5 Houston biotech companies taking health care to new levels

The future is now

With the Texas Medical Center in their backyard, these Houston biotech companies are creating breakthrough technologies. Getty Images

Houston is the home of the largest medical center in the world, so it comes as no surprise that the Bayou City is also home to breakthrough technologies. Here are five Houston companies developing some of this biotech advancements.

Moleculin Biotech Inc.

Houston-based Moleculin has three different oncology technologies currently in trials. Getty Images

Immunotherapy and personalized medicine get all the headlines lately, but in the fight against cancer, a natural compound created by bees could beat them in winning one battle.

In 2007, chairman and CEO Walter Klemp founded Moleculin Biotech Inc. as a private company. The former CPA had found success in life sciences with a company that sold devices for the treatment of acne. That introduction into the field of medical technology pushed him toward more profound issues than spotty skin.

"Coincidentally, the inventor of that technology had a brother who was a neuro-oncologist at MD Anderson," Klemp recalls.

The since-deceased Dr. Charles Conrad slowly lured Klemp into what he calls the "cancer ecosphere" of MD Anderson. In 2016, the company went public. And it looks like sooner rather than later, it could make major inroads against some of the toughest cancers to beat. Read the full story here.

Cavu Biotherapies

Dr. Colleen O'Connor has adapted immunotherapy treatments to be used in dogs. Courtesy of CAVU Biotherapies

Breakthrough biotech doesn't have to just be for humans. More than three years after its founding, Houston-based veterinary biotech company CAVU Biotherapies' had its first cancer patient: a black Labrador in Pennsylvania diagnosed with B-cell lymphoma.

Dr. Colleen O'Connor, CEO and founder of CAVU Biotherapies, established the company in July 2015 with a goal to help pets live longer post-cancer diagnoses. O'Connor, who earned a PhD in toxicology with a specialty in immunology, has more than a decade of hands-on experience researching cancer treatments.

"Our goal is to scale up and be able to increase our dogs' qualities of life with us," O'Connor said. "We want to keep families intact longer and we want to be able to modernize cancer care for our animals." Read the full story here.

Innovative Biochips

iBiochips, led by founder Lidong Qin, was awarded a $1.5 million grant in September to help develop a new technology that delivers data about the cell's genetic makeup and reports abnormalities. Courtesy of Lidong Qin

Innovative Biochips, a Houston-based biotechnology company, is one step closer to commercializing technology that the company hopes will provide an opportunity for researchers to detect diseases earlier.

The company was founded three years ago by Dr. Lidong Qin, a professor at the Houston Methodist Research Institute's department of nanomedicine. He launched iBiochips as an independent faculty startup that licensed technology from Houston Methodist. Qin says he wanted to engineer and manufacture devices that focus on revolutionizing single-cell isolation and genetic analysis. Read the full story here.

Celltex

Celltex's stem cell technology has received positive results from its multiple sclerosis, Parkinson's, and rheumatoid arthritis patients. Courtesy of Celltex

A Houston stem cell company is making strides in regenerative medicine. Celltex's treatment has been proved effective with its patients. Eighty-three percent of multiple sclerosis patients have reported improvement of symptoms specific to their disease, as have 73 percent of Parkinson's sufferers. But the staggering fact is that 100 percent of 58 respondents with rheumatoid arthritis say they have benefited.

David Eller, chairman, co-founder and CEO of the company, also recently announced the company's expansion to Saudi Arabia. Read the full story here.

Ridgeline Therapeutics

Houston-based Ridgeline Therapeutics isn't going to allow you beat aging, but someday it may well help you to live without muscle loss or diabetes. Getty Images

Stan Watowich pictures a world where elderly people have the same healthy muscles they had at a younger age. Watowich is CEO of Ridgeline Therapeutics, a spin-off company of the University of Texas Medical Branch in Galveston where he is an associate professor of biochemistry and molecular biology, and he wants to make it clear that he is not going to cure aging.

"You and I are still going to get old," he says. "But we have our hopes that as we get old our muscles will stay healthy."

