Houston expert shares 3 venture capital predictions for 2022

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Blockchain growth and funds reaching new groups of people — this Houston investor has VC trends for 2022. Image via Getty Images

New Year’s resolutions are all well and good, but this year, in true VC fashion, I’m making some New Year’s predictions, too. Though I’m not an oracle, I am an investor, which means I use what I learned in the past to guide my decisions in the present. With that in mind, here are three predictions for 2022.

Blockchain’s gaining ground and will be used to solve some of the world’s toughest problems.

This year, expect to see more corporates adopting blockchain. Blockchain is the digital recordkeeping technology that cryptocurrencies depend on, but its impact goes far beyond powering Bitcoin and giving speculative traders something to do. It allows corporations to do everything from transferring data more securely, to tackling supply chain issues (a problem we became all too familiar with last year), to eradicating the double spending problem in carbon credit markets and helping businesses prove their ESG claims.

When it comes to environmental, social, and governance (ESG) investing, blockchain will be a major part of the solution to a myriad of pressing issues, from climate change to social unrest.

On the environmental front, expect blockchain to be an essential tool in our quest to get to net zero: the technology allows companies to better track and trace their carbon footprint, and will lead to greater accountability across industries. It also has the potential to bring much-needed transparency to the global food supply chain, so that consumers can make informed decisions about the products they’re buying.

So much of the social unrest we are experiencing today is the result of power concentrated in too few hands and the lack of access to financial services. Blockchain is already being used to help the unbanked to improve their credit scores through microloans and to provide farmers with crop insurance. In 2022, blockchain will continue to democratize access to capital and unlock opportunities for retail investors to build wealth on their own terms.

As of last fall, 85 percent of the market cap of digital assets was driven by retail investor interest. In the first half of 2021 we saw a 100 percent increase in crypto users and a 700 percent growth in the DeFi token market cap. And there’s no signs of a slowdown. In December, Visa announced they were launching a “crypto advisory practice” to help their clients understand this next frontier. Visa’s announcement is just one of many announcements from major firms embracing the notion that digital assets will soon be a vital thread in the broader financial ecosystem.

If you let 2021 pass without getting educated on blockchain, 2022 is the time to dive deep.

The tech industry knows entrepreneurs can build from anywhere, and they’re doubling down on geographic diversity.

Until a few years ago, the conventional wisdom was that you couldn’t build a successful startup from anywhere but Silicon Valley. In 2022, entrepreneurs will build — and build successfully — in cities across the country, basing themselves in communities that best align with not only their industries, but their interests.

Rising innovation hubs will succeed based on how well they distinguish themselves from their counterparts. Want to build in a vibrant metropolitan area which is also the most diverse city in America and has built an inclusive startup ecosystem? Join us in Houston. Want to join a thriving ecosystem that is close to nature activities and still (somewhat) affordable? Move to Austin.

Though this geographic diversification started pre-pandemic, COVID-19 sped it up. In 2021, for the first time in more than 10 years, the percentage of seed capital going to Bay Area startups fell under 30 percent. The possibility of building an innovation community anywhere is finally becoming a reality as the pandemic years forced digital adoption and innovative thinking.

The upshot: if you’re a founder looking to lay roots, you can find the soil that’s best for your growth.

For women, Black and Latinx founders, the needle is moving in 2022.

For years now, a few in the tech industry have been working hard to diversify capital allocation, planting seeds aimed at getting more capital into the hands of women, Black and Latinx founders. In 2022, those seeds will sprout.

Two years ago, only 5.6 percent of VC firms in the U.S. were women-led, and of those 73 percent had been founded in the previous five years. But venture is a long game so investing initiatives can take years. When women are writing the checks, they tend to fund more diverse teams, which, in turn, routinely outperform teams with no women or people of color.

The work, in short, is paying off. In 2021, venture firms founded by women were on pace to bring in over 7 billion dollars, nearly one billion dollars over the previous high, from 2019. Expect the trend to continue into this year.

