This week's innovators to know in Houston includes Ayse McCracken of Ignite Healthcare Network, Philipp Sitter of VIPinsiders, and Diane Yoo of Medingenii. Photos courtesy

Editor's note: In today's Monday roundup of Houston innovators, I'm introducing you to three innovators — from health care investing to marketing technology — all making headlines in Houston this week.

Ayse McCracken, founder and board chair of Ignite Healthcare Network

Ayse McCracken joins the Houston Innovators Podcast to discuss women in health care and Ignite Madness. Photo courtesy of Ignite

When the pandemic hit and shut down businesses across the world, Ayse McCracken knew immediately what group of people were likely going to be the most affected: Women in health care. It just so happens that her nonprofit organization, Ignite Healthcare Network, exists to serve this same group of people, so she got to work on creating online events that were intentional and meaningful.

"With COVID, it has only escalated the importance of our work, so we've elevated our voices through our webinar series," McCracken says on this week's Houston Innovators Podcast.

This week, Ignite's virtual startup competition concludes with the finals. She shares more about the program and Ignite's mission on the episode. Click here to read more and stream the episode.

Philipp Sitter, founder of VIPinsiders

Restaurateur Philipp Sitter launched VIPinsiders last year. Photo courtesy of VIPinsiders

Restaurants have undoubtedly suffered due to loss of business during the shutdown, but they face an uphill battle back to normalcy, and restaurateur Philipp Sitter knew his tech tool could help. He created VIPinsiders as a marketing tool to reach customers in a data-driven way.

"The restaurant gets to know me [the customer], it understands how often I visit, it also gets to reward my visitation," explains Sitter. "Most importantly, it reminds me to come back when I haven't visited in a while."

Data recorded by VIPinsiders shows that 48 percent of users visit restaurants with the platform "more often" in the first 90 days. Click here to read more.

Diane Yoo, managing partner at Medingenii

Diane Yoo, who was hospitalized due to COVID-19 earlier this year, created a VC fund that's investing in health tech solutions for the disease. Photo courtesy of Medingenii

Just a few weeks after being hospitalized from COVID-19, Diane Yoo was investing in a medical device startup that could have made a world of difference to her recovery. After closing its initial fund, Medingenii invested in several Houston health startups including Vitls, a wearable device that can track and send vitals remotely.

"The pandemic has really validated some of the business models we're invested in," she tells InnovationMap.

Now, fueled by her first round of success and eager to advance other life-changing technologies, Yoo is looking toward a second fund. Click here to read more.

A Houston restaurateur and tech founder is giving the food and restaurant business a new marketing opportunity with VIPinsiders. Photo by Andrea Piacquadio from Pexels

Houston entrepreneur's mobile platform brings gains to small restaurant chains

tapping into tech

Food is the way to a Houstonian's heart. With critically-acclaimed cuisine and an abundance of diversity, Houston is the South's culinary pride. COVID-19 has now stirred uncertainty in a once definitive piece of the city's culture, and restaurateurs are looking for solutions. For Philipp Sitter, CEO of VIPinsiders, artificial intelligence is a step in the right direction.

Sitter holds many titles: CEO of KB Restaurant Group, President of EggHaus and King's Bierhaus — and now, tech founder. In 2019 he launched VIPinsiders, "a rewards program that uses artificial intelligence (AI) to understand the customer on an individual journey," he explains.

"I was born into the restaurant industry," says Sitter, as he remarks on immigrating from Vienna as a child and opening the first King's Biergarten in Pearland in 2011. As a fifth-generation restaurateur, he is familiar with "the love and pain of the industry." When he took on the challenge of marketing his family's "obscure German restaurant behind a car wash in Pearland," he became "obsessed" with the trade.

Philipp Sitter launched VIPinsiders last year. Photo courtesy of VIPinsiders

After building excitement around EggHaus, the Instagrammable haven that's attracted both breakfast lovers and influencers, Sitter wanted to find a way to build the same buzz at his other restaurants using technology.

