A COVID-19 research breakthrough out of a Texas university comes from unlikely source

have you heard the one about the llama?

COVID-19 antibody research coming out of the University of Texas stars an unlikely participant: A llama named Winter. University of Texas at Austin/Facebook

In the race to find a treatment for the novel coronavirus, researchers at the University of Texas at Austin have announced a potential breakthrough — thanks to a llama.

Scientists from Texas' flagship university who have been collaborating with the National Institutes of Health and Ghent University in Belgium identified an antibody treatment that could potentially neutralize the virus that causes COVID-19.

The researchers detail their work in the May 5 edition of Cell, a scientific journal.

"This is one of the first antibodies known to neutralize SARS-CoV-2," said Jason McLellan, associate professor of molecular biosciences at UT Austin and co-senior author of the paper, in a release. (FYI, SARS-CoV-2 is referring to the virus that causes COVID-19.)

Using a Belgian llama named Winter, scientists were able to identify two antibodies the animal produces when it comes into contact with a foreign body (such as the coronavirus). The first is similar to a human antibody and the second is much smaller, about one-quarter of the size of the other.

This is Winter. Photo courtesy of University of Texas at Austin

Researchers were able to link two copies of this special llama antibody to create a new antibody. This new antibody binds tightly to a key protein on the coronavirus germ that causes COVID-19 and could possible be nebulized and put into an inhaler.

"That makes them potentially really interesting as a drug for a respiratory pathogen because you're delivering it right to the site of infection," said Daniel Wrapp, a UT graduate student in McLellan's lab and co-first author of the paper.

Unlike vaccines, which can take up to two months to take effect, antibody treatment can be used in more vulnerable populations as a way to fight off the virus.

"Vaccines have to be given a month or two before infection to provide protection," McLellan said. "With antibody therapies, you're directly giving somebody the protective antibodies and so, immediately after treatment, they should be protected. The antibodies could also be used to treat somebody who is already sick to lessen the severity of the disease."

From here, research turns to preclinical studies, using hamsters and primates for testing. If successful, they will move onto humans.

If you're wondering just how a group of researchers living in different parts of the globe were able to make this discovery seemingly overnight, that's because they've actually been working on it since 2016, when Winter was just 9 months old.

The experiment began as a way to develop vaccinations for two earlier versions of the coronavirus: SARS-CoV-1 and MERS-CoV. Their years of research allowed the scientists to pivot in recent months to isolating the protein in COVID-19.

As for Winter, she's now 4 years old and still lives with about 130 llamas on a farm in Belgium, likely unaware of her contribution to potentially altering the course of COVID-19 forever.

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This article originally ran on CultureMap.

Coding camps continue to grow and expand in Houston. The most recent comes from the University of Texas. Getty Images

UT coding camp emerges in Houston as the city grows its tech and innovation ecosystem

Up to code

As Houston's innovation ecosystem grows, the need for tech talent grows too. It's why the University of Texas and workforce accelerator Trilogy Education decided to bring a series of coding boot camps designed to teach Houstonians the skills they need to excel in the fast-paced world of the tech economy to town.

"Too many working adults lack the skills to succeed in the digital economy," says Liliya Spinazzola, the senior director for professional education and strategic initiatives at the Texas Extended Campus of The University of Texas at Austin. "And that means that employers are lacking a talent pool."

The Houston Coding Boot Camp aims to change all that. The 24-week sessions teach web development and coding skills, allowing adults to take classes even as they're working. That kind of flexibility helps them increase their knowledge as they continue to build career paths.

Houston's seen a good amount of growth when it comes to new coding camps. Digital Crafts, for instance, grew from an inaugural class of eight students to 125 people in just two years. Women Who Code saw a need for female coders in Houston to have a network, and now the city has a newly launched chapter.

Student success
So far, 260 students have completed the programs, going on to work at companies such as JP Morgan, IBM, and Deloitte.