In summary, expect 2022 to be a blockbuster year for blockchain utility, and enjoy the increased capital deployed into previously underrepresented founders living all across America. We’ll check back in 2023 to see how I did.

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Samantha Lewis is principal at Houston-based venture capital firm, Mercury Fund.

Ashley Small, founder and CEO of Medley Inc., joins the Houston Innovators Podcast this week to discuss COVID-19's affect on her business and fostering diversity at startups. Photo courtesy of Medley Inc.

Houston founder calls for business leaders to 'make room for diverse voices'

HOUSTON INNOVATORS PODCAST EPISODE 70

Last year was one of quick pivots and tech solutions for Ashley Small and her company's clients. Small — the CEO and founder of Medley Inc., a Houston-based branding and public relations firm — works with both for-profit and nonprofit entities to tell their stories, and of course 2020 had its challenges in doing so. But they weren't anything Small, her team, and technology couldn't overcome.

Small founded Medley over 12 years ago, and for the past three of those years, her team has been completely virtual. She shares on the Houston Innovators podcast that this give her team a headstart on being able to find and quickly adopt quick tech solutions — but last year's shutdown also meant navigating this for all her clients.

"The biggest obstacle we had to overcome was figuring out what the best technology was for each client," Small says. "Where the learning curve has been is understanding all the available resources out there and understanding how offline experiences can help audiences connect online."

Founded in Houston, Medley has grown to the Los Angeles and Chicago markets over the years — and Small says that was intentional. An Oklahoma native, Small fell in love with Houston's diversity when she attended Texas Southern University, and sought out other diverse markets to expand her business. And, as a Black female founder, she fosters an inclusive community at her company — and wants to remind her fellow business owners how imperative it is to running an innovative company.

"Innovation is actually impossible without diversity," Small says, adding that when you bring different people to the table, you get new ways of thinking. "A part of this is also being really open minded to the fact that you are going to hear ideas that sound and look different. Be open to that, because that is 100 percent the point."

Small knows early-stage companies aren't always able to hire a bunch of people from diverse backgrounds right from the start, but there are other ways to surround yourself with diverse ideas.

"Make room for diverse voices -- and you may have to be a bit creative," Small says.

Medley's team also realizes that not every startup can afford to bring on an in-house or third-party PR team, but the company has a few options for startups, such as a three-month retainer to start as well as a series of workshops available online for as low as $19.

Small discusses more about how she's honoring Black History Month with her team and the evolution the PR and media industries have seen over the past decade on the episode. Listen to the full interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


The Equity Innovation Center Powered by Reliant will have online resources as well as an interactive learning lab at Tellepsen Family Downtown YMCA. Photo courtesy of Urban Land Institute Houston

YMCA of Greater Houston announces equity-focused innovation center backed by Reliant

it's fun to innovate at the

Houston is the most diverse city in the nation, and the YMCA of Greater Houston is looking to do its part to promote equity innovation by opening a new center.

The Equity Innovation Center Powered by Reliant will be the first of its kind in the region, and it will operate as a space for Houstonians to gather and collaborate.

"The YMCA of Greater Houston vows to stand with our brothers and sisters who are made to feel less safe by the many recent incidents – fighting for health equity in the face of the inequities being laid bare by the COVID-19 pandemic and unjust killings," says Stephen Ives, president and CEO, YMCA of Greater Houston, in a press release. "The Y will continue expanding and strengthening its commitment to combat racism, bias, prejudice and inequalities while fighting for justice."

The center will provide resources and activities so that visitors and collaborators can "walk away with a solid learning or unlearning" of social justice issues that are prominent in both Houston and nationally.

Rolling out in three phases, the project's first step is to foster conversations, consulting, and online trainings regarding systemic racial inequities. The next two phases will include setting up an interactive learning lab at Tellepsen Family Downtown YMCA, which would come to fruition by early next year.

The project is made possible by Reliant, a partner of the YMCA of Greater Houston.

