New accelerators, promising startups, and more of the most-read energy tech articles from the year. Photo via Getty Images

Editor's note: As the year comes to a close, InnovationMap is looking back at the year's top stories in Houston innovation. As the energy capital of the world, Houston has its fair share of energy tech stories that trended among readers. Be sure to click through to read the full story.

Houston accelerator names inaugural cohort to propel digital transformation in energy

The NOV Supernova Accelerator will work to cultivate relationships between startups and NOV. Photo via Getty Images

Houston-based Venture Builder VC has kicked off its NOV Supernova Accelerator and named its inaugural cohort.

The program, originally announced earlier this year, focuses on accelerating digital transformation solutions for NOV Inc.'s operations in the upstream oil and gas industry. It will support high-potential startups in driving digital transformation within the energy sector, specifically upstream oil and gas, and last five months and culminate in a demo day where founders will present solutions to industry leaders, potential investors, NOV executives, and other stakeholders.

The NOV Supernova Accelerator will work to cultivate relationships between startups and NOV. They will offer specific companies access to NOV’s corporate R&D teams and business units to test their solutions in an effort to potentially develop long-term partnerships. Read more.

Promising Houston startup expands energy efficiency product to Middle East, Singapore

NanoTech is targeting new overseas markets for its energy efficiency products. Photo via Getty Images

NanoTech Materials has announced a big expansion for its business.

The Houston company, which created a roof coating using nanotechnology that optimizes energy efficiency, has partnered with Terminal Subsea Solutions Marine Service SP to bring its products to the Gulf Cooperation Council and Singapore. TSSM will become a partner of Houston’s NanoTech Materials products, which will include the Cool Roof Coat, Vehicular Coat, and Insulative Coat for the GCC countries and Singapore.

NanoTech Materials technology that ranges from roof coatings on mid- to low-rise buildings to shipping container insulation to coating trucks and transportation vehicles will be utilized by TSSM in the partnership. NanoTech’s efforts are focused on heat mitigation that can reduce energy costs, enhance worker safety, and minimize business risks in the process. Read more.

Rice University launches $12.5M climate tech accelerator

Rice University announced a new climate tech initiative backed by Woodside Energy. Photo by Natalie Harms/InnovationMap

Rice University has announced its latest initiative to advance clean energy technology into commercialization with a new partnership with a global energy company.

Woodside Energy, headquartered in Australia with its global operations in Houston following its 2022 acquisition of BHP Group, has committed $12.5 million over the next five years to create the Woodside Rice Decarbonization Accelerator.

"The goal of the accelerator is to fast track the commercialization of innovative decarbonization technologies created in Rice labs," Rice University President Reginald DesRoches says to a crowd at the Ion at the initiative's announcement. "These technologies have the potential to make better batteries, transitistors, and other critical materials for energy technologies. In addition, the accelerator will work on manufacturing these high-value products from captured and converted carbon dioxide and methane." Read more.

10 most-promising energy tech startups named at annual Houston event

Over 500 people attended the 21st annual Energy Tech Venture Forum hosted by the Rice Alliance. Photo courtesy of Rice

Investors from around the world again identified the most-promising energy tech startups at the Rice Alliance for Technology and Entrepreneurship's annual event.

"The recognition that Houston is the epicenter of energy transition is growing. It's something we are championing as much as possible so that the world can know exactly what we're doing," Paul Cherukuri, chief innovation officer at Rice University says at the 21st annual Energy Tech Venture Forum.

The event took place during the inaugural Houston Energy and Climate Startup Week, and nearly 100 startups from 23 states and seven countries pitched investors Wednesday, September 11, and Thursday, September 12. At the conclusion of the event, the investors decided on 10 companies deemed "most promising" from the presentations. Read more.

Port Houston lands $3M EPA grant to drive green initiatives, cleantech innovation

The grant, funded by the federal Inflation Reduction Act, will help promote cleaner air, reduced emissions, and green jobs. Photo via Getty Images

Port Houston’s PORT SHIFT program is receiving nearly $3 million from the U.S. Environmental Protection Agency’s Clean Ports Program.

