The University of Michigan's Intero Biosystems was the star of the show at the 2025 Rice Business Plan Competition, bringing home both the top-place finish and the largest total investment. Photo courtesy Rice University.

Celebrating its 25th year, the Rice Alliance for Technology and Entrepreneurship hosted the celebrated Rice Business Plan Competition this month, doling out more than $2 million in investment and cash prizes to the top-performing teams.

“For 25 years, the Rice Business Plan Competition has helped shape how Rice Business shows up in the world by creating a platform where student-entrepreneurs can tackle some of the most complex challenges of our time in energy, in health care, in technology and beyond,” Peter Rodriguez, dean of Rice Business, the presenting sponsor of the event, said in a news release. “If we’re serious about changing the world — and I believe we are — then it’s our responsibility to open doors for students everywhere to imagine bold solutions and build what comes next.”

Over the course of the three-day event, the 42 startups competing this year from colleges or universities around the world presented their plans before more than 300 angel, venture capital, and corporate investors. The teams were selected from the event’s largest applicant pool to date and represented 34 universities across four countries, according to Rice. Winners were announced at the company showcase and awards ceremony April 12 in downtown Houston.

Seven finalists were selected, though each team left the competition with some form of funding, according to Rice. The University of Michigan's Intero Biosystems was the star of the show, bringing home both the top-place finish and the largest total investment. Rice's own Pattern Materials also had a strong showing, placing fourth in the pitch competition and also earning the fourth-highest investment total.

Here are the teams that won big in 2025. See a full list of winners and prizes here.

Intero Biosystems, University of Michigan - $902,000

The team finished in first place for its GastroScreen, the first stem cell-driven human “mini gut” that is ideal for organ function testing before testing on humans, and also claimed the largest total investments among the competition.

  • $150,000 Goose Capital Investment Grand Prize
  • $250,000 Goose Capital Investment Prize
  • $200,000 The OWL Investment Prize
  • $100,000 Houston Angel Network Investment Prize
  • $100,000 nCourage Investment Network’s Courageous Women Entrepreneur Investment Prize
  • $100,000 Investment Prize from Nancy Chang
  • $1,000 Mercury Elevator Pitch Competition - Overall Winner
  • $1,000 Anbarci Family Company Showcase Prize
  • TMC Innovation Healthcare Accelerator Bootcamp Invitation Prize

MabLab, Harvard University – $301,500

The team placed second for its rapid test capable of detecting multiple adulterants in laced drugs and spiked drinks.

  • $100,000 Investment Prize, sponsored by David Anderson, Anderson Family Fund, Jon Finger and Finger Interests
  • $100,000 The Indus Entrepreneurs (TiE) Texas Angels Investment Prize
  • $25,000 nCourage Investment Network’s Courageous Women Entrepreneur Investment Prize
  • $50,000 Valhalla Investment Network Investment Prize
  • $25,000 The Eagles Investor Investment Prize
  • $500 Mercury Elevator Pitch Competition - Life Science*
  • $1,000 Anbarci Family Company Showcase Prize

re.solution, RWTH Aachen University — $76,500

The team placed third for its water-based technology that recycles polyesters without generating salt waste, making textile recycling viable.

  • $50,000 Investment Prize, sponsored by David Anderson, Anderson Family Fund, Jon Finger and Finger Interests
  • $25,000 Pearland EDC Spirit of Entrepreneurship Cash Prize
  • $500 Mercury Elevator Pitch Competition - Energy/Cleantech
  • $1,000 Anbarci Family Company Showcase Prize

Pattern Materials, Rice University – $134,500

The Houston-based team placed fourth for its laser-induced graphene technology that can be rapidly performed, enabling low-cost, scalable production of the material.

  • $5,000 prize, sponsored by Norton Rose Fulbright
  • $50,000 Valhalla Investment Network Investment Prize
  • $25,000 Pearland EDC Spirit of Entrepreneurship Cash Prize
  • $25,000 New Climate Ventures Sustainable Investment Prize
  • $25,000 Amentum and WRX Companies Rising Stars Space Technology and Commercial Aerospace Cash Prize
  • $500 Mercury Elevator Pitch Competition - Hard Tech
  • $1,000 Anbarci Family Company Showcase Prize
  • $3,000 Venture Builder Innovation Prizes

Xatoms, Western University and University of Toronto — $30,000

The team placed fifth for its AI- and quantum-driven platform for discovering solar-activated semiconductor materials.

