LabReady ensures samples make it from the patient to the lab without compromising the quality of the sample. Photo via vaximmune.com

Houston-based Vax-Immune Diagnostics has commenced on a new multicenter clinical trial to roll out a specific lab test as a part of its LabReady product.

The 12-week study will analyze results from Group B Streptococcus lab tests in expecting mothers. Currently, 16 to 20 percent of pregnant women are affected by GBS, according to a news release, which will then infect their newborn through the childbirth process.

Vax-Immune's product, LabReady, enhances the transportation process of lab samples and aims to improve the quality of results in patients. The company is expected to report data from the trial this summer.

"Currently samples are not regulated through transport from the patient to the lab often causing inaccurate test results. And inaccurate test results can cause significant problems since medical decisions are based on these results," Dr. Leonard E. Weisman, president and chief technology officer at Vax-Immune Diagnostics, says in the release.

"Our device, LabReady collects, protects, processes, and prepares the sample from the patient through transport, so when it arrives at the laboratory, infection can easily and accurately be diagnosed."

This study is planned to randomize approximately 300 patients from 35 to 37 weeks of pregnancy, according to the release. GBS is the most common cause of infections such as sepsis, meningitis, and pneumonia among newborns. The Centers for Disease Control and Prevention, among other organizations, have launched efforts for screenings and tests to reduce cases of neonatal GBS disease.

Vax-Immune was a member of the Texas Medical Center's 2018 TMCx Medical Device cohort and pitched at the 7th TMCx Demo Day. The company is a JLABS @ TMC resident.

Over 700 people watched TMCx's Demo Day either in person or online. Photo by Cody Duty/TMC

5 Texas companies present the future of health care at TMCx's Demo Day

Homegrown heroes

After four months of product design, networking with medical professionals, pitching to investors, and more, 23 startup leaders had just a few minutes to show the medical community what they've achieved and where they're going next.

Over 700 attendees made it to TMCx's 7th Demo Day or tuned in online to see the results of Houston's award-winning medical devices accelerator program.

"It's really the draw of the experts within our 23 hospitals and clinics that really makes us quite special in our ecosystem compared to the East and West coasts," Texas Medical Center CEO Bill McKeon says. "We're proud to call ourselves the Third Coast of the life sciences."

The cohort, which is the most international to date with nine international companies, has already raised $73 million and confirmed 108 signed agreements for medical professional partnerships.

"The thing that cracks me up from time to time," says Erik Halvorsen, director of the TMC Innovation Institute, "is when you see these talks that say, 'what can the Houston ecosystem learn from Silicon Valley.' Well you know what, I think we're ready to flip that, and say, 'here's what can Silicon Valley learn from us here in Houston — what we've built and where we're headed.'"

From a wearable device that reduces back pain to a new technology that reduces suicidal thoughts, the cohort's presentations didn't disappoint. While all the cohorts made business connections to Houston in the months they were at TMCx, five of the 23 companies are based in Texas. Here are the companies with Lone Star State roots.

Articulate Labs

Articulate Labs' KneeStim allows for everyday activities to be muscle-building exercises.

Photo via articulatelabs.com

Herbie Kirn, co-founder and chief scientific officer of Articulate Labs, lost his leg from the knee down in a motorcycle accident and quickly wore through his other knee's cartilage. If he didn't do sufficient rehabilitation and physical therapy, he would lose function of that leg too.

Over 14 million people in the United States individuals suffer from chronic knee problems; however, whether it be due to time or cost, over 70 percent of those affected cannot attend the prescribed physical therapy.

Dallas-based Articulate Labs has a solution. The KneeStim device allows the patient to turn daily activities into rehabilitation exercises.

The company has raised a little over $500,000 already, but looks to raise $1 million with its next round of funding. Articulate Labs is also looking for more scientific and strategic partners.

Intelligent Implants

intelligent implants

Intelligent Implant's co-founder, Juan Pardo, told the crowd at Demo Day that his company's device allows for 50 percent faster bone growth in patients.

Photo by Cody Duty/TMC

Chronic lower back pain can result in a need for spinal fusion surgery — and 40 percent of those surgeries fail, says Juan Pardo, co-founder of Intelligent Implants, which has an office in Houston. Pardo and his team have come up with an implant that tracks post-op healing and introduces electronic stimulation wirelessly.

The device is the same size and shape as the spacer that surgeons currently use, but contains a technology that can deliver electronic stimulation therapy and monitor progress without needing batteries. The doctor is able to adjust treatment remotely, and the device can heal the patient 50 percent faster than the standard care.

