3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Tim Neal of AmPd Labs, Sandy Guitar of HX Venture Fund, and Sahir Ali of Modi Ventures. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from venture capital to manufacturing — recently making headlines in Houston innovation.

Tim Neal, CEO of AmPd Labs

Tim Neal is the new CEO of AmPd Labs, a unique additive manufacturing startup in Houston. Photo via LinkedIn

Houston entrepreneur Tim Neal joined next-generation additive manufacturing company AmPd Labs as CEO of the company. He tells InnovationMap that he'd always been interested in the additive manufacturing sector, and sees a lot of potential for AmPd Labs in the industrial world in Houston — now more than ever.

“Within additive manufacturing, a lot of people focus on the medical and the aerospace sectors, but the industrial sector has been largely overlooked. Being in Houston, that really resonates,” Neal says. “The technology is now at a place that it can be at this production scale.” Read more.

Sandy Guitar, general partner of HX Venture Fund

Sandy Guitar shares some lessons learned from the fallout of Silicon Valley Bank. Photo via HXVF

In its third year, Venture Houston — taking place on Rice University's campus on September 7 — has a theme of "decarbonization in a digital world," but that's not the only thing different this year. The one-day conference has added on a unique event on September 6 to help engage around 50 investors with over 100 Houston startups.

The new activation is called Capital Connect, and HX Venture Fund will matchmake investors and startups for one-on-one meetings meant to spur collisions and collaboration.

"It's not a pitch competition — it doesn't have the stress of that," Sandy Guitar, general partner of HX Venture Fund, tells InnovationMap. "It's really just a way of connecting with a longer term horizon. We didn't want to limit it just to those who are currently raising, but actually include people who maybe just raised six months ago or are not going to raise for 12 more months, but might still want to be in the room." Read more.

Sahir Ali, founder and general partner of Modi Ventures

Sahir Ali is the founder and general partner of Modi Ventures. Photo courtesy of Modi Ventures

It might be cool to arrive fashionably late to a party, but Houston investor Sahir Ali likes to be early when it comes to new technologies.

"What has been a part of my success and has driven a lot of my profesional, scientific, and financial growth has been being ahead of the curve a little bit in technologies. That is really the basis of the fund," Ali, founder and general partner of Modi Ventures, says on the Houston Innovators Podcast.

"Hardware and software have come to a point where now artificial intelligence is ready to go, and I think the biggest benefactor of that is going to be health care and the health and medicine space — and that space is not easy for investors to just jump in right away," he continues. Read more.

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Tim Neal is the new CEO of AmPd Labs, a unique additive manufacturing startup in Houston. Photo via LinkedIn

Exclusive: Houston additive manufacturing startup names new CEO

at the helm

As of last week, Tim Neal has a new job.

The Houston entrepreneur joined next-generation additive manufacturing company AmPd Labs founded by Sean Harkins and Brien Beach. Neal now serves as CEO of the company. He formerly served as co-founder and CEO of GoExpedi, a Houston-based industrial procurement solutions company.

Neal tells InnovationMap that he'd always been interested in the additive manufacturing sector, and sees a lot of potential for AmPd Labs in the industrial world in Houston — now more than ever.

“Within additive manufacturing, a lot of people focus on the medical and the aerospace sectors, but the industrial sector has been largely overlooked. Being in Houston, that really resonates,” Neal says. “The technology is now at a place that it can be at this production scale.”

The AmPd Labs facility, located in the Heights, works with its industrial clients through the entire life cycle — from initial design, fit and function, and onward. Neal says that what AmPd Labs provides for its customers is this comprehensive support at a rapid pace and in a nearshore capacity.

“We see a vision of ourselves as a digital manufacturing firm for manufacturers," he says. “The ability to very rapidly hard-to-make products and save that time, but also removing obsolete parts."

Additionally, AmPd Labs has a zero-waste process and can help its industrial clients with their ESG goals. The materials the company uses can be recycled and used again, Neal says.

"A lot of large industrial firms in Houston are focused on this new energy revolution, and that requires new technologies," he explains. "Many of these parts are hard to make."

Neal says he's sat on every side of the arena at this point, and he's bringing his background, including his experience with scaling a startup, to the table.

“We are big believers in the Houston economy," he says. "While the market might disagree at times, the green economy starts in Houston — the infrastructure is here, the companies wanting and needing to make that change are here.”

This week's roundup of Houston innovators includes Aleece Hobson of HX Venture Fund, Denis Akhiyarov of AiKYNETIX, and Sean Harkins and Brien Beach of AMPD Labs. Photos courtesy

4 Houston innovators to know this week

who's who

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from additive manufacturing to venture capital — recently making headlines in Houston innovation.

