Serafina Lalany of Houston Exponential sits down to discuss he ambitious investment-focused plans for Houston innovation. Photo courtesy of Serafina Lalany

Serafina Lalany is known to crunch the numbers. In her role as executive director of Houston Exponential, which she's held since September, she keeps a close eye on venture capital activity in Houston.

"Following VC data is the closest proxy to other data that is often hard to collect. It actually gives us a sense of the growth over time of the ecosystem," Lalany tells InnovationMap. "Also, it gives us the signal as to like what our strengths are and the areas that we need to continue to build out infrastructure."

This year, Lalany and her team at HX aren't just watching the numbers — they hope to make an impact on the VC activity in Houston with more of their VC immersion days. For those, HX and its partner Republic, a startup investing platform, find local startups and connect them with visiting venture capital firms in hopes to generate investment.

Lalany discusses more of her plans for HX for 2022 and shares how the organization is evolving to be what Houston's innovation ecosystem needs in an interview.

InnovationMap: You’re starting your first full year as executive director of HX — what are you most excited about for 2022?

Serafina Lalany: In my eyes, I think 2022 presents a really interesting opportunity. Just looking back the last year, we had a lot of successes as a collective community. For the first time we saw the rise of more than one unicorn. Outside of High Radius, we've seen Cart.com launch and expand and become a behemoth. We've seen Axiom Space make some cool, critical hires and attract talent from New York City and other high growth companies. We've seen the expansion of companies like Capsule, ClassPass, and GoPuff to the Houston region. We're starting to see some really positive signals here, but also what we're excited about at HX is that over the last two years, entrepreneurship as itself has become a lot more accessible.

We've seen the demographics of entrepreneurs rapidly change. The average founder is a lot younger now, and there are many reasons as to why that's happening. In the knowledge economy, there's a lot more resources available to you as the world switched to completely digital. Suddenly, we found a lot more time on our hands, and the proliferation of things like no code tools helped to launch companies. We've seen probably the highest concentration of early stage companies in Houston to date.

There's something interesting happening on the ground, and that plus the global attention Houston starting to get as a climatetech leader, as a health tech leader, aerospace commercialization — people are starting to recognize what a force Houston is to reckon with. Looking into 2022, I think we'll be elevating Houston on a more global scale.

IM: How has HX evolved since its inception and where is the organization at today?

SL: The interesting thing of being an organization of ex-startup operators is that we operate as a startup ourselves. Along the journey of supporting and building infrastructure for a startup community, we have also been seeking our own product market fit. I think we're at the place now where we have a profound realization of what that is and who we serve. We have crystal clear vision around that.

We exist to position Houston as one of the best places to launch and scale a company. We serve entrepreneurs and aspiring entrepreneurs in Houston. We do that in many ways. Of course, most of the community recognizes HX through efforts like the Houston Tech Rodeo, but we're also working on opportunities and initiatives to help lower the barrier of entry for entrepreneurs in Houston. So things like VC immersions, which which allow access to capital in ways that weren't previously accessible. And definitely ramping up our efforts around reporting marketing and media, helping to shine a brighter light on our city. There's more to come as we get into this new year.

IM: Tech rodeo is coming back in a couple of months. What’s should people know about this year’s experience?

SL: A lot has changed this year. We listened to feedback from the attendees last year, which was our highest attended event to date. About 8,600 people came out last year, which blew our expectations out of the water. Having it as a hybrid made lot more accessible to people even outside of the region. This year we learned that from previous years having 130 to 170 events across the week is awesome, but it also forces people to make hard decisions sometimes. So, we're centralizing all of our events downtown on Main Street. We've actually partnered with METRO, and there will be 20 official saloons for Houston Tech Rodeo all along the light rail. Monday through Sunday (Feb. 28 through March 6), We're activating all of downtown and it'll look and feel a lot like SXSW. People will be walking from venue to venue,and we have a few thematic focus areas — health tech, aerospace, climatetech, but also emerging sectors like CPG, which I think we need to give more credit to in Houston.

IM: Last year, you introduced a partnership with Republic. What instigated this collaboration and what's been the impact so far?

SL: Inspiration for partnering with the Republic actually came out of our internal discussions around the time of the transition where we assess that VC immersions program is one of the most vital programs for our ecosystem because it helps lower the barrier to entry for startups seeking capital, especially for their first round of institutional capital. We have seen lots of positive signals over the last like 18 months of having done this gram. We have seen about 1,500 applications come through, 150 or more meetings were facilitated, and $35 million of capital was deployed to those companies. Our number one challenge is scaling — it was really just time and resources. As you can imagine, looking through those applications and the communication with the companies, it takes a considerable amount of time.

