Houston's innovation leaders weigh in on community's growth, progress

Houston innovation awards

Get to know the Houston innovation community's top ecosystem builders. Photos courtesy

This year's finalists in the Ecosystem Builder category for the Houston Innovation Awards have a lot to say about the city's innovation community — and they are the right ones to say it.

Selected as finalists for the newly created category, each of the five finalists are leaders for the Houston innovation ecosystem. They were each asked some questions about the development of the Houston tech and startup community. Here's what they had to say.

InnovationMap: What is your favorite part of Houston's innovation ecosystem? How have you helped contribute to that aspect of the community?

Jan E. Odegard, executive director of the Ion: Can do attitude and willingness to make big bets that can solve hard problems with global societal impact. Creating and supporting a place where this can happen is critical to the success, a place where we create the necessary density for collisions and that will sprue the next ideas.

Jason Ethier, co-founder of Lambda Catalyzer and host of the Energy Tech Startups podcast: Perhaps small, but the Ion District in the small part we have to play in it. Being able to be in a place where you can cross paths with active investors, innovators and partners. This is the hub we hoped to build over the last few years. That connective tissue may be small and focused compared to other ecosystems, but it is very strong here.

Joey Sanchez, founder of Cup of Joey and senior director of ecosystems at the Ion: My favorite part of the Houston Innovation Ecosystem is the progress and potential. We have gone from talking about how to build a Houston ecosystem to now exploring our collective potential. The conversations are now tactical actions to scale our efforts.

Kendrick Alridge, senior manager of community at Greentown Labs: My favorite part of the ecosystem is the Cup of Joey gathering. It's a great opportunity to run into or catch up with people looking to get involved in the ecosystem or looking for support. It's a great networking opportunity.

Wade Pinder, founder of Product Houston: I love seeing how the community has really connected this past year specifically. We've gathered momentum and have a "gravity well" of community leaders feeding value to one another.

IM: What are the strengths of the Houston innovation ecosystem?

Odegard: Access to (engineering) talent, capabilities, and global connectivity that are not afraid of getting her hands dirty to build and scale.

Ethier: The diversity of the founders and the intrinsic diversity of the Houston ecosystem. There are few native Houstonians, and most of the fantastic founders we meet are from somewhere else. The energy industry brings the best of the best from around the world and they inject Houston with unique excellence.

Sanchez: We are a resource right environment. We have a plethora of talent and capital. With the economy the size of Belgium, we have access to industries and talent unlike any other city. Also the convergence of energy, medical and aerospace is one of a kind. Each industry is transforming and providing a ripe opportunity for innovation.

Alridge: The growing number of startup development organizations (SDOs), incubators and accelerators, makerspaces, co-working spaces, non-profits, and academic institutions that is available is a strength, because their are plenty of places to get support and your ideas off the ground.

Pinder: We do hard things here because the ARE hard! 1) Life and death situations en masse, 2) infrastructure at scale 3) Boldly going where no one has gone before! That's what we've done here. That's what we stand to innovate on! If it's a hard problem, Houston gets it done!

IM: What are the weaknesses of the Houston innovation ecosystem? Are you helping to make improvements to these weaker aspects of the community and, if so, how?

Odegard: Access to more risk capital.

Ethier: We need a skill set on scaling businesses. This is something the valley does exceptionally well. When there is product market fit, the startup ecosystem knows how to scale teams from 20-200 and do so repeatedly. Houston knows how to do big energy projects; from sput to TD, there is a skill set here around complexity...but how that applies to scaling businesses its unclear we have what it takes. This is why its imperative we bring in mature startups from around the country and try to transfer knowledge from the energy industry into the startup space. Building an acceleration program like Lambda is a step in solving this problem.

Sanchez: Density is our biggest challenge. The geographic sprawl of our region is vast. Serendipitous meetings are a challenging. The Ion has created a central place where our ecosystem can come together. Every Friday we meet for Cup of Joey and now we host a Cup of Joey in The Woodlands, Space Center Houston, Sugar Land and The Cannon West. Creating eight Cup of Joey meetups each month. The most exciting element of Cup of Joey is coming in an online platform for connection.

Alridge: We need a robust cadre of startup specialists, serial entrepreneurs who have successfully started companies. Especially in business and STEM fields, is needed in the innovation system. Higher education in providing talent is important, I'm doing my part by organizing opportunities for students to work with our startups which can directly and indirectly contribute to the workforce and the grown startup community.