He's talking about the drug candidate, RLT-72484. It has been shown to reactivate muscle stem cells and regenerate skeletal muscle in aged laboratory mice. Read the full story here.

Concession food to your seat? Sign InnovationMap readers up. Courtesy of sEATz

5 top trending innovation stories in Houston this week

What you're reading

Editor's note: Not entirely surprisingly, this week's views were skewed heavily toward an app that allows stadium food delivery right to your seat, wine-picking technology, a slideshow of a growing coworking space, and more.

Houston startup is making stadium food a whole new ballgame

A new app, sEATz, is the UberEats of stadium food. You order right from your phone in your seat. Getty Images

Marshall Law's wife, Melissa, surprised him and his two sons with tickets to see the Astros play at home in the 2017 World Series against the Los Angeles Dodgers, but a rush to get to the game and a packed stadium lead to him waiting in a long concessions line in the second inning.

Law watched on a TV screen next to the food counter as the fourth pitch from Yu Darvish to Yuli Gurriel hit two rows past the Laws' seats, bouncing back toward where they were supposed to be sitting. Law couldn't shake the feeling of missing out on the homer. Why couldn't someone have brought them the food, he thought. He'd have paid $50 — maybe more — to not miss that moment.

"Everything gets delivered these days. Any kind of food to your groceries, all right to you. Why isn't someone doing this?" Law says he was thought as he walked out of the game. Read the full story here.

Photos: West Houston coworking space 50 percent leased ahead of early 2019 opening

The Cannon's 120,000-square-foot space is on track to open March 1. Courtesy of The Cannon

Everything's bigger in Texas, and Houston will soon have a coworking space to reflect that. The Cannon is on track to open its West Houston 120,000-square-foot, 32-acre coworking and entrepreneurship campus by March 1.

"We're going to have, as far as I know, the biggest coworking space in the world," says Lawson Gow, founder and CEO of The Cannon. "It's a really Houston-sized solution to the problem of the challenge we set out to face." Read the full story here.

3 Houston health tech innovators to know this week

Armed with their doctorate degrees and startups, these three STEM biotech innovators are going places. Courtesy photos

Whether it's for dogs or dating, Houston is prime for innovative leaders in health science startups, and there are three in particular you need to know going into a new week. From a DNA-based dating app creator and a researcher curing cancer in dogs to cutting-edge biotech leader, here are the Houston innovators to know. Doctorate degrees and startup companies in hand, each of these entrepreneurs is going places. Read the full story here.

Houston company aims to equally equip female workers

SeeHerWork launched its line of female-gear in September. Courtesy of SeeHerWork

When Jane Henry was working on her home right after Hurricane Harvey — her house got three feet of mud in it — she went to throw a board into the dumpster, and her glove went with it.

Henry says the industry standard is to recommend small and extra-small sizes for women's workwear, but as a ladies large in athletic gloves, Henry still had a good inch or so of glove at her fingertips in her workwear gloves.

"I went upstairs to my sewing room, and I ripped that glove apart and I resewed it to fit my hand," Henry says. Read the full story here.

Houston entrepreneur makes a splash with wine-selecting technology

Houston-based VineSleuth created a custom algorithm to match you with new wines based on wines you've had in the past. Courtesy of VineSleuth

Amy Gross wants to find you the perfect wine. In fact, she wants it so much, she built her company, VineSleuth, around the concept that technology and machine learning could find the best wine to match individual palates.

VineSleuth's custom algorithm is backed by research from sensory scientists at Cornell University, and relies on both data collection and machine learning to determine specific wines that will match an individual customer's tastes. Flavor profiles from thousands of wines are incorporated into her database, and none of those are based on the typical wine scores you'll see in magazines or reviews of wines. Read the full story here.

