Rice University students collaborate on COVID-19 solutions

game changers

Rice 360˚ Institute of Global Health's student innovators created projects and devices — from disinfecting devices and optimized intubation tools — that respond to challenges presented by COVID-19. Courtesy of Rice University

An annual program with Rice University and its partners in Africa had to do things differently in light of the COVID-19 pandemic. Not only did operations have to shift to a virtual approach, but the projects themselves instead addressed the needs created by the disease.

Rice 360˚ Institute for Global Health, which collaborates with the Malawi University of Science and Technology (MUST) and the University of Malawi, The Polytechnic (Poly), continued their annual programming virtually over six weeks. The collaboration brings students together to solve global health issues, and this year's issue to address was overwhelmingly COVID-19.

"We had to give a lot of thought to whether we might have to cancel the program, and that was really heartbreaking to think about," says Rice 360˚ Director Rebecca Richards-Kortum, professor of bioengineering, in a news release. "Back in those days of late March and early April, I never really imagined how wonderful the virtual internship program could be."

Thirteen undergraduate interns and eight teaching assistants from Rice and Malawi, worked on six different projects, and three were presented in an online event on July 16. Here were the projects that were presented.

  • A disinfecting system that has the capability to sterilize multiple N95 masks at once. The system uses ultraviolet lights that can kill the coronavirus in around 30 minutes. Alternatively, the project included a smaller version that could be powered by solar energy. Yankholanga Pelewelo of MUST, Carolyn Gonawamba of Poly, and Andrew Abikhaled and Bhavya Gopinath of Rice developed the technology.
  • A walk-in decontamination unit that can decontaminate up to 3,000 people per day. The team of interns developed a prototype that consisted of PVC frame covered in plastic with nozzles to spray disinfectant. The project has already received interest from labs and hospitals for the device. Team members included Brenald Dzonzi of Poly, Mwayi Yellewa of MUST, and Kaitlyn Heintzelman, Krystal Cheung, and Sana Mohamed of Rice.
  • A redesigned intubation box that gives doctors better access to patients during the procedure. More than half of the 3,000 health care workers who have died from the coronavirus were doctors who focused on respiratory procedures, the team pointed out, and this daunting fact calls for redesigned tools. In total, the student innovators pitched three different designs that each included armholes in the sides, with a third hole on top to let a clinician or nurse assist with the procedure. The student team consisted of Chikumbutso Walani of Poly, Ruth Mtuwa of MUST, and Lauren Payne and Austin Hwang of Rice.

The other three projects included in the program but didn't present were designs for face shields, a hand sanitizer station and a contactless temperature monitor. All of the projects were led by teaching assistants Aubrey Chikunda and Chisomo Mukoka from MUST; Hannah Andersen, Nimisha Krishnaswamy, Alex Lammers and Ben Zaltsman of Rice; and Hope Chilunga and Francis Chilomo from Poly.

While pivoting the program to virtual comes with its challenges, Maria Oden — a professor of bioengineering, director of Rice's Oshman Engineering Design Kitchen and director of Rice 360˚ — recognizes the opportunities it provides as well.

"It would have been easy and understandable to cancel this internship, but that's not what happened, and look what the result was," Oden says in the release. "Over 90 people have tuned in to see the work of the interns. That's something we've never achieved with our in-person internships. We can learn from this experience."


Rice 360° Virtual Internship Highlights – Summer 2020www.youtube.com

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Rice biotech accelerator appoints 2 leading researchers to team

Launch Pad

The Rice Biotech Launch Pad, which is focused on expediting the translation of Rice University’s health and medical technology discoveries into cures, has named Amanda Nash and Kelsey L. Swingle to its leadership team.

Both are assistant professors in Rice’s Department of Bioengineering and will bring “valuable perspective” to the Houston-based accelerator, according to Rice. 

“Their deep understanding of both the scientific rigor required for successful innovation and the commercial strategies necessary to bring these technologies to market will be invaluable as we continue to build our portfolio of lifesaving medical technologies,” Omid Veiseh, faculty director of the Launch Pad, said in a news release.

Amanda Nash

Nash leads a research program focused on developing cell communication technologies to treat cancer, autoimmune diseases and aging. She previously trained as a management consultant at McKinsey & Co., where she specialized in business development, portfolio strategy and operational excellence for pharmaceutical and medtech companies. She earned her doctorate in bioengineering from Rice and helped develop implantable cytokine factories for the treatment of ovarian cancer. She holds a bachelor’s degree in biomedical engineering from the University of Houston.

“Returning to Rice represents a full-circle moment in my career, from conducting my doctoral research here to gaining strategic insights at McKinsey and now bringing that combined perspective back to advance Houston’s biotech ecosystem,” Nash said in the release. “The Launch Pad represents exactly the kind of translational bridge our industry needs. I look forward to helping researchers navigate the complex path from discovery to commercialization.”

Kelsey L. Swingle

Swingle’s research focuses on engineering lipid-based nanoparticle technologies for drug delivery to reproductive tissues, which includes the placenta. She completed her doctorate in bioengineering at the University of Pennsylvania, where she developed novel mRNA lipid nanoparticles for the treatment of preeclampsia. She received her bachelor’s degree in biomedical engineering from Case Western Reserve University and is a National Science Foundation Graduate Research Fellow.

