Houston's innovation leaders weigh in on community's growth, progress

Houston innovation awards

Get to know the Houston innovation community's top ecosystem builders. Photos courtesy

This year's finalists in the Ecosystem Builder category for the Houston Innovation Awards have a lot to say about the city's innovation community — and they are the right ones to say it.

Selected as finalists for the newly created category, each of the five finalists are leaders for the Houston innovation ecosystem. They were each asked some questions about the development of the Houston tech and startup community. Here's what they had to say.

InnovationMap: What is your favorite part of Houston's innovation ecosystem? How have you helped contribute to that aspect of the community?

Jan E. Odegard, executive director of the Ion: Can do attitude and willingness to make big bets that can solve hard problems with global societal impact. Creating and supporting a place where this can happen is critical to the success, a place where we create the necessary density for collisions and that will sprue the next ideas.

Jason Ethier, co-founder of Lambda Catalyzer and host of the Energy Tech Startups podcast: Perhaps small, but the Ion District in the small part we have to play in it. Being able to be in a place where you can cross paths with active investors, innovators and partners. This is the hub we hoped to build over the last few years. That connective tissue may be small and focused compared to other ecosystems, but it is very strong here.

Joey Sanchez, founder of Cup of Joey and senior director of ecosystems at the Ion: My favorite part of the Houston Innovation Ecosystem is the progress and potential. We have gone from talking about how to build a Houston ecosystem to now exploring our collective potential. The conversations are now tactical actions to scale our efforts.

Kendrick Alridge, senior manager of community at Greentown Labs: My favorite part of the ecosystem is the Cup of Joey gathering. It's a great opportunity to run into or catch up with people looking to get involved in the ecosystem or looking for support. It's a great networking opportunity.

Wade Pinder, founder of Product Houston: I love seeing how the community has really connected this past year specifically. We've gathered momentum and have a "gravity well" of community leaders feeding value to one another.

IM: What are the strengths of the Houston innovation ecosystem?

Odegard: Access to (engineering) talent, capabilities, and global connectivity that are not afraid of getting her hands dirty to build and scale.

Ethier: The diversity of the founders and the intrinsic diversity of the Houston ecosystem. There are few native Houstonians, and most of the fantastic founders we meet are from somewhere else. The energy industry brings the best of the best from around the world and they inject Houston with unique excellence.

Sanchez: We are a resource right environment. We have a plethora of talent and capital. With the economy the size of Belgium, we have access to industries and talent unlike any other city. Also the convergence of energy, medical and aerospace is one of a kind. Each industry is transforming and providing a ripe opportunity for innovation.

Alridge: The growing number of startup development organizations (SDOs), incubators and accelerators, makerspaces, co-working spaces, non-profits, and academic institutions that is available is a strength, because their are plenty of places to get support and your ideas off the ground.

Pinder: We do hard things here because the ARE hard! 1) Life and death situations en masse, 2) infrastructure at scale 3) Boldly going where no one has gone before! That's what we've done here. That's what we stand to innovate on! If it's a hard problem, Houston gets it done!

IM: What are the weaknesses of the Houston innovation ecosystem? Are you helping to make improvements to these weaker aspects of the community and, if so, how?

Odegard: Access to more risk capital.

Ethier: We need a skill set on scaling businesses. This is something the valley does exceptionally well. When there is product market fit, the startup ecosystem knows how to scale teams from 20-200 and do so repeatedly. Houston knows how to do big energy projects; from sput to TD, there is a skill set here around complexity...but how that applies to scaling businesses its unclear we have what it takes. This is why its imperative we bring in mature startups from around the country and try to transfer knowledge from the energy industry into the startup space. Building an acceleration program like Lambda is a step in solving this problem.

Sanchez: Density is our biggest challenge. The geographic sprawl of our region is vast. Serendipitous meetings are a challenging. The Ion has created a central place where our ecosystem can come together. Every Friday we meet for Cup of Joey and now we host a Cup of Joey in The Woodlands, Space Center Houston, Sugar Land and The Cannon West. Creating eight Cup of Joey meetups each month. The most exciting element of Cup of Joey is coming in an online platform for connection.