  • $5,000 prize, sponsored by EY
  • $25,000 nCourage Investment Network’s Courageous Women Entrepreneur Investment Prize

Mito Robotics, Carnegie Mellon University— $5,000

The team placed sixth for its automated manual cell culture with AI-powered robotic scientists for life science research

  • $5,000 prize, sponsored by Chevron Technology Ventures

FarmSmart.ai, LSU – $106,000

The team placed seventh for its AI—driven assistant that synthesizes vast agricultural research into actionable, tailored intelligence, but earned the fifth-most investments among the group.

  • $5,000 prize, sponsored by Shell Ventures
  • $100,000 The OWL Investment Prize
  • $1,000 Anbarci Family Company Showcase Prize
  • Edward H. Molter Memorial Prizes for Wildcard Round - 1st place - Advance to Finals


Other significant awards

GreenLIB Materials, University of Ottawa – $152,000

  • $150,000 Goose Capital Investment Prize
  • $2,000 Venture Builder Innovation Prizes

Microvitality, Tufts University – $26,500

  • $25,000 Southwest National Pediatric Device Consortium Pediatric Device Cash Prize
  • $1,500 Edward H. Molter Memorial Prizes for Wildcard Round - 3rd place overall in WC

Nanoborne, University of Texas at Austin - $25,000

  • $25,000 NOV Golden Ticket to Supernova Accelerator and Cash Prize

Last year, the Rice Business Plan Competition facilitated over $1.5 million in investment and cash prizes. MesaQuantum from Harvard University landed the highest total investment last year, although it was not named a finalist. Protein Pints from Michigan State University won the pitch competition.

According to Rice, 910 startups have raised more than $6.9 billion in capital through the competition over the last 25 years.

A Houston investor and leader at Houston Angel Network weighs in on the importance of angel investors in growing startup communities. Photo via Getty Images

Houston expert examines the importance of early-stage investors in the innovation ecosystem

guest column

In a flourishing startup ecosystem, the roles of entrepreneurs, venture capitalists, startup development organizations, policymakers, research institutions, and universities are well documented and understood. Less obvious, however, is the role of early-stage investors, aka, “angel investors.”

These unique people are often the first non-family money to invest in a young company, often while it is still refining its business model, completing its minimum viable product (MVP), or finding product-market fit. Excellent angel investors, however, provide value to the ecosystem far beyond their ability to write a check.

Most angel investors bring deep expertise within their domain. These can be 20- or 30-year industry veterans with invaluable been-there-done-that experience in a particular technology, discipline, vertical, or regulatory environment. They can share insights learned from various industry trends that have succeeded and failed, which often save startups significant time and effort. Or they may bring complementary business expertise such as legal, accounting, technology, financing, or startup strategy. Many angels have launched or worked in multiple startups themselves, which gives them an ability to quickly understand and assist with the unique challenges of early-stage business.

Additionally, good investors are aggregators of knowledge. They constantly read about the sectors in which they invest, learn the latest trends, and watch for innovations that they believe will change industries. As forward thinkers, they know how to look past buzzwords to find what is truly unique or different. They often ask the “hard questions” that cut to the heart of the matter. Wise founders learn how to listen and use this feedback to improve their company and strategy.

Many angel investors serve as mentors to startups and share their hard-won knowledge. Most start with informal or unpaid relationships either through an SDO or personal referral. If they form a meaningful connection with a particular startup, this could turn into an official role as a compensated advisor. The best of these relationships are mutually beneficial and ultimately profitable if the company has a successful exit. Similarly, angels may become advisors to venture capital funds that want to bring their insights to their portfolio companies.

Investors are natural connectors in an ecosystem. As they search for, invest in, and mentor great startups, they foster connections across the innovation community. Relationship-building is key to all business success, and a wise angel knows how to respectfully leverage connections for mutual benefit. However, be careful not to ask an investor to share connections too soon. One of the fastest turn-offs is someone who asks me to open my rolodex before earning my trust and respect.

