This week's Houston innovators to know includes Lenny Saizan of Urban Capital Network, Katie Eick of Rollin' Vets, and Tony Loyd of AECOM. Courtesy photos

Editor's note: This year has made for some pivotal moments for various Houston companies across industries. For some, the pandemic has meant reevaluating their business plans or increased a need for their product or service. For others, social unrest has called for systemic change. Technology emerges for these needs. This week's Houston innovators are addressing these needs with their innovative efforts.

Lenny Saizan, co-founder and managing partner

Lenny Saizan — along with three other Houston innovation leaders — founded Urban Capital Network to increase diversity and inclusion within the venture capital space. Photo via urbancapitalnetwork.com

While venture capital firms usually operate in a similar structure, Lenny Saizan and his co-founders wanted to set up Urban Capital Network differently in order to "democratize access to premium VC-backed investments," Saizan says. UCN invests into VCs that meet their diversity and inclusion requirements as a limited partner, but then also invests directly into startups as a sort of hybrid investor.

"We take a portion of our proceeds and invest in entrepreneurs of color, and we also donate to nonprofits that provide support resources for those entrepreneurs," Saizan says on this week's episode of the Houston Innovators Podcast. "We're completing the cycle. We find that it's easier to go to a VC and offer to give them money and also help them diversify their investor portfolio."

Saizan shares more about the group in the podcast episode and discusses what they've already accomplished in just a few months. Read more.

Katie Eick, founder of Rollin' Vets

Katie Eick always wanted to be able to offer mobile services. Photo courtesy of Rollin' Vets

Katie Eick founded her mobile vet company in 2016 after years of wanting to be able to provide the type and level of service she has now at Rollin' Vets. While convenience technologies like delivery apps buoyed her company's steady growth, the pandemic really established market need for her business model.

"We were continuously growing slowly — then COVID hit. It really cemented that … all the convenience services are in the forefront of people's minds." Eick tells InnovationMap. "COVID made it clear that this was a necessary service."

Now, she plans to adopt a franchising model and is planning an expansion into San Antonio and Dallas before going national. Read more.

Tony Loyd, vice president at AECOM

Just like Hurricane Harvey, COVID-19 is causing Houstonians to rethink how they operate — and that tech and innovation inversion is opening the door to new opportunities. Courtesy Photo

COVID-19 is affecting the evolution of technology — it's as simple as that, according to Tony Loyd. And it's not the first time — nor the last — that consumer needs affect tech innovation.

"Could COVID-19 be triggering an inversion paradigm? An inversion paradigm puts needs first rather than product first," writes Loyd in a guest column for InnovationMap. "We have experienced many historic technology inversions. Remember when our televisions were air-wave dependent and telephones were tethered to the wall? Because the need evolved for a phone that was mobile, today our TV's are wired, and our telephones are untethered." Read more.

Just like Hurricane Harvey, COVID-19 is causing Houstonians to rethink how they operate — and that tech and innovation inversion is opening the door to new opportunities. Photo via Getty Images

Houston primed for opportunity within the tech inversion caused by the pandemic

Guest column

For has long as I can remember, I had to live near water. That's why I moved to Houston. Recently, new neighbors moved next door from the downtown Galleria area. They loved it there until coronavirus turned shopping habits into stay-at-home habits. The experience led them to recognize they could do just fine without the Galleria-area routine, pivoting instead to a maritime lifestyle.

Could COVID-19 be triggering an inversion paradigm? An inversion paradigm puts needs first rather than product first. We have experienced many historic technology inversions. Remember when our televisions were air-wave dependent and telephones were tethered to the wall? Because the need evolved for a phone that was mobile, today our TV's are wired, and our telephones are untethered.

This technology inversion fundamentally found its way to the individual consumer and transformed entire industries. Houston businesses are responding to a rare COVID-19-induced disruption. Inversions are rare, but when they occur, opportunity follows.

Large infrastructure challenges are normally led by bureaucratic funding processes that result in productized solutions. Hurricane Harvey was a wake-up call to take decisive action to protect decades of private and public investment against future flood events. It was an analogue to removing the board with the nail in it from the driveway to avoid endless tire repairs.

Now, Houston's resilience infrastructure is going through a Hurricane Harvey-induced inversion. The fundamental approach to water management is experiencing a historic reversal which focuses on need rather than a response cycle. Largely dependent on surface run-off systems, Houston experienced a river running through it during Hurricane Harvey. In response, studies and projects are underway to consider a major underground storm drainage system. Water management is fundamentally changing to move stormwater from above ground to below grade, while domestic water is moving away from underground sources to surface supplies, such as lakes. These programs reduce threats to downtown, allowing urbanism and businesses to flourish, simply by addressing a human need in lieu of building another drainage product.

Fortunately for the Houston economy, pre-COVID, quasi-inversion programs already in place to address mobility needs, such as the $7.5 billion METRONext program and $4.8 billion for flood control essentials, are injecting billions of dollars into the local economy. At the federal level, future stimulus funding designed to address infrastructure needs and the economic impact of Coronavirus are likely to follow next year. Consequently, the current Hurricane Harvey, COVID-19 inversion could position Houston to rebound from a time of trial reimagining what a next generation city in the modern age should look like.

Graphic courtesy of AECOM

In fact, infrastructure programs have a long history of creating sustainable jobs and transforming cities. Did you know the River Walk in San Antonio, a downtown centerpiece that thrives today and contributes to thousands of job opportunities, was a construction project born during the Great Depression to address a disastrous flood occurring in the early 1920s? San Antonio architect Robert H. H. Hugman was elected to address a need to save lives and reimagine San Antonio's downtown. The city was altered forever by creating a flood resilience infrastructure that also transformed its city center into a civic gathering place that made San Antonio one of the largest destination cities in Texas.