Pinder: We're changing this... but we still have a ways to go with the "I'm good... what do I need to show up for?" thinking. It's not for lack of wanting to show up... traffic makes it tougher to show up most of the time.

IM: What do you wish more people knew about the Houston startup community?

Odegard: That Houston IS a tech hub addressing some of the biggest societal challenges we are face today, such as: power (security), healthcare (affordable and accessible), sustainability (clean and green), and equitable access to economic opportunities.

Ethier: How climate focused everyone is, from the founders, to the SMEs, industry and SMEs. Houston (and energy companies) know how to manage what's measured and now that we have targets around decarbonization, we are going to get it done.

Sanchez: I wish the world knew more about Houston and our Houston startup community. I believe that our foundation is strong and we are ready for scale. 2026 to 2036 will be a decade of massive growth for Houston and our ecosystem.

Alridge: We are more than oil and gas and health care.

Pinder: We've got the solutions to some huge problems sitting right here in Houston.

Click here to secure your tickets to the November 8 event where we announce the winner of this exciting new category.

From Your Site Articles
Capital Factory will have a branded area in The Cannon when it opens its new facility. Courtesy of The Cannon

Capital Factory hires two Houston-based employees to grow its local presence

Onboarding

A major Texas innovation player with roots in Austin has now staffed its recently announced Houston outpost in partnership with The Cannon Houston. Capital Factory hired two Houstonians to help provide resources for its growing Houston-based portfolio companies.

Kendrick Alridge has been hired as mentor coordinator, and Brittany Barreto, who founded Pheramor and WeHaveChemistry, has been named the venture associate. Aldridge will focus on growing and cultivating relationships with Houston mentors, and Barreto is dedicated to reaching out to Houston startups to gauge their potential for Capital Factory participation.

Hiring these Houstonians and having these new boots on the ground is a key factor for Capital Factory as it grows its Houston presence, says Gordon Daugherty, president at Capital Factory.

"It's important for us to think Texas, but act local," Daugherty says. "What that means is we can't just assume that the way we do things and the things that made us successful in Austin will directly translate to Houston. Houston is a different market. That's one of the things we learned from Dallas."

Acting locally entails listening and learning to what the community wants and engaging with local organizations to contribute value to the market.

"We don't know how or in which ways, but we know Houston will be different from Dallas and Austin," Daugherty says. "In this way, we are advantaged by our two employees being from the Houston area. They're our eyes and ears, for one, but they are also the voice of Houston to us along with other ecosystem players."

While local resources and personnel are both new for Capital Factory, the organization already has over 20 portfolio companies that are based in the Houston area. Now, these companies will have new resources close to home and can also act as Capital Factory representatives in the community, Daugherty says.

One of the biggest benefits Capital Factory is bringing into town is investment opportunities. Daugherty says that he predicts that Capital Factory, which tends to invest many small-sum deals, will quickly become the most active early stage investor in Houston. The organization has already made a few investments in Houston companies — and this isn't even counting the dollars invested by the investment partners.

"Our mission, as it pertains to Houston, is to help the best Houston startups get funded. We will tap into our network of investors across the state and country to try to find the best matches."

If Houston can take any indication from Capital Factory's Dallas location, which opened earlier this year, Capital Factory will be making a big impact on Houston startups.

"In 2018, 25 percent of the startups we onboarded into the accelerator were from outside of Austin," Daugherty tells InnovationMap. "The first half of this year, a third or more have come from Dallas alone. And I expect the same from Houston. Next year, easily more than half of our new accelerator companies will be outside of Austin."

Capital Factory will have branded space in The Cannon when it opens its new facility later this month.

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Houston researcher secures $1.7M to develop drug for aggressive form of breast cancer

cancer research

A University of Houston researcher has joined a $3.2 million effort to develop a new drug designed to attack a cancer-driving protein commonly found in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is one of the most difficult-to-treat forms of cancer and accounts for 10 percent to 15 percent of all breast cancer cases. The disease gets its name because tumors associated with it test negative for estrogen receptors, progesterone receptors and excess HER2 protein, making it difficult to target. Due to this, TNBC is often treated with general chemotherapy, which can come with negative side effects and drug resistance, according to UH.

UH College of Pharmacy research associate professor Wei Wang is developing a drug that can target the disease more specifically. The drug will target MDM2, a protein often overproduced in TNBC that also contributes to faster tumor growth.

