Houston health tech startup scores $2.5M SBIR grant to advance unique cell therapy AI technology

fresh funding

CellChorus created a visualization AI program that helps scientists to better understand the functioning of cells, including their activation, killing and movement. Photo via Getty Images

A Houston biotech company just announced a new award of $2.5 million.

CellChorus, a spinoff of the Single Cell Lab at the University of Houston, announced the fresh funding, which comes from an SBIR (Small Business Innovation Research) grant from the National Institute of Health (NIH) through its National Center for Advancing Translational Sciences (NCATS).

CellChorus is the business behind a technology called TIMING, which stands for Time-lapse Imaging Microscopy In Nanowell Grids. It’s a visualization AI program that helps scientists to better understand the functioning of cells, including their activation, killing and movement. This more in-depth knowledge of immune cells could be instrumental in developing novel therapies in countless disorders, including cancers and infectious diseases.

“While many cell therapies have been approved and are in development, the industry needs an integrated analytical platform that provides a matrix of functional readouts, including cell phenotype and metabolism on the same cells over time,” Rebecca Berdeaux, vice president of science at CellChorus, says in a press release. “We are grateful to NCATS for its support of the development of application-specific kits that apply dynamic, functional single-cell analysis of immune cell phenotype and function. The product we will develop will increase the impact of these therapies to improve the lives of patients.”

A two-year, $2.1 million Phase II grant will begin after the company achieves predetermined milestones under a $350,000 Phase I grant that is currently taking place. As Berdeaux explained, the funds will be used to develop TIMING kits which will manufacture analytics that provide end-users with rapid, specific and predictive results to accelerate translational research and the development and manufacture of more effective cell therapies.

TIMING is more than a great idea whose time has yet to come. It has already been proven in great depth. In fact, last June, CellChorus CEO Daniel Meyer told InnovationMap that he was initially attracted to the technology because it was “very well validated.” At the time, CellChorus had just announced a $2.3 million SBIR Fast-Track grant from the National Institute of General Medical Sciences. The company also went on to win an award in the Life Science category of the 2023 Houston Innovation Awards.

That confirmation of success comes from more than 200 peer-reviewed papers that describe myriad cell types and types of therapy, all of which used data from TIMING assays. TIMING data has benefited industry leaders in everything from research and clinical development to manufacturing. With the new grant, TIMING will become more widely available to scientists making important discoveries relating to the inner workings of the cells that drive our immunity.

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The projects are among 16 other early-stage research projects at U.S. colleges and universities to receive a total of $17.4 million from the DOE's Office of Fossil Energy and Carbon Management. Photo courtesy of University of Houston

3 UH projects land $17.4M in DOE funding for early-stage research

follow the money

Three projects from the University of Houston have been awarded funds from the U.S. Department of Energy for research on decarbonization and emissions.

The projects are among 16 other early-stage research projects at U.S. colleges and universities to receive a total of $17.4 million from the DOE's Office of Fossil Energy and Carbon Management (FECM).

“These three projects show the relevance and quality of the research at UH and our commitment to making a meaningful impact by addressing society’s needs and challenges by doing critical work that impacts the real world,” Ramanan Krishnamoorti, vice president for energy and innovation at UH, says in a statement. “The success of these project could attract investment, create jobs, produce clean energy, save costs, reduce carbon emissions, and benefit not only the greater Houston area, but the Gulf Coast and beyond.”

The projects were selected under FECM’s University Training and Research program, which aims to support "research and development opportunities for traditionally underrepresented communities and tap into the innovative and diverse thinking of student researchers," according to an announcement from the DOE.

Here are the projects from UH and their funding amounts:

A Comprehensive Roadmap for Repurposing Offshore Infrastructure for Clean Energy Projects in the Gulf of Mexico, $749,992 — Led by Ram Seetharam, UH Energy program officer, this project looks at ways to prolong the life of platforms, wells and pipelines in the Gulf Coast and will create a plan "covering technical, social, and regulatory aspects, as well as available resources," according to UH.

Houston Hydrogen Transportation Pilot, $750,000— Led by Christine Ehlig-Economides, Hugh Roy and Lillie Cranz Cullen, and managed by Joe Powell, this project will demonstrate the potential for a hydrogen refueling pilot in Houston. The first phase will create a system to optimize hydrogen and the second will create a workforce training network. The project is in collaboration with Prairie View A&M University.