The grant, funded by the federal Inflation Reduction Act, will help promote cleaner air, reduced emissions, and green jobs.

“With its ambitious PORT SHIFT program, Houston is taking a bold step toward a cleaner, more sustainable future, and I’m proud to have helped make this possible by voting for the Inflation Reduction Act,” U.S. Rep. Sylvia Garcia says in a news release. Read more.

Federal funding, startup pitches, and more of the most-read energy tech articles from the year. Photo via Getty Images

These were the 5 most-read Houston energy tech stories of 2023

year in review

Editor's note: As the year comes to a close, InnovationMap is looking back at the year's top stories in Houston innovation. As the energy capital of the world, Houston has its fair share of energy tech stories that trended among readers — including the launch of EnergyCapitalHTX, InnovationMap's sister publication. Be sure to click through to read the full story.

Houston-based battery innovators receive $4M in federal funding

Houston-based Zeta Energy has fresh funding from the government. Image via Zeta Energy

Houston-based Zeta Energy announced this week that it was selected to receive $4 million in federal funding for the development of efficient electric vehicle batteries.

The funds come from the U.S. Department of Energy's ARPA-E Electric Vehicles for American Low-Carbon Living, or EVs4ALL, program, which aims to increase the number of EVs on the roads by boosting the country’s supply chain of affordable, convenient, reliable and safe batteries.

Zeta Energy is one of 12 groups in the U.S. to receive funding from the program, which awarded $42 million in total.

“Electric vehicle sales in America have tripled since the start of this Administration and by addressing battery efficiency, resiliency and affordability, the projects announced today will make EVs attractive to even more drivers,” U.S. Secretary of Energy Jennifer M. Granholm said in a statement released earlier this week. “This is a win-win for our efforts to fight climate change and power America’s clean transportation future with technologies produced by researchers and scientists right here at home.”

Continue reading the article from January.

8 energy tech startups recognized at Houston's CERAWeek pitch competition

Here's what startups took home wins at CERAWeek. Photo by Natalie Harms/InnovationMap

Over 200 startups participated in CERAWeek this year, and 18 of those companies pitched at a Greater Houston Partnership event.

The Houston Energy Transition Initiative, an initiative to promote Houston's work within the energy transition, hosted its second annual HETI Energy Ventures Competition at CERAWeek Innovation Agora. The competition was divided into four categories. The first batch of startups consisted of five companies from the Texas Entrepreneurship Exchange for Energy, or TEX-E, a collaboration with Greentown Labs, MIT’s Martin Trust Center for Entrepreneurship, and universities across Texas.

The winning startups shared $50,000 of prizes, sponsored by TEX-E. Houston-based Helix Earth Technologies — which has developed high-speed, high-efficiency filter systems derived from technology originating at NASA — won both the first place prize and fan favorite for the category. Helix's co-founders, Rawand Rasheed and Brad Husick from Rice University, walked away with $25,000 in prizes

Continue reading the article from March.

Gow Media announces new energy transition media platform backed by GHP

Houston, we have a new energy transition news outlet. Photo via Getty Images

Houston has historically been home to a significant portion of the energy industry. Now, among the energy transition, the city has plans to hold a big role in that sector too, and a news outlet is emerging to cover that journey.

Houston-based Gow Media, a multi-platform media company and the parent company of InnovationMap, CultureMap, SportsMap, and ESPN Radio 97.5FM and 92.5FM, announced its plans to launch energycapitalhtx.com.

“Houston is aligning some of the city’s best and brightest to lead the energy transition,” says David Gow, CEO of Gow Media. “We have been deeply impressed by the efforts of the Greater Houston Partnership’s Houston Energy Transition Initiative and are excited for EnergyCapitalHTX to be the voice of the energy transition.”