Armed with their doctorate degrees and startups, these three STEM biotech innovators are going places. Courtesy photos

3 Houston heath tech innovators to know this week

Who's Who

Brittany Barreto, co-founder and CEO of Pheramor

Courtesy of Pheramor

Brittany Barreto was studying genetics in college, and her professor was talking about how there are 11 genes in DNA that can determine physical compatibility with others. She had the idea right then and there in the classroom to make a DNA-based dating app. Almost 10 years later, she's done it, with Pheramor.

The Houston startup has launched nationwide and is in the midst of another capital campaign. Barreto is also looking to expand her team to account for the growth and success.

Lidong Qin, founder of Innovative Biochips

Courtesy of Lidong Qin

Lidong Qin spends his days as a professor at the Houston Methodist Research Institute's department of nanomedicine, but three years ago, he expanded his resume. He launched his biotech startup, Innovative Biochips, as an independent faculty startup that licensed technology from Houston Methodist.

Qin says it can be difficult to launch a biotech startup in Houston, since the industry requires hefty initial funds to open a facility, get patents and hire a team of researchers. Now, iBiochips is armed with private investments and a $1.5 million grant from the National Institutes of Health's Small Business Technology Transfer program to continue researching and developing early disease detection technologies.

Colleen O'Connor, founder of CAVU Biotherapies

Courtesy of CAVU Biotherapies

Losing a pet is awful, and for so many people, pets are full-blown family members. When Colleen O'Connor lost her furry family members to cancer, she knew she had to do something about it. Cancer treatment in humans had evolved to include immunotherapy, and O'Connor thought man's best friend deserved an upgrade from the 1980s practices veterinarians use.

She created Houston-based CAVU Biotherapies, and, in September, the first treatment was administered to a black lab named Franklin. O'Connor is focused on expanding her treatment and its access to pups so that no pet owner has to prematurely say goodbye to good boys and girls.

iBiochips was awarded a $1.5 million grant in September to help develop a new technology that delivers data about the cell's genetic makeup and reports abnormalities. Getty Images

Houston-based biotech company aims to revolutionize cellular dissection technology

digital disease detective

Qin says it can be difficult to launch a biotech startup in Houston, since the industry requires hefty initial funds to open a facility, get patents and hire a team of researchers.

"In the Houston area, even though it looks like it's a lot of state money (grants) around, it's very limited, and that's been a challenge of ours," Qin says.

But with the help of a $1.5 million investment from a private investor, Qin was able to launch iBiochips in 2015, and shortly after opened his own lab on Kirby Drive.

Recently, iBiochips was awarded a $1.5 million grant in September from the National Institutes of Health's Small Business Technology Transfer program. The grant will further support the company's research and development of an automated yeast dissection chip, which is designed to perform a raw analysis of single cells and deliver data about the cell's genetic makeup and report abnormalities.

Prior to the phase two grant, iBiochips was also awarded NIH's phase one grant of $225,000 in September 2017 to develop a prototype for the company's flagship cell isolation product, the Smart Aliquotor.

The Smart Aliquotor is a single-cell isolation dissection platform that allows scientists to analyze larger amounts of cells at a much faster rate than traditional isolation methods, Qin says. He says the system is also more convenient for researchers to operate because traditional cell isolation techniques require a lot of human effort.

To isolate the cells with a Smart Aliquotor, a scientist would take a patient's blood sample and inject it into a single point in the device. The blood sample would then travel through microfluidic channels into the device's 60 to 100 isolated holes, Qin says.

"In three days, we can handle about one million cells," Qin says. "In a traditional approach, people can handle only one or two cells in three days. So that is how we came to the [idea of the] chip can help a scientist do 20 years of work in three days."

The Smart Aliquotor can then be examined with iBiochips' newly funded automated dissection chip, which Qin says has the potential to detect cancer or infectious diseases earlier than before.

"If you isolate a cell by itself — even in the very beginning stage when the aggressive cells are not as dominating yet — you can still see that [abnormality in the sample]," Qin says.

iBiochips' products are currently only being manufactured for research use at clinical labs, universities and pharmacies. However, with the recent grant award, Qin says the company's research team plans to spend the next three to five years preparing the products for worldwide commercialization.

