3 Houston innovators to know this week

who's who

This week's Houston innovators to know include Yared Akalou of Alcove Group, Serafina Lalany,of Houston Exponential, and Patrick Lewis of Sustainability Ventures Group. Photos courtesy

Editor's note: This week's group of Houston innovators you need to know might be pretty familiar to you, however each of them have a new endeavor they are excited to launch — from an energy investment group with a new name to new virtual platforms to benefit entrepreneurs.

Yared Akalou, founder-and-CEO of Alcove Group

Yared Akalou founded IAmOther50 to capture the brand of the freelancer along with their personality and experience. Photo courtesy of Alcove

Yared Akalou describes himself as a designer-focused entrepreneur. As founder-and-CEO of Alcove Group, his latest venture, IAmOther50, is a platform for creatives and freelancers to connect to work. This innovation he's focused on is in light of the growth in jobs that are freelance and remote.

"I am really on a mission," Akalou tells InnovationMap. "I have been talking about the future of work for over a decade now. The paradigm will change to viewing work as a service, so it is important to tell a freelancer's story through a more engaging and novel way." Read more.

Serafina Lalany, chief of staff at Houston Exponential

Serafina Lalany joins the Houston Innovators Podcast to discuss the HTX TechList, which launches this week. Photo courtesy of Serafina Lalany

Serafina Lalany is pinpoint focused on creating resources for Houston innovators through her work at Houston Exponential. Most recently, that's meant creating and launching the HTX TechList, which went live last week. For her, one of the most important benefits the platform will afford the city is access to data about the ecosystem.

"We needed a centralized datasource classifying startups, investors, startup development organizations, and corporate innovators," she says on the Houston Innovators Podcast. "There was not any good resource on the internet that was verified, centralized, and adhered to a data standard." Read more and stream the episode.

Patrick Lewis, managing partner of Sustainability Ventures Group

Houston-based Sustainability Ventures Group is focused on connecting energy companies to innovative, sustainable solutions. Photo courtesy of SVG

As Patrick Lewis started to get a feel for what his network within the energy industry was looking for amid the pandemic, he thought some of the sustainability-focused ventures might be on the back burner.

"We thought we would hear that sustainability in this environment may have slipped down the priority list, but it was the exact opposite," Lewis says. "Pretty consistently across all the operators, sustainability, reducing emissions, and greenhouse gases — those are all even more important today."

This confirmation that the energy industry is committed to innovative sustainability projects led Lewis to rebrand his energy tech investment group from BBL Ventures to Sustainability Ventures Group, or SVG. The investment team focuses on reverse engineering the startup innovation process by sourcing the concerns and goals of the energy companies, then finding solutions from the startup world through reverse pitch competitions and challenges. Read more.

Houston — much like the rest of the world — has a growing freelance economy. A local innovator has created a platform for freelancers to find work. Photo courtesy of Common Desk

Houston entrepreneur creates a new digital platform to help connect freelancers to clients

calling all creatives

By 2027, freelancers will account for the majority of the American workforce — and Houston is already well represented by the freelance space.

According to a recent study, Houston is home to 117,260 skilled freelancers who generated more than $4.1 billion in revenue in 2018. This burgeoning environment for freelancers presents many opportunities for innovations in the tech world, as one Houston entrepreneur has already discovered.

Yared Akalou, founder-and-CEO of Alcove Group and self-described designer-focused entrepreneur, released his third innovation catering to freelancers of the Houston area. His digital solutions platform, IAmOther50, assists freelancers with securing new clients by sharing their personal stories rather than just submitting their professional experience, it uses videos and articles to promote the work of a freelancer and connect them to their next client.

At first glance, the digital platform seems like a departure for Akalou who in 2017 founded Alcove, a portable laptop case that serves as a private workspace for freelancers to use amid coffee shops or coworking spaces. However, IAmOther50 serves as a distinctly separate yet integral part of his innovation landscape.

"These projects have been a combination of my focus and research," says Akalou. "My new platform works hand in hand with Alcove, supporting the mission to help people stay productive from anywhere."

The digital platform serves to capture the brand of the freelancer along with their personality and experience. It lives at the intersection of popular social media platforms and professional platforms such as LinkedIn, except just for freelancers in the Houston area. Currently, any freelancing professional in the Houston area can join for free by filling out a survey that customizes their goals for their profile.

"IAmOther50 provides information in a contextual way," says Akalou. "We have this guiding principle of delivering value even before the prospective client contacts the freelancer for an interview or potential position. It's about going beyond just a resume of what you've done and showcasing how you add value right now."

Akalou, who is also one of the mentors in The Ion Smart and Resilient Cities Accelerator, is focused on elevating the professional profiles of many freelancers, including those outside the Houston area. He is aiming to grow the platform to a self-service platform that can connect freelancers to clients all over the biggest metropolitan areas soon.

