Annual report highlights Houston's big innovation wins across tech, life science, space, VC funding, and more

by the numbers

The Greater Houston Partnership's annual Houston Facts report recently released. Here's what to know across the city's five most innovative sectors. Photo via Getty Images

Houston, a city known for its energy legacy, is rapidly transforming into a diverse hub of innovation, life science, technology, and aerospace, according to the 2023 Houston Facts report, released by the Greater Houston Partnership.

Here are some highlights from the report.

​The thriving tech ecosystem

Chart via 2023 Houston Facts

With over 230,800 tech workers representing 6.9 percent of the workforce, Houston has firmly established itself as a digital tech talent hub, per the report, which adds that the city is home to a staggering 9,100 tech-related firms, including more than 1,000 venture-backed startups. These startups have secured $6.42 billion in venture capital funding over the past five years, with $1.95 billion in funding in 2022 alone, according to GHP analysis of Pitchbook data.

Houston's technology landscape witnessed significant growth in 2022, with the most heavily invested industries being Energy, Information Technology, and Business Products and Services. A study by Dice revealed that Houston led all cities in tech job posting growth in 2022, boasting a remarkable 45.6 percent year-over-year increase.

Among Houston's largest employers are tech giants such as Asurion, AWS, Dell, HighRadius, HP Enterprise, HP Inc., IBM, PROS, BMC Software, Siemens, Honeywell, Oracle, and Microsoft.

Health startups and biotech advancements

Houston's health tech and life science innovation sector will continue to grow with Helix Park. Courtesy of Elkus Manfredi Architects

Houston's life science and biotech sector is continuing to develop, the GHP finds, with a vast pool of medical professionals, including over 161,800 healthcare practitioners and technical workers, as well as 15,400 life science and biotech researchers.

In 2022, several health startups received significant venture capital funding, showcasing Houston's commitment to advancing medical technologies. The largest deals were from: NuProbe, RadioMedix, Medical Informatics, XCath, Stream Biomedical, Decisio, Adient Medical, Coya Therapeutics, Octagos Health, and Luna Genetics. Collectively, these startups raised over $220 million in funding to develop innovative solutions in diagnostics, monitoring, therapeutics, and more.

The Texas Medical Center Innovation Factory serves as the nucleus of Houston's life science startup activity. With the TMC's Helix Park continuing to rise as an expanded campus, even more activity is on its way to Houston.

Growing innovation infrastructure

Houston's innovation corridor continues to develop. Map via 2023 Houston Facts

When it comes to the development of Houston's innovation ecosystem, the report called out a few milestones the region reached in 2022. Here are some of those wins from last year.

  • The Houston area grew to include more than 80 SDOs, including incubators and accelerators, makerspaces, coworking spaces, nonprofits, and academic institutions. Per the report, there are at least 30 incubator and accelerator programs currently running in Houston — including MassChallenge, Ion Smart Cities Accelerator, Gener8tor, JLABS, Greentown Labs, TMC Innovation and more.
  • The Houston Innovation corridor, which consists of a a four-mile expanse across the city’s urban core and is anchored by Rice University's Ion, continues to take shape.
  • Both Rice University and University of Houston held onto the top spots on The Princeton Review's report on top entrepreneurship programs. And, the annual Rice Business Plan Competition remains the richest pitch competition in the country, according to the Princeton Review, doling out nearly $2.0 million in prizes.

Aerospace advancement

Axiom Space — as well as a few other Houston space tech companies — had some big wins in 2022. Photo courtesy of NASA

Anchored by NASA's Johnson Space Center and the Houston Spaceport, the city's aerospace industry continues to play a major role in the future of space exploration and commercialization.

The Orion, Gateway, and Human Landing System programs, which are part of NASA's Artemis missions, are headquartered at JSC.

Three Houston space tech companies made major moves recently, as Houston Facts calls out:

  • Axiom Space broke ground on the first phase of a 22-acre campus that will house astronaut training and develop Axiom Station, a commercial module that will attach to the ISS.
  • Intuitive Machines, which went public last year, started construction on a 12.5-acre campus. "Intuitive will build lunar landers, operate its mission control center, and make guidance, navigation, and make guidance, navigation, and control products at its site," per Houston Facts.
  • Collins Aerospace, which has a significant presence in Houston, began operations at their eight-acre campus where it will develop systems for NASA’s human spaceflight programs. The company is working with Axiom Space to create the next generation of NASA spacesuits via a NASA contract that is valued at up to $3.5 billion.

Tracking the energy transition

Chart via 2023 Houston Facts

The report highlights the fact that last year Houston's energy transition brought in $6.1 billion in financing from private market investments, which represents a 61.9 percent increase compared to 2021.