The most obvious benefit that investors bring to the innovation ecosystem is funding for early-stage businesses. This infusion of capital enables young businesses to identify, create, and grow value, which is the ultimate point of innovation. I mention it last, however, because savvy entrepreneurs know the difference between “smart money” and “dumb money.” Dumb money is not a pejorative but a label for money that has no voice or utility beyond its monetary value (which makes it silent or “dumb”).

Smart money, on the other hand, brings many or all of the other attributes discussed above: knowledge, expertise, mentoring, and connections. In terms of value, smart money is worth many times more than its cash value.

As the Houston innovation ecosystem grows, we need more accredited investors with a passion for innovation to learn about angel investing and determine if it is a fit for them. Given its very high-risk profile, it certainly isn’t appropriate for everyone. However, angel investing is a powerful way that investors can help solve society’s biggest challenges and contribute to a thriving innovation community.

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Mitra Miller is the vice president and board member of Houston Angel Network.

Houston-based Eden Grow Systems hopes to disrupt the agtech industry and revolutionize — and localize — produce. Photo via edengrowsystems.com

Houston startup with next-gen farming tech calls for crowdfunding as it plans to grow

seeing green

Whether it’s on Mars or at the kitchen table, entrepreneur Bart Womack wants to change what and how you eat.

But the CEO and founder of next-generation farming startup Eden Grow Systems is seeking crowdfunders to help feed the venture.

The company evokes images of a garden paradise on earth. But the idea behind the Houston-based NASA spinoff came from a more pragmatic view of the world. Womack’s company sells indoor food towers, self-contained, modular plant growth systems built on years of research by NASA scientists looking for the best way to feed astronauts in space.

The company has launched a $1.24 million regulated crowdfunding campaign to raise the money it needs to scale and expand manufacturing outside the current location in Washington state.

Additionally, the U.S. Air Force recently chose Eden as a food source for the U.S. Space Force base on remote Ascension Island, in the Atlantic Ocean, Womack tells InnovationMap. Another project with Space Center Houston is also in the works.

“We want to be the government and DOD contractor for these kind of next-generation farming systems,” he says.

The Houston-based company includes former NASA scientists, like recent hire Dr. L. Marshall Porterfield, of Purdue University, as an innovation advisor.

Womack, a former digital marketer, Houston public channel show host, night club owner and entertainment entrepreneur, left those ventures in 2012, after the birth of his first child. While taking a year to study trends research, in 2014, what he read intrigued and alarmed him.

“I’ll never forget, I came across a report from Chase Manhattan Bank….of the top 10 disruptive investment sectors, over the next decade,” he says. “At the very top of the list was food.”

Bart Womack founded Eden Grow Systems in 2017. Photo courtesy

His conclusions on the fragility of the world’s food supply system, due to overpopulation, and scarcer land, led him to launch Eden in 2017, funded by venture capital firm SpaceFund, Womack, his family, friends and angel investors.

Womack believes “black swan” events will only increase, disrupting the food supply system and further jeopardizing food supplies.

“We’re going to enter a period of hyper novelty in history,” Womack says.. "The system we’ve built for the last 100 years, the super optimized system, is going to begin to break apart."

To avert a centralized food production outcome, operated by corporate giants like Amazon or Walmart, Womack’s vision offers a decentralized alternative, leaving it in local hands.

With $2 million put into the company so far and a half million-dollars in sales last year, Womack argues that Eden has achieved much and can make food independence within reach for everyday families.

The company commercialized NASA technology to fill what it viewed as “a huge gap within the controlled…agricultural space.”

The tower is the building block of a modular, automated and vertical indoor plant growth system, with calibrated misting, fans, and LED lighting, controlled by an app.

The company website touts the towers as an easy way to grow plants like lettuce, carrots, tomatoes, and potatoes, with little water, no soil, and lots of air, without the expense and work of cultivating an earth-based garden.

For those who want to eat more than greens, the towers provide a way to breed fish and shrimp in an aquaponic version, recycling fish waste as plant fertilizer.