Intelligent Implants was announced as the first in-residence company at the Center for Device Innovation by Johnson and Johnson and also launched its large animal studies. The company has a goal to raise $1.6 million, and has already secured $900,000 — $250,000 of which came from the new TMC Venture Fund.

Noleus Technologies

Swarna Balasubramaniam, an experienced surgeon, created a device that heal gastrointestinal surgery patients faster.

Photo by Cody Duty/TMC

Swarna Balasubramaniam watched helplessly as her mom slowly healed from gastrointestinal surgery. She couldn't eat and had trouble sleeping — both of which hindered her ability to heal quickly.

Balasubramaniam, founder of Houston-based Noleus Technologies, created a solution that reduces swelling in the bowels after operation. The disposable device is inserted into the abdomen at the time of surgery, and folds up like a fan to be removed without another surgery.

The invention is attractive to all parties involved. Patients are able to heal quicker, and surgeons are able to provide better care for their patients. Additionally, hospitals, which have bundled reimbursement for surgeries like this, are able to shorten the recovery time for patients thus reducing the costs spent on caring for the patient. Balasubramaniam says she estimates the device saving hospitals $4,000 per patient.

Vax-Immune Diagnostics

LabReady ensures samples make it from the patient to the lab without compromising the quality of the sample.

Photo via vaximmune.com

Over 70 percent of care decisions come from lab results, but more than 20 percent of microbiology lab tests are inaccurate due to problems in transport from the patient to the lab. Leonard Weisman, founder and chief technology officer of Houston-based Vax-Immune Diagnostics, invented Lab Ready — a tool for protecting the quality of the sample for testing.

The device is easy for patients to use at home and send to the lab directly, and the device is likewise easy to use by lab technicians.

Lab Ready is prepared to launch in 2019, immediately following FDA approval. Vax-Immune is on track to meet its funding goal of $5 million in the first quarter of 2019.

VenoStent

VenoStent wants every external stent procedure is successful on its first try.

Photo via venostent.com

Patients with kidney disease or diabetes have four chances to get an external stent successfully inserted into their arms for dialysis treatment, and the current standard of care results in a failure in half of these access sites, says Tim Biore, founder of Houston-based VenoStent.

It was Biore's vision to create a device that allows a successful stent implementation on the first try. VenoStent's SelfWrap is made from a shape-memory polymer that uses body heat to mold the stent into the vein-artery junction.

One in eight people suffer from kidney disease, and Biore says SelfWrap would save Medicare upwards of $200 million annually, while improving the success rate by 20 to 30 percent.

VenoStent has seven signed agreements from partners as a result of the accelerator program. The company is seeking $2.4 million to continue manufacturing as they await FDA clearance — expected in early 2022.

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Houston energy blockchain company announces $7.7M in funding, plans to expand to the Middle East

money moves

A Houston-based tech company has announced another round of funding to support its blockchain network growth as well as to establish a presence in the Middle East.

Data Gumbo has closed its series B funding round totaling $7.7 million with follow-on investments led by Equinor Ventures. The round includes participation from Saudi Aramco Energy Ventures and Bay Area and Houston-based venture firm L37. The round's first close was announced in September 2020 at $4 million. The additional funds to close the Series B will be used to scale Data Gumbo to serve demand for GumboNet™ and GumboNet™ ESG. Additionally, Data Gumbo plans to establish a presence in the Middle East to cover expected demand growth in the region.

"The successful close of our series B is continued proof of the efficacy and booming interest in our ability to capture critical cost savings, deliver trust and provide transparency across commercial relationships," says Andrew Bruce, founder and CEO of Data Gumbo, in a news release. "Compounded by the growing demand for transparent, accurate sustainability data and the launch of our automated ESG measurement solution, GumboNet™ ESG, Data Gumbo's trajectory is well-positioned to serve our growing customer base by ensuring economic productivity and value. This infusion of capital will support our expansion efforts as we bring more international users to our network."

With this latest raise, Data Gumbo's total funding raised to date is $18.4 million.

"Data Gumbo's success is marked by a wide variety of business use cases and opportunities for expansion," says Bruce Niven, chief investment officer at Aramco Ventures, in the release. "Our continued investment is a testament to our continued support as the company attracts new customers, experiences further demand for its network and gains traction in new markets."

The company's technology features smart contract automation and execution, which reduces contract leakage, frees up working capital, enables real-time cash and financial management, and delivers provenance with unprecedented speed, accuracy, visibility and transparency, per the release.

