Houston innovator dedicated to fostering community within local founders

HOUSTON INNOVATORS PODCAST EPISODE 194

Every month, Adrianne Stone of Bayou City Startups hosts a happy hour for startup founders to create a safe space to network, collaborate, commensurate, and more. Photo courtesy of Adrianne Stone

Starting a company can be daunting and lonely, but entrepreneurs — at least those who call Houston home — have a monthly opportunity to connect with fellow founders thanks to Adrianne Stone.

Stone, who's had a varied career from getting her PhD in Translational Biology & Molecular Medicine at Baylor College of Medicine and joining the 23andMe team as a scientist to supporting founders at Capital Factory, launched Bayou City Startups last year to help connect Houston founders over beers. Now, Stone shares on the Houston Innovators Podcast that her monthly Bayou City Startups meetups attract over 50 attendees on average.

"Being the venture associate with Capital Factory in Houston, I'd seen what the Houston ecosystem had to offer. There were events — happy hours, coffee meet-ups, all these things," Stone says. "But it was not just a casual networking event usually. I wanted a consistent community where I could show up and say, 'guys, I had the worst week,' to people who got where I was coming from and who could commensurate or lean in and help."

Stone observes a need for that type of community more in Houston than Silicon Valley, where she worked when she was at 23andMe. The Bayou City has less of a concentrated startup scene.

"Houston and the Bay Area could not be more different in a lot of ways," she explains. "Everybody I met had a startup in California — it didn't matter if they worked somewhere else, they had a startup.

"I would love to see more of that here in Houston," Stone continues. "Our founders in Houston are super scrappy. They do so much with so little, and we just do not have the amount of capital floating around this ecosystem that you do in SF. I'd love to see more of that here too."

The next opportunity to network with Bayou City Startups is Tuesday, July 18, from 5 to 7 pm at Kirby Ice House. Stone says she picks different types of bars all over the city to meet people where they are and to offer a variety of locations. She adds that she's always up for co-hosts and partners.

Part of what makes Stone, who consults with startups in a professional capacity, an interesting point of view is her "zig-zagging" career. She's held a wide range of roles at an even wider range of professions before she made it to tech startups.

“The through line for me is following my curiosity,” she says on the show. “I was interested in politics, so I did a White House internship. I had a background in science, so I wanted to do something with it, so I went into teaching. Through teaching, I got interested in web development and blogging, so that's how I made the transition into the digital space.”

Her advice to fellow zig-zaggers? Knowing when to say no to things.

"You can overcommit yourself and you're going to burnout or drop the ball or end up disappointing people," she says, admitting she's had to get better at this herself. "Practice saying no. Make it your default. Founders tend to say yes first."

Stone shares more about her career and her observations on Houston's startup ecosystem on the show. Listen to the interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.

This week's episode of the Houston Innovators Podcast features five mini interviews with Houston innovators. Photos courtesy

Podcast: Here's what innovators think of Houston's innovation ecosystem

HOUSTON INNOVATORS PODCAST EPISODE 175

It's the fourth year for Houston Tech Rodeo — a four-day event that takes over Houston's innovation ecosystem — and the programming is in full swing.

The week, put on by Houston Exponential, shines a spotlight on Houston innovators, investors, startup development organizations, and more and invites everyone to the table to learn more about the goings on within Houston's business community and connect with fellow Houstonians.

In honor of the week, today's edition of the Houston Innovators Podcast is a bit different. Rather than sit down with one Houston innovator, I got to chat briefly with five movers and shakers within Houston tech: Damyanna Cooke of Boozed and the Black Founders Network,Joshua Taylor of Capital Factory and the Black Founders Network,LaGina Harris of The US Space,Brandy Guidry of the Pearland Innovation Hub, and Chad Spensky of Allthenticate.

I took the opportunity to ask each of them about how they have engaged with the Houston innovation ecosystem and how they've seen it evolve and grow. Each of them also told me what they thought the city still needed to work on as well as its greatest asset to founders and the greater innovation community.

Listen to the interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


With Clutch, connecting brands with creators has never been easier and more inclusive. Photo courtesy of Clutch

Houston-based creator economy platform goes live nationally

so clutch

An app that originally launched on Houston college campuses has announced it's now live nationwide.

Clutch founders Madison Long and Simone May set out to make it easier for the younger generation to earn money with their skill sets. After launching a beta at local universities last fall, Clutch's digital marketplace is now live for others to join in.