It's not easy getting green. Getty Images

3 tips for a successful crowdfunding campaign

Know before you hit go

Kickstarter is a widely popular crowdfunding platform that helps people to raise money and awareness for their creative projects. While known for product-focused campaigns, musicians to film producers have also achieved success on the platform. In September of 2017, my Houston-based startup GetAlcove.com launched our first kickstarter campaign. While we exceeded our campaign goal, it was a very intense 45 day campaign. Let's consider the statistics:

Yes, almost 70 percent of projects fail. Don't fret. Understanding how to effectively plan and launch your campaign will increase your chances for meeting your campaign goals.

By March 2017, my co-founder and I received enough customer feedback to warrant the pursuit of developing Alcove Workstation™ further. We were attracted to crowdfunding as it presented a viable option for validating our concept with a wider audience while also raising the initial working capital necessary to mass producing Alcove. After researching the various crowdfunding platforms, we decided on Kickstarter as it is well known for launching product-focused campaigns and has a strong brand that we could leverage during our marketing efforts. While we read countless publications on how to prepare for our crowdfunding campaign, our experience on Kickstarter garnered three key lessons.

1. Spend up to one year prepping before launching your campaign.

I can't stress this enough. After we decided to launch, we spent six months engaging with our target audience and obtaining verbal commitments from friends and family and past colleagues to back our project. We also presented at local events and evangelized our brand via social media marketing. In hindsight, we should have spent additional time finalizing the production ready sample of our product prior to launching.

Once you launch your campaign, the clock starts ticking and you'll need deliver fast. Due to a myriad of issues with remote manufacturing, we inevitably missed our original ship date. Fortunately, the kickstarter community is forgiving and recognizes the inherent challenges with bringing a product to market. Even so, I recommend launching your campaign as close to your final concept as possible to reduce unforeseen delays with manufacturing and shipping logistics.

Once you launch your campaign, the clock starts ticking and you'll need deliver fast.

2. Determine which crowdfunding platform is right for your project.

There are four main types of crowdfunding platforms. Kickstarter and Indiegogo are rewards-based whereas platforms like GoFundMe are donation-based. More recently, equity, and debt based platforms like Houston's NextSeed have garnered attention from campaigners seeking alternative methods to raising funds and deferring payment.

Take the time to read about each type and contact each platform for specifics about how they will support your campaign during and after campaign. Indiegogo does a solid job of highlighting their partnerships with vendors that can assist you during different stages of your campaign; offering marketing promotion, direct links to manufacturing vendors, and additional funding options even after your campaign ends.

The next step to determining the right platform for your project is to search for similar "like" products. If you are launching the most revolutionary ear buds on the planet, then you want to ensure people are backing ear buds or similar product on the platform/s you are considering. A simple search on each site will pull up all ear bud projects to date. Then, you can quickly assess the patterns of the most successful vs. unsuccessful campaigns.

3. Launch the right campaign goal, with the right team, at the right time.

This is both important and hard to determine. Let's break it down.

The right campaign goal
The campaign goal is the total dollar amount you want to raise by the end of your campaign. The goal amount can be adjusted once on Kickstarter but I recommend that you keep it low — $5,000-$10,000 — to ensure you meet your goal within two days — three days max. Keep in mind you are competing with four to five thousand live projects at any given time. If you make your campaign goal, Kickstarter's algorithm pushes your project up the list and you have a good shot of being listed or even featured on the front page of Kickstarter's website. If you make your campaign goal too high and don't meet your goal with those couple days, Kickstarter's algorithm pushes your project down the list. If I recall, our campaign went from approximately 115 to 800 after day two. Each day that passes, your project is pushed even further down the list of over 4000 projects. What this means to your project is that unless you have a serious marketing engine behind you, no one will see your project outside of your immediate contact list or followers on social media. This is where hiring the right team of marketers and PR can be invaluable.

The right team
Think of the development of your crowdfunding campaign as a micro-enterprise site that requires the right mix of talent to build out. Funded startups with established teams and products in market, for instance, are launching on Kickstarter as a way to increase market awareness of their new products. For the boot-strapped startups with small teams, leverage your strengths and hire for gaps in skills to ensure you develop the right communications, pricing strategy, and overall layout of your page. To be clear, a production quality video is an absolute must.

The right time
Finally, consider the timing of your launch to align with complimentary events or holidays. If your product is focused on education/learning, the obvious timeframe would be to launch during back to school. Another way to galvanize your target audience is to identify popular conferences for your industry. For our campaign, we aligned with the Tech Disrupt conference in San Francisco and literally went live on Kickstarter directly from our exhibit booth!