So, what we really needed to help us scale was additional venture analysts to look through those applications. Almost serendipitously as we were discussing the program with one of our friends, Abe Chu of previously NextSeed now Republic, we found that there's actually a lot of synergy here. They certainly have the capacity to look through applications — they've got a whole venture team — and we have the reach in the community. We work across the entire region. It ended up being a really cool collaboration. Now with their help, we can actually serve more entrepreneurs and more investors.

With this new model, where we're bringing in five to 15 investors to the city each quarter. Instead of those investors meeting with one founder, as they often do when they're in town, they're meeting with five to 15 founders. It's reducing friction for outside investors — that trip to Houston is very impactful, very busy, but very impactful. For the startups, it's really a great way to get the face time with investors that they can potentially be working with.

IM: HX has made some recent hiring moves — what were your goals in those strategic hires and are still growing your team?

SL: We made two critical hires in the last 30 or so days. One is our new director of inclusive innovation — that's Ivery Boston III. He actually was in the Miami ecosystem on Mayor Suarez's task force, so he's seen it all. We're really grateful to have that institutional knowledge here in Houston, but, more importantly, I think Ivery brings a really interesting perspective to the team and helps to fill a gap in our ecosystem today. I think we all realize and value the diversity in Houston, and how that is a core strength of our community. But we also have to be mindful about creating on ramps for underrepresented communities as well as we build and accelerate our tech economy in Houston.

Part of his responsibilities will be working directly within these communities and alongside these communities to help ensure that all HX activities are of course are built with an inclusive mindset, and they're taking considerations from the community in mind as well as we develop them out. This is all for the goal of helping to create the most equitable startup community we've seen in the country. To our benefit of being a last mover, an advantage, of which there are few, is that we actually get to do things hopefully in a much better way than we've seen on the coasts.

As far as future hires, I think this is pretty much the core team we're looking at for the next 12 months.

IM: I know something super important to you has been tracking venture capital activity in Houston. Why has that been a metric your you've been closely watching throughout your time at HX and what does the data show?

SL: Following VC data is the closest proxy to other data that is often hard to collect. It actually gives us a sense of the growth over time of the ecosystem. It gives us insights into the rate of capital that is deployed and how that's growing over time and where it's getting deployed. Also gives us the signal as to like what our strengths are and the areas that we need to continue to build out infrastructure. Over the last few years we've noticed that there has been more attention around hard tech and in biotech. As ecosystem developers, we must ask ourselves, "do we have the entire life cycle of resources and infrastructure to support companies within those sectors along their journey to scale?" If the answer is no, then we run the risk of potentially losing that talent or losing those companies to other places where there are supportive resources. So, it helps inform a lot of what we do. But it's also one of the few indicators of ecosystem growth in a way that is typically really hard to collect.

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This conversation has been edited for brevity and clarity.

Despite the effect COVID-19 has had on Houston venture capital, this Kansas City, Missouri-based VC is looking to continue to connect with the local tech scene remotely. Getty Images

Out-of-state VC firm with eyes on Houston actively — but cautiously — continues to invest amid COVID-19

money moves

A Kansas City, Missouri-based venture capital firm has had its eyes on Houston since fall of last year, and it's not letting the pandemic slow down its immersion into the local startup ecosystem.

Flyover Capital focuses on tech startups based in the middle of the country — from Denver to Atlanta, and the Twin Cities down to Houston. Usually funding seed to series A rounds, Flyover's thesis is geared at "creating the next generation of tech success stories outside traditional tech hubs," says Dan Kerr, principal at the firm.

This region, which Crunchbase dubbed "The Mighty Middle" in a recent report, has seen a growth in venture capital invested over the past decade. Annual investment grew from $5.8 billion invested in 2010 to $20.2 billion in 2019 alone, according to the report, and Texas is leading the pack. The Lone Star State accounted for $24 billion of the region's $92.6 billion venture capital invested in the past decade, per the report.

Flyover Capital, which was founded in 2014, has connected a couple dozen Houston startups in the past six months, Kerr says, and the firm is keeping up with several of those to this day. He predicts the firm will "dive in deeper" into some of those companies in the next six months.