The platform connects brands to its network of creators for reliable and authentic work — everything from social media management, video creation, video editing, content creation, graphic design projects, and more. With weekly payments to creators and an inclusive platform for users on both sides of the equation, Clutch aims to make digital collaboration easier and more reliable for everyone.

“We’re thrilled to bring our product to market to make sustainable, authentic lifestyles available to everyone through the creator economy," says May, CTO and co-founder of Clutch. "We’re honored to be part of the thriving innovation community here in Houston and get to bring more on-your-own-terms work opportunities to all creators and businesses through our platform.”

In its beta, Clutch facilitated collaborations for over 200 student creators and 50 brands — such as DIGITS and nama. The company is founded with a mission of "democratizing access to information and technology and elevating the next generation for all people," according to a news release from Clutch. In the beta, 75 percent of the creators were people of color and around half of the businesses were owned by women and people of color.

“As a Clutch Creator, I set my own pricing, schedule and services when collaborating on projects for brands,” says Cathy Syfert, a creator through Clutch. “Clutch Creators embrace the benefits of being a brand ambassador as we create content about the products we love, but do it on behalf of the brands to help the brands grow authentically."

The newly launched product has the following features:

  • Creator profile, where users can share their services, pricing, and skills and review inquiries from brands.
  • Curated matching from the Clutch admin team.
  • Collab initiation, where users can accept or reject incoming collab requests with brands.
  • Collab management — communication, timing, review cycles — all within the platform.
  • In-app payments with a weekly amount selected by the creators themselves.
  • Seamless cancellation for both brands and creators.
Clutch raised $1.2 million in seed funding from Precursor Ventures, Capital Factory, HearstLab, and more. Clutch was originally founded as Campus Concierge in 2021 and has gone through the DivInc Houston program at the Ion.

Madison Long, left, and Simone May co-founded Clutch. Photo courtesy of Clutch

Capital Factory's Houston HQ will be in The Ion. Photo courtesy of The Ion

Texas-based startup investor and mentorship network announces new Houston HQ

innovation collaboration

A company that supports entrepreneurship and startups across the Lone Star State with mentorship and funding has announced its new homebase in Houston.

Capital Factory has revealed a new programming partnership with The Ion. Through the collaboration, Capital Factory will host programming, events, and resources within the innovation hub to grow, educate, and support Houston-based startups and entrepreneurs.

"Capital Factory's presence at The Ion will further expand the opportunities for startups and innovators in the Houston region, while strengthening an important pillar of the Texas Startup Manifesto," says Joshua Baer, founder and CEO of Capital Factory, in a news release.

Capital Factory was founded in Austin in 2009 and boosts on being the most active investor in Texas, deploying smaller investments to a multitude of early-stage startups. According to Crunchbase's data, the entity has invested in over 160 companies with 20 exits. Capital Factory officially entered the Houston market in 2019 and doubled down its presence last year when it merged with Station Houston.

Now, with its Houston headquarters moving into The Ion, the two innovation partners will take an inclusive approach to creating connections between innovators, mentors, investors, and markets, per the release.

"We are thrilled to have Capital Factory as a programming partner at The Ion" says Jan E. Odegard, executive director of The Ion, in the release. "The Ion seeks to work with key partners and established brands to help build a rich and inclusive set of startup services that can support all innovators and startups wherever they are in their entrepreneurial journey. Capital Factory brings a proven track record for providing entrepreneurs with services and investments that brings great value not only to The Ion ecosystem, but also to the entire Houston innovation ecosystem."

Capital Factory's first event at The Ion will be Open Coffee on November 16th followed by Open Coworking all day, Baer adds in his statement.

From enlightening talks to anniversary celebrations, here's where you need to be in August. Getty Images

10 can't-miss Houston business and innovation events in August

where to be

This month, Houstonians have yet another good batch of in-person and online innovation events — from Zoom panels to conferences — and you and your tech network need to know about them.

Here's a roundup of virtual events not to miss this month — like demo days, workshops, conventions, and more.

Note: This post might be updated to add more events.

August 4 — Bayou Startup Showcase

Join Rice University and the University of Houston to celebrate the launch of the newest startups from OwlSpark and RED Labs. The Eighth Annual Bayou Startup Showcase will have founders from Class 9 showcase their summer progress. Come listen to pitches, network and get a first look at Houston's newest startups.

The event is on Wednesday, August 4, at 6 pm. It's free and happening at The Cannon (1334 Brittmoore Rd). Click here to register.