Synergizing Minority-Serving Institution Partnerships for Carbon-Negative Geologic Hydrogen Production, $1.5 million — This project is in collaboration with Stanford Doerr School of Sustainability and Texas Tech. The project will create a visiting scholars program for students from UH and TTU, who will spend one month per year at Stanford for three years. While in the program, students will focus on creating carbon-negative hydrogen from rocks beneath the Earth's surface. Kyung Jae Lee, associate professor in the Department of Petroleum Engineering at UH, is working alongside colleagues at TTU and Stanford on this project.

Other projects in the group come from the University of Texas at El Paso, New Mexico Institute of Mining and Technology, Tennessee State University, North Carolina Agricultural and Technical State University, Duke University and more.

Last year the DOE also awarded $2 million to Harris and Montgomery counties for projects that improve energy efficiency and infrastructure in the region. Click here to read about those projects.

The DOE also granted more than $10 million in funding to four carbon capture projects with ties to Houston last summer.
Greentown Houston has received funding from the EDA. Photo via GreentownLabs.com

Houston energy tech startup incubator secures federal support to accelerate tech entrepreneurship

seeing green

Sixty organizations across the country have received a grant from the United States Department of Commerce — and one recipient is based in Houston.

Greentown Labs, dual located in Houston and Somerville, Massachusetts, has received a grant from the 10th cohort of the Economic Development Administration's “Build to Scale” program for its Houston location. The $53 million of funding was awarded to 60 organizations across 36 states, the District of Columbia, and Puerto Rico. All of the programs support technology entrepreneurs across industries.

“The Biden-Harris Administration is Investing in America to help create entrepreneurial ecosystems across the country and put quality, 21st century job opportunities in people’s backyards,” Secretary of Commerce Gina Raimondo says in the press release. “The ‘Build to Scale’ program will unlock innovation potential in regions all over the nation, improving our economic competitiveness now, and for decades to come.”

According to the EDA, Greentown, located in a growing innovation district, will receive $400,000 with a $400,000 local match confirmed. The project, named Houston Ion District Investor Activation, is described as a way to create economic opportunity through equitable capital access.

"This project capitalizes on the need for jobs and economic development, especially in communities most vulnerable to the impacts of natural disasters," reads the project abstract. "EDA funding will enable the expansion of Greentown’s Investor Program into EDIJ, in partnership with the Ion, to further climate equity and resilience in Houston and empower underrepresented entrepreneurs as the city transitions from fossil fuels to a clean energy economy."

Greentown receives of of the 2023 Capital Challenge Grant Recipients. The other competition, the Venture Challenge, also awarded funding to another Houston organization. The Urban Partnerships Community Development Corporation received $741,925 to support the BioWell Start Accelerator Program, which is committed to scaling of bio-industrial startups.

“EDA is proud to partner with this year’s ‘Build to Scale’ grantees as they fuel regional innovation hubs and technology-based economic development strategies throughout the U.S.,” Assistant Secretary of Commerce for Economic Development Alejandra Y. Castillo says in the release. “Investing in scalable startups and expanding access entrepreneurial capital will yield good-paying jobs, economic resiliency, and equitable growth in communities throughout America.”

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This article originally ran on EnergyCapital.

Houston-based Zeta Energy has fresh funding from the government. Image via Zeta Energy

Houston-based battery innovators receive $4M in federal funding

money moves

Houston-based Zeta Energy announced this week that it was selected to receive $4 million in federal funding for the development of efficient electric vehicle batteries.

The funds come from the U.S. Department of Energy's ARPA-E Electric Vehicles for American Low-Carbon Living, or EVs4ALL, program, which aims to increase the number of EVs on the roads by boosting the country’s supply chain of affordable, convenient, reliable and safe batteries.

Zeta Energy is one of 12 groups in the U.S. to receive funding from the program, which awarded $42 million in total.

“Electric vehicle sales in America have tripled since the start of this Administration and by addressing battery efficiency, resiliency and affordability, the projects announced today will make EVs attractive to even more drivers,” U.S. Secretary of Energy Jennifer M. Granholm said in a statement released earlier this week. “This is a win-win for our efforts to fight climate change and power America’s clean transportation future with technologies produced by researchers and scientists right here at home.”