"At Reliant, we respect, recognize and celebrate that our differences shape us, and that diversity and inclusion make us stronger. We're committed to powering change and supporting progress in the places where we live and work," says Elizabeth Killinger, president at Reliant, in the release. "By powering the Equity Innovation Center, we hope to further strengthen Houston so we can harness our full potential and make lasting change for future generations."

Reliant has donated $100,000 to the project, which will be distributed in $50,000 commitments over two years. The sum is a part of Reliant and NRG's "Powering Change" initiative, which has committed $1 million to go to organizations that combat racial inequities, injustice, and related violence, according to the release.

"We are grateful Reliant is joining our efforts to implement lasting and meaningful change within our community and beyond. We know that when we work as one, we move people and communities forward," Ives says.

Stephen Ives (left) is the president and CEO of YMCA of Greater Houston, and Elizabeth Killinger is president of Reiliant. Images courtesy

The Ion has tapped DivInc. as a partner. Courtesy of Rice University

The Ion announces partnership with nonprofit to serve Houston's diverse entrepreneurs

diving into diversity

Houston is ranked the No. 1 diverse city in the nation, and a local organization has forged a new partnership to make sure that diversity is represented within the city's innovation ecosystem.

The Ion, an innovation hub currently rising in Midtown Sears Building, and DivInc, a Texas nonprofit, have agreed to partner to advance diversity among Houston entrepreneurs. It's Austin-based DivInc's first Houston initiative, according to a news release.

"Our experience equipping diverse entrepreneurs with strategies to create exceptional companies, coupled with the Ion's enthusiasm and thoughtful approach to building an inclusive space where entrepreneurs from all walks of life can thrive is a winning combination," says Preston L. James, founder and CEO of DivInc, in the release.

"No matter where they are in their entrepreneur journey, we want all Houstonians to know DivInc is here to help you achieve your biggest dreams."

Since its founding in 2016, DivInc has worked to provide over 60 founders and more than 50 tech companies with resources and support for growth. Locally, DivInc is already working on programming to extend its reach to Houston entrepreneurs, including a kick-off event at The Ion on Tuesday, March 3, at 5:30 pm.

"As The Ion looked for a partner to provide best practices and resources to our local business communities and leaders that have historically been overlooked, we knew our partner needed to be ambitious, thoughtful and encouraging, but also have a record of success and experience working shoulder-to-shoulder with entrepreneurs," says Deanea LeFlore, senior director of The Ion, in the release.

"Our efforts and relationship with DivInc will do just that. We can't wait to help our stakeholders take their businesses to new heights and further demonstrate Houston is the best city in America for diverse entrepreneurs to thrive."

A new study ranks Houston as the country's 10th most ethnically diverse large city. Getty Images

Houston named a top 10 big city for ethnic diversity by new study

BAYOU CITY BRAGGING RIGHTS

Houston prides itself on its diversity — and rightfully so. A new study ranks Houston as the country's 10th most ethnically diverse large city.

Among 501 U.S. cities, Houston also ranks 28th overall and first in Texas, according to the study, released February 11 by personal finance website WalletHub.

To come up its ranking, WalletHub measured three key indicators of ethnic diversity: language, ethnicity and race, and birthplace. Houston ranks 25th for language diversity, 36th for ethnic and racial diversity, and 244th for birthplace diversity.

This finding differs from a study by Rice University's Kinder Institute for Urban Research that found Houston was the most ethnically and racially diverse metro area in the U.S. as of 2010. Why the disparity? The WalletHub study looked at data for the city of Houston, while the Kinder Institute study examined data for the entire Houston metro area.

The new finding also differs from a broader WalletHub study published in April 2019. In that study, Houston was crowned the most diverse city in the U.S., based on socioeconomic, cultural, economic, household, and religious diversity. Ethnic diversity is only one component of that ranking.

"Houston is the most diverse city in the United States. But diversity alone is not enough — we must always strive to be more inclusive," Houston Mayor Sylvester Turner tweeted in December 2019. "As your mayor, I know that diversity and inclusivity are what makes us strong. And I will always work to build one complete Houston."