Wang is working on a team led by Wei Li, director of the University of Tennessee Health Science Center College of Pharmacy’s Drug Discovery Center. She has received $1.7 million to support the research.

Wang and UH professor of pharmacology and toxicology Ruiwen Zhang have discovered a compound that can break down MDM2. In early laboratory models, the compound has shown the ability to shrink tumors.

Wang and Zhang will focus on understanding how the treatment works and monitoring its effectiveness in models that closely mirror human disease.

“We will study how the drug targets MDM2 and evaluate the most promising drug candidates to determine effective dosing, understand how the drug behaves in the body, compare it with existing treatments and assess early safety,” Wang said in a news release.

Li’s team at the University of Tennessee will be working on the chemistry and drug design end of the project.

“This work could lead to an entirely new class of therapies for triple-negative breast cancer,” Li added in the release. “We’re hopeful that by directly removing the MDM2 protein from cancer cells, we can help more patients respond to treatment regardless of their tumor type.”

10+ Houston innovation leaders in the spotlight at SXSW 2026

where to be

Houston's innovation scene will be well represented at South by Southwest (SXSW) this month.

The week-long, Austin-based conference and festival will spotlight some of the Bayou City's leaders in health care, energy, space and more. The event kicks off today, March 12, and runs through March 18. The SXSW Innovation Conference will feature keynotes, workshops, mentoring sessions and more throughout various venues in the city.

Here's who to see and when and where to find them:

March 12

Aileen Allen, venture partner at Mercury Fund

Mentor Session from 4-5:15 p.m. at Hilton Austin Downtown

Allen will host a mentoring session focused on funding, marketing, advertising, PR and the future of work.

March 13

Heath Butler, partner at Mercury Fund

SXSW Pitch-Smart Cities, Transportation, Manufacturing & Logistics from 2:30-3:30 p.m. at the J.W. Marriott

Butler will judge five innovative startups as they pitch their solutions to advance smart cities, enhance transportation systems, modernize manufacturing, transform logistics, and strengthen government infrastructure and civic operations.

Jonathan Cirtain, CEO and president of Axiom Space

The Clock is Ticking for Space - Replacing the ISS from 4-5 p.m. at the J.W. Marriott

Cirtain will discuss Axiom's pursuit of building the world’s first commercial space station.

March 14

Jesse Martinez, founder and CEO of LSA Global

SXSW Pitch-Intelligent Systems, Robotics, & Multisensory Technology from 10-11 a.m. at the J.W. Marriott

Martinez will judge five innovative startups as they pitch their technologies that aim to enhance the way people connect, communicate and share unique life experiences with those around them in a digital ecosystem.

Jennifer Schmitt, head of operations at Rhythm Energy

Powering Texas with Reliable Integrated High-Demand Energy from 10-11 a.m. at Marlow

Schmitt will join a panel to discuss how EirGrid, the state-owned electric power transmission operator in Ireland, is pioneering solutions as the country works toward 80 percent renewable integration by 2030.

Saki Sasagawa, director of business development for JETRO Houston

Now is Japan's Time: Leading the Future with Deep Tech from 10-11 a.m. at the J.W. Marriott

Sasagawa joins a panel that will share real-time insights from diverse perspectives on the forefront of Japan’s deep tech and IP businesses.

March 15

Bosco Lai, CEO and co-founder of Little Place Labs

SXSW Pitch Alumni: Where Are They Now? from 10-11 a.m. at the J.W. Marriott

Lai joins a panel of four former SXSW Pitch winners to share how they leveraged the platform to take their startups to the next level.

Tara Karimi, cofounder and chief science and sustainability officer at Cemvita

South by South America: The Rise of Southern Brazil Tech from 2:30-3:30. p.m. at The Line

Karimi will participate in a panel to discuss how Rio Grande do Sul, Brazil's southernmost state, is attracting elite talent and AI infrastructure and share insights on navigating the next wave of South American tech growth.

March 16

Dr. Pavitra P. Krishnamani, emergency medicine physician at The University of Texas MD Anderson Cancer Center

Viva La Revolution: How the Digital Age is Transforming Wellness from 11:30 a.m.-12:30 p.m. at Hilton Austin Downtown

Krishnamani will discuss the latest advancements and policies that can accelerate the digital age of health care, such as wearables, telehealth and artificial intelligence.

