The Ion Smart and Resilient Cities Accelerator has selected its next cohort. Courtesy of The Ion

As the world celebrated the 50th annual Earth Day on April 22, a Houston innovation organization announced a new group of startups for its accelerator program that will focus on cleantech solutions within the city of Houston and beyond.

The Ion's accelerator, which recently renewed its focus on resiliency, announced its second cohort with six startups that will create solutions for Houston's air quality, water purification, and other cleantech needs.

"Through leveraging the power of our local Ion community, The Ion Smart and Resilient Cities Accelerator is committed to solving challenges Houstonians face every day," says Christine Galib, senior director of accelerator programs at The Ion and the director of the accelerator, in a news release. "We connect participating startups with mentors, partners, and stakeholders, so they gain access to the resources they need to build, validate, and scale their technologies. Together, we are building a safer, smarter, and more accessible city for all Houstonians."

The program is supported by Intel, Microsoft, and TX/RX and has began its programming for the new cohort. The six startups selected for the program are:

  • Houston-based Eigen Control uses machine learning and chemical engineering models to combat rising CO2 emissions. Distillation process plants emit so much CO2 — and Eigen Control's processes are working to change that.
  • Houston-based Annapurna Solutions has cloud-based solutions for hazardous and solid waste management.
  • Mexico City-based S2G Energy focuses on sustainable and optimized solutions for businesses and governments with its energy-management-as-a-service technology.
  • Houston-based re:3D is a 3D-printing nonprofit that is democratizing small-scale manufacturing. Its Gigabot can use recycled and reclaimed materials for more sustainable and affordable production. The company, which has offices in Puerto Rico and Austin, donates a printer to someone making a difference with every 100 printers it sells.
  • Austin-based LifePod Corps is a nonprofit that provides disaster relief through renewable and sustainable technologies built and delivered by military veterans.
  • Houston-based Water Lens has created a real-time water data analytics platform for industries that use a lot of water — like oil and gas, agriculture, power generation, coal mining, and food processing. The technology allows for quicker, more reliable results.

The accelerator's leaders chose its theme for the cohort based on the City of Houston's Resilient Houston Strategy and Climate Action Plan. The program has identified these six startups as movers and shakers within these Smart Cities challenges.

"We are thrilled to collaborate with these startups to further develop Houston as one of America's smartest and most resilient cities," says Gabriella Rowe, executive director of The Ion, in the release. "By leveraging our resources and networks, the accelerator and Cohort 2 improve living conditions for all Houstonians. In this way, we stimulate our local economy with new jobs and economic opportunities."

Last year's inaugural cohort was announced in August and focused on resilience and mobility. After a demo day in December, the cohort continued its work in Houston through 15 pilot programs the startups had with the city. The third cohort is expected to launch toward the end of 2020, but the next theme has not yet been decided.

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Houston brain health co. secures $6.5M for rare disease study

neuro funding

Houston-based Goldenrod Therapeutics, part of Fannin Partners' portfolio, has announced the initial close of a $6.5 million series seed preferred stock round.

The round was led by Ataxia Ventures and an affiliate of Fannin, according to a news release.

Goldenrod Therapeutics plans to use the funding to support manufacturing, formulation optimization, IND-enabling studies and a Phase I study of its drug to treat brain inflammation, known as 11h.

The study will consider how 11h, which blocks the enzyme PDE4, could treat Friedreich’s ataxia (FA), a rare genetic disease that affects movement, speech and balance. To date, other PDE4 inhibitors have proven to regulate neuroinflammation and neuronal signaling, but have had adverse gastrointestinal side effects or have not reached enough of the central nervous system, according to Goldenrod.

The company says its 11h is expected to have "broad applicability" with limited emetric side effects.

“Our 11h program is a next-generation, orally bioavailable, brain-penetrant PDE4 inhibitor, where researchers overcame longstanding limitations associated with earlier PDE4 inhibitors," Dr. Dev Chatterjee, CEO of Goldenrod, said in the news release. "We believe this creates the potential for a best-in-class therapy for Friedreich’s Ataxia and a potential foundation for development across multiple neurodegenerative and neuroinflammatory disorders.”

11h was first developed at the University of Nebraska Medical Center (UNeMed). Houston-based Fannin Partners in-licensed the product 2020 and landed SBIR Phase I funding to support its initial development for opioid use disorder soon after.

Goldenrod has also received funding to study 11h's effectiveness for multiple sclerosis, methamphetamine addiction and cocaine addiction.

Goldenrod says it is developing 11h to target a variety of neurological and inflammatory conditions, including Alzheimer's disease, multiple sclerosis, ALS, substance use disorders, Batten disease, pain and traumatic brain injury.

27 Houston companies make Fortune 500 for 2026, led by energy giants

Houston HQs

Editor's note: This article has been updated to correct the number of companies based in the Dallas-Fort Worth area.

Houston is a giant among U.S. hubs for corporate headquarters.

The 2026 Fortune 500 lists 27 companies based in the Houston area, with many energy companies claiming top spots. Houston ties with Chicago for the second-most Fortune 500 headquarters, preceded only by New York City (53). Dallas-Fort Worth is home to 24 Fortune 500 headquarters.

Texas leads the nation for Fortune 500 headquarters (57), with California in the No. 2 spot and New York at No. 3.

“Texas is the undisputed headquarters of headquarters,” Gov. Greg Abbott said in a news release. “The world’s leading businesses invest with confidence in Texas because of our welcoming business climate, predictable regulatory environment, and skilled and growing workforce. People and businesses are choosing Texas because Texas works.”

The 2026 Fortune 500 ranks the largest U.S. corporations based on revenue in fiscal year 2025.

Here’s a rundown of the 27 Fortune 500 companies based in the Houston area.

  • No. 9 ExxonMobil
  • No. 21 Chevron
  • No. 29 Phillips 66
  • No.55 Sysco
  • No. 75 ConocoPhillips
  • No. 89 Enterprise Products Partners
  • No. 103 Plains GP Holdings
  • No. 133 Hewlett Packard Enterprise
  • No. 149 NRG Energy
  • No. 157 Quanta Services
  • No. 164 Baker Hughes
  • No. 173 Occidental Petroleum
  • No. 179 Waste Management
  • No. 201 EOG Resources
  • No. 204 Group 1 Automotive
  • No. 207 Halliburton
  • No. 223 Cheniere Energy
  • No. 236 Corebridge Financial
  • No. 262 Targa Resources
  • No. 266 Kinder Morgan
  • No. 388 Westlake
  • No. 435 CenterPoint Energy
  • No. 438 APA
  • No. 440 Comfort Systems USA
  • No. 455 NOV
  • No. 488 KBR
  • No. 496 Coterra Energy. Oklahoma City, Oklahoma-based Devon Energy and Houston-based Coterra Energy merged in early May, with the combined company retaining the Devon Energy name and the Houston headquarters.

The Greater Houston Partnership notes the Houston area soon will welcome its 28th Fortune 500 company. Expand Energy (formerly Chesapeake Energy), appearing at No. 362 on the 2026 list, says it’s moving its headquarters from Oklahoma City to Spring this year.

As the natural gas producer prepares to relocate to Texas, it’s hunting for a new leader. Nick Dell’Osso stepped down as president and CEO earlier this year. Board Chairman Michael Wichterich is interim president and CEO.

Dell’Osso became president and CEO of Oklahoma City-based Gulfport Energy effective May 28.

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This article first appeared on EnergyCapitalHTX.com.