August 5 — Ask-Me-Anything Event With Carin Luna-Ostaseski: Tackling Roadblocks as a Solopreneur

A Hello Alice alum and first-generation Cuban American, Carin Luna-Ostaseski has truly achieved the unexpected, launching her one-woman operation through crowdfunding and becoming one of the first Hispanic entrepreneurs in history to create a scotch whisky brand. During the virtual event, she'll answer all of your questions, offer tips on navigating uncharted territory in business, and share details on the newly launched Entrepreneurial Spirit Fund by SIA Scotch that's awarding $10,000 grants to small business owners of color.

The event is on Thursday, August 5, at 1:30 pm. It's free and happening online. Click here to register.

August 10 — FTE Show: Creating a Digitally Enabled Innovation Community that Works with Jon Lambert and Lawson Gow

The way entrepreneurial communities interact and collaborate today cannot keep pace with the ever increasing speed of innovation. What are best ways to leverage physical and virtual hub interactions to create a digitally enabled innovation community with that works? Join The Cannon Founder Lawson Gow and CEO Jon Lambert as they share specifics around what they are trying, where they are getting traction and where they are most challenged.

The event is on Tuesday, August 10, at noon. It's free and happening online. Click here to register.

August 10-13 — HealthTech Beyond Borders

This online event created to offer business opportunities and global collaboration focused on innovation and technology in medicine between companies in Chile and the United States. Join the International Summit to explore the future and impact of new technologies in the health sector.

The event is on Tuesday, August 10. It's free and happening online. Click here to register.

August 11 — Open Project Night: Building an Equitable, Inclusive and Resilient Houston

Impact Hub Houston is proud to bring you a monthly opportunity to come together to work on solutions for some of Houston's most pressing issues. Our city is full of changemakers across all ages, cultures, skillsets, and industries. This is your chance to conned and collaborate for the greater good.

The event is on Wednesday, August 11, at 5 pm. It's free and happening online. Click here to register.

August 11 — Women in AI USA: WaiACCELERATE 2021 Demo Day

Ethical leadership & business acceleration program, WaiACCELERAT USA, aims to bridge the gender gap in the industry and targets female innovators looking to start a business in the fields of AI, Machine Learning and Data Science. With the final Pitch Event "ACCELER-AI-TE!" organized in VR, we will celebrate 40+ impact and commercially-proof early-stage startups and their founders

The event is on Wednesday, August 11, at 6 pm. It's free and happening online. Click here to register.

August 12-13 — EVOLVE 2021: How AI is Transforming Industry

Join industry leaders from the world's largest and most innovative companies for this 2-day hybrid event featuring both technical and business presentations focused on the real-world value of Artificial Intelligence. Evolve will provide a unique, interactive experience where you will learn from and engage with thought leaders from across North America.

The event is on Thursday, August 12, to Friday, August 13. It's free and happening at Houston Marriott Sugar Land and online. Click here to register.

August 17 — Texas Startup Scene & Ask Me Anything with Wogbe Ofori

Are you an entrepreneur starting a new company? Recently moved your company to Texas? Want to find out how to connect with other entrepreneurs, mentors, and investors in the startup ecosystem? Join Capital Factory to hear an overview from experienced entrepreneurs, venture capitalists, investors, and community partners at Intro to Texas Startup Scene & Ask Me Anything. Get a chance to introduce yourself and ask any questions on entrepreneurship and other related topics.

The event is on Tuesday, August 17, at 2 pm. It's free and happening online Click here to register.

August 18 — Tips for Working with a Gen Z Intern

Ampersand CEO, Allie Danziger, will speak to business owners and founders on the benefits of hiring an intern for your growing business, and tips for managing a remote, or in person, intern. It has to be a lot more than just "getting coffee" in order to maximize the experience on both sides and Allie will talk through tips on clear communication, ideal assignments, best way to structure the relationship and more. She will answer attendees questions, live, and discuss real-life scenarios the aspiring professionals and business partners in Ampersand have faced.

The event is on Wednesday, August 18, at 11 am. It's free and happening at The Cannon (1334 Brittmoore Rd). Click here to register.

August 19 — LatinX in Tech presented by Accenture

Capital Factory is dedicated to increasing diversity in the tech community and making its co-working space an inclusive environment for people of all backgrounds and identities. Attendees can look forward to a keynote address from a serial entrepreneur or investor, insightful discussion sessions, a startup showcase pitch competition, and informative panels.