While I can not make any guarantees for your campaign's success, I am confident that if you apply these tips, you will be that much closer to achieving your campaign goals.

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Yared Akalou is the founder of Houston-based Alcove.

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Houston foundation grants $27M to support Texas chemistry research

fresh funding

Houston-based The Welch Foundation has doled out $27 million in its latest round of grants for chemical research, equipment and postdoctoral fellowships.

According to a June announcement, $25.5 million was allocated for the foundation's longstanding research grants, which provide $100,000 per year in funding for three years to full-time, regular tenure or tenure-track faculty members in Texas. The foundation made 85 grants to faculty at 16 Texas institutions for 2025, including:

Michael I. Jacobs, assistant professor in the chemistry and biochemistry department at Texas State University, who is investigating the structure and thermodynamics of intrinsically disordered proteins, which could "reveal clues about how life began," according to the foundation.
Kendra K. Frederick, assistant professor in the biophysics department at The University of Texas Southwestern Medical Center, who is studying a protein linked to Parkinson’s disease.
Jennifer S. Brodbelt, professor in chemistry at The University of Texas at Austin, who is testing a theory called full replica symmetry breaking (fullRSB) on glass-like materials, which has implications for complex systems in physics, chemistry and biology.

Additional funding will be allocated to the Welch Postdoctoral Fellows of the Life Sciences Research Foundation. The program provides three-year fellowships to recent PhD graduates to support clinical research careers in Texas. Two fellows from Rice University and Baylor University will receive $100,000 annually for three years.

The Welch Foundation also issued $975,000 through its equipment grant program to 13 institutions to help them develop "richer laboratory experience(s)." The universities matched funds of $352,346.

Since 1954, the Welch Foundation has contributed over $1.1 billion for Texas-nurtured advancements in chemistry through research grants, endowed chairs and other chemistry-related ventures. Last year, the foundation granted more than $40.5 million in academic research grants, equipment grants and fellowships.

“Through funding basic chemical research, we are actively investing in the future of humankind,” Adam Kuspa, president of The Welch Foundation, said the news release. “We are proud to support so many talented researchers across Texas and continue to be inspired by the important work they complete every day.”

New Houston biotech co. developing capsules for hard-to-treat tumors

biotech breakthroughs

Houston company Sentinel BioTherapeutics has made promising headway in cancer immunotherapy for patients who don’t respond positively to more traditional treatments. New biotech venture creation studio RBL LLC (pronounced “rebel”) recently debuted the company at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago.

Rima Chakrabarti is a neurologist by training. Though she says she’s “passionate about treating the brain,” her greatest fervor currently lies in leading Sentinel as its CEO. Sentinel is RBL’s first clinical venture, and Chakrabarti also serves as cofounder and managing partner of the venture studio.

The team sees an opportunity to use cytokine interleukin-2 (IL-2) capsules to fight many solid tumors for which immunotherapy hasn't been effective in the past. “We plan to develop a pipeline of drugs that way,” Chakrabarti says.

This may all sound brand-new, but Sentinel’s research goes back years to the work of Omid Veiseh, director of the Rice Biotechnology Launch Pad (RBLP). Through another, now-defunct company called Avenge Bio, Veiseh and Paul Wotton — also with RBLP and now RBL’s CEO and chairman of Sentinel — invested close to $45 million in capital toward their promising discovery.

From preclinical data on studies in mice, Avenge was able to manufacture its platform focused on ovarian cancer treatments and test it on 14 human patients. “That's essentially opened the door to understanding the clinical efficacy of this drug as well as it's brought this to the attention of the FDA, such that now we're able to continue that conversation,” says Chakrabarti. She emphasizes the point that Avenge’s demise was not due to the science, but to the company's unsuccessful outsourcing to a Massachusetts management team.

“They hadn't analyzed a lot of the data that we got access to upon the acquisition,” explains Chakrabarti. “When we analyzed the data, we saw this dose-dependent immune activation, very specific upregulation of checkpoints on T cells. We came to understand how effective this agent could be as an immune priming agent in a way that Avenge Bio hadn't been developing this drug.”

Chakrabarti says that Sentinel’s phase II trials are coming soon. They’ll continue their previous work with ovarian cancer, but Chakrabarti says that she also believes that the IL-2 capsules will be effective in the treatment of endometrial cancer. There’s also potential for people with other cancers located in the peritoneal cavity, such as colorectal cancer, gastrointestinal cancer and even primary peritoneal carcinomatosis.

“We're delivering these capsules into the peritoneal cavity and seeing both the safety as well as the immune activation,” Chakrabarti says. “We're seeing that up-regulation of the checkpoint that I mentioned. We're seeing a strong safety signal. This drug was very well-tolerated by patients where IL-2 has always had a challenge in being a well-tolerated drug.”