"Over the last five years, Houston has seen constant growth in annual energy transition investments, with a notable surge observed from 2020 onwards," reads the report.

Corporate and strategic merger and acquisition investments are what dominated the five deal types, according to the report, representing 68.8 percent of the total investment in 2022. Additionally, private equity accounted for 19.3 percent of all deals, with venture capital comprising 9.5 percent.

EnergyCapital, a sister site to InnovationMap, covered the complete section on the energy industry in the Houston Facts in an article. Read it here.

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"Houston is a thriving hub of digital tech talent." Photo via Getty Images

Report: Venture capital funding, tech jobs up in Houston

by the numbers

In just a five-year span, Houston's annual haul of venture capital has skyrocketed by nearly 200 percent.

Startups in the region raised $283.8 million in 2016, according to Pitchbook data cited in the Greater Houston Partnership's newly released 2021 Houston Facts report. Last year, the figure climbed to a record-breaking $823.9 million. That represents a five-year jump of 190.3 percent.

Health care attracted by far the most venture capital of any sector last year — $323.9 million — with the IT sector in second place ($203.7 million), the report says.

Over the five-year span, the health care sector also reigns as the area's VC leader, with a total of more than $1.1 billion in venture capital, making up 41 percent of the region's venture capital. IT ranks second, collecting $722.7 million in venture capital, or 27 percent of the entire VC pie.

In all, the Houston area is home to over 700 VC-backed startups, with at least 10 of them valued at more than $100 million, the report says.

The Houston Facts report also sheds light on other facets of the regional economy. Here are six of them.

Tech workforce

Economically speaking, Houston may be best known for energy and health care. But the Greater Houston Partnership report shows the tech sector deserves to be part of the conversation.

With more than 243,900 tech workers, the Houston area boasts the 11th largest tech workforce in the U.S. In 2019, Houston's tech industry contributed $29.2 billion to the region's gross domestic product (GDP), a key measure of economic activity.

To put the size of the region's tech workforce into perspective, the number of tech workers in the Houston area is roughly double the population of Pearland.

"Houston is a thriving hub of digital tech talent," the report says.

Economic power

Citing data from the U.S. Bureau of Economic Analysis, the report notes the Houston area's GDP stood at an estimated $512.2 billion in 2019. That makes Houston the seventh largest economy of U.S. metro areas.

If the Houston area were a state, its GDP would rank 15th, behind Michigan ($536.9 billion) and ahead of Maryland ($426.7 billion) and Colorado ($393 billion).

If the region were an independent nation, it would rank as the world's 27th largest economy, behind Belgium ($529.7 billion) and ahead of Nigeria ($448.1 billion) and Austria ($446.3 billion).

Expanding corporate hub

The Houston area ranks third in the U.S. for the Fortune 500 headquarters and fifth for Fortune 1000 headquarters. The 20 companies on the Forbes Global 2000 list that are based in the Houston area have combined revenue of $413.6 billion.

International reach

The Houston areas maintains trading relationships with more than 200 countries.

The Houston/Galveston Customs District handled 266.6 million metric tons of exports valued at $129.5 billion in 2020, according to WISERTrade data cited in the report. These exports accounted for 65.8 percent of the total value that passed through the region last year, up from 44.5 percent in 2011.

Top port

In 2019, the Port of Houston ranked first in total tonnage (foreign and domestic) — after 27 consecutive years in second place — and first in foreign tonnage (imports and exports) for the 24th consecutive year, according to the most recent data from the U.S. Army Corps of Engineers. Globally, the Port of Houston ranked as the world's 16th largest port based on total tonnage.

Business presence

The Houston area was home to more than 160,000 business establishments in 2020, according to Texas Workforce Commission data cited in the report. The three industries with the most establishments were professional, scientific, and technical services; health care and social assistance; and retail. These three industries made up 38 percent of the region's business establishments.


The Greater Houston Partnership has released its 2020 Houston Facts — here's what you need to know. Getty Images

5 innovation-focused takeaways from the Greater Houston Partnership's annual report

BY THE NUMBERS

In an annual economic report from the Greater Houston Partnership, researchers and data scientists outlined the city's economy by the numbers, and Houston's industries such as technology, health care, energy, and more were all represented.

The 2020 Houston Facts was released in an virtual event hosted by GHP and its team of data specialists. Here's what you need to know from the event and the report, which can be found online.