However you slice it, Houston leads the pack in Texas for ethnic and racial diversity. Here's how other major cities in the Lone Star State fare in the new WalletHub study:

  • Arlington, No. 38
  • Plano, No. 46
  • Dallas, No. 47
  • Fort Worth, No. 62
  • Austin, No. 73
  • San Antonio, No. 136

While Austin and cities in the Dallas-Fort Worth area don't rank particularly high in the WalletHub study, Austin and DFW do show up on a recent list of the country's most racially diverse metro areas.

DFW held the No. 11 spot in the Bloomberg news service's 2018 ranking of racial diversity among the 100 largest U.S. metros, while Austin stood at No. 19. Houston bested both of those areas, though, landing at No. 5.

Austin and Dallas didn't perform as well in a racial and ethnic index compiled by U.S. News & World Report.

The index shows the racial and ethnic diversity of Dallas actually slipped 3.4 percent from 2010 to 2018, with Austin's diversity declining by 0.10 percent. The decrease was 2.6 percent in San Antonio and 1.2 percent in Houston, the index shows.

The diversity picture was brighter in other Texas cities included in the U.S. New & World Report index, which measured racial and ethnic diversity in U.S. cities with at least 300,000 residents. Arlington saw its racial and ethnic diversity rise 3.6 percent from 2010 to 2018, with Fort Worth at 1.8 percent.

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This article originally ran on CultureMap.

Houston-based Work & Mother is rethinking how new mothers pump in the office. Courtesy of Work & Mother

This growing Houston company is revolutionizing the way new mothers pump in the office

Pump it up

A new mom returning to work is probably dreading her new daily inconvenience of taking the time out of the workday to pump her breast milk.

While some employers provide a wellness room to us, but the more likely scenario is that she will have to pump in your car, an empty conference room or the bathroom. And once she is done pumping, she'll have to wash her equipment in the kitchen sink, alongside her coworkers' coffee mugs or dirty Tupperware containers.

One newly launched company mission is to make that scenario a thing of the past.

Work & Mother is a boutique pumping and wellness center that opened its first location in downtown Houston in 2017 and is planning its second downtown location. The 600-square-foot space opened on the first floor of 712 Main St. and offers memberships to companies and individuals, regardless of whether they work in the building.

Abbey Donnell founded the company after speaking with friends who recently returned to work after giving birth.

"There were constant stories about [women] being told the use the IT closet, or the conference room, or the bathroom or their cars," Donnell says. "Some of them were pretty big oil and gas firms companies that should've had the resources and space to do better than that."

Work & Mother offers its members several private pumping rooms, private pumping office spaces, a kitchen area, member lockers and a small retail section where members can buy pumping and wellness equipment. The company's pitch to individual mothers is simple: come to us for privacy and community. But its pitch to companies is more rooted in regulations.

Per the Fair Labor Standards Act Section 7(r), companies with 50 or more employees are required to provide "a place, other than a bathroom, that is shielded from view and free from intrusion from coworkers and the public, which may be used by an employee to express breast milk." Companies that aren't in compliance with Section 7(r) — and lack the resources to do so — can either purchase individual or company memberships to Work & Mother.

"The reception from moms has been incredible," Donnell says. "I've gotten a lot of support from women who are older in their fields, who talk about how [pumping in the office] was a horrible experience for them."

Work & Mother is planning its second location, which will also be in downtown Houston, but Donnell declined to share additional details. When she started the company in 2017, she took minimal investments from friends and family, she says. But in anticipation of the company's second location, Work & Mother will likely launch a pre-seed fundraising round this summer, Donnell says. No financial figures have been finalized, but Donnell says the tentative plan is to raise roughly $1 million.

The company is also hoping to open in cities such as Chicago, New York, Austin, and Dallas in the near future.

Work & Mother isn't targeting companies that are solely concerned about meeting Section 7(r) compliance, Donnell says. Rather, she's hoping to show companies that investing in the well-being of new mothers is essential to running a successful business – and it's the right thing to do.

"If there's an employer who really only cares about the compliance, then they're not exactly a good fit, because they'll convert a closet and check that box," Donnell says.