Houston is "one of the cities among those that fall in our region where we plan to spend a significant amount of time," Kerr tells InnovationMap. "We cover a lot of ground, but there are certain cities were we try to get there quarterly. Houston is definitely one of those places."

Kerr says his first impression of Houston was its strength as a B2B — especially as that pertains to its entrepreneurs.

"There are a lot of people who are experienced in their career, maybe with a technical background, and are looking to build a business going after some problem that they see," Kerr says.

In a similar vein, Houston's corporate involvement with its startup ecosystem has been a big indicator of opportunity.

"One of the things we've identified as a strength in a lot of the middle America ecosystems is if they get the corporations involved, then that is a good marker for success, especially if you have some of the other ingredients involved," Kerr says.

Houston Exponential, which Kerr says has been helpful in allowing Flyover to tap into the ecosystem — especially in times like these — has also demonstrated Houston's strength as a B2B community with deep corporate connections.

And Flyover isn't the only VC firm that HX has seen interest from recently. This month, HX has planned more immersion days — where it connects VCs to startup development organizations and startups across town — than it's ever had in a single month, says Harvin Moore, president of HX. The immersion days will be happening completely online.

"It's clear from the indication that we get from VCs and angel networks that people are saying, 'Okay, we need to be looking for new deals,'" Moore says.

For Flyover Capital, Kerr describes the VC as "active, but of course cautious" when it comes to investing in new deals in the current economic environment.

"We're not alone in saying we're actively investing," Kerr says. "I think I've seen some surveys that 60 or so percent of investors are saying they're staying the course."

In fact, finding a positive spin, Kerr says the pandemic has had a "moderating effect" to the investment environment. "Rounds were happening in some cases in a crazy manner," he says of pre-COVID conditions.

Plus, while he hasn't seen a huge change to valuations, the economic conditions caused by COVID-19 could correct some of the over-valuations on the coasts.

"As unfortunate as these times are for lots of people, this is where many companies ultimately find their footing and success," Kerr says.

Houston startups have raised millions so far this year. Getty Images

Here's what 6 Houston startups have raised millions of dollars this year so far

VENTURE ADVENTURES

This year is starting strong when it comes to Houston startups receiving funding. From a $125 million raise from Houston's first unicorn to a local fund gathering up $50 million to deploy in mobility startups, Houston funding news has been pretty exciting.

In case you missed some of these headlines, InnovationMap has rounded up these seven deals based on previous reporting. Scroll through to see which Houston startups are catching the eyes — and cashing the checks — of investors.

HighRadius Corp.

Houston-based HighRadius has reported reaching unicorn status following a $125 million raise. Photo via highradius.com

Let's start with the biggest one, shall we? Houston-based HighRadius, an artificial intelligence-powered fintech software company, closed a $125 million raise, which earned it a a new title: Unicorn.

The series B round, which achieved this status for HighRadius, was led by ICONIQ Capital, with participation from existing investors Susquehanna Growth Equity and Citi Ventures, according to a news release from the company.

The company, which offices in West Houston, was founded in 2006 founded in 2006 and employs more than 1,000 people in North America, Europe, and Asia. In November, HighRadius opened an office in Amsterdam. According to the news release, the company will use the funds to further expand its global footprint.

Read the full story here.

Proeza Ventures

Auto Driving Smart Car image

A new venture capital fund based in Houston and Monterrey, Mexico, has raised $50 million to back mobility startups. Hiroshi Watanabe/Getty Images

New fund Proeza Ventures, which is based in Houston and Monterrey, Mexico, reportedly closed its first fund Proeza Ventures I at $50 million. The fund is backed by Grupo Proeza, a Mexican portfolio management company with two global platforms operating in the mobility and agroindustry sectors, according to the fund's website.

With the fund's money, Proenza Ventures will invest in 12 to 15 early or growth-stage startups with solutions or new technology within industrial, smart components, new vehicles, MaaS, and digital data services.

Read the full story here.

Ambyint

oil and gas

Ambyint, which has offices in Calgary and Houston, has secured funding from Houston venture capital firms. Getty Images

Canada-based Ambyint, which has an office in Houston, has closed its $15 million series B funding. Houston-based Cottonwood Venture Partners led the round, and Houston-based Mercury Fund also contributed — as did Ambyint's management team, according to a news release.

The money will be used to grow both its Houston and Calgary, Alberta, offices and expand its suite of software solutions for wells and artificial lift systems. Ambyint's technology pairs artificial intelligence with advanced physics and subject matter expertise to automate processes on across all well types and artificial lift systems.