The Texas Medical Center is focusing on five new institutes

Screenshot via Houston Facts 2020

The Texas Medical Center has established itself as a topic of its own in the Houston Facts report. The 61-member nonprofit that connects medical institutions across the city. The organization is working on a new campus, TMC3, that is expected to complete in 2022 and bring an annual economic impact of $5.2 billion to the state of Texas along with 30,000 jobs. From

According to the report, TMC is continuing to develop five institutes that compliment the organization's focus on innovation, regenerative medicine, health policy, and more:

  1. TMC Innovation Institute
  2. TMC Health Policy Institute
  3. TMC Clinical Research Institute
  4. TMC Regenerative Medicine Institute
  5. TMC Genomics Institute

Houston's port business continues to stay strong, with potential for growth following expansion

Screenshot via Houston Facts 2020

The Port of Houston has long been a key part of Houston's history and its economic impact. Across four seaports in the Houston area, the city moved 242.9 million metric tons of trade last year, and the district has been consistently named the busiest or one of the busiest by tonnage for over a decade.

With over 200 companies calling the port home and a busy port district, the Houston Ship Channel has been working on an expansion project, called Project 11. Construction on the project could begin as early as next year, per the report.

Venture capital is on the rise as tech jobs stays steady

Screenshot via Houston Facts 2020

Again, Houston Facts has called out the growth Houston has seen in venture capital investment. According to the report, top industries for VC funding include health tech, software, and energy. Houston Facts reports the ecosystem saw $600 million invested last year. While numbers vary based on sources, Houston Exponential recently reported over $466 million of venture capital invested in Houston between January and July of 2020.

Meanwhile, when it comes to tech jobs in Houston, the city has held its place as 12th in the nation for cities with the most tech jobs. Last year, Houston had 235,802 tech workers according to data from CompTIA, Cyberstates 2020. That count is slightly increased from 2018's 223,000 tech workers in Houston.

Houston's evolving demographics continues to shape the city

Screenshot via Houston Facts 2020

Houston is regularly touted as the most diverse city in the nation, and that diversity has affected the city's business sector. As of last year, largest ethnic population in Houston is hispanic. Houston now has the fourth largest hispanic population in the country, however, according to the report, Houston's percent of African-American citizens has remained consistent.

COVID-19's full effect on Houston is still to be determined, but business has taken a hit

Getty Images

The 2020 edition of Houston Facts doesn't have much on the impact of COVID-19 — the 2021 issue should have more facts and figures from looking back on the pandemic. However, the GHP's team did address some of the economic impacts the coronavirus had on the city.

According to Yelp data based on listings, 3,518 businesses closed due to COVID-19 — of which, only 578 had reopened by mid-June.

The Greater Houston Partnership has the facts. Nick Bee/Pexels

4 things you need to know from the Greater Houston Partnership's annual report as it pertains to innovation

By the numbers

Every year, the Greater Houston Partnership — the city's economic development arm — gathers up data and reports to paint a full picture of the Bayou City. In the past few editions, innovation has been a key component.

The GHP's innovation coverage spans three pages under the top industry and sectors category. From tech startup growth to money raised, here's what you need to know from the 2019 Houston Facts.

Houston has the 12th largest tech sector in the United States

Christina Morillo/Pexels

The innovation section starts pretty strong with this fun fact. The No. 12 tech sector ranking comes from Computing Technology Industry Association, which cites that Houston has more than 223,000 tech workers. According to the report, about two-thirds of Houston's tech workers are in industries outside of computer and software.

GHP credits Houston's large population of tech workers to its connection to aerospace and oil and gas.

"As the home of NASA's Johnson Space Center and headquarters to the global energy industry, Houston has long been a global hub of engineering talent," the report reads. "In recent years, those skills have given rise to a thriving ecosystem of digital technology companies."

GHP's data reflect that Houston has more than 8,200 tech-related firms, which includes over 500 tech startups.

Venture funding was up over 50 percent between 2017 and 2018

Via Houston Facts


Houston's recorded venture funding doesn't have a hockey stick chart to brag about. Over the past few years, venture funding has been up and down, according to S&P Capital IQ.

"Houston companies in clean energy, health innovation and digital technology have received $3.1 billion in venture capital and growth funding across 333 deals since 2014, averaging $576 million every year," the report reads.

But between 2018 and 2017, VC funds were up 50.9 percent. Of the three categories, clean energy technology pulled in the most money each year and was responsible for 64 percent of the funding during the 2014-2018 period. Sunnova, a residential solar company, had the most money raised during this time with $1.3 billion.