The event is on Thursday, August 19, at noon. It's free and happening online Click here to register.

August 25 — The Cannon + Dell Pitch Party

Calling all member startups that are fundraising or are planning to open a round in 2021. The Cannon has partnered with Dell to host a virtual Pitch Party. Prizes will include up to $10k in Dell Equipment and the opportunity to pitch in the winners round later this year. If you would like to learn more and be considered to pitch, please fill out the application here.

The event is on Wednesday, August 25, at noon. It's free and happening online. Click here to register.

Several Houston startups won kudos and more at recent competitions — plus more Houston innovation news. Photo via Getty Images

Houston energy startups claim big wins, space health fellows named, and more innovation news

Short stories

What's the latest in news for the Houston innovation ecosystem? So glad you asked. Here's some local startup and tech news you might have missed.

In this roundup of short stories within Houston innovation, an energy transition startup snagged $100,000 in a recent competition, four space health researchers were named to a Houston program, a Houston tech startup was tapped by Google for its recent cohort, and more.

Cemvita Factory wins $100,000 in clean energy competition

Cemvita Factory has secured wins in two recent startup competitions. Photo courtesy of Cemvita

A Houston company has been named the the $100,000 cash winner of an inaugural competition.

The GS Beyond Energy Innovation Challenge from Cleantech.org named Cemvita Factory as the big winner — out of six finalists. Another Houston company, Amperon Inc. , came in second place, followed by Skycool Systems in third place. The third Houston startup named to the finals, Veloce Energy, was named the crowd's favorite. The three Houston finalists were announced in June.

"Our top three startups face many challenges on the path to accelerating the energy transition, and we are honored to be a part of their journey. Startuplandia is a rough and tumble world, and it was a very close competition. Congrats to Moji Karimi and the Cemvita Factory team. Can't wait to see what you do next," says Neal Dikeman, chairman of Cleantech.org and a partner at one of the prize sponsors, Energy Transition Ventures,in a news release. "And a huge thanks to our accelerator and incubator partners. We look forward to working with everyone again in the future."

Cemvita Factory was also named the winner of The Ion's Houston Startup Showcase a few weeks ago.

Google taps Houston startup for latest cohort

Google has named DOSS to its Black Founders Accelerator. Photo via Pexels

A Houston startup has made it into the Google for Startups Accelerator: Black Founders cohort. DOSS, a digital, voice-activated real estate tool, was selected for the second cohort of the accelerator.

Bobby Bryant leads the company as founder and CEO. DOSS is joined by 10 other startups — including two other Texas companies, Dallas-based Zirtue and Fêtefully.

"Being a digital real estate search and transactional marketplace, this is a perfect opportunity for DOSS to have direct access to Google Engineers and Developers. This is a startup founder's dream to work with Google," Bryant writes in a LinkedIn post.

The program concludes with a showcase on Thursday, October 21 from 11:30 am to 1:00 pm.

Space health organization selects four fellows

These four fellows will continue their space health research with the support of TRISH. Photo via Pexels

Houston-based Translational Research Institute for Space Health, known as TRISH, at Baylor College of Medicine has named four scientists to receive postdoctoral fellowship awards to further their career in space health. Each fellow will work on a two-year project that "addresses challenges to astronaut health during deep space exploration missions," according to a news release. The fellows also become part of the TRISH Academy of Bioastronautics, a forum for postdoctoral researchers working on TRISH research projects.

"The space industry needs a strong pool of highly-trained scientists focused on human health to return us to the moon," says Zélia Worman, TRISH scientific program manager and lead for postdoctoral career development, in the release. "TRISH has selected four postdoctoral fellows who are ready for the challenge. We are proud to welcome these outstanding scientists to our Academy of Bioastronautics and work with them to launch their career in space health and reach for the Moon and Mars safely."

The postdoctoral fellows are:

  • Kaylin Didier of the University of Wisconsin, Madison — focused on ionizing radiation and immune responses: exploring sex differences
  • James Jahng of Stanford University, California — focused on countermeasure development against myocardial mitochondrial stress by space radiation exposure
  • Heather McGregor of the University of Florida, Gainesville — focused on investigating planta somatosensory noise as a countermeasure for balance and locomotion impairments in simulated lunar and Martian gravity
  • Mallika Sarma of Johns Hopkins University, Baltimore, Maryland — focused on stress response and neurovestibular compensation and the potential ameliorative effects of team support

Houston energy consortium names winners in startup competition

Energy tech founders pitched at the Society of Petroleum Engineers' summit. Photo via Getty Images

The Innovation and Entrepreneurship Summit from the Society of Petroleum Engineers-Gulf Coast Section concluded with a startup pitch event earlier this month. Three startups were recognized at the Shark Tank-style competition.