Read the full story here.

vChain Inc.

Houston-based vChain, creator of CodeNotary, has raised $7 million in a series A financing round. Pexels

Houston-based vChain, which created the CodeNotary Open Source code trust solution, has raised $7 million in a series A funding round. Paris-based Elaia Partners led the investment round, and other contributors include Zug, Switzerland-based Bluwat and Seattle-based Acequia Capital.

The software tool, which is used to ensure code is securely transmitted throughout the entire development to production process, has several platform integrations and works with languages such as JavaScript, Python, Go, Java, and more.

Read the full story here.

Vivante Health

good intestine health intestine Food for bowel Health

Vivante Health, which uses technology and at-home testing to help users treat chronic digestive health issues, has raised $5.8 million. Getty Images

Vivante Health raised $5.8 million in a series A1 round, according to a news release. The round was led by California-based Lifeforce Capital and Athens, Greece-based Big Pi Ventures. Additionally, NFP Ventures, FCA Venture Partners, and Longmont Capital contributed to the round.

With the fresh funds, Vivante will continue to develop its GI health platform, GIThrive. The digital tool has an at-home microbiome test kit for users, as well as a breath tester that monitors food sensitivities. GIThrive also connects users to on-demand support from nutritionists and experts on the GIThrive app.

Read the full story here.

Hitched Inc.

Houston-based Hitched has dug up new investment money from a local private equity firm. Pexels

Hitched Inc. raised $5.5 million in its series A funding led by Houston-based Cottonwood Venture Partners, a growth equity firm that focuses on digital tech solutions in the energy industry.

The company, which was founded in 2018, coordinates the rentals — from hosting and chartering to managing them — all on one centralized platform. Hitched has a catalogue of equipment from generators and cranes to light towers, pumps to forklifts, and the site lists out the cost per day of each piece of machinery.

Read the full story here.

LetsLaunch, a Houston-based fundraising platform, has teamed up with The Cannon. Courtesy of LetsLaunch

Houston fintech startup partners with local coworking space to grow investment opportunities

Funding friends

A Houston fintech software company has joined forces with The Cannon to help connect its members to capital. LetsLaunch, a platform that allows for smaller investments from non-accredited investors, and The Cannon — along with its venture arm, Cannon Ventures — have officially entered a partnership as of this month.

"We're basically providing a transactional tool to allow Cannon Ventures to access more members who, legally, they couldn't access before," says Nick Carnrite, co-founder and CEO of LetsLaunch. "For us, it's a good thing because instead of having to go out and create a community of startups and investors, that gets brought to us."

The partnership will allow for The Cannon's members to have access to the platform, and LetsLaunch can piggyback off the Cannon's existing network and programming. For instance, if The Cannon hosts a pitch night, LetsLaunch could enable live investing so that anyone in the crowd could invest that night.

Additionally, companies backed by Cannon Ventures can easily do a dual raise — one side open to accredited investors writing big checks and the other on LetsLaunch open to anyone. For this setup, LetsLaunch investors get the perk of having the company vetted by the Cannon Ventures investors.

"[The partnership] allows us to further the vision of Cannon Ventures, which is to truly democratize angel investing," says Lawson Gow, founder and CEO of The Cannon and Cannon Ventures. "We want to activate and allow anyone who is interested in making investments of any size and in any way." (Gow is the son of the CEO of InnovationMap's parent company.)

LetsLaunch opened for business at the end of last year. The site works, in many ways, like a crowdfunding site, only investors receive equity for their money. Due to regulations, investment campaigns max out at around a million dollars, and how much one can invest depends on their annual income. For LetsLaunch's demographic, most users can invest up to $20,000 a year, Carnrite says. There is a minimum of a $250 investment per transaction, but Carnrite says he expects the average investment to be closer to $1,000 per transaction.

According to Carnrite, LetsLaunch is solving the exclusivity problem that traditional investing creates. Such a small pool of people can invest in companies for equity.

"There's something like 30 million people globally that have a $1 million net worth, which is the definition of being an accredited investor," Carnrite says. "Thirty million people out of 7.7 billion, so it's a little less than half a percentage."

And, according to Gow, this is a huge problem in Houston for companies who don't have access to funding.

"We had a company leave The Cannon last week and move to New York because they couldn't get funding in Houston," Gow says. "We're still losing battles every day — and one of the main reasons is getting early stage funding in companies."