Alridge: We need a robust cadre of startup specialists, serial entrepreneurs who have successfully started companies. Especially in business and STEM fields, is needed in the innovation system. Higher education in providing talent is important, I'm doing my part by organizing opportunities for students to work with our startups which can directly and indirectly contribute to the workforce and the grown startup community.

Pinder: We're changing this... but we still have a ways to go with the "I'm good... what do I need to show up for?" thinking. It's not for lack of wanting to show up... traffic makes it tougher to show up most of the time.

IM: What do you wish more people knew about the Houston startup community?

Odegard: That Houston IS a tech hub addressing some of the biggest societal challenges we are face today, such as: power (security), healthcare (affordable and accessible), sustainability (clean and green), and equitable access to economic opportunities.

Ethier: How climate focused everyone is, from the founders, to the SMEs, industry and SMEs. Houston (and energy companies) know how to manage what's measured and now that we have targets around decarbonization, we are going to get it done.

Sanchez: I wish the world knew more about Houston and our Houston startup community. I believe that our foundation is strong and we are ready for scale. 2026 to 2036 will be a decade of massive growth for Houston and our ecosystem.

Alridge: We are more than oil and gas and health care.

Pinder: We've got the solutions to some huge problems sitting right here in Houston.

Click here to secure your tickets to the November 8 event where we announce the winner of this exciting new category.

From Your Site Articles
Capital Factory will have a branded area in The Cannon when it opens its new facility. Courtesy of The Cannon

Capital Factory hires two Houston-based employees to grow its local presence

Onboarding

A major Texas innovation player with roots in Austin has now staffed its recently announced Houston outpost in partnership with The Cannon Houston. Capital Factory hired two Houstonians to help provide resources for its growing Houston-based portfolio companies.

Kendrick Alridge has been hired as mentor coordinator, and Brittany Barreto, who founded Pheramor and WeHaveChemistry, has been named the venture associate. Aldridge will focus on growing and cultivating relationships with Houston mentors, and Barreto is dedicated to reaching out to Houston startups to gauge their potential for Capital Factory participation.

Hiring these Houstonians and having these new boots on the ground is a key factor for Capital Factory as it grows its Houston presence, says Gordon Daugherty, president at Capital Factory.

"It's important for us to think Texas, but act local," Daugherty says. "What that means is we can't just assume that the way we do things and the things that made us successful in Austin will directly translate to Houston. Houston is a different market. That's one of the things we learned from Dallas."

Acting locally entails listening and learning to what the community wants and engaging with local organizations to contribute value to the market.

"We don't know how or in which ways, but we know Houston will be different from Dallas and Austin," Daugherty says. "In this way, we are advantaged by our two employees being from the Houston area. They're our eyes and ears, for one, but they are also the voice of Houston to us along with other ecosystem players."

While local resources and personnel are both new for Capital Factory, the organization already has over 20 portfolio companies that are based in the Houston area. Now, these companies will have new resources close to home and can also act as Capital Factory representatives in the community, Daugherty says.

One of the biggest benefits Capital Factory is bringing into town is investment opportunities. Daugherty says that he predicts that Capital Factory, which tends to invest many small-sum deals, will quickly become the most active early stage investor in Houston. The organization has already made a few investments in Houston companies — and this isn't even counting the dollars invested by the investment partners.

"Our mission, as it pertains to Houston, is to help the best Houston startups get funded. We will tap into our network of investors across the state and country to try to find the best matches."

If Houston can take any indication from Capital Factory's Dallas location, which opened earlier this year, Capital Factory will be making a big impact on Houston startups.

"In 2018, 25 percent of the startups we onboarded into the accelerator were from outside of Austin," Daugherty tells InnovationMap. "The first half of this year, a third or more have come from Dallas alone. And I expect the same from Houston. Next year, easily more than half of our new accelerator companies will be outside of Austin."

Capital Factory will have branded space in The Cannon when it opens its new facility later this month.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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