Aleece Hobson, venture partner for the HX Venture Fund

Aleece Hobson of HX Venture Fund shares what people can expect from Venture Houston on this week's episode of the Houston Innovators Podcast. Photo courtesy of HXVF

Today is a big day for Aleece Hobson — venture partner for the HX Venture Fund, a fund of funds investing in venture capital firms across the country that have interest in investing in Houston companies. She joined the Houston Innovators Podcast last week to discuss Venture Houston, which takes place today, and why it is so important to HXVF to showcase Houston.

"Houston is a destination for innovation — we are not a flyover city," she says on the show. Click here to read more and stream the podcast.

Denis Akhiyarov, CEO and co-founder of AiKYNETIX

Houston-based AiKYNETIX is equipping runners with high-tech tracking tools. Image courtesy of AiKYNETIX

Houstonain Denis Akhiyarov wanted to design a way to easily improve running performance. He founded AiKYNETIX uses real-time technology to provide a new option for runners on treadmills.

“Runners spend a lot of time, energy and money to run better,” says Akhiyarov, CEO and co-founder of the company. “In my personal life with training for nine marathons, I’ve seen limitations with wearables, they don’t actually track running form while running. Overall, our technology tracks not only your basic parameters but it can also analyze the human running form while in motion.”

AiKYNETIX, which was founded in January 2021, is positioned to replace power meters and can make a treadmill smarter. It has ability to plug into interactive video platforms for sports and serves as a much cheaper and more widely available analysis tool outside of motion capture labs, he says. Click here to read more.

Sean Harkins and Brien Beach, co-founders of AMPD Labs

Sean Harkins and Brien Beach opened AmPd Labs' space in the Heights last month. Images via ampdlabs.llc

Last year, Sean Harkins introduced his friend Brien Beach to the world of additive manufacturing, and together the duo saw a business opportunity not only for themselves — but also for all of Houston.

Harkins had been working in 3D printing and additive manufacturing — the process of creating an object by building it one layer at a time — for the last decade and studied industrial design at the University of Houston. Working together, Harkins and Beach launched AmPd Labs, Houston’s next-generation additive manufacturing facility for industrial design and production.

“There is a hill to climb with market acceptance, but we want to be the champions of that and Houston is just a great place to start this because it's the largest industrial city in America and there's so much industry here and there's tons of engineers in this community,” says Beach. “Houston is such a business-forward place. A ‘how can I help you’ type of business place.” Click here to read more.

Two innovators are bringing additive manufacturing opportunities to Houston. Image via Getty Images

New venture brings next-generation additive manufacturing to Houston

new to hou

Last year, Sean Harkins introduced his friend Brien Beach to the world of additive manufacturing, and together the duo saw a business opportunity not only for themselves — but also for all of Houston.

Harkins had been working in 3D printing and additive manufacturing — the process of creating an object by building it one layer at a time — for the last decade and studied industrial design at the University of Houston. Working together, Harkins and Beach launched AmPd Labs, Houston’s next-generation additive manufacturing facility for industrial design and production.

“I met Brien through a mutual friend and we started discussing this idea of an additive manufacturing center in Houston,” says Harkins, president of AmPd Labs.

AmPD Lab’s focus is to break down traditional engineering design constraints, forcing the question “can this be additively manufactured?” The facility uniquely enables the printing of metals through metal binder jetting technology.

Last week, the company opened its first dedicated space near the Heights that was built to be the production studio as well as a place to bring in potential partners interested in additive manufacturing.

“There is a hill to climb with market acceptance, but we want to be the champions of that and Houston is just a great place to start this because it's the largest industrial city in America and there's so much industry here and there's tons of engineers in this community,” says Beach. “Houston is such a business-forward place. A ‘how can I help you’ type of business place.”

In addition to the launch of the new facility, Beach and Harkins visualize they will soon create a trade-school-type concept of “Digital Craftsmen” for additive manufacturing and offer an educational platform to help build a skilled workforce in this space.

“AM is not a fit for everything, but by working together, we can find those parts and products in which an AM solution can give you an operational or competitive advantage,” says Beach. “We will work with you through the design process, provide samples for testing, work through parts quality and qualification, and eventually find some products that you can permanently implement into your business.”

AmPd Labs will focus its business on these dedicated areas of impact:

  • Manufacturing technology choice
  • Part design
  • Material selection
  • Material performance
  • Assembly and workflow assessment
  • Business model impact
  • Supply chain impact
  • Increased data generation
  • Sales and marketing approach

Sean Harkins and Brien Beach opened AmPd Labs' space in the Heights last week. Images via ampdlabs.llc

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance. Reale is co-founder of the Station Houston startup hub and a startup investor. He was also recently named director for startups and investor engagement at the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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