A new venture capital firm launched in Houston to focus on female-led startups. Courtesy of The Artemis Fund

Female-led venture capital firm launches in Houston to move the needle on investment in women-owned companies

Who runs the world?

Three powerhouse investment minds have teamed up to launch a female-focused seed and series A venture capital firm in Houston.

In its first $20 million fund, The Artemis Fund will invest in around 30 women-led companies, and will award a $100,000 investment prize at the Rice Business Plan Competition, which takes place April 4 through 6. According to the company's press release, The Artemis Fund is the first of its kind — being female-led and female-focused — in Houston.

"There is a wealth of female leadership in the Houston innovation ecosystem, and we would like to see the same representation in the investor the investor community to help female founders thrive," says Stephanie Campbell, co-founder and principal of The Artemis Fund.

Campbell, and her co-founders, Leslie Goldman and Diana Murakhovskaya, all have extensive experience in venture capital. Campbell has served as managing director for The Houston Angel Network since 2016, while Goldman currently sits on the board of the organization and Murakhovskaya has been a previous investor member. Murakhovskaya worked for a long time in New York City and co-founded the Monarq Incubator, which focuses on women-led startups.

Women make up only 9 percent of decision makers in VC firms in the United States, and women-led companies only receive of 2 percent of venture capital, the release cites. This imbalance is something Artemis exists to change, especially since two-thirds — $22 trillion — of the nation's personal wealth will be controlled by women by 2020, the release states, citing the BMO Wealth Institute, and women currently drive 85 percent of purchases, or $150 billion.

While fewer and farther in between, venture-backed, women-led startups are more profitable. Reportedly, they achieve higher revenues by 12 percent, according to the Kauffman Fellows Report, and higher returns by 63 percent, per First Round's 10-Year Report.

"I'm enthusiastic about launching The Artemis Fund in Texas and reaching a new class of funders to invest in the most diverse tech-enabled companies from across the country," says Murakhovskaya in the release. "Houston, in particular, is uniquely positioned to be the next big tech hub with one of the most active angel groups, a burgeoning innovation ecosystem, support from Houston Exponential, top universities, and historically sidelined capital ready to be activated."

The three principals and co-founders are arguably the fund's greatest asset — from their connections, experience, and reputation. Together, they have in backgrounds in business, law, and engineering.

"We want female entrepreneurs to feel that Houston is a welcoming place to start, grow, and support female-led businesses," says Goldman in the release. "The Artemis Fund will play an integral part in creating this environment."

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Houston VC funding surged in Q1 2025 to highest level in years, report says

by the numbers

First-quarter funding for Houston-area startups just hit its highest level since 2022, according to the latest PitchBook-NVCA Venture Monitor. But fundraising in subsequent quarters might not be as robust thanks to ongoing economic turmoil, the report warns.

In the first quarter of 2025, Houston-area startups raised $544.2 million in venture capital from investors, PitchBook-NVCA data shows. That compares with $263.5 million in Q1 2024 and $344.5 million in Q1 2023. For the first quarter of 2022, local startups nabbed $745.5 million in venture capital.

The Houston-area total for first-quarter VC funding this year fell well short of the sum for the Austin area (more than $3.3 billion) and Dallas-Fort Worth ($696.8 million), according to PitchBook-NVCA data.

While first-quarter 2025 funding for Houston-area startups got a boost, the number of VC deals declined versus the first quarters of 2024, 2023 and 2022. The PitchBook-NVCA Monitor reported 37 local VC deals in this year’s first quarter, compared with 45 during the same period in 2024, 53 in 2023, and 57 in 2022.

The PitchBook-NVCA report indicates fundraising figures for the Houston area, the Austin area, Dallas-Fort Worth and other markets might shrink in upcoming quarters.

“Should the latest iteration of tariffs stand, we expect significant pressure on fundraising and dealmaking in the near term as investors sit on the sidelines and wait for signs of market stabilization,” the report says.

Due to new trade tariffs and policy shifts, the chances of an upcoming rebound in the VC market have likely faded, says Nizar Tarhuni, executive vice president of research and market intelligence at PitchBook.

“These impacts amplify economic uncertainty and could further disrupt the private markets by complicating investment decisions, supply chains, exit windows, and portfolio strategies,” Tarhuni says. “While this may eventually lead to new domestic investment and create opportunities, the overall environment is facing volatility, hesitation, and structural change.”