The largest deals reported in Houston in 2018 were:

  • Sunnova Energy — $183 million
  • OncoResponse — $40 million
  • Trisun Energy Services — $39 million
  • Arundo Analytics — $25 million
  • Procyrion — $16 million
  • QuVa Pharma — $15 million
  • NeoSensory — $12 million

University-backed entrepreneurship remains strong

Courtesy of Rice University

The Princeton Review ranks Rice University and the University of Houston as having among the best entrepreneurship programs in the country. Rice runs its Rice Alliance for Technology and Entrepreneurship out of its Jones Graduate School of Business, while University of Houston's Cyvia and Melvyn Wolff Center for Entrepreneurship is housed in the Bauer College of Business.

Both schools have run accelerator programs for seven years — the past six of which have been in collaboration. Rice's OwlSpark and UH's RED Labs finished this summer's program on August 1 at the Bayou Startup Showcase with 16 startup pitches.

Meanwhile, the Rice Business Plan Competition is deemed the "richest pitch competition" in the country. In 2019, the competition saw $3 million invested. RBPC companies have gone on to raise $1.2 billion in capital during the competition's 18-year history.

At UH, which has its own set of pitch events, the Wolff Center's graduate students manage a million-dollar Cougar Venture Fund. The fund has a group of experts that analyze and invest in early stage technology companies.

The life science industry continues to grow

Via Houston Facts

In 2018, Houston housed 20.5 percent of the country's clinical trials, with over 1,800 active. The city has more than 1,760 life sciences companies and over 25,100 biotech experts and 7,200 medical researchers.

Thankfully, the money seems to match this volume of activity. Last year, Houston's medical research grant funding from the National Institutes of Health, which totaled $668 million in 2018, was up almost 7 percent from 2017. The city's medical institutions have received nearly $3 billion from NIH since 2014 — an average of $600 million a year.

According to the GHP, the top Houston institutions receiving NIH funding in 2018 were:

  • Baylor College of Medicine — $255 million
  • University of Texas MD Anderson Cancer Center — $149 million
  • University of Texas Health Science Center — $90 million
  • University of Texas Medical Branch Galveston — $87 million
  • University of Houston — $24 million
  • Methodist Hospital Research Institute — $19 million
  • Rice University — $14 million
  • Texas Southern University — $3 million

As mentioned before, venture capital and private equity investment has increased in Houston, and that trend is also represented in the life science sector. In 2018, life science startups raked in $119 million, which represents a a 41.7 percent increase from $84 million in 201717, according to S&P Capital IQ.

In 2018, the top biotech firms receiving investment were:

  • OncoResponse — $40 million
  • Procyrion — $16 million
  • QuVa Pharma — $15 million
  • Pulmotect — $10 million
  • Tvardi Therapeutics — $9 million

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Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

Houston booms as No. 2 U.S. metro for new home construction

Construction Boom

Driven by population growth, more residential rooftops are popping up across Houston and the rest of Texas than anywhere else in America.

Using data from the U.S. Census Bureau and Zillow, Construction Coverage found 65,747 new residential units were authorized in greater Houston in 2024. That figure landed Houston in second place among major metro areas for the total number of housing permits, including those for single-family homes, apartments, and condos.

Just ahead of Houston was the Dallas-Fort Worth Metroplex, which took first place with 71,788 residential permits approved in 2024. In third place was the country’s largest metro, New York City (57,929 permits).Elsewhere in Texas, the Austin metro ranked sixth (32,294 permits), and the San Antonio metro ranked 20th (14,857 permits).

Construction Coverage also sorted major metro areas based on the number of new housing units authorized per 1,000 existing homes in 2024. Raleigh, North Carolina, held the No. 1 spot (28.8 permits per 1,000 existing homes), followed by Austin at No. 2 (28.6), DFW at No. 3 (22.2), Houston at No. 4 (21.6), and San Antonio at No. 13 (13.6).

A Newsweek analysis of Census Bureau data shows building permits for 225,756 new residential units were approved in 2024 in Texas — a trend fueled largely by activity in DFW, Houston, Austin, and San Antonio. That put Texas atop the list of states building the most residential units for the year.

Through the first eight months of last year, 145,901 permits for new residential units were approved in Texas, according to Census Bureau data. That’s nearly 80,000 permits shy of the 2024 total.

Among the states, Construction Coverage ranks Texas sixth for the number of residential building permits approved in 2024 per 1,000 existing homes (17.9).

Extra housing is being built in Texas to meet demand spurred by population growth. From April 2020 to July 2024, the state’s population increased 7.3 percent, the Census Bureau says.

While builders are busy constructing new housing in Texas, they’re not necessarily profiting a lot from homebuilding activity.

“Market conditions remain challenging, with two-thirds of builders reporting they are offering incentives to move buyers off the fence,” North Carolina homebuilder Buddy Hughes, chairman of the National Association of Home Builders, said in a December news release. “Meanwhile, builders are contending with rising material and labor prices, as tariffs are having serious repercussions on construction costs.”