However, big plans come with big costs. The towers range in price from $5,000 to $7,000, although payment plans for those who qualify make it affordable.

Eden has sold around 100 of their towers so far, to a variety of customers. But rising costs and shipping delays have led to a a three-month backlog.

The manufacturing and shipping associated with larger installations means that even if the company made a million-dollar sale, delivery of the product would take a year.

“One of the hardest things…as a start-up, the last couple of years, is trying to narrow down exactly where the biggest payback is,” Womack says. “There is the lower hanging fruit, of small sales to individual buyers, but there’s the larger fruit of institutional buyers. But they can take months and years to convert into an actual buyer.”

Customers include several universities, including Texas A&M University and Prairie View A&M University, and talks are underway with other large academic institutions.

For now, attracting investors so the company can reach its funding goal poses the biggest challenge.

“Texas investors are very, very hard-nosed, and they’re not like West Coast investors. They want to understand exactly how they’re going to get their money back, and exactly how quickly,” he says.

Womack says the crowdfunding round would allow the company to expand manufacturing operations into Houston, deliver product faster, and invest in advertising.

“When we complete this round, and become completely self sufficient, we’re planning on moving to a $25 million valuation,” Womack says. “We can show, given money, we can scale the company.”

The city of Nassau Bay, next to NASA’s Johnson Space Center, has purchased towers and plans to purchase more, not for the production of food, but to grow ornamental flowers.

Womack says that city officials there found that it’s cheaper to grow the decorative plants themselves, rather than buying them.

The towers are adaptable, and can grow not only food but cannabis and other plants, and if buyers want to use them other purposes, that adds to the product’s appeal, Womack says.

Eden has also sold some towers to Harris County Precinct 2 and the city of Houston, as part of a project he says will turn food deserts throughout the area into “food prosperity zones.”

“Our goal is to be the farming equivalent of Boeing,” Womack says.

Teamwork makes the dream work, and this new investor alliance hopes to make Houston startups' dreams of seed funding come true. Getty Images

Investors join forces for citywide alliance to increase access to early-stage capital

Teamwork makes the dream work

Securing funding for your startup is now a one-stop shopping experience. Over 200 accredited investors have teamed up to create the Houston Investment Network Alliance — a platform that promotes investment opportunities and mentorship for early-stage companies.

HINA is a collaboration where participating investors can partner up to co-invest in startups, co-host investor events, and share opportunities.

Behind the alliance are four Houston investment entities: the Houston Angel Network, Rice Angel Network, GOOSE Society of Texas, and Cannon Ventures.

"HAN and the Goose Society have invested over $150M in early stage companies over the last decade. The appetite for startup investing continues to be alive and strong in Houston," says Stephanie Campbell, HAN managing director, in a release. "The birth of new groups like RAN and Cannon Ventures demonstrates a new and growing appetite for investment."

Each of the organizations have connections to Rice University and previously worked together on a sports technology-focused pitch night hosted at The Cannon, a West Houston coworking space lead by CEO and founder, Lawson Gow. Gow is the son of David Gow, owner of InnovationMap's parent company Gow Media.

The Cannon launched its own fund, Cannon Ventures, about seven months ago. It has four startup partners: SEATz, Win-Win, Data Gumbo, and SeeHerWork. Each Cannon Ventures startup partner will received anywhere between $100,000 to $400,000 of seed funding as well as access to space in The Cannon and its accelerator opportunities, Gow says.

Cannon Ventures has already also collaborated with the other HINA organizations. The Rice Angel Network is even based out The Cannon.

"We're increasingly co-investing with other angel networks," Gow says, "because it's hard to start a company and raise money, so the more we can do that to help Houston startups get the money they need."

According to Gow, Houston's thriving startup scene and deep pockets is a perfect opportunity for HINA.

"One of the great things about Houston is we've got a lot of money here," he says. "One of the most transformative things we can do for the startup community is get a lot of high-net worth individuals is get them off the bench and onto the field and activate them as regular angel investors into Houston-based startups. That's a really important goal of Cannon Ventures is to grow our membership base and get ore people involved."