Expert: Texas is building a cybersecurity wall — but it needs more bricklayers

Guest Column

Texas has always been a state that thinks in terms of scale. Big energy, big ambitions and now, big action in cybersecurity.

With the creation of the Texas Cyber Command under the Department of Information Resources, the state is recognizing what many of us in the industry have long understood: cybersecurity is not just an IT issue, it's a matter of public safety and economic resilience. Protecting municipal systems, schools, and critical energy infrastructure from cyber threats is no longer optional. It is essential.

For these efforts to succeed, Texas must invest as much in people as it does in technology. Without a capable, well-trained workforce to carry out the mission, even the strongest cyber strategies will struggle to hold the line.

The scope of the threat

Cyberattacks are not theoretical. In the last year alone, several cities in Texas experienced major ransomware attacks. One incident in Fort Worth took down core city systems, affecting everything from email access to permitting operations. The ripple effects were significant.

The energy sector is also under constant pressure. As a cornerstone of both the Texas and national economy, the it is a high-value target. Hackers are probing systems that manage oil, gas, and renewable energy infrastructure, looking for weaknesses that could be exploited to steal data or disrupt operations.

Texas has responded by centralizing its cyber incident response capabilities. The Texas Cyber Command is a smart step forward. It brings coordination and focus to an increasingly complex landscape. But its effectiveness will depend entirely on the professionals tasked with doing the work. And that’s where the challenge lies.

The workforce gap

Across the U.S., there are an estimated 400,000 unfilled cybersecurity positions. In Texas, more than 40,000 roles remain vacant, according to CyberSeek. These are not just numbers in a report. They represent a growing vulnerability with gaps in frontline defenses against real and persistent threats.

We cannot afford to rely solely on traditional pathways to fill this gap. Four-year degree programs are important, but they are not designed to scale fast enough or flexibly enough to meet today’s needs. Instead, we need to broaden our view of what a cybersecurity talent pipeline looks like and who it includes.

There needs to be an expanded focus on practical, skills-based training that takes high-aptitude individuals, including those from non-traditional backgrounds, and prepares them for success in cybersecurity careers through rigorous hands-on training that reflects the demands of real-world cyber roles. With the right structure and support, people from all walks of life are already proving they can become capable defenders of our digital infrastructure.

The same entrepreneurial spirit that drives innovation in other sectors can be applied to cybersecurity workforce development. We don’t have to wait years to grow the next generation of defenders. We can do it now, with the right focus and investment.

Texas has taken a critical first step by creating the Cyber Command, but if we want to build lasting resilience, we need to address the workforce bottleneck head-on. Cybersecurity needs more than tech…it needs talent.

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Dean Gefen is theCEO, NukuDo, a San Antonio-based cybersecurity workforce development and staffing company.

Rice Business Plan Competition doles out $2M to 2025 student teams

big winners

Celebrating its 25th year, the Rice Alliance for Technology and Entrepreneurship hosted the celebrated Rice Business Plan Competition this month, doling out more than $2 million in investment and cash prizes to the top-performing teams.

“For 25 years, the Rice Business Plan Competition has helped shape how Rice Business shows up in the world by creating a platform where student-entrepreneurs can tackle some of the most complex challenges of our time in energy, in health care, in technology and beyond,” Peter Rodriguez, dean of Rice Business, the presenting sponsor of the event, said in a news release. “If we’re serious about changing the world — and I believe we are — then it’s our responsibility to open doors for students everywhere to imagine bold solutions and build what comes next.”

Over the course of the three-day event, the 42 startups competing this year from colleges or universities around the world presented their plans before more than 300 angel, venture capital, and corporate investors. The teams were selected from the event’s largest applicant pool to date and represented 34 universities across four countries, according to Rice. Winners were announced at the company showcase and awards ceremony April 12 in downtown Houston.

Seven finalists were selected, though each team left the competition with some form of funding, according to Rice. The University of Michigan's Intero Biosystems was the star of the show, bringing home both the top-place finish and the largest total investment. Rice's own Pattern Materials also had a strong showing, placing fourth in the pitch competition and also earning the fourth-highest investment total.

Here are the teams that won big in 2025. See a full list of winners and prizes here.

Intero Biosystems, University of Michigan - $902,000

The team finished in first place for its GastroScreen, the first stem cell-driven human “mini gut” that is ideal for organ function testing before testing on humans, and also claimed the largest total investments among the competition.

