up in landfills. Brothers-in-law Chris Wood and Joe Villa co-founded Moonshot Composting in hopes of improving Houston's environmental future.

After the birth of his second child, Wood stepped away from his career as a corporate attorney to stay home and find new opportunities outside of law.

"Just through conversations and reading, it became clear that Houston had not yet picked up the pace on diverting food waste as a city," says Wood.

Composting, a method of decomposing organic solid wastes that's growing in popularity, diverts trash like food and paper towels into compost that can be used to grow plants. While letting your waste have a second life sounds like a sweet deal, it's also a sustainable one. More compost means less waste in landfills, a major contributor to harmful greenhouse gas emissions.

The scarcity of composting options left Wood with answers to what was holding Houston back. Was it the sheer size of the city alone? He reached out to Villa, who had spent 15 years in transportation logistics, with a laundry list of questions.

"How do we minimize a real waste stream that's going to the landfill and maximize streams of materials that we're not using anymore to be reused in some new form or fashion," poses Wood.

It wasn't long before Villa and Wood entrenched themselves in research. The two traveled to South Carolina for the U.S. Composting Council's annual conference last January and left feeling inspired to bring their idea to fruition. Like the rest of the world, they couldn't have anticipated that COVID-19 would rattle the nation in the weeks to come and cause a string of lockdowns across the U.S.

Brothers-in-law Chris Wood and Joe Villa co-founded Moonshot Composting in hopes of improving Houston's environmental future. Photo courtesy of Moonshot

"Even though the pandemic hit before we launched our business, we were far enough along that we felt like we could do this safely," says Wood. A benefit of Moonshot Composting's structure was its drop-off and pick-up style program for both businesses and consumers.

The two co-founders weren't the only people finding a newfound passion for. According to Google Trends, users were searching for ways to compost at home at increased rates after the first stay-at-home order was announced last March. As people were learning to back sourdough and building their puzzle collections, they were also wondering how to be more sustainable in their households. The keywords "composting at home" surged to its greatest peaks during April, July and September in 2020.

With a growth-focused plan to help Houston be greener, Moonshot Composting recently participated in cohort 3 of The Ion's Smart and Resilient Cities Accelerator, where Villa and Wood gained insights from mentors and business leaders.

The momentum has continued with the company's latest release: a digital Diversion Dashboard for residential customers who track their composting totals, compare their composting to other communities, and share the statistics on social media.

"We knew from the time that we started, that there was an opportunity to introduce technology to improve people's behavior around the trash can," says Wood. "Our plan was to operate for at least a year and understand what it's like to help people compost in their business and at home. From the beginning [of our business], we weighed everything we picked up, because we knew that what you can't measure you can't change."

After putting in place a system to weigh each compost pick-up, the two reached out to their network to bring in outside developers.

The proprietary dashboard also translates the weight of compost to residential impact. Looking at Wood's own dashboard, he can see that his compost weighs the equivalent to 168 pineapples and can notice that his neighborhood is ranked second on Moonshot Composting's list of serviceable areas.

A version of the Diversion Dashboard was first made available to commercial subscribers in the spring on a trial basis. Similar to the consumer platform, the commercial dashboard provides carbon equivalencies to compare your environmental impact like pounds of carbon dioxide removed from the atmosphere and "un-driven" miles.

Moonshot Composting's commercial subscribers include Rice University, Houston Baptist University, The Awty International School, ConocoPhillips, Tacodeli, Snooze Eatery, Ostia, and Amli Residential.

Since Moonshot Composting's inception, its subscribing businesses and residents have diverted more than 209 thousand pounds of food waste from landfills.

While the gamification of composting is new, research on the subject is promising. Gamification has been a powerful tool in the consumer technology apparatus for years. Various studies have analyzed the effectiveness of gamification as a self-motivating tool that has a positive impact on health and wellbeing and increases the meaningfulness of an action.

You can drink from a water bottle that awards you for reaching your daily intake, compete with your friends to see who took the most steps using AppleWatches or FitBits, and run miles to earn money for charity. When not enter some healthy competition with your neighbors using the Diversion Dashboard?

When creating the dashboard, Wood and Villa sought to create a fun way to motivate Houstonians to compost and connect with others over their environmental efforts. While cities like Seattle and San Francisco have established city-wide composting program, the co-founders are enthusiastic about expanding a coalition of eco-savvy Houstonians.

"Whether it's good or bad, we [Houston] don't always lead with government mandates, but we always lead with businesses working together with communities to try to do good," says Wood, "We can do it through innovation and that kind of matches the Houston spirit."

The Ion Smart and Resilient Cities Accelerator has announced its most recent cohort ahead of moving into the physical hub later this year. Photo by Natalie Harms/InnovationMap

Houston accelerator announces third cohort focused on sustainability

seeing green

The Ion Smart and Resilient Cities Accelerator has named the five companies participating in its latest cohort, which starts next week.

Launched in 2019, the programing for the accelerator and its member companies focus on addressing the needs and challenges the city of Houston and other major metros are facing — including climate change. The five selected companies will start the 12-week program next week with a goal of securing a pilot with the city.

"We're thrilled to kick-off Cohort 3," says Christine Galib, senior director of programs at The Ion, in a news release. "The ISRCA remains a core asset in The Ion's Programs portfolio, since it enables recurring collisions, connections, and collaborations among startups, stakeholders, and subject-matter experts."