Continue reading the article from March.

Report: Texas is the best place to lead hydrogen economy

According to a new report, the existing energy infrastructure of Texas makes it a great spot to lead the development of the hydrogen economy. Photo via Getty Images

All signs point to Texas leading the development of a hydrogen market, says one new report out of Rice University.

The Baker Institute for Public Policy released a new report this week about the hydrogen economy and the role Texas will play in it. According to the experts, Texas’ legacy energy industry — as well as its geology — makes it an ideal hub for hydrogen as an energy source. Ken Medlock, senior director of the Baker Institute’s Center for Energy Studies, and Shih Yu (Elsie) Hung, research manager at the center, wrote the report.

“Texas is in a very advantageous position to play a leading role in driving hydrogen market growth, but the evolution of policy and market structure will dictate whether or not this comes to pass,” write the co-authors.

Continue reading the article from February.

Fast-growing startup with carbon-free solution sets up pilot plant in Houston

The opening of the pilot plant marks the debut of Cemvita’s eCO2 business as a wholly owned subsidiary. Photo courtesy of Cemvita

Cleantech startup Cemvita has set up a pilot plant in its hometown of Houston to develop technology for converting carbon emissions as feedstock to make products like fertilizer, plastics, methane, and fuel.

The opening of the pilot plant marks the debut of Cemvita’s eCO2 business as a wholly owned subsidiary. The term eCO2 refers to equivalent carbon dioxide, or a way to measure a combination of greenhouse gases such as carbon dioxide and methane.

With a capacity of more than 14,000 gallons, the plant is producing eCO2 oil, an alternative to soybean oil. The company already is shipping samples of eCO2 products to customers, including renewable-fuel companies and plastics manufacturers.

Continue reading the article from April.

Ambyint has fresh funding and a new main office. Photo via Getty Images

Canadian energy company secures Houston funding, relocates HQ

money moves

An AI-powered energy tech company has raised additional funding and relocated it's main office to Canada.

Ambyint, a Canadian company that's had a Houston presence for a few years, has announced its latest round of funding and new headquarters. The software company provides energy customers with its AI-powered production and artificial lift optimization platform.

The funding comes from existing investors, Houston-based Mercury and Montrose Lane, plus two new investors, BDC Capital and Accelerate Fund III. The undisclosed amount of funding will go toward customer growth, hiring, and new enhancements to the technology, including expanding emissions mitigation capabilities.

"We have the wind in our sails and are extremely proud to see this transaction close,” Benjamin Kemp, CEO of Ambyint, says in a news release. “This investment allows us to double down on the energy market and further our AI-enabled optimization platform. Validation from our customers, talented employees, and investors is most welcome as we continue to scale.”

"Given the uncertainty in the venture capital market, attracting new investors like BDC Capital and Accelerate Fund III, who have followed Ambyint’s journey for several years, demonstrates how far we have come and the exciting future ahead of us," Kemp, who's served as CEO since 2021, adds.

The company also announced its new main office in Calgary. Previously, the Houston office operated as the company's headquarters.

Mercury, which has invested in the company since 2017, contributed to the company's series B in 2020, along with Montrose Lane (née Cottonwood Venture Partners).

“We have had the benefit of seeing the Ambyint platform and team develop over the past six years," says Mercury Managing Director Adrian Fortino says in the release. "We believe they are now poised to dramatically expand their industry footprint and improve customer emissions.”

Ambyint continues to add sustainability and emissions-related functions platform, including CO2 and methane emission tracking and mitigation.

"Utilizing advanced AI, Ambyint is addressing a significant opportunity in upstream oil and gas by increasing production while reducing GHG emissions," Joseph Regan, managing partner from BDC Capital’s Innovation Venture Fund, says in the statement. "They are leading the charge between their impressive technological progress and respected, industry-leading customers. We believe Ambyint’s AI software will be the standard operating procedure in this sector."

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This article originally ran on EnergyCapital.