  • The judges selected Houston-based SaaS startup InerG as the winner.
  • The People's Choice winner was New Jersey-based Anax Power.
  • North Carolina-based Revolution Turbine was the runner-up, according to the judges, as well as received honorable mention from the People's Choice portion of the competition.
The judges of the event — or the "sharks" — included Plug and Play Director Payal Patel, Montrose Lane Managing Partner Ryan Gurney, CSL Ventures Vice President Abhinav Jain, and SCF Ventures Managing Director Hossam Eldadawy.

Capital Factory is calling for all female founders

Attention female founders — Capital Factory has a competition you need to know about. Photo via Getty Images

Austin-based Capital Factory's Texas Fund, in partnership with Beam Angel Network, Seven Seven Six Fund, and Golden Seeds (Houston), has announced a $100,000 Investment Challenge for its 4th Annual Women In Tech Summit on October 4. Capital Factory is looking for five technology startup finalists to pitch to a panel of advisors and judges made up of successful investors, entrepreneurs, and industry leaders. The prize on the line? A $100,000 investment and membership into Capital Factory.

Any software, hardware, or CPG startup in Texas with a female founder or co-founder can apply to participate. The finalists will all be fast tracked into the Capital Factory portfolio, access to the Capital Factory Mentor network and coworking space, and up to $250,000 in potential total hosting credits from AWS, Google Cloud, Microsoft Azure and other major hosting providers. Capital Factory will receive: 1 percent common stock grant as advisor equity (separate from the investment) and the right to invest up to $250,000 in the next round of funding.

One winner will receive a $100,000 cash investment on a SAFE or Convertible Note using Capital Factory's term sheet and your most recent funding valuation, or a qualified term sheet provided by the company. The deadline is September 12. Submit your application

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CultureMap Emails are Awesome

Houston leaders form coalition to boost Texas power grid with new tech

a better grid

A Houston-based coalition that launched this month aims to educate Texas officials about technology designed to shore up the state’s power grid.

The public-private Texas Reliability Coalition says it will promote utility-scale microgrid technology geared toward strengthening the resilience and reliability of the Texas power grid, particularly during extreme weather.

A utility-operated microgrid is a group of interconnected power loads and distributed energy sources that can operate in tandem with or apart from regular power grids, such as the grid run by the Electric Reliability Council of Texas (ERCOT). Legislation passed in 2023 enables the use of utility-scale microgrid technology in Texas’ deregulated energy market, according to the coalition.

John Elder, executive director of the coalition, says that with the legal framework now in place, the Public Utility Commission of Texas and ERCOT need to create rules to establish the Texas marketplace for microgrid technology. The goal, he says, is to “take the Texas grid from good to great” by installing microgrid technology, improving the infrastructure, and strengthening the system — all targeted toward meeting power needs during extreme weather and amid growing demand.

Houston-based CenterPoint Energy will test the utility-scale microgrid technology being promoted by the coalition. In a January 31 filing with the Public Utility Commission, CenterPoint says microgrid technology will be featured in a $36.5 million pilot program that’ll set up an estimated three to five microgrids in the company’s service area. The pilot program is slated to last from 2026 to 2028.

In the public affairs arena, five Houston executives are leading the new reliability commission’s microgrid initiative.

Elder, one of the coalition’s founding members, is president and CEO of Houston-based Acclaim Energy. Other founders include Ember Real Estate Investment & Development, Park Eight Development, and PowerSecure. Ember and Park Eight are based in Houston. Durham, North Carolina-based PowerSecure, which produces microgrid technology, is a subsidiary of energy provider Southern Co.

Aside from Elder, members of the coalition’s board are:

  • Stewart Black, board secretary of the coalition and vice president of Acclaim Energy’s midstream division
  • Todd Burrer, president of municipal utility districts at Inframark
  • Harry Masterson, managing principal of Ember
  • Martin Narendorf, former vice president at CenterPoint Energy

———

This article originally appeared on our sister site, EnergyCapital.

This Houston neighbor is the fastest growing wealthy suburb in America

By The Numbers

The Houston-area city of Fulshear is booming like nowhere else: It's now the No. 1 fast-growing affluent suburb in the country.

