This week's roundup of Houston innovators includes Phillip Yates of Equiliberty, Chris Quintanilla, of Mexcor International, and David Hudson of Circulus. Courtesy photos

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from diversity and inclusion tech to sustainable plastics — recently making headlines in Houston innovation.

Phillip Yates, founder of Equiliberty

Phillip Yates joins the Houston Innovators Podcast to discuss two initiatives he's launching to support diverse founders in Houston. Photo courtesy of Equiliberty

Houston is currently celebrating its first Black Entrepreneurship Week, thanks to local entrepreneur and lawyer, Phillip Yates, who founded Equiliberty — a tech company focused on connecting and supporting entrepreneurs of color.

BEW has put on several opportunities — from the Black Market, which will allow people to shop local Black merchants, to a special Giving Tuesday event to support Black-focused nonprofits in Houston. Specifically, Yates wants to target a multi-generational crowd — that's what's goring to drive lasting changes.

"When you have a wealth initiative, you can't just talk to the parents or the youth — you're still going to have a missing link there," Yates says on last week's episode of the Houston Innovators Podcast, explaining the week's wealth challenge that will reinforce this idea. Click here to read more.

Chris Quintanilla, chief sales officer at Mexcor International

This Houston company created its own in-house tech infrastructure — led by Chris Quintanilla — to stay competitive within the alcohol distribution industry. Photo courtesy of Mexcor International

When Chris Quintanilla wasn't happy with his company's software, he built it himself. Mexcor International is a Houston-based importer and distributor of wine, spirits, and other types of alcohol. On his own, Quintanilla has developed 46 dashboards that supply details about things such as wine and beer inventory, contacts for account managers, product catalogs, and key performance indicators (KPIs) for the sales team.

Quintanilla says in-house creation of this system aligns with Mexcor International's culture of "wearing multiple hats" to move the business forward, demanding in-house innovation on the tech front.

"If you want to see something happen, you have to grab the bull by the horns and do it yourself," he says. "We are a medium-sized company. We just hired a true IT person in the last two or three years. We don't have million-dollar budgets for big IT departments. We kind of figure it out as we go." Click here to read more.

David Hudson, founder and CEO of Circulus

Houston-based Circulus, which just received a $100 million credit facility, focuses on innovative plastics recycling. Photo via circulus.com

Circulus Holdings secured a $100 million credit facility from Riverstone Credit Partners, which has an office in Houston. This "green" loan is aimed at supporting environmental sustainability.

David Hudson, founder and CEO of Circulus, says in a news release that the credit facility "enables Circulus to rapidly develop a broad network of facilities and further the company's commitment to sustainable manufacturing. We look forward to supporting green-based jobs and preserving our environment for future generations."

Circulus, a portfolio company of Houston-based private equity firm Ara Partners, recently opened its first plastics recycling facility. The 110,000-square-foot plant is in Riverbank, California, near Modesto. It employs 45 people. So far, other Circulus plants, each of which will be larger than the California facility, are planned for Alabama, Oklahoma, the Midwest, and the Northeast. Click here to read more.

This Houston company created its own in-house tech infrastructure — led by Chris Quintanilla — to stay competitive within the alcohol distribution industry. Photo courtesy of Mexcor International

How this Houston-based alcohol importer, distributor uses tech to stay ahead of the curve

boozy innovation

You might say that Mexcor International, a Houston-based importer and distributor of wine, spirits, and other types of alcohol, relies on a single bottle of vodka rather than a case of vodka when it comes to its tech capabilities.

The annual tech budget for the 300-employee company, founded in 1989, falls well below $500,000. Mexcor International's annual revenue hovers around $300 million.

"We do have a decent size tech budget, but it's tiny in comparison to large distributors with multimillion-dollar tech budgets," says Chris Quintanilla, chief sales officer at Mexcor International.

The company leans on an IT director, an IT specialist, and an IT support company to handle tech needs. In other words, Mexcor International's in-house tech resources are minimal.

So, when the company's sales and administration sales team needed to step up its tech game, Quintanilla created a cloud-based software system combining customer relationship management (CRM) and enterprise resource planning (ERP) functions to churn out real-time reporting on inventory, deliveries, and other business matters. He took on the project equipped with IT knowledge he picked up online and at a three-day training session in Colorado, coupled with some simple tech tinkering.

On his own, Quintanilla has developed 46 dashboards that supply details about things such as wine and beer inventory, contacts for account managers, product catalogs, and key performance indicators (KPIs) for the sales team. About 230 employees, or roughly three-fourths of the company's workforce, can access these dashboards. Information on these dashboards can help employees answer myriad questions, such as "Which delivery trucks are arriving today?" or "What percentage of orders are being picked up tonight?"

Quintanilla says one of the key benefits of the dashboards is the ability to see how soon the company will run out of various products at its Texas, California, Florida, and Louisiana warehouses. This functionality enables the company to swiftly head off shortages. It has come in especially handy amid ongoing supply chain snags triggered by the COVID-19 pandemic, he says.

The dashboards also let Mexcor International track which customers' sales have risen or fallen compared with the same time a month or a year ago. With this information at their fingertips, salespeople can chat with customers about whether, for instance, they might like to substitute a brand of poorly selling tequila for another brand of tequila, according to Quintanilla.

In short, the innovation spearheaded by Quintanilla has helped propel Mexcor International well beyond the old days of pen and paper, photocopies, and faxes.

So, why are companies like Quintanilla's turning to in-house capabilities to push past the pen-and-paper approach?

"Companies that develop their own technology have more control over their strategic direction and can better respond to the needs of the market. This can mean a significant competitive advantage when a company develops a compulsory technology before the competition," technology and innovation strategist Evans Baiya wrote for AllBusiness.com.

In a 2020 survey by Boston Consulting Group, 46 percent of corporate executives around the world planned to invest more in their in-house tech capabilities.

"Every enterprise must re-evaluate the capabilities that it can develop in-house with the talent it has and determine which ones to procure from service providers," the consulting giant says. "By building capabilities in-house, companies can reduce the risk of their transformation projects stalling and turn to service providers in areas where they suffer from talent gaps."

At Mexcor International, Quintanilla has stepped in to fill much of the company's gap in tech talent.

Mexcor International established the new cloud-based CRM and ERP system in 2019. It replaced a clunky network-based setup hampered by unwieldy financial, sales, delivery, and routing modules.

"It was just so slow. You could not get the information you needed, and the network was always down," says Quintanilla, adding that the company's network-based system had sustained ransomware and malware attacks.

With the cloud-based system now in place, Mexcor International employees can perform an array of tasks via laptop, desktop, tablet, or smartphone, he says.

Quintanilla says in-house creation of this system aligns with Mexcor International's culture of "wearing multiple hats" to move the business forward, demanding in-house innovation on the tech front.

"If you want to see something happen, you have to grab the bull by the horns and do it yourself," he says. "We are a medium-sized company. We just hired a true IT person in the last two or three years. We don't have million-dollar budgets for big IT departments. We kind of figure it out as we go."

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”