One of those is Rebecca Gemeinhardt, now a full stack developer at Shell. She graduated with her bachelor's in graphic arts from the Kansas City Art Institute in 2017, and found that she missed being in a classroom. When she started the boot camp, she was immediately drawn to the challenge the subject matter offered, as well as the flexible schedule.

"The boot camp was just as formidable as the curriculum promised but extremely fulfilling," she says. "Going into boot camp, I didn't tell anyone I was doing it — what if I struggled and couldn't get through it? I kept it a secret until I found the confidence to identify as a developer."

Once she completed the program, she was hired at Shell.

"My life had changed so much in just six months but definitely for the better," Gemeinhardt says. "By focusing on the ability to adopt new technologies, [the coding boot camp instructors] left us with the invaluable skill of being adaptable and fast-learning full stack developers. This has helped me immensely at my current position as we are always incorporating new languages to our architecture depending on individual project needs."

Filling the need
Spinazzola says the camps deliberately try to create environments that foster the level of problem solving and exploration Gemeinhardt describes. The program partners with employers to discover what skills are most needed, and tailors the curriculum to dovetail with them. She says the skills most in demand right now are coding, cyber security, IT project management, and digital marketing.

"We also look at job description data here in Texas to see what skills are listed," she says. "And while students are in the program, we have a robust network that engages with them upfront, talking to them about what jobs are out there. And we host career fairs where they can show off their portfolios and discuss their skills set with potential employers."

Spinazzola says that students come from all walks of life and employment backgrounds, and that 26 percent of the participants are women. With 25 students per boot camp session, the small classes make for deep instruction. UT offers between three and fours sessions in Houston each year. She says that she finds participants are looking to either break into the tech sector, learn new skills or re-train to be able to advance their careers. The average age of students is somewhere in the low-30s, she says.

"We had a student who owned a cooking school and wanted to start a new career," she says. "[Rebecca] trained as a graphic artist and wanted to be a developer. One student shut down his medical practice and says that he wanted to learn coding so that he could go work for a pharmaceutical company. To me, that's the beauty of this program. These skills are in demand, and our students are able to take what they already know and enhance their abilities to be able to take on new career paths."

The University of Texas System scooted up three spots from 2017. University of Texas at Austin/Facebook

University of Texas ranks as one of the world's most innovative schools

Hook 'em

A new ranking from Reuters has placed the University of Texas System among the world's most innovative universities.

According to an October 11 release, the Reuters Top 100: The World's Most Innovative Universities "identifies and ranks the educational institutions doing the most to advance science, invent new technologies and power new markets and industries." The UT System ranked No. 6 out of the 100 best in the world. The 2018 ranking is a jump up from its No. 9 spot in 2017.

In addition to the flagship University of Texas at Austin, the system is comprised of seven other public universities across the state as well as six health institutions. Reuters notes that because of how the UT System reports on innovation, it assessed the entire enterprise rather than individual universities.

As a whole, the UT System boasts an impressive number of accolades that helped it scoot up three spots. As Reuters notes, chief among these accolades is the National Science Foundation's $60 million grant to the Texas Advanced Computing Center at the University of Texas at Austin to build a supercomputer and the system's $2.7 billion in annual research expenditures. (Not to mention numerous Nobel Laureates among both faculty and alumni.)

Overall, the U.S. dominated the list, claiming 46 out of the 100 spots. Rounding out the top 10 for 2018 is: No. 1, Stanford University; No. 2, Massachusetts Institute of Technology; No. 3, Harvard University; No. 4, University of Pennsylvania; No. 5, University of Washington; No. 7, Belgium's KU Leuven, No. 8, U.K.'s Imperial College London; No. 9, University of North Carolina at Chapel Hill; and No. 10, Vanderbilt University.

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This story originally appeared on CultureMap.

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Houston Technology Center founder dies, leaves legacy of innovation

saying goodbye

The Houston innovation ecosystem is mourning the loss of one of its early leaders, Paul Frison, who died on September 5. He was 87.

A long-time Houston businessman, Frison founded the Houston Technology Center in 1999 and served as its CEO and president. The organization evolved into Houston Exponential several years ago. Frison remained active within Houston innovation until 2020.