Here's what energy transition companies stood out to Rice Alliance's experts. Photo via Rice Alliance

10 startups named most-promising in energy tech at Houston conference

rising stars

At the 20th annual Energy Tech Venture Forum presented by Rice Alliance for technology and Entrepreneurship, 11 startups scored recognition from the event's investors who evaluated over 90 early-stage energy transition companies.

"The selection process was both exhilarating and challenging given the incredible ideas we've seen today," says Jason Sidhu, director of information services business engagement at TC Energy, who announced the top companies. "I want to extend my gratitude to every company that participate din this year's Energy Tech Venture Forum. Your commitment to solving energy problems and pursuing ambitions ideas is truly commendable."

In addition to the top 10 most-promising companies, the event's attendees decided the people's choice pick out of the 50 or so pitching companies. The winner of that recognition was Calgary, Alberta-based Galatea Technologies, which has created a tech platform to enhance workflows for operational, financial, and environmental performance.

The top companies, according to the Rice Alliance experts and investors, were:

  • Circular economy startup, Polystyvert. Based in Montreal, the company has created a unique dissolution recycling process that creates a material that can contribute to cutting carbon emissions by up to 90 percent.
  • United Kingdom-based Mirico provides a tracking technology to its customers to measure climate gases (like methane, carbon dioxide, nitrous oxide, and ammonia), across areas up to half a square mile and in all conditions.
  • Protein Evolution, from New Haven, Connecticut, taps into a combination of green chemistry and enzyme technology to break down synthetic polymers.
  • Another Canadian company, Ayrton Energy, based in Calgary, created a liquid organic H2 carrier (LOHC) storage technology presents an opportunity for large, scalable and efficient transport of H2 over long distances.
  • Also representing New Haven, Connecticut, Carbon Loop is on a mission to make carbon capture and conversion scalable through carbon dioxide electrolysis using a proprietary catalyst to convert captured carbon dioxide into methanol.d
  • Based in London, Mobilus Labs has designed a new way for frontline communication with an in-helmet hardware and software solution. software solution designed for the frontline workforce.
  • 1s1 Energy, based in California, is working on producing low-cost green hydrogen by creating new materials to unlock unprecedented electrolyzer efficiency, durability, and more.
  • From Skokie, Illinois, Numat is specializing in solutions within Metal-organic framework (MOF) research to enhance the process of separating the hazardous chemicals negatively impacting human health and the environment.
  • Mantel, headquartered in Cambridge, Massachusetts, created a molten borate technology to capture CO2 in a new and efficient way.
  • The lone Houston-based company, Mars Materials is working to produce acrylonitrile using CO2 and biomass to enable decarbonization applications in carbon fiber and wastewater treatment.
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This article originally ran on EnergyCapital.

Currently, methane leak detection requires human evaluation. With this innovative new company's tech, this process can be automated. Photo via Getty Images

Houston startup advances in Chevron's unique business accelerator

scaling up

A Houston startup that is developing a technology to detect methane leaks has moved on to phase two in Chevron's unique business accelerator.

Aquanta Vision Technologies, a Houston-based climate-tech startup, was selected to participate in the scale-up phase of Chevron Studio, a Houston program that matches entrepreneurs with technologies to turn them into businesses. Aquanta's computer vision software completely automates the identification of methane in optical gas imaging, or OGI. The technology originated from Colorado State University and CSU STRATA Technology Transfer.

Babur Ozden, a tech startup entrepreneur, along with Marcus Martinez, the lead inventor and Dan Zimmerle, co-inventor and director of METEC at CSU Energy Institute, came up with the technology to identify the presence and motion of methane in live video streams. Currently, this process of identifying methane requires a human camera operator to interpret the images. This can often be unreliable in the collection of emissions data.

Babur Ozden is the founder of Aquanta Vision. Photo via LinkedIn

Aquanta’s technology requires no human intervention and is universally compatible with all OGI cameras. Currently, only about 10 percent of the 20.5 million surveys done worldwide use this type of technology as it is extremely expensive to produce. Ozden said he hopes Aquanta will change that model.