The selected startups are:

  • Phase Filter/Kinetic Synergies: The university-born startup has created an automatically changing air filter that works with existing HVAC systems to lower cost and energy use as well as eliminate the annoying chore.
  • Frakktal: In an effort to create a circular economy, Frakktal repurposes and reuses discarded polymer materials from the greater Gulf Coast region to also use in the same region.
  • Moonshot Compost: The company collects food waste from Houston residents and businesses via curbside pickup and drop-off while also collects and provides data on each pickup.
  • Teratonix: Using radio frequency (RF) electromagnetic from radio /TV broadcast, cell phone tower, wifi routers, and more, Teratonix provides solutions to generate electricity.
  • Smart Watts:The company taps into smart meter sensors to enable a personalized energy monitoring dashboard that provides users with data to make better energy use decisions.

"The ISRCA Cohort 3 will highlight companies that focus on making sure Houston is here for generations to come," says Courtney Cogdill, program manager for The Accelerator Hub at The Ion, in the release. "By activating the Houston innovation ecosystem and showcasing Houston's talent, Cohort 3 will spotlight Houston as a city committed to sustainability."

The previous cohorts of the program focused on resilience and mobility in Cohort 1 and cleantech for Cohort 2.

"As the world-at-large expands their mobility with social distancing restrictions lifted, it's important cities and businesses review their sustainability practices and carbon footprint and continue to improve upon the progress that's been made," says Jan E. Odegard, interim executive director of The Ion, in the release. "The Ion is excited to empower entrepreneurs who will play a critical role in improving sustainability. With Houston and our diverse and innovative industries as a backdrop, The Ion is prepared to address the challenges sustainability will face in a post COVID-19 world."

The program will be housed in The Ion, a 266,000-square-foot mixed-use structure, which is expected to open within the next few months, along with the organization's other accelerator programs.

Learn more about The Ion's accelerators by streaming this recent Houston Innovators Podcast with Galib and Cogdill:

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 23 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.

Elon Musk's SpaceX is about to make its debut on Wall Street

Money Moves

Elon Musk's rocket company SpaceX will make its debut on Wall Street Friday, June 12, and both institutional and retail investors are expected to gobble up the 555.6 million shares going up for sale at $135 apiece. Musk, already the world's richest man, could become its first trillionaire.

SpaceX is likely to become the biggest IPO ever, with proceeds of around $75 billion. SpaceX hopes to become the first company to send people to Mars. In fact, part of Musk’s future compensation depends on SpaceX eventually establishing a colony of at least 1 million people on the red planet.

Why SpaceX is going public now

In a video conference on Musk's social media platform X, he told JPMorgan CEO Jamie Dimon that people have suggested for the last 10 years that he take SpaceX public. He's doing it now because the company plans to put 100,000 next-generation Starlink satellites into orbit. Deploying AI data centers in space is a “massive new growth base and you need capital for that,” he said.

Going public provides access to the capital that SpaceX needs. But it also exposes it to more scrutiny from shareholders and more regulatory oversight. That includes filing quarterly financial reports, which critics say incentivizes short-term thinking over longer-term planning and creates unnecessary costs for a company. Securities regulators are currently soliciting public comment on a proposal to require public companies to file the financial reports only twice every year.

How the IPO impacts the company

Musk will hold the majority of a special class of shares, giving him control over decisions related to company strategy, finances and personnel. On the latter, because of his ownership of most of these Class B shares, the only person who can fire Musk as CEO is Musk.

The company credits Musk with being the “driving force” behind its growth, innovation and success. But what happens if Musk is no longer in the picture? SpaceX warns that the loss of Musk could disrupt its ability to execute its strategy as well as hurt its “reputation and relationships with customers, partners and other stakeholders.”

The company also warns that finding a replacement with the same skills and experience as Musk would be time-consuming, if not nearly impossible. As Wedbush Securities analyst Dan Ives wrote Wednesday, “At the end of the day Musk is SpaceX and SpaceX is Musk.”

What could make or break SpaceX

Currently in the test phase, the gigantic reusable Starship rocket is key to SpaceX realizing Musk's ambitions. Much of the commercial space business hinges on SpaceX developing Starship’s capability to be fully reusable and hearty enough for a quick turnaround between flights. If that doesn't happen, SpaceX warns that putting data centers and satellites in space will take longer and cost more money, meaning it risks customers bailing on the company.

Analysts say that by pioneering reusable rockets, SpaceX has established a clear lead on competitors such as Blue Origin, led by Amazon founder Jeff Bezos. The Starlink satellite business competes with, among others, AST SpaceMobile – which is relying on a SpaceX rocket to send its latest generation of satellites into orbit next week.

The prospectus filed last week says SpaceX’s biggest potential market is the sale of business-oriented artificial intelligence products designed to transform how people get work done. It’s an opportunity SpaceX predicts would be worth $22.7 trillion if it could somehow dominate rivals like Anthropic, OpenAI and Microsoft in a highly competitive industry. But the prospectus shows no clear path to profitability for the xAI business, which merged with SpaceX earlier this year.

Why Wall Street is paying attention

If the SpaceX IPO is as successful, the stock could quickly join the Nasdaq 100, a widely followed index that tracks the 100 largest non-financial companies in the composite. That's important because some popular funds, such as the $460 billion QQQ exchange-traded fund, mimic the index and will automatically buy whatever is listed in the index.

Nasdaq recently changed its rules to allow select companies to enter the Nasdaq 100 after just 15 trading days.

S&P Dow Jones Indices, on the other hand, is sticking to established and more traditional thresholds that will not allow SpaceX or other companies with gargantuan IPOs faster entry into its S&P 500 index. That means even high-profile companies will still need to wait for their stocks to trade a full 12 months before they can enter the index.

Companies want to be in the S&P 500 in particular because it's arguably the most important index on Wall Street, with trillions of dollars either mimicking it exactly or benchmarked against it. Vanguard's VOO fund that tracks the S&P 500 has roughly $950 billion invested in it, for example.