“What draws me to the Rice Biotech Launch Pad is its commitment to addressing the most pressing unmet medical needs,” Swingle added in the release. “My research in women’s health has shown me how innovation at the intersection of biomaterials and medicine can tackle challenges that have been overlooked for far too long. I am thrilled to join a team that shares this vision of designing cutting-edge technologies to create meaningful impact for underserved patient populations.”

The Rice Biotech Launch Pad opened in 2023. It held the official launch and lab opening of RBL LLC, a biotech venture creation studio in May. Read more here.

University of Houston archaeologists make history with Mayan tomb discovery

History in the Making

Two University of Houston archaeologists have made scientific history with the discovery of a Mayan king's tomb in Belize.

The UH team led by husband and wife scientists Arlen F. Chase and Diane Z. Chase made the discovery at Caracol, the largest Mayan archeological site in Belize, which is situated about 25 miles south of Xunantunich and the town of San Ignacio. Together with Belize's Institute of Archeology, as well as support from the Geraldine and Emory Ford Foundation and the KHR Family Fund, they uncovered the tomb of Caracol's founder, King Te K’ab Chaak. Their work used airborne light detection and ranging technology to uncover previously hidden roadways and structures that have been reclaimed by the jungle.

The tomb was found at the base of a royal family shrine. The king, who ascended the throne in 331 AD, lived to an advanced enough age that he no longer had teeth. His tomb held a collection of 11 pottery vessels, carved bone tubes, jadeite jewelry, a mosaic jadeite mask, Pacific spondylus shells, and various other perishable items. Pottery vessels found in the chamber depict a Maya ruler wielding a spear as he receives offerings from supplicants represented as deities; the figure of Ek Chuah, the Maya god of traders, surrounded by offerings; and bound captives, a motif also seen in two related burials. Additionally, two vessels had lids adorned with modeled handles shaped like coatimundi (pisote) heads. The coatimundi, known as tz’uutz’ in Maya, was later adopted by subsequent rulers of Caracol as part of their names.

 Diane Chase archaeologist in Mayan tomb Diane Z. Chase in the Mayan tomb. Photo courtesy of University of Houston

During the Classical Period, Caracol was one of the main hubs of the Mayan Lowlands and covered an area bigger than that of present-day Belize City. Populations survived in the area for at least 1,000 years before the city was abandoned sometime around 900 AD. The royal dynasty established by Te K’ab Chaak continued at Caracol for over 460 years.

The find is also significant because this was roughly when the Mexican city of Teotihuacan made contact with Caracol, leading to a long relationship of trade and cultural exchange. Cremation sites found in Caracol contain items that would have come from Teotihuacan, showing the relationship between the two distant cities.

"Both central Mexico and the Maya area were clearly aware of each other’s ritual practices, as reflected in the Caracol cremation," said Arlen F. Chase, professor and chair of Comparative Cultural Studies at the University of Houston.

“The connections between the two regions were undertaken by the highest levels of society, suggesting that initial kings at various Maya cities — such as Te K’ab Chaak at Caracol — were engaged in formal diplomatic relationships with Teotihuacan.”

The Chases will present their findings at a conference on Maya–Teotihuacan interaction hosted by the Maya Working Group at the Santa Fe Institute in New Mexico in August 2025.

 UH professors Chase make Mayan Discovery UH archaeologists Arlen F. Chase and Diane Z. Chase Photo courtesy of University of Houston

 

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This story originally appeared on CultureMap.com.

Houston palliative care company integrates with Epic platforms

epic scale

Patients and medical teams using MyChart and other Epic Systems' software will now be able to access Houston-based Koda Health's AI-enhanced end-of-life planning platform.

The Houston-based palliative care company, which was born out of the TMC's Biodesign Fellowship, has integrated its advance care planning platform with Epic, one of the most widely used electronic health record (EHR) systems in the U.S., according to a news release.

Epic estimates that more than 325 million patients have a current electronic record in its systems.

“This is a significant milestone for our mission to make advance care planning scalable, meaningful, and seamless,” Tatiana Fofanova, CEO and co-founder of Koda Health, said in the release. “By integrating into systems already used by care teams, we help eliminate friction and ensure that care delivery honors what patients truly want—especially during serious illness and at the end of life.”

The partnership will streamline processes for both patients and clinicians. Users will be able to drop advance care plans directly into the Epic charts, which will be accessible through MyChart for patients and proxies and through Epic Hyperspace/Hyperdrive for care teams. Doctors can also initiate and manage advance care plans through a simple Epic order for patients.

According to Koda Health, its platform saves an average of $10,000 to $15,000 per patient. Roughly 85 percent of users complete advance care plan documents when using the platform, which is four times the national average.

“We developed Koda to give providers the time, training, and tools to guide these critical conversations," Dr. Desh Mohan, co-founder and chief medical officer at Koda Health, added in the statement. "Our integration now makes it possible to operationalize ACP at scale—aligned with value-based care goals and clinical reality.”

The company announced a partnership with Dallas-based Guidehealth, which integrates into primary care workflows and allows providers to identify high-risk patients, coordinate care and reduce administrative burden. Guidehealth works with more than 500,000 patients

Koda Health was founded in 2020 and closed an oversubscribed seed round for an undisclosed amount last year, with investments from AARP, Memorial Hermann Health System and the Texas Medical Center Venture Fund. The company also added Kidney Action Planning to its suite of services in 2024.

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