Houston startup raises $10M, A&M names TMC campus, and more innovation news

short stories

The latest Houston innovation news includes a name for the burgeoning Texas A&M University campus in the Texas Medical Center. Photo courtesy of TAMU

Houston's innovation ecosystem has been booming with news, and it's likely some might have fallen through the cracks. From a Texas university naming its burgeoning new campus to a Houston SaaS startup with fresh funds, here are some short stories in Houston innovation.

ThoughtTrace raises $10M series B

ThoughtTrace has received investment from Chevron Technology Ventures. Photo via thoughttrace.com

ThoughtTrace Inc., a Houston-based software-as-a-service startup closed a $10 million series B round led by Canadian venture capital fund McRock Capital with contribution from Houston-based Chevron Technology Ventures.

"Chevron Technology Ventures (CTV) pursues externally-developed technologies and new business solutions that have the potential to enhance the way Chevron produces and delivers affordable, reliable and ever-cleaner energy," says Barbara Burger, president of CTV, in a release. "ThoughtTrace fits that mandate with the potential to automate the complex, time-consuming, and document-intensive workflows required for our ongoing business operations."

ThoughtTrace's software quickly analyzes documents and contracts and produces results at a fraction of the cost and time of traditional methods. With the fundraising deal, Scott MacDonald, McRock's co-founder and managing partner, will join ThoughtTrace's Board of Directors.

"We are extraordinarily excited to have both McRock and Chevron join the team. McRock brings a great background in the industrial space, which we see as a great fit. In the case of Chevron, they went from being a new customer in 2019 to an investor in 2020," says Nick Vandivere, ThoughtTrace CEO, in a release.

"With the new capital raise, ThoughtTrace will accelerate its investment in creating AI with unparalleled speed and accuracy, grow strategic partnerships and platform integrations, and add to its existing team of talented professionals, all of which will bring further value to the growing ThoughtTrace customer-base," Vandivere continues.

Texas A&M names its Texas Medical Center campus

The new campus will be called Texas A&M Innovation Plaza. Photo courtesy of Texas A&M University System

After announcing its plans for a $546 million medical complex in Houston's Texas Medical Center in February, Texas A&M University has released the name of the 5-acre campus rising at the intersection of Holcombe Boulevard and Main Street: Texas A&M Innovation Plaza.

The project will be completed in phases. The first phase, which will open later this year, is a renovation of an 18-floor building at 1020 Holcombe Blvd., which will to be the new home for EnMed, a dual degree program that produces both a master's in engineering and a medical degree.

"EnMed is just the first example of innovation that Texas A&M System intends to bring to the Texas A&M Innovation Plaza," says Chancellor John Sharp in a news release. "We are excited to have such a visible location in the Texas Medical Center."

Rice Business Plan Competition lays out virtual plans

The competition must go on. Photo via rbpc.rice.edu

This year's Rice Business Plan Competition, which was planned for March 26 to 28, was canceled due to COVID-19, but the Rice Alliance for Technology and Entrepreneurship has decided to offer up an alternative: A virtual RBPC. Forty two student teams will compete over three virtual events.

  • Elevator Pitch Competition on June 17 (Open to the public): Each team will deliver 60-second pitches.
  • Round 1 on June 18 (Open to startups and judges only ): Each team will deliver 10-minutes to pitch to a panel of judges followed by Q&A.
  • Live finals on June 19 (open to the public): The seven finalists will pitch to the judges, and following a round of questions from judges, the winners and prizes will be announced.

Two health care educational institutions team up for new program

Xavier University and Baylor College of Medicine have launched a collaborative medical track. Photo by Dwight C. Andrews/Greater Houston Convention and Visitors Bureau

Louisiana's Xavier University and Baylor College of Medicine in Houston have joined forces to allow Xavier students a smooth transition into Baylor's graduate programs. Xavier students, including traditionally underrepresented minorities — according to a press release — will have the opportunity to apply for the program in November. Three students will be selected for the program, which facilitates acceptance into the medical school.

"Our commitment at Baylor College of Medicine to diversity and inclusion creates the best environment for success across our mission areas of healthcare, research, education and community outreach," says Dr. Paul Klotman, president, CEO and executive dean of Baylor College of Medicine, in the release. "This important collaboration with Xavier University will strengthen this commitment, and I look forward to welcoming students from this new partnership into the Baylor family."

Klotman continues to express how inclusiveness is a priority for BCM and for this partnership.

"We live in a world where healthcare is changing and evolving," says Dr. Anne McCall, provost and senior vice president for Academic Affairs at Xavier, in the release. "This partnership will further equip our students with the diverse tools and training that they'll need to foster equity in the medical field and compete on an international level."

University of Houston begins offering virtual tours for perspective students

Potential UH Cougars can get the 411 on campus via a virtual tour tool. Photo via uh.edu

Before COVID-19 sent everyone home and canceled gatherings, classes, and events across the world, the University of Houston was already working on a way for potential students to tour and learn more about the campus. Now, in light of the pandemic, UH has released this virtual tour offering complete with live interaction from UH student ambassadors.

"I'm really excited about the live component we just added because prospective students can ask questions just like during a face-to-face campus tour and that interaction is invaluable," says Mardell Maxwell, executive director of UH Admissions, in a release. "UH is so committed to access, and we see this as a great opportunity not only for students in Houston and Texas, but for those coming from out of state. We are opening up access to campus across the world."

Anyone can sign up for a tour online through the university's website.

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Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

Houston booms as No. 2 U.S. metro for new home construction

Construction Boom

Driven by population growth, more residential rooftops are popping up across Houston and the rest of Texas than anywhere else in America.

Using data from the U.S. Census Bureau and Zillow, Construction Coverage found 65,747 new residential units were authorized in greater Houston in 2024. That figure landed Houston in second place among major metro areas for the total number of housing permits, including those for single-family homes, apartments, and condos.

Just ahead of Houston was the Dallas-Fort Worth Metroplex, which took first place with 71,788 residential permits approved in 2024. In third place was the country’s largest metro, New York City (57,929 permits).Elsewhere in Texas, the Austin metro ranked sixth (32,294 permits), and the San Antonio metro ranked 20th (14,857 permits).

Construction Coverage also sorted major metro areas based on the number of new housing units authorized per 1,000 existing homes in 2024. Raleigh, North Carolina, held the No. 1 spot (28.8 permits per 1,000 existing homes), followed by Austin at No. 2 (28.6), DFW at No. 3 (22.2), Houston at No. 4 (21.6), and San Antonio at No. 13 (13.6).

A Newsweek analysis of Census Bureau data shows building permits for 225,756 new residential units were approved in 2024 in Texas — a trend fueled largely by activity in DFW, Houston, Austin, and San Antonio. That put Texas atop the list of states building the most residential units for the year.

Through the first eight months of last year, 145,901 permits for new residential units were approved in Texas, according to Census Bureau data. That’s nearly 80,000 permits shy of the 2024 total.

Among the states, Construction Coverage ranks Texas sixth for the number of residential building permits approved in 2024 per 1,000 existing homes (17.9).

Extra housing is being built in Texas to meet demand spurred by population growth. From April 2020 to July 2024, the state’s population increased 7.3 percent, the Census Bureau says.

While builders are busy constructing new housing in Texas, they’re not necessarily profiting a lot from homebuilding activity.

“Market conditions remain challenging, with two-thirds of builders reporting they are offering incentives to move buyers off the fence,” North Carolina homebuilder Buddy Hughes, chairman of the National Association of Home Builders, said in a December news release. “Meanwhile, builders are contending with rising material and labor prices, as tariffs are having serious repercussions on construction costs.”

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