Other teams to receive funding include 24M Technologies, national laboratories and universities like The Ohio State University, University of Maryland, Virginia Tech, among others. Zeta is the only Texas-based company to receive funds. It received one of the largest grants among the group.

"We are thrilled to have been selected for funding by the ARPA-E EVs4ALL program," Zeta Energy CEO Tom Pilette said in a statement. "We have been working hard to make this technology a reality, and we are really grateful to receive this recognition of the promise of our technology and the progress we have made on it."

Zeta Energy is known for its lithium sulfur batteries that traditionally have not been long lasting. While sulfur is an economical and abundant material, it traditionally would dissolve after a few uses in lithium sulfur batteries.

However, Zeta uses its proprietary sulfur-based cathodes and lithium metal anodes that have shown to have higher capacity and density and better safety profiles, according to the company's website.

According to ARPAE, the company will create a new anode that will "be highly accessible and rechargeable" with the funding.

Zeta Energy

closed a $23 million series A round led by New York VC firm Moore Strategic Ventures about a year ago. In addition to applications for electric vehicles, the company's technology is also expected to have uses in grid energy storage.
Federal relief efforts can be confusing — are are four options from a local tax expert that are reliable for small business owners. Getty Images

Tax expert shares 4 COVID-19 relief options for Houston small businesses

Guest article

There's been a lot in the news lately about large companies securing large federal grants to soften the financial blow of the CORONA shutdown — to the exclusion of smaller businesses. And even with new legislation that could provide additional funding, small companies could still be left out.

Here are four ways that companies can garner some financial relief in these challenging financial times:

1. Delay of employer FICA contributions 

While most of the attention has been focused on the forgivable loans that are part of the CARES Act, the good news is that — if you dig deeper — the legislation also provides a postponement (not forgiveness) of the employer portion of FICA payments. These are available for payroll taxes due beginning on March 27 through year's end. Payments can be deferred with half due on December 31, 2021, and the remaining half on December 31, 2022.

2. Employee retention credits

This is fully refundable tax credit available for employers equal to 50 percent of qualified wages paid to employees. The retention credit applies to qualified wages paid after March 12, 2020, though the balance of this calendar year.

There is a cap to the amount of the credit, and the credit is only available to companies that either:

  1. Fully or partially suspended operation during any calendar quarter in 2020 due to orders from an appropriate governmental authority limiting commerce, travel, or group meetings (for commercial, social, religious, or other purposes) due to COVID-19; or
  2. Experienced a significant decline in gross receipts during the calendar quarter.

3. Carrying back Net Operating Losses (NOL)

Another often missed provision of the CARES Act is the ability for companies to carry back net operating losses from 2018 or 2019 to prior years (going back 5 years) and obtain refunds of previously paid taxes. The 2017 tax reform eliminated the ability to carry back NOLs, but the CARES Act has resurrected them.

4. Families First Coronavirus Response Act (FFCRA) 

Employers with fewer than 500 employees may qualify for tax credits under the FFCRA, which was enacted on March 18. The legislation has two main sections: the Emergency Paid Sick Leave Act (EPSLA), and the Emergency Family and Medical Leave Expansion Act (FMLA Expansion).

An eligible employer may claim a fully refundable tax credit equal to 100 percent of the qualified family leave wages (and allocable qualified health plan expenses and the eligible employer's share of Medicare tax on the qualified family leave wages) it pays.

Each company's situation is different, so we strongly suggest you speak with your tax adviser to see how these provisions might apply to you.

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Jason Sharp, CPA, is tax partner at Briggs & Veselka, Houston's largest locally owned CPA firm. He can be contacted a jsharp@bvccpa.com.

Houston startup Grant Source, which helps its clients find the right grants to apply for, has seen a surge in business amid the coronavirus shutdown. Getty Images

This Houston tech startup is helping businesses find the funds during COVID-19 crisis and beyond

Taken for granted

Since 2015, Grant Source has perfected the art of helping businesses, foundations, and organizations find and secure grant funding — and now their expertise has become vital to COVID-19 response initiatives.

With the devastation caused by the novel coronavirus, America's medical organizations have been scrambling to obtain the funds required to purchase the testing kits, masks, PPE, and other life-saving products needed to help curb the effects of the global pandemic and now, thanks to the mobile and web platform, they're getting the assistance they need to accomplish that goal.