“What we are doing — we are democratizing this feature, this capability, independent of the camera make and model,” Ozden tells EnergyCapital.

Aquanta’s software will be downloadable from App stores to the technician’s computers or phones.

“Our goal is to eliminate the absolute reliance of human interpretation and to give operators a chance to make detections faster and more accurately,” Ozden says.

“Our ultimate ambition is to reduce our footprint.” he continues. “Companies like Chevron and other leading players in the oil and gas industry are becoming much more committed (to reducing emissions)."

Aquanta will now test its software under various scenarios and develop an early commercial version of the product. In the next and final phase of the program, the company will begin marketing the technology for commercial use.

The goal of Chevron Studio is to take innovative new technologies out of the labs at universities and to scale them up to commercial ventures. The company takes the intellectual property developed at these labs and provides a platform to match entrepreneurs with the technology. The program provides funding to take the technologies from the very beginning to pilot and field trials. The National Renewable Energy Laboratory, or NREL, manages Chevron Studio and works closely with the entrepreneurs to guide them through the program.

Gautam Phanse, the strategic relations manager for Chevron Technology Ventures says he was impressed with Ozden’s background as an entrepreneur and in the technology he brought to the table.

“We are looking at experienced entrepreneurs. People who can take an idea and stand on their own and develop it into a business,” he tells EnergyCapital.

Earlier this year, Phanse spoke to InnovationMap about Chevron Studio and its mission to match entrepreneurs with promising technologies coming out of universities and labs. He said the current focus areas for Chevron Studio are: carbon utilization, hydrogen and renewable energy, energy storage systems and solutions for circular economy.

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This article originally ran on EnergyCapital.

A Houston energy professional shares his advice for those looking for a job in climate tech. Photo via Getty Images

5 tips for people looking to expand their career into climate tech, according to this Houston expert

guest column

If hard times build strong people, then extreme weather events build strong climate tech ecosystems. Nobody knows this conventional wisdom better than Houston.

The past six years alone have seen the second costliest natural disaster in United States history (Hurricane Harvey), the longest power outage in Texas history (Winter Storm Uri), and this June, a heat wave that pushed the ERCOT power grid to record levels.

Combine our ever more volatile climate with a post-COVID-19 reckoning of what it means to work for what you believe in, and you get a recipe for the most significant workforce shift the world has ever seen. This workforce shift rules in favor of climate tech, and it will largely target those who’ve grown up, come of age and started their careers in the midst of this increasing volatility. Climate tech will no longer be considered a standalone industry; it will be baked into all existing industries, and those that don’t accept it will die.

I’m proud to be a climate optimist, but I’m also a realist. The truth is no matter what we do, our volatile climate is going to get worse before it gets better. But if extreme weather events build strong climate tech ecosystems, I can live with that.

To students and young professionals considering a jump into climate tech: There is no better place to be right now. Here are five things to keep in mind as you make that jump.

1. Meet as many people from diverse backgrounds working on as many different things as you can. You will likely feel awkward at first, especially if you don’t naturally gravitate toward conferences and happy hours. At the risk of sounding trite, just treat every stranger like a friend you haven’t met yet. Some of us could probably use more friends anyway.

2. The advice in the self-help book How to Win Friends and Influence People, originally published in 1936, is timeless. Possibly the most useful (and most obvious) point is this: Remember that a person’s name is to that person the sweetest and most important sound in any language. Whenever possible, repeat your new friends’ names when you meet them. Especially if you’re seeking a business development, sales or other external-facing role, perfecting this point should be your Holy Grail.

3. Depending on how new you are to energy and climate tech, you’ll hear lots of unfamiliar lingo. Ask questions, take note of what you still don’t get, and do your best to fill in the gaps on the side. Eventually, acronyms will become your best friend. For example: Have you seen what the ITC and the PTC from the IRA will do to the LCOE of PV according to NREL? IYKYK.