Dr. Lidong Qin is a professor at the Houston Methodist Research Institute's department of nanomedicine. He launched iBiochips as an independent faculty startup that licensed technology from Houston Methodist.Courtesy of Lidong Qin

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Houston expert: 5 things to consider when tackling DEI at your organization

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Houston is often touted as the most diverse city in the country, but with that comes the responsibility of making sure we are creating inclusive and equitable opportunities that reflect the communities we serve.

With the current state of our country dealing with the COVID-19 pandemic, as well as social and political issues, employers across the city have searched for the right thing to say and do to help their employees and customers during this time when personal feelings and beliefs impact the workplace more now than ever. While there isn't a one-size-fits-all approach to implementing DEI across an organization, here are a few steps and considerations companies can take to ensure DEI is a priority moving forward.

Understand your audience

It's important to understand the perspectives of those you serve. Identifying your audience will help develop a DEI strategy that addresses concerns from multiple lenses. At Houston Methodist, we focus on our patients, employees and the communities we serve. Anyone building a DEI program needs to not only be cognizant of their audience, but also understand their needs in today's climate before spending time and resources to develop initiatives that will address those needs. Ultimately, this will help shape a more impactful approach to DEI within your organization.

Define success

When developing a DEI strategy, success may seem overwhelming or lofty. But, viewing success as progress will help your organization accomplish your goals in a way that employees and other stakeholders will benefit from in the long run.

Set strategic and measurable goals that clearly state what your organization wants to achieve through its DEI efforts. These goals need not be big at the onset; make sure they are attainable. Most importantly, it's critical to revisit your goals on a regular basis and identify gaps, and be willing to pivot, if needed, along the way so your organization eventually reaches its goals. At the hospital, we've developed a DEI dashboard for all departments in our hospitals to help us with setting those measurable goals. Once measurable goals are identified, a DEI scorecard will be used to identify progress for departments and our organization year over year. When people are able to easily track and see progress or gaps, it will make it easier to reach desired goals.

An organization can't be successful with any new type of program if everyone within the organization doesn't understand the importance of DEI in their department and within the company as a whole. Progress often starts with one person. Providing training to employees about the impact that DEI can have on their day-to-day work will help them champion that within the organization. For example, we've launched something at our hospital called "Together We Grow," a training program aimed at building a foundation for what DEI is by exploring everyday scenarios employees may encounter. This program first started with leadership and is now available to all employees within the hospital system.

Establish a timeline

Once measurable goals have been established, develop a timeline for accomplishing those goals. By selecting two or three goals that can be focused on over a particular time period (i.e., six months or one year), your organization can implement targeted programs and best practices to drive the success of DEI for a more long-term plan. It's ok if not every program is up and running within the year; creating milestones along the way will give your organization time to grow its DEI efforts and aspire to something meaningful for your employees, customers or community. The need for DEI doesn't go away, so it's important to continue efforts year-round with a growth mindset.

Evaluate how DEI holistically fits into your business

A DEI department, team or individual can't be successful if the work isn't aligned with the mission of the organization. It does not help if an organization has competing priorities, so DEI goals must be embedded in your organization's business goals.

Additionally, it's also important to have leadership set the tone for the rest of the organization to follow. Executive leaders that fully commit to the organization's DEI efforts and promote transparency, feedback and accountability for those programs will yield the most meaningful and lasting results.

Recognize your ‘why’

As a business, it's important to understand why DEI is important for your organization's success. You need to both be able to understand and articulate the business case for why diversity matters in your organization. Studies like this one from Boston Consulting Group continue to show a positive correlation between workforce diversity, innovation and overall company performance. The workforce is constantly changing and becoming more diverse, so making sure your organization is adapting to those different perspectives and taking into consideration why this work is vital to your employees, customers and your community will help turn DEI ideas into action.

For many health care organizations, health equity has shaped community engagement efforts and programs. Addressing health equity for racial, ethnic and social minorities in the Greater Houston area has been a priority for Houston Methodist for nearly 30 years, and this work has also informed and strengthened our DEI efforts in the communities we serve.