While technology inversions are occurring more often than before, they are still rare, and each one is very important. Infrastructure inversions that transform cites are even more exceptional. In a COVID-19-induced inversion period, the possibilities are limitless, and the time is now. With programs underway and potential stimulus funding to support additional investment to address city needs, Houston is positioned for something amazing.

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Tony Loyd is based in Houston and vice president at AECOM.

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Houston space company lands latest NASA deal to advance lunar logistics

To The Moon

Houston-based space exploration, infrastructure, and services company Intuitive Machines has secured about $2.5 million from NASA to study challenges related to carrying cargo on the company’s lunar lander and hauling cargo on the moon. The lander will be used for NASA’s Artemis missions to the moon and eventually to Mars.

“Intuitive Machines has been methodically working on executing lunar delivery, data transmission, and infrastructure service missions, making us uniquely positioned to provide strategies and concepts that may shape lunar logistics and mobility solutions for the Artemis generation,” Intuitive Machines CEO Steve Altemus says in a news release.

“We look forward to bringing our proven expertise together to deliver innovative solutions that establish capabilities on the [moon] and place deeper exploration within reach.”

Intuitive Machines will soon launch its lunar lander on a SpaceX Falcon 9 rocket to deliver NASA technology and science projects, along with commercial payloads, to the moon’s Mons Mouton plateau. Lift-off will happen at NASA’s Kennedy Space Center in Florida within a launch window that starts in late February. It’ll be the lander’s second trip to the moon.

In September, Intuitive Machines landed a deal with NASA that could be worth more than $4.8 billion.

Under the contract, Intuitive Machines will supply communication and navigation services for missions in the “near space” region, which extends from the earth’s surface to beyond the moon.

The five-year deal includes an option to add five years to the contract. The initial round of NASA funding runs through September 2029.

Play it back: Houston home tech startup begins 2025 with fresh funding

HOUSTON INNOVATORS PODCAST EPISODE 272

One of the dozen or so Houston startups kicking of the new year with fresh funding is SmartAC.com, a company that's designed a platform that enables contractors in the HVAC and plumbing industries to monitor, manage, and optimize their maintenance memberships through advanced sensors, AI-driven diagnostics, and proactive alerts.

Last month, the SmartAC.com raised a follow-on round with support from local investor Mercury to continue growth and expansion of the product, which has evolved on many ways since the company launched in 2020, emerging from stealth with $10 million raised in a series A. In a May 2023 interview for the Houston Innovators Podcast, Founder and CEO Josh Teekell explained how he embraced the power of a pivot.

The company's sensors can monitor all aspects of air conditioning units and report back any issues, meaning homeowners have quicker and less costly repairs. While SmartAC.com started with providing the service and tech to homeowners directly, Teekell says he's had a greater interest in working with plumbers and HVAC companies who then deploy the technology to their customers.

"It became quite evident that homeowners don't care about air conditioning really at all until their system breaks," Teekell says on the show. "The technology is really built around giving those contractors as another way to gain a customer relationship and keep it."

Revisit the podcast episode below where Teekell talks about SmartAC.com's last raise.

SmartAC.com's previous round in 2023 — a $22 million series B — was used grow its team that goes out to deploy the technology and train the contractors on the platform.

"We've been very fortunate to get some of the biggest names in Houston on our cap table," Teekell says in the May 2023 conversation. "Since we're raising a bunch of money locally, everyone understands what a pain air conditioning can be."

Houston biotech company tests hard-to-fight cancer therapeutics

fighting cancer

A Houston-based, female-founded biotech company has developed a treatment that could prove to be an effective therapy for a rare blood cancer.

Cellenkos Therapeutics has completed promising Phase 1b testing of its Treg cell therapy, CK0804, in the fight against myelofibrosis. According to a news release from the Cellenkos team, the use of its cord-blood-derived therapeutics could signal a paradigm shift for the treatment of this hard-to-fight cancer.

Cellenkos was founded by MD Anderson Cancer Center physician and professor Simrit Parmar. Her research at the hospital displayed the ability of a unique subset of T cells’ capability to home in on a patient’s bone marrow, restoring immune balance, and potentially halting disease progression.

Myelofibrosis has long been treated primarily with JAK (Janus Kinase) inhibitors, medications that help to block inflammatory enzymes. They work by suppressing the immune response to the blood cancer, but don’t slow the progression of the malady. And they’re not effective for every patient.

“There is a significant need for new therapeutic options for patients living with myelofibrosis who have suboptimal responses to approved JAK inhibitors,” Parmar says. “We are greatly encouraged by the safety profile and early signs of efficacy observed in this patient cohort and look forward to continuing our evaluation of the clinical potential of CK0804 in our planned expansion cohort.”

The expansion cohort is currently enrolling patients with myelofibrosis. What exactly are sufferers dealing with? Myelofibrosis is a chronic disease that causes bone marrow to form scar tissue. This makes it difficult for the body to produce normal blood cells, leaving patients with fatigue, spleen enlargement and night sweats.

Myelofibrosis is rare, with just 16,000 to 18,500 people affected in the United States. But for patients who don’t respond well to JAKs, the prognosis could mean a shorter span than the six-year median survival rate outlined for the disease by Cleveland Clinic.

Helping myelofibrosis patients to thrive isn’t the only goal for Cellenkos right now.

The company seeks to aid people with rare conditions, particularly inflammatory and autoimmune disorders, with the use of CK0804, but also other candidates including one known as CK0801. The latter drug has shown promising efficacy in aplastic anemia, including transfusion independence in treated patients.

The company closed its $15 million series A round led by BVCF Management, based in Shanghai, in 2021. Read more here.