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Shipley Donuts launches AI-powered ordering assistant

fresh tech

Popular Houston-born doughnut chain Shipley Donuts has added a first-of-its-kind AI-powered assistant to its online ordering platform.

The new assistant can create personalized order recommendations based on individual or group preferences, according to a news release from the company. Unlike standard chatbox features, the new assistant makes custom recommendations based on multiple customer factors, including budgetary habits, individual flavor preferences and order size.

"We're not just adding AI for the sake of innovation — we're solving real customer pain points by making ordering more intuitive, personalized and efficient," Kerry Leo, Shipley Vice President of Technology, said in the release.

The system also works for larger events, as it can make individual orders and catering recommendations for corporate events and meetings by suggesting quantities and assortments based on group size, event type and budget.

According to Shipley, nearly 1 in 4 guests have completed orders with the new AI technology since it launched on its website.

“The integration of the AI ordering assistant into our refreshed website represents a significant leap forward in how restaurant brands can leverage technology to enhance the customer experience,” Leo added in the release.

Houston company wins AHA competition for pediatric heart valve design

winner, winner

Houston-based PolyVascular, which develops minimally invasive solutions for children with congenital heart disease, was named the overall winner of the American Heart Association’s annual Health Tech Competition earlier this month.

The company was founded in 2014 by Dr. Henri Justino and Daniel Harrington and was part of TMCi's 2017 medical device cohort. It is developing the first polymer-based transcatheter pulmonary valve designed specifically for young children, allowing for precise sizing and redilation as the child grows while also avoiding degradation. PolyVascular has completed preclinical studies and is working toward regulatory submissions, an early feasibility study and its first-in-human clinical trial thanks to a recent SBIR grant from the National Heart, Lung, and Blood Institute.

With the new AHA honor, PolyVascular will be invited to join the association’s Center for Health Technology & Innovation Innovators’ Network, which connects entrepreneurs, providers and researchers to share and advance innovation in cardiovascular and brain health.

“This is a tremendous honor for PolyVascular—we’re especially proud to bring hope to families and children living with congenital heart defects,” Justino said in a news release. “Our technology—a minimally invasive valve that can be expanded over time to grow with the child—has the potential to dramatically reduce the need for repeated open-heart surgeries.”

The Health Tech Competition is a live forum for health care innovators to present their digital solutions for treating or preventing cardiovascular diseases and stroke.

Finalists from around the world addressed heart failure, hypertension, congenital heart defects and other issues that exist in cardiovascular, brain and metabolic health. Solutions were evaluated on the criteria of validity, scientific rigor and impact.

The judges included Texas-based Dr. Eric D. Peterson, professor of medicine in the division of cardiology at UT Southwestern Medical Center, and Dr. Asif Ali, clinical associate professor of cardiovascular medicine at the University of Texas Medical School in Houston and director at Cena Research Institute.

According to the American Heart Association, nearly half of U.S. adults live with some form of cardiovascular disease or stroke.

“The American Heart Association plays a pivotal role in advancing innovative care pathways, and we’re excited that our solution aligns with its guidelines and mission,” Justino said in a news release. “It’s time these life-changing technologies reach the youngest patients, just as they already do for adults.”

EO Houston is where ambitious founders go to scale smarter

Don't Go It Alone

Scaling a business from early traction into true growth is one of the most exciting — and punishing — chapters of entrepreneurship. Houston founders know this better than most. Our city is built on ambition: fast-moving industries, talent from around the world, and opportunities that expand as large as the Texas sky.

But as many entrepreneurs eventually learn, scaling isn’t simply “more of what worked.” It requires new systems, new thinking, and often, a new version of the founder. Even the most capable founders eventually face decisions, pressures, and turning points that only other entrepreneurs can truly understand.

Entrepreneurs’ Organization, a global peer-to-peer network of more than 18,000 business owners across 220 chapters in 75+ countries, exists for exactly this stage. One of the largest chapters in the organization, EO Houston brings that global community to life locally, offering founders the connection, learning, and accountability needed to grow sustainably and to grow up as leaders.

A community where founders learn at the highest level
The real value of EO emerges in the lived experiences of other entrepreneurs. When Houston-area founders talk about the moments growth nearly broke their companies, a universal theme appears: you can’t do it alone.