March 18

Charlie Childs, co-founder and CEO of Intero Biosystems

Spinning Out: What It Takes to Build a University Startup from 2:30-3:30 p.m. at The Line

Childs will join founders who spun their companies out of the University of Michigan to share the real story of navigating IP, early capital, team building, market validation and the “valley of death.”

Dr. James Allison, regental chair of immunology and director of The Allison Institute at The University of Texas MD Anderson Cancer Center

Dr. Padmanee Sharma, professor in the Department of Genitourinary Medical Oncology, Division of Cancer Medicine at The University of Texas MD Anderson Cancer Center

Beyond Checkpoints: Immunotherapy’s Next Act from 2:30-3:30 p.m. at the J.W. Marriott

Allison and Sharma will sit down with 21-year-old, Stage 4 cancer survivor Sharon Belvin and Time Magazine journalist Alice Park will discuss the future of immunotherapy and what challenges remain.

Last year, Houston startups Little Places Labs and Helix Earth won top prizes in their respective categories at the prestigious SXSW Pitch event, held this year from March 13-14. No Houston startups were named finalists to compete in this year's event.

NASA revamps Artemis moon landing program by modeling it after Apollo

To the moon

NASA is revamping its Artemis moon exploration program to make it more like the fast-paced Apollo program half a century ago, adding an extra practice flight before attempting a high-risk lunar landing with a crew in two years.

The overhaul in the flight lineup came just days after NASA’s new moon rocket returned to its hangar for more repairs, and a safety panel warned the space agency to scale back its overly ambitious goals for humanity’s first lunar landing since 1972.

Artemis II, a lunar fly-around by four astronauts, is off until at least April because of rocket problems.

The follow-up mission, Artemis III, had been targeting a landing near the moon’s south pole by another pair of astronauts in about three years. But with long gaps between flights and concern growing over the readiness of a lunar lander and moonwalking suits, NASA’s new administrator Jared Isaacman announced that mission would instead focus on launching a lunar lander into orbit around Earth in 2027 for docking practice by astronauts flying in an Orion capsule.

The new plan calls for a moon landing — potentially even two moon landings — by astronauts in 2028.

“Everybody agrees. This is the only way forward,” Isaacman said.

The hydrogen fuel leaks and helium flow problems that struck the Space Launch System rocket on the pad at NASA's Kennedy Space Center in February also plagued the first Artemis test flight without a crew in 2022.

Another three-year gap was looming between Artemis II and the moon landing by astronauts as originally envisioned, Isaacman said.

Isaacman stressed that “it should be incredibly obvious” that three years between flights is unacceptable. He'd like to get it down to one year or even less.

Isaacman, a tech billionaire who bought his own trips to orbit and performed the world’s first private spacewalk, took the helm at NASA in December.

During NASA’s storied Apollo program, he said, astronauts’ first flight to the moon was followed by two more missions before Neil Armstrong and Buzz Aldrin landed on the moon. What's more, he added, the Apollo moonshots followed one another in quick succession, just as the earlier Projects Mercury and Gemini had rapid flight rates, sometimes coming just a few months apart.

Twenty-four Apollo astronauts flew to the moon from 1968 through 1972, with 12 of them landing.

“No one at NASA forgot their history books. They knew how to do this," Isaacman said. “Now we're putting it in action.”

To pick up the pace and reduce risk, NASA will standardize its Space Launch System rockets moving forward, Isaacman said. These are the massive rockets that will launch astronauts to the moon aboard Orion capsules. At the same time, Elon Musk's SpaceX and Jeff Bezos' Blue Origin are speeding up their work on the landers needed to get the astronauts from lunar orbit down to the surface.

Isaacman said next year will see an Orion crew rendezvousing in orbit around Earth with SpaceX's Starship, Blue Origin's Blue Moon or both landers. It's similar to the methodical approach that worked so well during Apollo in the late 1960s, he noted. Apollo 8, astronauts' first flight to the moon, was followed by two more missions before Armstrong and Aldrin aimed for the lunar surface.

“We should be getting back to basics and doing what we know works,” he said.

The Aerospace Safety Advisory Panel recommended that NASA revise its objectives for Artemis III “given the demanding mission goals.” It’s urgent the space agency do that, the panel said, if the United States hopes to safely return astronauts to the moon. Isaacman said the revised Artemis flight plan addresses the panel's concerns and is supported by industry and the Trump administration.

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