5+ must-know application deadlines for Houston innovators

apply now

Editor's note: As 2026 ramps up, the Houston innovation scene is looking for the latest groups of innovative startups that'll make an impact. A number of accelerators and competitions have opened applications. Read below to see which might be a good fit for you or your venture. And take careful note of the deadlines. Please note: this article may be updated to include additional information and programs.

Did we miss an accelerator or competition accepting applications? Email innoeditor@innovationmap.com for editorial consideration.

2026 HCC Business Plan Competition

Deadline: Jan. 26

Details: HCC’s annual Business Plan Competition (BPC) is an opportunity for proposed, startup and existing entrepreneurs to develop focused plans to start or grow their businesses. Accepted teams will be announced and training will begin in late February and run through early June, with six free, three-hour training sessions. Advising will be provided to each accepted team. Applicants can apply as a team of up to five persons. Finalists will present to to gudges on May 27, 2026. Last year, $26,000 was awarded in seed money to the top five teams. In-kind prizes were also awarded to all graduating teams including free products, services and memberships, with an estimated in-kind value totaling $147,000. Find more information here.

University of Houston Technology Bridge Innov8 Hub (Spring 2026)

Deadline: Jan . 30

Details: UHTB Innov8 Hub’s immersive, 12-week startup acceleration program designed to help early-stage founders launch and scale their technology startups. Selected participants will gain access to expert mentors and advisors, collaborate with a cohort of peers, and compete for cash prizes during our final pitch event. The cohort begins Feb. 16, 2026. The program culminates in Pitch Day, where participants present their ventures to an audience of investors and partners from across the UH innovation ecosystem. Find more information here.

Rice Business Plan Competition 2026

Deadline: Jan. 31

Details: The Rice Business Plan Competition, hosted by the Rice Alliance for Technology and Entrepreneurship, gives collegiate entrepreneurs real-world experience to pitch their startups, enhance their business strategy and learn what it takes to launch a successful company. Forty-two teams will compete for more than $1 million in cash, investments and prizes on April 9-11, 2026. Find more information here.

Rice Veterans Business Battle 2026

Deadline: Jan. 31

Details: The Rice Veterans Business Battle is one of the nation’s largest pitch competitions for veteran-led startups, providing founders with mentorship, exposure to investors and the opportunity to compete for non-dilutive cash prizes. The event has led to more than $10 million of investments since it began in 2015. Teams will compete April 8-9, 2026. Find more information here.

TEX-E Fellows Application 2026-2027

Deadline: Feb. 10

Details: The TEX‑E Fellowship is a hands-on program designed for students interested in energy, climate, and entrepreneurship across Texas. It connects participants with industry mentors, startup founders, investors and academic leaders while providing practical, "real-world" experience in customer discovery, business modeling, and energy-transition innovation. Fellows gain access to workshops, real-world projects, and a statewide network shaping the future of energy and climate solutions. Participants must be a student at PVAMU, UH, UT Austin, Rice University, MIT or Texas A&M. Find more information here.

2026 Energy Venture Day & Pitch Competition

Deadline: Feb. 13

Details: The Rice Alliance, the Houston Energy Transition Initiative (HETI) and TEX-E will present the annual Energy Venture Day and Pitch Competition during CERAWeek on March 24-25, 2026. Energy Venture Day features two days of presentations by energy tech ventures driving efficiency and advancements toward the energy transition. On March 24, the Pitch Preview at the Ion will feature over 50 companies presenting in front of Rice Alliance's robust network of investors and industry partners. On March 25, the Energy Venture Day and Pitch Competition during CERAWeek will showcase 36 ventures at the George R Brown Convention Center. The pitch competition is divided up into the TEX-E university track, in which Texas student-led energy startups compete for $50,000 in cash prizes, and the industry ventures track. The industry track is subdivided into three additional tracks, spanning materials to clean energy. The top three companies from each industry track will be named. The winner of the CERAWeek competition will also have the chance to advance and compete for the $1 million investment prize at the Startup World Cup. Find more information here.

Greentown Go Make 2026

Deadline: March 10

Details: Greentown Go Make 2026 is an open-innovation program with Shell and Technip Energies. The six-month program is advancing industrial decarbonization by accelerating catalytic innovations. Selected startups will gain access to a structured platform to engage leadership from Shell and Technip Energies and explore potential partnership outcomes, including pilots and demonstrations. They’ll also receive networking opportunities, partnership-focused programming, and marketing visibility throughout the program. The cohort will be selected in May. Find more information here.

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