"COVID-19 response is actually our claim to fame right now," says Allen Thornton, founder and CEO of Grant Source. "We have probably done more business in the last few months than we have since we started. Simply because we are helping people find grants with the CARES Act. There's over $500 billion out there, which has created overnight a $40 billion market opportunity for us."

Grant Source has worked extensively with city, county, state, and government agencies to secure grant funding, which is why they have become a game changer for those that need emergency capital to combat COVID-19's challenges.

"Initially, it was scary because we lost some of our clients, but then a bunch of medical clients came to us and asked if we could help them find funding for COVID-19 outreach," Thornton says. "We've found that they have a higher probability of success right now because with COVID-19 outreach, the procurement cycle has gone from six to nine months down to 30 days, which is unheard of."

In addition to telemedicine companies, Grant Source has been helping write grants for clients that range from airports to technology companies in order to help provide them with a path forward in the fight against the novel coronavirus.

Grant Source has created a database and a suite of resources for companies looking for grants. Photo via grantsource.com


Preventing federal funding waste

Outside of the context of a pandemic, the government uses grants as a way to fund ideas and projects that provide public services and stimulate the economy.

Grants are also essential when it comes to supporting critical recovery initiatives and innovative research, but on a fundamental level, very few even know how or where to start when it comes to applying for one and it becomes even more esoteric when it comes to getting funded. That's why so much grant money goes unclaimed, with millions of nonprofits and businesses going underfunded and not maximizing their impact.

"Over $3.2 billion in grant money goes unclaimed every single year," says Thornton. "We have a broken system and we wondered what we could do to change it, so we started Grant Source, our revolutionary grant funding system, to help organizations find and secure money for their mission."

Client-focused services and support

In addition to helping clients find grants, Grant Source assists with the necessary pre-work to apply for a grant.

"We started out as just a database where you could find grants and grant writers," says Thornton. "But in listening to our customers, they wanted us to do everything full service, too. So, I flew all across the country from Minneapolis to Kansas to Los Angeles to Toronto and put all the top grant writing associations on retainer and created what is Grant Source today, which is pretty much mobile for grants."

Thornton says Grant Source has more than 1,500 consultants across the U.S. and Canada, and these professionals each have different specialties — much like a lawyer or a doctor — and relationships in different states.

For a flat fee that ranges from $500 to $5,000 per month, Grant Source will set out to procure its clients grants that range anywhere from $50,000 to $1 million based on their goals. To date, Grant Source has helped businesses and organizations find and secure over $6 million in grant funding.

New clients first sign up for an assessment with Grant Source that establishes what the client's goals are and how the company is set up. Once Grant Source has established a few options for the client, they get started on submitting to the grants. In order to protect its customers from the uncertainty of the process, Grant Source offers investment protection for 12 months.

"We have the investment protection so customers won't be left empty handed," says Thornton. "It's risk free, so if they don't at least get their investment back within the first 12 months, we'll either continue their grant at no cost or we'll give them a credit for the difference."

Founded from a personal need

Treating customers with fairness is important for Grant Source because they started out as a nonprofit seeking grant funding themselves and soon learned that there was a lot that they did not know about the process.

"When I was at UTSA in 2006, the African American graduation population was less than 6 percent, which was unacceptable, so we started a nonprofit," says Thornton. "We made a lot of impact in just a few years. We increased the graduation population from 6 percent to about 38 percent, And, for the 2008 election, we were able to register over 3,200 students."

After graduation, Thornton says he saw an opportunity to expand to other colleges, but lacked funding to do so.

"We saw grants as a huge opportunity and they are, but unfortunately, they're also a huge hassle and it takes a lot of time and energy and effort to even find one that you qualify for," he remembers. "And even when you do, if you don't know how to write the proposal, you're dead in the water."

After the grant process failed, Thornton's money was gone with no communication or valid reason as to why. That frustrated him to the point where he wanted to provide coherent solutions to the problem himself.

"I spent a ton of money on education and researching top grant writing associations," says Thornton. "Most people don't know where to find grants, and there are so many different types of grants and places you can find them. For instance, we're working on a federal proposal with the federal government, there's 26 different agencies that still don't even know how to talk to each other."