Fulshear's No. 1 status was unveiled in a new GoBankingRates' study that ranked the "30 Fastest Growing Wealthy Suburbs in America" for 2025. The report examined population changes from 2018 to 2023 among cities and towns in major U.S. metro areas with populations between 25,000 and 100,000 residents. Median household income, average home value, and a "livability score" were also calculated for each locale.

Fulshear, located 34 miles west of downtown Houston, experienced the most dramatic population increase out of all 30 cities in the report. Though the suburb only has an estimated population of 42,616 residents, that number has skyrocketed 237 percent during the five-year period.

A Fulshear resident's median income is $178,398 annually, and the average value of a home in the city comes out to $521,157, the report additionally found.

Fulshear was the second fastest growing city in America in 2023. The city's growth is further reflected by the number of new apartments that were built in the area in 2024.

Texas is tops
Texas cities took the top three fastest growing U.S. suburbs for 2025, with Dallas-area cities of Celina (No. 2) and Prosper (No. 3) experiencing wildly different (yet still sky high) population changes. Celina's population ballooned 190 percent to 43,317 residents, while Prosper's grew 81 percent to an estimated 41,660 people.

Other Texas cities that earned spots in the report include Flower Mound (No. 19), Southlake (No. 27), University Park (No. 28) and Colleyville (No. 29), all in the Dallas-Fort Worth area.

"The old adage that everything is bigger in Texas is true, considering the number of Lone Star State suburbs that are quickly growing in population and overall wealth," the report's author wrote.

The top 10 fastest growing wealthy suburbs in America are:

  • No. 1 – Fulshear, Texas
  • No. 2 – Celina, Texas
  • No. 3 – Prosper, Texas
  • No. 4 – Erie, Colorado
  • No. 5 – Clarksburg, Maryland
  • No. 6 – Zionsville, Indiana
  • No. 7 – Redmond, Washington
  • No. 8 – Dublin, California
  • No. 9 – Parkland, Florida
  • No. 10 – Eastvale, California
---

This story originally appeared on our sister site CultureMap.com.

Rice research breakthrough paves the way for advanced disease therapies

study up

Bioengineers at Rice University have developed a “new construction kit” for building custom sense-and-respond circuits in human cells, representing a major breakthrough in the field of synthetic biology, which could "revolutionize" autoimmune disease and cancer therapeutics.

In a study published in the journal Science, the team focused on phosphorylation, a cellular process in the body in which a phosphate group is added to a protein, signaling a response. In multicellular organisms, phosphorylation-based signaling can involve a multistage, or a cascading-like effect. Rice’s team set out to show that each cycle in a cascade can be treated as an elementary unit, meaning that they can be reassembled in new configurations to form entirely novel pathways linking cellular inputs and outputs.

Previous research on using phosphorylation-based signaling for therapeutic purposes has focused on re-engineering pathways.

“This opens up the signaling circuit design space dramatically,” Caleb Bashor, assistant professor of bioengineering and biosciences and corresponding author on the study, said in a news release. “It turns out, phosphorylation cycles are not just interconnected but interconnectable … Our design strategy enabled us to engineer synthetic phosphorylation circuits that are not only highly tunable but that can also function in parallel with cells’ own processes without impacting their viability or growth rate.”

Bashor is the deputy director for the Rice Synthetic Biology Institute, which launched last year.

The Rice lab's sense-and-respond cellular circuit design is also innovative because phosphorylation occurs rapidly. Thus, the new circuits could potentially be programmed to respond to physiological events in minutes, compared to other methods, which take hours to activate.

Rice’s team successfully tested the circuits for sensitivity and their ability to respond to external signals, such as inflammatory issues. The researchers then used the framework to engineer a cellular circuit that can detect certain factors, control autoimmune flare-ups and reduce immunotherapy-associated toxicity.

“This work brings us a whole lot closer to being able to build ‘smart cells’ that can detect signs of disease and immediately release customizable treatments in response,” Xiaoyu Yang, a graduate student in the Systems, Synthetic and Physical Biology Ph.D. program at Rice who is the lead author on the study, said in a news release.

Ajo-Franklin, a professor of biosciences, bioengineering, chemical and biomolecular engineering and a Cancer Prevention and Research Institute of Texas Scholar, added “the Bashor lab’s work vaults us forward to a new frontier — controlling mammalian cells’ immediate response to change.”