Thai Lee, of Austin, remains at the top of the list in Texas. Photo courtesy of SHI

Of the country's 100 most successful female entrepreneurs, 12 call Texas home, according to Forbes and its 2023 list of America's Richest Self-Made Women, released June 1.

"Bolstered in part by a rebound in the stock market, [the richest 100 female entrepreneurs] are cumulatively worth a record $124 billion, up nearly 12 percent from a year ago," says Forbes.

To make the Forbes list, women had to garner wealth on their own, rather than by inheriting or winning it. Texas' wealthiest women have made their fortunes in fields ranging from home health care, insurance, and aviation logistics to jewelry design, dating apps, and running the show at SpaceX. Austin is home to the largest concentration of these self-made Texans with eight Austinites making the list.

With an estimated net worth at $4.8 billion, Thai Lee, of Austin, remains at the top of the list in Texas, and ranks No. 5 nationally.

She falls behind only No. 1 Diane Hendricks of Wisconsin (co-founder of ABC Supply, $15 billion net worth); No. 2 Judy Love of Oklahoma (chairman and CEO, Love's Travel Stops And Country Stores, $10.2 billion); No. 3 Judy Faulkner of Wisconsin (founder and CEO, Epic Systems, $7.4 billion); and No. 4 Lynda Resnick of California (co-founder and co-owner of Wonderful Company, $5.3 billion) among America's richest self-made women.

For some additional perspective, Oprah Winfrey lands at No. 13 on the list for 2023. The TV titan (and most famous woman on the planet) has an estimated net worth of $2.5 billion, Forbes says.

Austin's Lee, a native of Bangkok who holds an MBA from Harvard University, is founder, president, and CEO of SHI International Corp., a provider of IT products and services with a projected revenue of $14 billion in 2023. Fun fact: "Lee majored in both biology and economics," Forbes says, "in part because her English was less than perfect and she wanted to avoid writing and speaking in class."

The other seven Austin women on the list are:

  • Lisa Su, No. 34, Austin. Forbes pegs Su’s net worth at $740 million, tying her with April Anthony of Dallas. The native of Taiwan is president and CEO of Santa Clara, California-based semiconductor company Advanced Micro Devices.
  • Kendra Scott, No. 47, of Austin.Forbes says she has amassed a net worth of $550 million as founder of Kendra Scott LLC, which designs and sells jewelry in more than 100 stores (and is worth $360 million). The celebrity entrepreneur is also a judge on TV's Shark Tank.
  • Whitney Wolfe Herd, No. 52, of Austin. She is worth an estimated $510 million. Herd is co-founder and CEO of Bumble Inc., which operates two online dating apps: Bumble and Badoo. She owns a 17% stake in Bumble and became the youngest self-made woman billionaire after it went public in February 2021.
  • Paige Mycoskie, No. 73, of Austin. She is worth an estimated $380 million. Mycoskie created founded her 1970s-inspired California lifestyle brand, Aviator Nation, which took off during the pandemic and now has 16 retail locations across the U.S. If the name sounds familiar, that's because she's the sister of TOMS founder Blake Mycoskie, with whom she competed on TV's The Amazing Race.
  • Imam Abuzeid, No. 77, of Austin. Her net worth is estimated at $350 million. Abuzeid is the co-founder and CEO of Incredible Health, which she started in 2017 to help alleviate America's nursing shortage. Forbes describes it as "a souped-up version of LinkedIn for nurses." Abuzeid is one of only a handful of Black female founders to run a company valued at more than $1 billion, Forbes notes.
  • Julia Cheek, No. 92, of Austin. Her net worth is estimated at $260 million. Cheek founded at-home testing company Everly Health in 2015 "out of frustration at having to pay thousands for lab testing to diagnose issues related to vitamin imbalance," Forbes says. It got a Shark Tank deal with Lori Greiner and is now worth roughly $1.8 billion.
  • Belinda Johnson, No. 96, of Austin. She is worth an estimated $250 million. Johnson was Airbnb's first chief operating officer and led many of its legal disputes. She stepped down from that role in March 2020, Forbes says, and left the company's board in June 2023.

The remaining Texas women on the list include:

  • Gwynne Shotwell, No. 27, of Jonesboro (Coryell-Hamilton counties). Her net worth is estimated at $860 million. Shotwell is president and COO of Elon Musk's SpaceX. She manages the operations of the commercial space exploration company and owns an estimated stake of 1 percent, Forbes says.
  • Robyn Jones, No. 29, of Fort Worth. Her net worth is estimated at $830 million. Jones is founder of Westlake-based Goosehead Insurance Agency LLC. She started the property and casualty insurance agency in 2003 after being frustrated with her truck-driver husband's "road warrior lifestyle," Forbes says. He joined her in 2004 and they took the company public in 2018. It has nearly 1,000 franchised offices.
  • April Anthony, No. 34, of Dallas. Forbes puts her net worth at $740 million. She founded the Dallas-based home health and hospice division of Encompass Health Corp and sold it for $750 million to HealthSouth. In 2022, she was named CEO of VitalCaring, a home health and hospice care firm.
  • Kathleen Hildreth, No. 44, of Aubrey. Her net worth is estimated at $590 million. Hildreth is co-founder of M1 Support Services LP, an aviation logistics company based in Denton. A service-disabled Army veteran, she graduated from West Point in 1983 and was deployed all around the world as a helicopter pilot.
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This article originally ran on CultureMap.

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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

  • Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
  • Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
  • Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

     
  • $1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
  • $922 million for the University of Houston System
  • $167 million for Texas Southern University
  • $10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

     
  • Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
  • Created the Lake Houston Dredging and Maintenance District
  • Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.