In conclusion, remember progress and feedback will help you reach your organization's DEI goals. For these initiatives to be effective, everyone within your organization must understand that each person plays a role in shaping the success of DEI efforts.

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Arianne Dowdell is vice president, chief diversity, equity and inclusion officer at Houston Methodist.

Google grants Houston founders funds, The Ion looks for artists, and more local innovation news

short stories

The Houston innovation ecosystem is bursting at the seams with news, and for this reason, local startup and tech updates may have fallen through some of the cracks.

In this roundup of short stories within Houston innovation, the Comcast RISE program expands to grant more funds, Google names Houston-area recipients from its Black Founder Fund, The Ion is looking for artists to participate in a new initiative, and more.

Google cohort awards Black founders $100,000 each

Google has granted funds to two Houston companies. Photo via Pexels

DOSS and SOTAOG, two Houston-based startups, have received $100,000 each as a part of the second cohort of the Google for Startups Black Founders Fund, a $10 million initiative for Black founders. Originally reported to be a part of Google's accelerator early this summer, DOSS is a digital brokerage that uses tech to make homeownership more affordable, and SOTAOG is an enterprise solutions provider within the oil and gas and heavy industrial industries.

"The Google for Startups Black Founders Fund embodies our mission of helping underrepresented founders grow their businesses. We are excited to continue the fund and contribute funding to Black founders, with no strings attached. Black founders currently receive less than 1 percent of total VC funding," says Jewel Burks Solomon, head of Google for Startups US, in a news release. "We heard loud and clear from the 2020 fund recipients that Google for Startups and Goodie Nation have been crucial to their success not only through funding, but through community, mentorship, network connections and technical expertise."

Last year, Google for Startups awarded 76 Black-led startups up to $100,000 in non-dilutive funding, as well as technical support from tools and teams across Google, including as much as $120,000 in donated search Ads from Google.org and up to $100,000 in Google Cloud credits, according to the release.

In addition to the two companies from Houston, eight companies from Austin and Dallas were also chosen for the second program.

The Ion calls for local artists

The Ion is looking for local artists to create innovative window displays. Photo courtesy of The Ion

The Ion, a Midtown innovation hub that's owned and operated by Rice Management Company, is looking for local artists to work on two prominent display windows at the front of the newly renovated historic Sears building.

"As a nexus for creativity of many different kinds, The Ion welcomes Houston's talented artists to tap into their unique skill sets and diverse backgrounds to submit inventive proposals that will ultimately comprise two different art installations. Each installation will contribute to Houston's innovation ecosystem by inspiring the growing community of creators who will see the building's display windows on a daily basis," says Artistic Consultant Piper Faust in a news release.

The two art installations will reside for six months — from February to August of next year. The submissions will be evaluated by a team of experts identified by Rice Management Co. and Piper Faust. The budget for each project will be $20,000.

According to the release, the submissions are open to Houston-area artists and should be in line with The Ion's "vision and mission of accelerating innovation, connecting communities and facilitating partnerships to create growth and opportunity in Houston."

Artists can apply online until October 1 at 5 pm.

Comcast RISE announces additional $1 million for Houston founders

Comcast to dole out $1M in grants to BIPOC-owned small businesses in Houston

The Comcast RISE program will give out another batch of $10,000 grants to BIPOC-owned small businesses in Houston. Photo via Getty Images

The Comcast RISE Investment Fund, which announced funding for 100 small businesses in Houston earlier this year, has expanded to provide an additional $1 million in support. The program is focused on BIPOC-owned small businesses in Harris and Fort Bend Counties that have been in business for three or more years with 1 to 25 employees.

Eligible businesses can apply online at ComcastRISE.com beginning October 1 through October 14 for one of the one hundred $10,000 grants.

Houston startup wins $25,000

Day Edwards, founder and CEO of Church Space

Day Edwards, founder and CEO of Church Space, won $25,000 for her company. Photo courtesy of Church Space

Dallas-based Impact Ventures, a nonprofit startup accelerator focused on empowering women and communities of color, hosted its bi-annual event, The Startup Showcase. A Houston-based company, Church Space, took the top prize of $25,000.