Going mobile

From Starbucks Rewards' gold stars to Chick-Fil-A One, reward programs have been tested and utilized by the Goliaths of the restaurant industry for years.

When looking at the cost of building a mobile app like Starbucks, he determined it to be impossible.

"We're talking about millions that go into developing technology. What restaurant is going to be able to afford something like that?" he asked.

The plan soon crystallized: Sitter decided to create a mobile platform that uses AI to personalize unique offers and experiences for customers while taking the responsibility from the shoulders of restaurant owners with smaller, multi-unit concepts. By developing and scaling the mobile platform by providing its services to other businesses, "then it would all of the sudden become affordable for everybody," he realized.

Deciding to create a mobile platform was the easy part.

"I wasn't born with the emotion of fear in business," shares Sitter, who has dabbled in obscure endeavors from washing cars to flipping classic cars on eBay.

After formulating the VIPinsiders concept, he hired a team of developers to "use the psychology of everything I've learned in marketing and put it into a technology platform," he explains.

The user experience

Each client gets a tailor-made approach, ensuring the rewards and loyalty features are made to fit the restaurant. The VIPinsiders staff builds custom mobile platforms for its small and medium-sized restaurant chain clients that utilize the restaurant's branding, menus and events for $299 per month.

"We got through a discovery call in which our team will actually build the rewards journey for them and show it to the business owner for approval," explains Sitter, "We don't want to give the owners and managers a homework assignment."

Once the platform is approved, Sitter's team trains restaurant owners. In-house copywriters and designers then develop print material for the restaurant to cross-promote the rewards program.

According to VIPinsiders' internal data, 95 percent of users find the app "easy to use." Using QR technology, customers can sign up by scanning a QR code rather than downloading an app.

"The restaurant gets to know me [the customer], it understands how often I visit, it also gets to reward my visitation," explains Sitter. Rather than a one-size-fits-all reward program, the platform is meant to showcase different menu items and offerings.

"Most importantly, it reminds me to come back when I haven't visited in a while."

Data recorded by VIPinsiders shows that 48 percent of users visit restaurants with the platform "more often" in the first 90 days.

Text message marketing 

When stay-at-home orders first took effect in Harris County, many business owners could not update their business hours or post new content on the Google My Business platform due to the site's halted review process during COVID-19.

The issue left business owners with one less form of contact, creating a vulnerability in customer communication. Social media marketing doesn't quite come to the rescue either, with Facebook's algorithm showing an average of 5.5 percent of a brand's following will see its post.

To Sitter, text messaging is "the next frontier."

Due to COVID-19, VIPinsiders recently ran a promotion to provide free platform use and unlimited text capabilities for a limited time to restaurants. "We've gotten a lot of incredible emails and feedback saying thank you for letting us use this and helping us [get] back our business," says Sitter.

"It's time for all of us to take our power back, to own our customer [data] and be able to talk with them directly and not have to pay the middleman [like social media companies] and really have the relationship that customer opted in for," says Sitter.

As one of the first mobile platforms approved by the Texas Alcoholic Beverage Commission, restaurant clients can extend happy hour offerings and provide customers with free alcoholic beverages.

At King's Bierhaus, Sitter was able to deploy an alcohol-to-go offer via text message that resulted in $40,000 of bottled King's Whiskey sold.

"I was able to sell that because I was able to text my customers directly," Sitter says.

Clients outside of Sitter's own properties also see growth. Ninety-three percent of restaurants using the VIPinsiders platform reported an increase in sales.

"I would absolutely recommend other operators to sign up for VIPinsiders because it has increased our sales, our guests love it, and the support we get from them makes it effortless," explains Usman Dhanani, President of Operations for Cyclone Anaya's Tex-Mex Kitchen, in a VIPinsiders testimonial video.

El Toro, a Mexican restaurant chain with six Texas locations, generated an estimated additional $735,000 in sales with a total of more than 35,000 additional customer visits, according to VIPinsiders data.

"The biggest brands in the world and celebrities lead a charge into marketing initiatives," says Sitter, "A company like ours will bring that to small businesses and make it affordable for them so they can compete at the highest level."

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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.