"Data Gumbo is the market leader for smart contracts backed by blockchain, and the coming year will be a period of exponential growth for the company as they penetrate new industrial markets," says Kemal Farid, partner at L37, in the release. "We believe strongly that GumboNet will become the de facto network for smart contracts across industries for capturing value and solving enormous pain points in contractual relations. Additionally, as companies move to meet increasing sustainability measurement demands and ESG improvements, there is a huge growth path available for Data Gumbo with the launch of GumboNet ESG."

Earlier this year, the company announced its environmental, social and corporate governance tracking and reporting tool.

"Equinor's recent pilot at the Johan Sverdrup field has demonstrated that GumboNet can create strong value for the partnership," says Gareth Burns, head of Equinor Ventures, in the release. "Our follow-on investment confirms Equinor Ventures' confidence in Data Gumbo's solution for our company and the broader energy industry."

3 Houston startups announce strategic appointments across health tech, materials, and software

short stories

Three Houston tech startups have new hires they're excited about this summer. From new board members to c-level execs, here's who's moving and shaking in Houston innovation.

Former Memorial Hermann CEO joins board of ZIBRIO

This Houston medical device startup has added a big name to its board. Photo courtesy of ZIBRIO

Dan Wolterman, who served as president and CEO of Memorial Hermann Health System for 15 years, has been named to the board of directors of Houston-based ZIBRIO. The health tech company, which was founded based on NASA technology, has developed a device that measures balance.

"We're delighted to have Dan on the team," says Katharine Forth, ZIBRIO CEO and co-founder, in a news release. "He understands ZIBRIO's vision to work across the full continuum of care, empowering older patients and clinicians with quantifiable fall prevention. His experience and enthusiasm will be invaluable in helping us to achieve it."

Falling is the top cause of trauma injury and trauma death across all age groups, according to ZIBRIO's release, and the current cost of falls in people over 65 is $50 billion – which is expected to double.

"ZIBRIO is coming to market at a time when population health and prevention are key for Healthcare systems to generate outcomes. They have a strong team and an elegant solution to a complex problem that will help millions," Wolterman says in the release.

Inhance adds to its C-suite

Inhance Technologies has added an integral member to its leadership. Photo via inhancetechnologies.com

Inhance Technologies, an international provider of polymer material science solutions based in Houston, has named its new CFO. Andrew Leeser, previously at Cimarron Energy, has joined the company to lead global finance, accounting and treasury functions, as well as human resources and information technology.

"I'm delighted to welcome Andrew to the Inhance Technologies family. He has an excellent track record in organizations spanning a range of industries, and I'm sure that his experience will help us continue on our upward trajectory," says Andrew Thompson, president and CEO of Inhance Technologies, in a news release. "We look forward to working with him to build a bright future for the company and our customers as we help them make a conscious choice towards more sustainable plastics."

The company just recently announced its expansion, including another new C-level exec and a new 75,000-square-foot site in St. Louis.

"I'm very pleased to have joined Inhance Technologies and I look forward to helping the organization achieve its goals over the next few years. With the significant growth in demand for our fully recyclable barrier technology Enkaseä, as well as our global expansion, there is no doubt I'm joining the company at an exciting time," says Leeser in the release.

Houston fintech unicorn names new council

Meet the new council dedicated to supporting HighRadius's new platform. Photo via LinkedIn

HighRadius, a Houston-based fintech company that reached unicorn status last year, has announced the members of its advisory council for its new microlearning and community platform Highako Academy.

Bob Shultz, managing partner of Quote-to-Cash Consulting, will serve as chairman of the council.

Other council members include:

  • John LaRocca, Sr. Director of Global Credit, Hitachi Vantara
  • Roger Torneden, Director of Business, Management and Legal Programs for UCLA Extension
  • R. Britt Hastey, Chair, Business Administration Department, Los Angeles City College
  • Bruce Lynn, Managing Partner, the FENG LLC
  • Scott Blakeley, Partner, Blakeley LLP

The council "will identify and improve courseware, certification programs and the methods of delivery based on current and future industry and professional trends," according to an email from the company. Highako Academy is aimed at helping teams and customers develop critical industry skills.

"Our customers have asked us for an online self-service learning platform, and that led us to launch highako.com as a beta platform last year," says Urvish Vashi of HighRadius in a recent release. "With 10,000+ users on the platform and a vibrant partner ecosystem consisting of credit groups, collection agencies, attorneys and industry associations, we see this echoing a larger trend of millennials and Gen Z gravitating towards microlearning platforms."

Expert: How to ensure your tech is ready for a hurricane in Houston

Guest column

Houstonians are no strangers to hurricanes. We've already seen some activity this summer, and we still have a few months to go. Although we can't prevent every negative situation when it comes to weather, AT&T has picked up a few tried and true tips that can help you stay safe prepared during this hurricane season.