“Paul Frison was a visionary and energetic leader who always presented a positive outlook on what the Houston technology entrepreneurship community could become," Brad Burke, associate vice president for industry and new ventures at Rice University's Office of Innovation, remembers. "He was one of the pioneers in the community who established the Houston Technology Center as one of the early leaders of the Houston ecosystem. I admired how he helped launch the ecosystem and created the platform for many others to build upon.”

Prior to HTC, he served in various executive roles at American Hospital Supply, LifeMark, ComputerCraft, and LifeCell, spending the last 50 of his years in Houston. Born in Glendale, California, he served in the Unites States Coast Guard.

Blair Garrou, co-founder and managing director of Mercury Fund, says Frison was his first boss and mentor in the tech and entrepreneurship sector.

“When people look back to how the Houston tech community was founded, it starts with Paul Frison," Garrou says. "Paul had run multiple companies and I was lucky to have him as CEO when I worked for him at the Houston Technology Center. He quickly became a mentor, and over time, a good friend and confidant. I have Paul to thank for launching my career in tech and venture capital.

"My favorite quote of Paul’s was, 'Do not confuse effort with results,'” Garrou continues. "Despite his results-driven work ethic – which was legendary — Paul was also deeply-rooted in family and faith, and has been a role model for me over my entire professional life.”

He is preceded in death by his wife, Barbara, and his grandson, Christian David Elders. He is survived by his daughters Maryanne Elders and Jill Cortez and their families, including grandchildren Matthew Elders, Laney Elders, Max Cortez, Jake Cortez, and Sofie Cortez.

A celebration of life will be held for Frison on September 16 at 1 pm at Second Baptist Church, with a reception following in the Deacon’s Parlor. More details are available online. In lieu of flowers, Frison's wishes were for for donations to Second Baptist Church to be made in his honor.

Artist collective brings carbon-absorbing murals to Houston

WHEN FINE ART MEETS FRESH AIR

Anthony Rose, the CEO of creative agency United By Design, is on a mission to brighten Houston’s urban spaces and improve the city’s air quality one carbon-absorbing mural at a time.

Rose originally founded United By Design, or UXD, in 2019 to connect muralists like himself and commercial businesses seeking to beautify their spaces and form brand identities. After creating vibrant murals for Lockhart Elementary School, the Houston Astros, and Smoothie King, Rose expanded UXD’s vision to include environmental sustainability in their artistic collaborations in 2022.

“This city’s vibrant art scene and growing focus on sustainability makes it an ideal location for our projects,” Rose says. “We’re not just creating eco-friendly murals, we’re reimagining how art can actively contribute to environmental solutions.”

In search of ecologically-conscious paints, Rose formed a partnership with Spain-based, natural paint company Graphenstone. Rose says he was drawn to the company’s eponymous Graphenstone coating because of its nontoxic ingredients and exclusively uses the product for UXD’s carbon-absorbing murals.

"Between Land and Sky" by artist David Maldonado was UXD's first carbon-absorbing painting. Photo courtesy of Dario DeLeon and Tommy Valdez

The Graphenstone coating consists of a limestone base which goes through a process called photocatalysis, during which carbon dioxide from the atmosphere is absorbed into the surface, and is then sealed in with graphene, a thin layer of carbon atoms. The murals absorb carbon dioxide throughout the coat’s drying process which typically takes 30 days.

“Each of our murals absorbs about 1600 grams of CO2 during that curing process which is the equivalent daily absorption of about 33 growing trees,” Rose explains.

UXD’s largest carbon-absorbing mural to date is a floor-to-ceiling panorama in downtown Houston’s historic Mellie Esperson building, home to the company’s new creative hub. Painted by Houston-born artist Emily Ding, the mural is a tribute to the establishment’s namesake: an innovative, early 20th century entrepreneur who constructed the opulent building.