EO Houston member Robert De Los Santos of Sky High Party Rentals learned this the hard way when rapid post-COVID growth made expansion feel limitless — until it wasn’t.

“After COVID, we doubled every year and assumed inventory was the limit. In 2023 we overbought, only to realize demand had peaked. That taught us a hard truth: growth in one city has ceilings. Expanding into Austin and Dallas — the Texas Triangle — gave us new markets to put our inventory to work while we figured out how to penetrate Houston better. The challenge shifted from a strategy of ‘buy more units for demand’ to learning how to tackle the challenges of ‘leading across cities.’”

Founders often enter EO exhausted from trying to maintain control as things grow more complex. Many discover, like Jarred King of Summit Firms, that scaling requires the difficult shift from doing everything to building the team that can.

“We grew quickly because of my network, relationships, and hustle… but I was doing all the work,” King says. “I realized at that point you have to delegate — not just busy work, but important decisions to your key team, as well as set up really effective SOPs.”

“The uncomfortable truth is that you are no longer the best person for most jobs in your company," agrees Darren Randle of Houston Tents & Events. "Your inability to delegate or hire people smarter than you in key leadership and management level roles will become the single biggest drag on the entire business. You have to accept that your original 'hustle' is now a scalability risk."

Making hard decisions, such as walking away from customers or contracts, can feel like less of a sting when you know others have also been faced with tough choices. Aaron Gillaspie of West U's My Salon Suite recalls, “You can’t be everything to everyone, it’s ok to say no, and just understand some customers aren’t the right fit. It’s a two way street and both must win.”

Perspective is perhaps the most important reality check that members find at EO.

“Bigger volume will not make problems go away — you just got to get used to walking the tightrope," says Roger Pombrol of Emerald Standard. "Develop a system for good balance and do not freak out. Scared is no way to live your life. It’s ok if you fall. Your family will still love you. Money is just money. Love is love. The world tries to make you conflate them, but don’t."

Actionable insights from entrepreneurs who’ve already scaled
Conversations like these are happening every month inside EO Forum Meeting. Each EO chapter is divided into several small Forums. These confidential, committed group of 7–10 entrepreneurs who meet to share the real five percent of what they’re experiencing. It’s not advice, but experience — shared candidly, respectfully, and with the kind of vulnerability that leads to breakthroughs.

What makes Forum so impactful is the honesty it draws out. Entrepreneurs are often surrounded by employees, partners, and even family members who rely on them for answers, but seldom do they have a group where vulnerability is not only welcomed, but expected.

Learning experiences that match your ambition
EO supports that growth far beyond peer groups. Through the organization’s global partnerships with institutions like Harvard, Oxford, and INSEAD, Houston members gain access to executive-level learning experiences designed specifically for entrepreneurs.

These programs help founders step out of the day-to-day and think strategically about competitive advantage, innovation, and organizational leadership. Paired with ongoing learning through EO Jumpstart, Nano Learning, and its global library of member-created content, founders stay informed, challenged, and ahead of emerging trends.

And through global communities — ranging from EO Women and EO Under 35 to industry-specific groups — Houston members tap into expertise that spans continents and sectors. Whether someone is navigating M&A, exploring international expansion, or integrating new technologies, the right perspectives are always within reach.

What truly distinguishes EO Houston, however, is its culture. Houston’s entrepreneurial landscape is uniquely diverse and resilient, filled with founders who are hungry to build, innovate, and elevate the city’s business community. EO Houston amplifies that spirit, creating relationships that are as supportive as they are strategic. Many members describe the chapter not simply as a network, but as a catalyst for becoming better leaders, better thinkers, and — just as importantly — better human beings.

Your next level starts here
For entrepreneurs who are ready to scale—beyond their first million, beyond their current comfort zone, and toward a future that requires sharper leadership and stronger community—EO Houston offers an unmatched platform. It is a place where ambitious founders grow faster, think bigger, and gain the confidence to take bold next steps.

If you’re ready to elevate your business and your leadership alongside people who understand the journey, EO Houston is ready to welcome you. Your next level starts with the peers who can help you reach it. Learn more and become a member here.