Tips to plan ahead:

  • Save your smartphone's battery life. In case of a power outage, extend your device's battery life by putting it in power-save mode, turning off Bluetooth and Wi-Fi, deleting apps, or putting your phone in Airplane Mode. This may prevent you from using certain features but will ultimately save battery power.
  • Keep your mobile devices charged. Be sure to have another way to charge your smartphone if the power goes out. One option might be using your car's USB port or a USB car charger.
  • Keep your mobile devices dry. Mobile phones can be a critical lifeline during a storm. To protect yours, store it in a water-resistant case, floating waterproof case, or plastic bag. A car charger or back-up battery pack can come in handy. If you have multiple devices to keep charged, consider a multi-port back-up battery pack.
  • Back up important information and protect vital documents. Consistently back up insurance papers, medical information and the like to the Cloud or your computer. With cloud storage, you can access your data from any connected device.
  • Have a family communications plan. Choose someone out of the area as a central contact in case your family is separated. Most importantly, practice your emergency plan in advance.
  • Store emergency contacts in your mobile phone. Numbers should include the police department, fire station, hospital, and family members.
  • Forward your home number to your mobile number in the event of an evacuation. Because call forwarding is based out of the telephone central office, you will get calls from your landline phone even if your local telephone service is down.
  • Track the storm on your mobile device. If you lose power at your home during a storm, you can use your mobile device to access local weather reports.

Likewise, we take a series of steps to ensure our Houston area network is ready to withstand the storm season each year.

Preparing our network in Houston:

When we know a storm is coming, we immediately assess what is needed to prepare our network. Some of those measures include:

  • Engaging Network Operations Center to monitor the network and partner with local personnel for recovery efforts.
  • Maintaining backup generators at cell sites and switching facilities in case of power loss.
  • Staging portable generators at strategic locations for deployment after an event.
  • Working with State and Federal Emergency Operations Centers to ensure first responders have the mobile connectivity they need before, during and after an event.

Keeping first responders connected:

Communication is critical to rescue and recovery efforts. That's why we were selected by the First Responder Network Authority (FirstNet Authority) – an independent agency within the federal government – to deliver FirstNet® to first responders and the extended public safety community. FirstNet is the only nationwide network built with and for America's first responders. In the Houston area, agencies using FirstNet include Law Enforcement, Fire, EMS, and Emergency Management, among others. FirstNet is used in day-to-day operations and during emergency response, including hurricane preparedness and response. In addition, organizations and agencies that could be called on to help support public safety also use FirstNet. These include healthcare, public works, essential government services, school security, utilities, energy, and transportation that operate in support of primary public safety entities and are critical to the response efforts. Together, these agencies utilize the FirstNet network for broadband connectivity for voice and data to prepare for and respond to hurricane events. FirstNet provides the connectivity they need with:

  • Priority & Preemption: In emergencies and disasters, commercial networks can quickly become congested. That's why FirstNet is the only nationwide network that gives first responders always-on priority and preemption. It puts them at the front of the "communications line."
  • Greater Command & Control: Public safety agencies have access to a fleet of more than 100 dedicated mobile cell sites that link to FirstNet via satellite and do not rely on commercial power availability. New this storm season, there's a giant addition to the FirstNet disaster response arsenal: FirstNet One – an approximately 55-foot aerostat, more commonly known as a blimp. And, to give first responders greater command and control of their network, the FirstNet Response Operations Program aligns with the National Incident Management System to better guide the deployment of these assets.
  • Enhanced Coverage and Capacity: We've also deployed FirstNet Band 14 spectrum. Band 14 is nationwide, high-quality spectrum set aside by the U.S. government specifically for FirstNet. We refer to it as public safety's VIP lane- during an emergency, this band can be cleared and locked just for FirstNet subscribers.

Recovery and relief:

During those unfortunate times when recovery response is needed, our Natural Disaster Recovery program and FirstNet Response Operations Group have technology and equipment to help with relief efforts such as:

  • Mobile cell sites and mobile command centers, like Cell on Wheels (COWs) and Cell on Light Trucks (COLTs)
  • Emergency Communications Vehicles (ECVs)
  • Flying Cell on Wings (Flying COWs)
  • Drones
  • A self-sufficient base camp: complete with sleeping tents, bathrooms, kitchen, laundry facilities, an on-site nurse, and meals ready to eat (MREs)
  • Hazmat equipment and supplies
  • Technology and support trailers to provide infrastructure support and mobile heating ventilation and air conditioning
  • Internal and external resources for initial assessment and recovery efforts

Together, let's have a smart and safe hurricane season.

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Luis Silva is vice president and general manager at AT&T.