"Future's Past" by Emily Ding in partnership with UXD tells the story of the Mellie Esperson building. Photo courtesy of Dario DeLeon

Rose says UXD plans to expand their carbon-absorbing murals project in collaboration with more local artists and establishments, while creating an artist-in-residency program themed around sustainability. Though Rose acknowledges in the grand scheme of carbon pollution these murals are not a silver bullet, he says the non-toxic paints are encouraging conversations about how artists can be conservation-minded.

“We’re trying to figure out how art as a messaging tool can help break down scientific data, a language not many people practice daily, can break down barriers and help bridge the gap to a more intuitive knowledge of sustainability,” Rose says. “We’re bringing the community together, helping them feel empowered, and giving them actionable information to help them live more sustainable lives.”

Houston innovators to know this week

who's who

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes a health tech innovator, an investor, and a startup CEO.

Jon Nordby, managing director of Anthropy Partners

Jon Nordby's career has been focused on cultivating a culture for innovation, and now he's focused on human potential technology opportunities. Photo courtesy

In his role overseeing startup accelerators for MassChallenge, Jon Nordby started noticing one industry vertical stood out in terms of success and opportunities: Human potential. Now, Nordby is a founding member of an investment firm looking for those opportunities.

Nordby, who served in various leadership roles at MassChallenge — including managing director and head of ecosystems — said he started realizing the opportunities within the organization's space and sports tech programs.

"What we realized over a couple of years running the program was that sports tech as a theme was too limiting," Nordby says on the Houston Innovators Podcast. "We were finding really great technologies, but we were limited at the market size of teams and leagues to deploy those technologies."

"Over the course of that program, we found that the things that were related more to human health and performance tended to out perform all of the other things related to sports tech — like media, entertainment, gambling," Nordby continues. "Still really great markets for those technologies, but we found a lot more traction for human performance." Read more.

Benjamin Musher, professor at Baylor College of Medicine and medical director of medical oncology at the Duncan Cancer Center McNair Campus

The new center is specifically designed to allow patients to be on the cutting edge of testing brand-new therapies that could save their lives. Photo via BCM

Cancer treatment in Houston just became even more promising — and forward-thinking.

Phase 1 clinical trials are necessary to prove the efficacy in humans of treatments that have appeared promising in lab trials. In the name of cancer-fighting innovation, Baylor College of Medicine’s Dan L. Duncan Comprehensive Cancer Center has launched the Albert and Margaret Alkek Foundation Center for Experimental Therapeutics.

The new center is specifically designed to allow patients to be on the cutting edge of testing brand-new therapies that could save their lives.

“Clinical trials are critical for advancing the field of oncology and improving outcomes for cancer patients. Phase 1 trials are the first step in bringing innovative therapies to the clinic,” says Dr. Benjamin Musher, Barry S. Smith endowed professor at Baylor and medical director of medical oncology at the Duncan Cancer Center McNair Campus, in a news release. “Our new program will build on the success of previous phase 1 trials at Baylor and provide robust infrastructure to offer more clinical trial opportunities to our patients.” Read more.

Mark Semmelbeck, founder and CEO of A Better Meal

A Better Meal — a new app from a Houston founder — gives you all the tools you need to make healthier food choices. Photo courtesy

After many years of living to eat, a large swath of American society is now facilitating a seismic shift to the healthier alternative, eating to live.

But here’s the rub: eating healthy is confusing, time consuming and, unfortunately, oftentimes pricey.

So, anyone that can come in and cut through the healthy eating machine can carve out a necessary niche in the marketplace.

Enter Houstonian Mark Semmelbeck, founder and CEO of A Better Meal, a platform created to help busy families plan healthy meals easier and to make gradual improvements to their health and well-being.

“My vision is to use rapidly expanding AI technology together with the knowledge and wisdom of an active community to take the stress out of meal planning and improving nutrition,” says Semmelbeck, a seasoned oil and gas executive with over 30 years of experience in founding companies. “While developing the technology for the app, my daughter gave me two beautiful grandkids who both have significant food allergies. Combine that with the fact I now have five cardiac stents and the significance of eating well while paying attention to the details has only grown in importance.” Read more.

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