Creating a lasting impact

From the outset, Grant Source started creating corporate responsibility programs and impact within a cost center for organizations that were for profit companies. They seek to put them in ideal situations to create the kind of impact that warrants grant funding.

"What we teach our clients is that you can't approach the process with the idea that you will get the grant money and then go out and create come impact," says Thornton. "You have to focus on being able to showcase the impact that you're already creating and then we can go find money for that. If you can articulate the impact of whatever you're doing is creating, we can find the person that cares about that.

In addition providing the software and platform for grant seekers, Grant Source offers a book, courses, seminars, workshops, and conferences that offer the baseline information needed to secure grant funding.

"At the end of the day, Grant Source is a technology platform that helps organizations find money for their mission," says Thornton. "We've streamlined the grant writing process and the grant finding process. At Grant Source, we don't focus on the money, we focus on the impact and then we give people a clear path to make it happen."

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UH-backed project secures $3.6M to transform CO2 into sustainable fuel with cutting-edge tech

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A University of Houston-associated project was selected to receive $3.6 million from the U.S. Department of Energy’s Advanced Research Projects Agency-Energy that aims to transform sustainable fuel production.

Nonprofit research institute SRI is leading the project “Printed Microreactor for Renewable Energy Enabled Fuel Production” or PRIME-Fuel, which will try to develop a modular microreactor technology that converts carbon dioxide into methanol using renewable energy sources with UH contributing research.

“Renewables-to-liquids fuel production has the potential to boost the utility of renewable energy all while helping to lay the groundwork for the Biden-Harris Administration’s goals of creating a clean energy economy,” U.S. Secretary of Energy Jennifer M. Granholm says in an ARPA-E news release.

The project is part of ARPA-E’s $41 million Grid-free Renewable Energy Enabling New Ways to Economical Liquids and Long-term Storage program (or GREENWELLS, for short) that also includes 14 projects to develop technologies that use renewable energy sources to produce sustainable liquid fuels and chemicals, which can be transported and stored similarly to gasoline or oil, according to a news release.

Vemuri Balakotaiah and Praveen Bollini, faculty members of the William A. Brookshire Department of Chemical and Biomolecular Engineering, are co-investigators on the project. Rahul Pandey, is a UH alum, and the senior scientist with SRI and principal investigator on the project.

Teams working on the project will develop systems that use electricity, carbon dioxide and water at renewable energy sites to produce renewable liquid renewable fuels that offer a clean alternative for sectors like transportation. Using cheaper electricity from sources like wind and solar can lower production costs, and create affordable and cleaner long-term energy storage solutions.

Researchers Rahul Pandey, senior scientist with SRI and principal investigator (left), and Praveen Bollini, a University of Houston chemical engineering faculty, are key contributors to the microreactor project. Photo via uh.edu

“As a proud UH graduate, I have always been aware of the strength of the chemical and biomolecular engineering program at UH and kept myself updated on its cutting-edge research,” Pandey says in a news release. “This project had very specific requirements, including expertise in modeling transients in microreactors and the development of high-performance catalysts. The department excelled in both areas. When I reached out to Dr. Bollini and Dr. Bala, they were eager to collaborate, and everything naturally progressed from there.”

The PRIME-Fuel project will use cutting-edge mathematical modeling and SRI’s proprietary Co-Extrusion printing technology to design and manufacture the microreactor with the ability to continue producing methanol even when the renewable energy supply dips as low as 5 percent capacity. Researchers will develop a microreactor prototype capable of producing 30 MJe/day of methanol while meeting energy efficiency and process yield targets over a three-year span. When scaled up to a 100 megawatts electricity capacity plant, it can be capable of producing 225 tons of methanol per day at a lower cost. The researchers predict five years as a “reasonable” timeline of when this can hit the market.

“What we are building here is a prototype or proof of concept for a platform technology, which has diverse applications in the entire energy and chemicals industry,” Pandey continues. “Right now, we are aiming to produce methanol, but this technology can actually be applied to a much broader set of energy carriers and chemicals.”

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This article originally ran on EnergyCapital.

Houston innovator drives collaboration, access to investment with female-focused group

HOUSTON INNOVATORS PODCAST EPISODE 262

After working in technology in her home country of Pakistan, Samina Farid, who was raised in the United States, found her way to Houston in the '70s where business was booming.