4. Coachability is key. You may feel like you’re getting rejected 99 percent of the time, but the way you respond to and learn from those experiences will ensure the other one percent makes all the difference. At the end of the day, climate tech is so vast that it’s impossible to become an expert in everything, and that’s okay. We may not know what’s going on 70 percent of the time, but I’ll take a .300 batting average any day.

5. It may be impossible to become an expert in everything, but you should proactively learn as much as you can, especially given how quickly the ecosystem is expanding. If you’re not embarrassed by how little you knewone year ago, two years ago or even five years ago, then you’re probably not trying hard enough.

These are only five of my takeaways over the past few years and I’ll be the first to admit that I have a long way to go in implementing them. In a way, that’s what makes this journey what it is. I just can’t wait to see what we build.

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Ryan Davidson is business development lead for CalWave Power Technologies, a California-based company and Greentown Houston member that's focused on converting ocean waves’ hydrokinetic energy into reliable electricity. This article originally ran on EnergyCapital.

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Houston leaders form coalition to boost Texas power grid with new tech

a better grid

A Houston-based coalition that launched this month aims to educate Texas officials about technology designed to shore up the state’s power grid.

The public-private Texas Reliability Coalition says it will promote utility-scale microgrid technology geared toward strengthening the resilience and reliability of the Texas power grid, particularly during extreme weather.

A utility-operated microgrid is a group of interconnected power loads and distributed energy sources that can operate in tandem with or apart from regular power grids, such as the grid run by the Electric Reliability Council of Texas (ERCOT). Legislation passed in 2023 enables the use of utility-scale microgrid technology in Texas’ deregulated energy market, according to the coalition.

John Elder, executive director of the coalition, says that with the legal framework now in place, the Public Utility Commission of Texas and ERCOT need to create rules to establish the Texas marketplace for microgrid technology. The goal, he says, is to “take the Texas grid from good to great” by installing microgrid technology, improving the infrastructure, and strengthening the system — all targeted toward meeting power needs during extreme weather and amid growing demand.

Houston-based CenterPoint Energy will test the utility-scale microgrid technology being promoted by the coalition. In a January 31 filing with the Public Utility Commission, CenterPoint says microgrid technology will be featured in a $36.5 million pilot program that’ll set up an estimated three to five microgrids in the company’s service area. The pilot program is slated to last from 2026 to 2028.

In the public affairs arena, five Houston executives are leading the new reliability commission’s microgrid initiative.

Elder, one of the coalition’s founding members, is president and CEO of Houston-based Acclaim Energy. Other founders include Ember Real Estate Investment & Development, Park Eight Development, and PowerSecure. Ember and Park Eight are based in Houston. Durham, North Carolina-based PowerSecure, which produces microgrid technology, is a subsidiary of energy provider Southern Co.

Aside from Elder, members of the coalition’s board are:

  • Stewart Black, board secretary of the coalition and vice president of Acclaim Energy’s midstream division
  • Todd Burrer, president of municipal utility districts at Inframark
  • Harry Masterson, managing principal of Ember
  • Martin Narendorf, former vice president at CenterPoint Energy

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This article originally appeared on our sister site, EnergyCapital.

This Houston neighbor is the fastest growing wealthy suburb in America

By The Numbers

The Houston-area city of Fulshear is booming like nowhere else: It's now the No. 1 fast-growing affluent suburb in the country.

Fulshear's No. 1 status was unveiled in a new GoBankingRates' study that ranked the "30 Fastest Growing Wealthy Suburbs in America" for 2025. The report examined population changes from 2018 to 2023 among cities and towns in major U.S. metro areas with populations between 25,000 and 100,000 residents. Median household income, average home value, and a "livability score" were also calculated for each locale.