When phase II will take place is up to the success of Sentinel’s fundraising push. What we do know is that it will be led by Amir Jazaeri at MD Anderson Cancer Center. Part of the goal this summer is also to create an automated cell manufacturing process and prove that Sentinel can store its product long-term.

“This isn’t just another cell therapy,” Chakrabarti says.

"Sentinel's cytokine factory platform is the breakthrough technology that we believe has the potential to define the next era of cancer treatment," adds Wotton.

How Houston's innovation sector fared in 2025 Texas legislative session

That's a Wrap

The Greater Houston Partnership is touting a number of victories during the recently concluded Texas legislative session that will or could benefit the Houston area. They range from billions of dollars for dementia research to millions of dollars for energy projects.

“These wins were only possible through deep collaboration, among our coalition partners, elected officials, business and community leaders, and the engaged members of the Partnership,” according to a partnership blog post. “Together, we’ve demonstrated how a united voice for Houston helps drive results that benefit all Texans.”

In terms of business innovation, legislators carved out $715 million for nuclear, semiconductor, and other economic development projects, and a potential $1 billion pool of tax incentives through 2029 to support research-and-development projects. The partnership said these investments “position Houston and Texas for long-term growth.”

Dementia institute

One of the biggest legislative wins cited by the Greater Houston Partnership was passage of legislation sponsored by Sen. Joan Huffman, a Houston Republican, to provide $3 billion in funding over 10 years for the Dementia Prevention and Research Institute of Texas. Voters will be asked in November to vote on a ballot initiative that would set aside $3 billion for the new institute.

The dementia institute would be structured much like the Cancer Prevention and Research Institute of Texas (CPRIT), a state agency that provides funding for cancer research in the Lone Star State. Since its founding in 2008, CPRIT has awarded nearly $3.9 billion in research grants.

“By establishing the Dementia Prevention and Research Institute of Texas, we are positioning our state to lead the charge against one of the most devastating health challenges of our time,” Huffman said. “With $3 billion in funding over the next decade, we will drive critical research, develop new strategies for prevention and treatment, and support our healthcare community. Now, it’s up to voters to ensure this initiative moves forward.”

More than 500,000 Texans suffer from some form of dementia, including Alzheimer’s disease, according to Lt. Gov. Dan Patrick.

“With a steadfast commitment, Texas has the potential to become a world leader in combating [dementia] through the search for effective treatments and, ultimately, a cure,” Patrick said.

Funding for education

In the K-12 sector, lawmakers earmarked an extra $195 million for Houston ISD, $126.7 million for Cypress-Fairbanks ISD, $103.1 million for Katy ISD, $80.6 million for Fort Bend ISD, and $61 million for Aldine ISD, the partnership said.

In higher education, legislators allocated:

$1.17 billion for the University of Houston College of Medicine, University of Texas Health Science Center at Houston, UT MD Anderson Cancer Center, and Baylor College of Medicine
$922 million for the University of Houston System
$167 million for Texas Southern University
$10 million for the Center for Biotechnology at San Jacinto College.

Infrastructure

In the infrastructure arena, state lawmakers:

Approved $265 million for Houston-area water and flood mitigation projects, including $100 million for the Lynchburg Pump Station
Created the Lake Houston Dredging and Maintenance District
Established a fund for the Gulf Coast Protection District to supply $550 million for projects to make the coastline and ship channel more resilient

"Nuclear power renaissance"

House Bill 14 (HB 14) aims to lead a “nuclear power renaissance in the United States,” according to Texas Gov. Greg Abbott’s office. HB 14 establishes the Texas Advanced Nuclear Energy Office, and allocates $350 million for nuclear development and deployment. Two nuclear power plants currently operate in Texas, generating 10 percent of the energy that feeds the Electric Reliability Council Texas (ERCOT) power grid.

“This initiative will also strengthen Texas’ nuclear manufacturing capacity, rebuild a domestic fuel cycle supply chain, and train the future nuclear workforce,” Abbott said in a news release earlier this year.

One of the beneficiaries of Texas’ nuclear push could be Washington, D.C.-based Last Energy, which plans to build 30 micro-nuclear reactors near Abilene to serve power-gobbling data centers across the state. Houston-based Pelican Energy Partners also might be able to take advantage of the legislation after raising a $450 million fund to invest in companies that supply nuclear energy services and equipment.

Reed Clay, president of the Texas Nuclear Alliance, called this legislation “the most important nuclear development program of any state.”

“It is a giant leap forward for Texas and the United States, whose nuclear program was all but dead for decades,” said Clay. “With the passage of HB 14 and associated legislation, Texas is now positioned to lead a nuclear renaissance that is rightly seen as imperative for the energy security and national security of the United States.”

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A version of this article first appeared on EnergyCapitalHTX.com.

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