She was recruited to work at Houston Natural Gas — a company that would later merge and create Enron — where she rose through the ranks and oversaw systems development for the company before taking on a role running the pipelines.

"When you're in technology, you're always looking for inefficiencies, and you always see areas where you can improve," Farid says on the Houston Innovators Podcast, explaining that she moved on from Enron in the mid-'80s, which was an exciting time for the industry.

"We had these silos of data across the industry, and I felt like we needed to be communicating better, having a good source of data, and making sure we weren't continuing to have the problems we were having," she says. "That was really the seed that got me started in the idea of building a company."

She co-founded Merrick Systems, a software solutions business for managing oil and gas production, with her nephew, and thus began her own entrepreneurial journey. She came to another crossroads in her career after selling that business in 2014 and surviving her own battle with breast cancer.

"I got involved in investing because the guys used to talk about it — there was always men around me," Farid says. "I was curious."

In 2019, she joined an organization called Golden Seeds. Founded in 2005 in New York, the network of angel investors funding female-founded enterprises has grown to around 280 members across eight chapters. Suzan Deison, CEO of the Houston Women's Chamber, was integral in bringing the organization to Houston, and now Farid leads it as head of the Houston Chapter of Golden Seeds.

For Farid, the opportunity for Houston is the national network of investors — both to connect local female founders to potential capital from coast to coast and to give Houston investors deal flow from across the country.

"It was so hard for me to get funding for my own company," Farid says. "Having access to capital was only on the coasts. Software and startups was too risky."

Now, with Golden Seeds, the opportunity is there — and Farid says its an extremely collaborative investor network, working with local organizations like the Houston Angel Network and TiE Houston.

"With angel investing, when we put our money in, we want these companies to succeed," she says."We want more people to see these companies and to invest in them. We're not competing. We want to work with others to help these companies succeed."

Building a biotech workforce: How this Houston program is shaping the next generation

future focused

Houston is currently in need of biomanufacturing professionals to keep up with the ever-growing industry. That's what Saniya Mansuri, health care consultant for BioPath @ TMC, says.

“Houston has lost out on a big biopharmaceutical company. And when there was a feasibility study that was done, it was identified that one of the reasons that Houston wasn't chosen was the lack of a workforce and a lack of workforce development programs,” she explains.

Mansuri and the TMC Innovation team are doing just that with the introduction of the new program. She moved from Toronto in 2023. When she applied for a role at TMC Innovation, she was handpicked to help shepherd the BioPath program, thanks to her background that included starting a nonprofit for underserved youth in Canada.

The goal of the BioPath program is to attract young people considering going into the trades to learn the skills to become biomanufacturing professionals. According to BioPath’s website, 42 percent of TMC institutions anticipate a great need for biotechnicians in the near future, but there’s a lack of places for workers to train that aren’t part of a four-year degree. BioPath not only helps to recruit youths to careers that only require two years of training, but educates them for success in their newly chosen jobs.

“For the role of biomanufacturing technician, you can do a certificate program, get certified and enter into an entry level career that pays upwards of $50,000 — a stable career where there is a lot of development and job mobility involved,” says Mansuri.

This school year saw the debut of a pilot program that began with marketing and awareness to begin to get kids excited. Working with the organization Bridge Year, BioPath has created a booth for career fairs at which there’s a simulation of the skills involved in column chromatography that potential technicians would be learning. The booth is currently touring HISD high schools.

BioPath is also partnering with the national nonprofit, Learning Undefeated, to create a mobile STEM lab that will park at schools starting in January.

“Instead of students going to a biology class, you would swap it out for a class on this mobile STEM lab, and we have a biomanufacturing activity and curriculum that the students would learn,” explains Mansuri.

But that’s only the beginning. BioPath is looking at securing internships for the students, as well as sponsoring interested students in attending a biomanufacturing summer camp run by Texas A&M. Once educated, Mansuri and her team will help their charges with certification, mentorship and finding jobs post-certification.

Mansuri says she’s already received emails from interested students who have taken part in the “Career Test Drive” booth, but expects more after a soft launch in February in which 200 high school students will come to the TMC to learn more. The future for biomanufacturing in Houston is looking more promising already.

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