  • $150,000 Goose Capital Investment Grand Prize
  • $250,000 Goose Capital Investment Prize
  • $200,000 The OWL Investment Prize
  • $100,000 Houston Angel Network Investment Prize
  • $100,000 nCourage Investment Network’s Courageous Women Entrepreneur Investment Prize
  • $100,000 Investment Prize from Nancy Chang
  • $1,000 Mercury Elevator Pitch Competition - Overall Winner
  • $1,000 Anbarci Family Company Showcase Prize
  • TMC Innovation Healthcare Accelerator Bootcamp Invitation Prize

MabLab, Harvard University – $301,500

The team placed second for its rapid test capable of detecting multiple adulterants in laced drugs and spiked drinks.

  • $100,000 Investment Prize, sponsored by David Anderson, Anderson Family Fund, Jon Finger and Finger Interests
  • $100,000 The Indus Entrepreneurs (TiE) Texas Angels Investment Prize
  • $25,000 nCourage Investment Network’s Courageous Women Entrepreneur Investment Prize
  • $50,000 Valhalla Investment Network Investment Prize
  • $25,000 The Eagles Investor Investment Prize
  • $500 Mercury Elevator Pitch Competition - Life Science*
  • $1,000 Anbarci Family Company Showcase Prize

re.solution, RWTH Aachen University — $76,500

The team placed third for its water-based technology that recycles polyesters without generating salt waste, making textile recycling viable.

  • $50,000 Investment Prize, sponsored by David Anderson, Anderson Family Fund, Jon Finger and Finger Interests
  • $25,000 Pearland EDC Spirit of Entrepreneurship Cash Prize
  • $500 Mercury Elevator Pitch Competition - Energy/Cleantech
  • $1,000 Anbarci Family Company Showcase Prize

Pattern Materials, Rice University – $134,500

The Houston-based team placed fourth for its laser-induced graphene technology that can be rapidly performed, enabling low-cost, scalable production of the material.

  • $5,000 prize, sponsored by Norton Rose Fulbright
  • $50,000 Valhalla Investment Network Investment Prize
  • $25,000 Pearland EDC Spirit of Entrepreneurship Cash Prize
  • $25,000 New Climate Ventures Sustainable Investment Prize
  • $25,000 Amentum and WRX Companies Rising Stars Space Technology and Commercial Aerospace Cash Prize
  • $500 Mercury Elevator Pitch Competition - Hard Tech
  • $1,000 Anbarci Family Company Showcase Prize
  • $3,000 Venture Builder Innovation Prizes

Xatoms, Western University and University of Toronto — $30,000

The team placed fifth for its AI- and quantum-driven platform for discovering solar-activated semiconductor materials.

  • $5,000 prize, sponsored by EY
  • $25,000 nCourage Investment Network’s Courageous Women Entrepreneur Investment Prize

Mito Robotics, Carnegie Mellon University— $5,000

The team placed sixth for its automated manual cell culture with AI-powered robotic scientists for life science research

  • $5,000 prize, sponsored by Chevron Technology Ventures

FarmSmart.ai, LSU – $106,000

The team placed seventh for its AI—driven assistant that synthesizes vast agricultural research into actionable, tailored intelligence, but earned the fifth-most investments among the group.

  • $5,000 prize, sponsored by Shell Ventures
  • $100,000 The OWL Investment Prize
  • $1,000 Anbarci Family Company Showcase Prize
  • Edward H. Molter Memorial Prizes for Wildcard Round - 1st place - Advance to Finals


Other significant awards

GreenLIB Materials, University of Ottawa – $152,000

  • $150,000 Goose Capital Investment Prize
  • $2,000 Venture Builder Innovation Prizes

Microvitality, Tufts University – $26,500

  • $25,000 Southwest National Pediatric Device Consortium Pediatric Device Cash Prize
  • $1,500 Edward H. Molter Memorial Prizes for Wildcard Round - 3rd place overall in WC

Nanoborne, University of Texas at Austin - $25,000

  • $25,000 NOV Golden Ticket to Supernova Accelerator and Cash Prize

Last year, the Rice Business Plan Competition facilitated over $1.5 million in investment and cash prizes. MesaQuantum from Harvard University landed the highest total investment last year, although it was not named a finalist. Protein Pints from Michigan State University won the pitch competition.

According to Rice, 910 startups have raised more than $6.9 billion in capital through the competition over the last 25 years.