Fulshear, located 34 miles west of downtown Houston, experienced the most dramatic population increase out of all 30 cities in the report. Though the suburb only has an estimated population of 42,616 residents, that number has skyrocketed 237 percent during the five-year period.

A Fulshear resident's median income is $178,398 annually, and the average value of a home in the city comes out to $521,157, the report additionally found.

Fulshear was the second fastest growing city in America in 2023. The city's growth is further reflected by the number of new apartments that were built in the area in 2024.

Texas is tops
Texas cities took the top three fastest growing U.S. suburbs for 2025, with Dallas-area cities of Celina (No. 2) and Prosper (No. 3) experiencing wildly different (yet still sky high) population changes. Celina's population ballooned 190 percent to 43,317 residents, while Prosper's grew 81 percent to an estimated 41,660 people.

Other Texas cities that earned spots in the report include Flower Mound (No. 19), Southlake (No. 27), University Park (No. 28) and Colleyville (No. 29), all in the Dallas-Fort Worth area.

"The old adage that everything is bigger in Texas is true, considering the number of Lone Star State suburbs that are quickly growing in population and overall wealth," the report's author wrote.

The top 10 fastest growing wealthy suburbs in America are:

  • No. 1 – Fulshear, Texas
  • No. 2 – Celina, Texas
  • No. 3 – Prosper, Texas
  • No. 4 – Erie, Colorado
  • No. 5 – Clarksburg, Maryland
  • No. 6 – Zionsville, Indiana
  • No. 7 – Redmond, Washington
  • No. 8 – Dublin, California
  • No. 9 – Parkland, Florida
  • No. 10 – Eastvale, California
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This story originally appeared on our sister site CultureMap.com.

Rice research breakthrough paves the way for advanced disease therapies

study up

Bioengineers at Rice University have developed a “new construction kit” for building custom sense-and-respond circuits in human cells, representing a major breakthrough in the field of synthetic biology, which could "revolutionize" autoimmune disease and cancer therapeutics.

In a study published in the journal Science, the team focused on phosphorylation, a cellular process in the body in which a phosphate group is added to a protein, signaling a response. In multicellular organisms, phosphorylation-based signaling can involve a multistage, or a cascading-like effect. Rice’s team set out to show that each cycle in a cascade can be treated as an elementary unit, meaning that they can be reassembled in new configurations to form entirely novel pathways linking cellular inputs and outputs.

Previous research on using phosphorylation-based signaling for therapeutic purposes has focused on re-engineering pathways.

“This opens up the signaling circuit design space dramatically,” Caleb Bashor, assistant professor of bioengineering and biosciences and corresponding author on the study, said in a news release. “It turns out, phosphorylation cycles are not just interconnected but interconnectable … Our design strategy enabled us to engineer synthetic phosphorylation circuits that are not only highly tunable but that can also function in parallel with cells’ own processes without impacting their viability or growth rate.”

Bashor is the deputy director for the Rice Synthetic Biology Institute, which launched last year.

The Rice lab's sense-and-respond cellular circuit design is also innovative because phosphorylation occurs rapidly. Thus, the new circuits could potentially be programmed to respond to physiological events in minutes, compared to other methods, which take hours to activate.

Rice’s team successfully tested the circuits for sensitivity and their ability to respond to external signals, such as inflammatory issues. The researchers then used the framework to engineer a cellular circuit that can detect certain factors, control autoimmune flare-ups and reduce immunotherapy-associated toxicity.

“This work brings us a whole lot closer to being able to build ‘smart cells’ that can detect signs of disease and immediately release customizable treatments in response,” Xiaoyu Yang, a graduate student in the Systems, Synthetic and Physical Biology Ph.D. program at Rice who is the lead author on the study, said in a news release.

Ajo-Franklin, a professor of biosciences, bioengineering, chemical and biomolecular engineering and a Cancer Prevention and Research Institute of Texas Scholar, added “the Bashor lab’s work vaults us forward to a new frontier — controlling mammalian cells’ immediate response to change.”