Billed as the "Netflix of churches," Church Space originally started as a way to allow groups to rent spaces for worship. But, in light of the pandemic, the company is pivoted to launch Church Space TV, a streaming program that allows churches and ministries to stream worship services for free.

"It felt like the perfect opportunity to give churches a way to reach more people during the pandemic," Day Edwards, founder and CEO of Church Space, previously told InnovationMap. "This would create more impact than anything we could possibly offer at this time."

The company is also one of MassChallenge Texas's 2021 cohort.

Houston health care leader receives prestigious award

Dr. Peter Hotez, a leader in the development of Texas Children's and Baylor's COVID-19 vaccine construct, has been named the recipient of a prestigious award. Photo courtesy of TCH

Dr. Peter Hotez, Texas Children's Hospital Chair in Tropical Pediatrics, has been awarded the 2021 David E. Rogers Award. Hotez is co-director of the Center for Vaccine Development at Texas Children's Hospital and Professor of Pediatrics and Molecular Virology and dean of the National School of Tropical Medicine at Baylor College of Medicine.

The annual award, presented by the Robert Wood Johnson Foundation and the Association of American Medical Colleges, "honors a medical school faculty member who has made major contributions to improving the health and health care of the American people," according to a news release.

"I am thrilled to be honored with the David E. Rogers Award," Hotez says in the release. "As we continue this fight against COVID-19, having the additional support from the AAMC will amplify our efforts to improve public health nationally and globally."

The award will be presented to Dr. Hotez at the 2021 AAMC Awards Recognition Event on Wednesday, October 27.

Hotez is leading the development of Texas Children's and Baylor's COVID-19 vaccine construct, according to the release, and he has dedicated much of his time to vaccine advocacy efforts, countering rising antivaccine and anti-science sentiments in the United States while promoting vaccine diplomacy efforts globally.

Houston Exponential appoints new executive director and restructures its board

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Houston's nonprofit focused on accelerating the growth of the local innovation ecosystem has named its new leader.

Serafina Lalany has been named Houston Exponential's executive director. She has been serving in the position as interim since July when Harvin Moore stepped down. Prior to that, she served as vice president of operations and chief of staff at HX.

"I'm proud to be leading an organization that is focused on elevating Houston's startup strengths on a global scale while helping to make the world of entrepreneurship more accessible, less opaque, and easier to navigate for founders," Lalany says in a news release. "My team and I will be building upon the great deal of momentum that has already been established in this effort, and I look forward to collaborating closely with members of our community and convening board in this next chapter of HX."

According to the release, the organization is also "sharpening its focus and governing structure." HX's current board of directors will transition into a "convening board." In this new structure, Houston innovation leaders will come together to support one another and share advice and opportunities, as well as launch working groups to address emerging tech ecosystem challenges. An executive committee made up of five to seven members will oversee HX's operations and staff. These changes will be in effect on October 1.

"Houston's innovation ecosystem has been on an incredible run over the last four years as evidenced by the tripling of venture capital funding for local startups and the sharp increase in the number of startup development organizations supporting our emerging companies and founders," says HX Chair Barbara Burger, who is the vice president innovation at Chevron and president of Chevron Technology Ventures. "Houston Exponential has been a key catalyst for building momentum, and it's important for the organization to adapt to best meet the needs of the maturing ecosystem."

Moving forward, HX will have a strengthened focus on key efforts, like convening a startup development organization roundtable, the VC Immersions program, monthly networking events, and the annual Houston Tech Rodeo.

Additionally, as the organization's new leader, Lalany will spearhead HX's goal for Houston-based startups raising $10 billion in venture capital annually by 2030, per the release.

"Serafina has been a steadfast leader of the HX team, and we believe she is the right person to take the organization through this next chapter in its evolution," Burger says. "I'm excited to see what's next for HX under her guidance."

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