But what Donnell says she's found refreshing is that most of the companies she's interacted with have had great feedback for her. They're trying to recruit — and retain — top female talent, she says.

More soon

Courtesy of Work & Mother

Donnell has plans for a second Houston location, as well as an expansion to other major United States cities.

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Rice researchers score $45M from NIH for cancer-fighting tech

freshly funded

A research funding agency has deployed capital into a team at Rice University that's working to develop a technology that could cut cancer-related deaths in half.

Rice researchers received $45 million from the National Institutes of Health's Advanced Research Projects Agency for Health, or ARPA-H, to scale up development of a sense-and-respond implant technology. Rice bioengineer Omid Veiseh leads the team developing the technology as principal investigator.

“Instead of tethering patients to hospital beds, IV bags and external monitors, we’ll use a minimally invasive procedure to implant a small device that continuously monitors their cancer and adjusts their immunotherapy dose in real time,” he says in a news release. “This kind of ‘closed-loop therapy’ has been used for managing diabetes, where you have a glucose monitor that continuously talks to an insulin pump. But for cancer immunotherapy, it’s revolutionary.”

Joining Veiseh on the 19-person research project named THOR, which stands for “targeted hybrid oncotherapeutic regulation,” is Amir Jazaeri, co-PI and professor of gynecologic oncology at the University of Texas MD Anderson Cancer Center. The device they are developing is called HAMMR, or hybrid advanced molecular manufacturing regulator.

“Cancer cells are continually evolving and adapting to therapy. However, currently available diagnostic tools, including radiologic tests, blood assays and biopsies, provide very infrequent and limited snapshots of this dynamic process," Jazaeri adds. "As a result, today’s therapies treat cancer as if it were a static disease. We believe THOR could transform the status quo by providing real-time data from the tumor environment that can in turn guide more effective and tumor-informed novel therapies.”

With a national team of engineers, physicians, and experts across synthetic biology, materials science, immunology, oncology, and more, the team will receive its funding through the Rice Biotech Launch Pad, a newly launched initiative led by Veiseh that exists to help life-saving medical innovation scale quickly.

"Rice is proud to be the recipient of the second major funding award from the ARPA-H, a new funding agency established last year to support research that catalyzes health breakthroughs," Rice President Reginald DesRoches says. "The research Rice bioengineer Omid Veiseh is doing in leading this team is truly groundbreaking and could potentially save hundreds of thousands of lives each year. This is the type of research that makes a significant impact on the world.”

The initial focus of the technology will be on ovarian cancer, and this funding agreement includes a first-phase clinical trial of HAMMR for the treatment of recurrent ovarian cancer that's expected to take place in the fourth year of THOR’s multi-year project.

“The technology is broadly applicable for peritoneal cancers that affect the pancreas, liver, lungs and other organs,” Veiseh says. “The first clinical trial will focus on refractory recurrent ovarian cancer, and the benefit of that is that we have an ongoing trial for ovarian cancer with our encapsulated cytokine ‘drug factory’ technology. We'll be able to build on that experience. We have already demonstrated a unique model to go from concept to clinical trial within five years, and HAMMR is the next iteration of that approach.”

TMC again expands global impact with new Netherlands partnership

breaking news

The Texas Medical Center may be based in Houston, but the organization has again grown its global impact.

Since 2016, TMC’s BioBridges have worked with 88 startup companies. Those include strategic alliances with four other countries. Australia, the United Kingdom, Denmark and Ireland are all among TMC’s BioBridges partners. As of today, add the Netherlands to that list.

On September 27, TMC president and CEO, William F. McKeon, and Carmen van Vilsteren, chair of Health~Holland, Top Sector Life Sciences & Health (LSH), signed an agreement in Rotterdam. The TMC Netherlands BioBridge Memorandum of Understanding codifies the innovative goals of the partnership. Essentially, the BioBridge program provides a means for entrepreneurs, researchers, clinicians and industry partners from other countries to access the US market, as well as TMC experts.

“The TMC Netherlands BioBridge represents an unparalleled opportunity for collaboration and growth,” Ashley McPhail, chief external affairs & administration officer at Texas Medical Center said in a press release. “The Netherlands has solidified its position as a global leader in the field of life sciences and health, with a thriving ecosystem of research institutions, innovative companies, and highly skilled professionals. This strategic partnership will bring positive benefits to patients, clinicians and industry partners on a global scale.”

This lifeline for international healthcare companies makes expansion into the United States far smoother. The Global Innovators Launch Pad allows for startup founders to take part in a 10-week residency at the TMC Innovation Factory that will teach them about foundational infrastructure, clinical evidence and funding in the US.

“Since Texas is an important hub for innovation in the MedTech and digital health sectors, the collaboration with Texas Medical Center creates opportunities for Dutch companies looking to expand their international reach. Vice versa, it gives companies in Texas access to the vibrant Dutch Life Sciences & Health sector,” said van Vilsteren.

That exchange includes members of the TMC gaining the opportunity to participate in the Health~Holland Visitors Programme (HVP), “Shaping the Healthcare of the Future.”

The annual event invites high-level representatives from the private sector, NGOs, knowledge institutions, healthcare providers and different tiers of government to share their expertise.

It's the fifth partnership of its kind for TMC, with the last one being with Ireland, announced last year. TMC's other global initiatives include accelerators with Denmark and the United Kingdom, both announced earlier this year.

Houston startup founders prepare to scale globally following Shark Tank success

HOUSTON INNOVATORS PODCAST EPISODE 205

While Milkify's founders — husband and wife team Pedro Silva and Berkley Luck — secured partners on a popular business pitch and investment show, the entire experience almost didn't happen.

Silva and Luck, who got her PhD in molecular and biomedical s at Baylor College of Medicine, founded the company to provide breast milk freeze drying as a service to Houston-area families. Now, Milkify has customers across the country, but the duo didn't know if going through the process would be worth the investment and publicity, or if it would just be a distraction.

"The competitor in me wanted to be the first breast milk company to go on the show and to tell our story to the world — to show the world what my wife came up with that we thought was so great," Silva says on the Houston Innovators Podcast. "It was probably the scariest 45 minutes of my life."

But the sharks bit. Milkify's episode aired in April, and two investors — Gwyneth Paltrow and Lori Greiner — agreed to a $400,000 convertible note for 20 percent equity in the company. Paltrow even said on the show that she would have used the service when she was breastfeeding.

"It was empowering," Luck says of getting to wear her white coat on TV and share the story of how she came up with the idea of Milkify. "It was important to me when we went on the show to express that this had a scientific basis, that we didn't start this lightly, and that we've made huge strides in doing this in the absolute safest way possible."

Silva says they can't talk about some of the details of the show or the deal, but since then, Milkify has reached new customers, received additional investment interest, grown its team, and built out its plan to scale, the founders shared on the podcast. The team also shares its big-picture scale plans, which include tapping international partners to potentially take Milkify's tech global.

"Our vision is for every family to have access to breast milk formula, but instead of re-creating breast milk in a lab, we're doing it with mom's own milk," Silva says, mentioning a partnership with a breast milk bank that will convert its operation from freezing to freeze drying donated milk. "We're also working with groups in the UK and Australia to launch similar services using our patented technology."

"By the end of the year, we hope to see some announcements with those partnerships across the globe."

From the beginning, the importance of Milkify's team has been on supporting working parents to give them the best way to care for their families, Silva says. And for Luck — who says she's proud of the integrity Milkify has at its core despite competitors offering lower-quality and, in some cases, dangerous alternatives — she sees a lot of research benefits for the company.

"It's amazing to be at this leading edge, not just of innovation but of research, and to be able to still put out meaningful advances as an industry partner, not just as an academic," Luck says, adding that she hopes to be able to continue to contribute to the ongoing research into breast milk.

Luck and Silva share more about their Shark Tank experience, their co-founder strengths, and the future of Milkify on the podcast. Listen to the interview here — or wherever you stream your podcasts — and subscribe for weekly episodes.

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