3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Sameer Soleja of Molecule, Gabriela Gerhart of The Motherhood center, and 50 Cent. Courtesy photos

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — software, education, and more — recently making headlines in Houston innovation.

Sameer Soleja, CEO of Molecule

Sameer Soleja, CEO of Molecule, joins the Houston Innovators Podcast to discuss his startup's recent fundraise — and how he's planning on being at the forefront of the evolving electricity commodities industry. Photo courtesy of Molecule

A 9-year-old software startup has been reinvigorated by fresh funds and a new opportunity to emerge as a leader in enterprise software for commodities — especially for electricity traders. Sameer Soleja, CEO of Molecule, joins the Houston Innovators Podcast to discuss the company's latest funding round — a $12 million series A.

"The commodities industry is looking really hard at electricity as the growth commodity of the 2020s — renewables and conventionally generated electricity," Soleja says. "Everybody in our client base and in the market is looking at electricity. Well, we happen to have more than have of our customer base be in electricity."

Click here to listen to the podcast and read more.

Gabriela Gerhart, founder of The Motherhood Center

Houston entrepreneur recounts journey from communism to U.S. success in new book

Gabriela Gerhart recounts her journey from communism to American success in her new book. Photo courtesy of Gabriela Gerhart

Gabriela Gerhart remembers that day, back in 1989, when her teacher walked into her classroom in Czechoslovakia and announced that communism was over. Further, she told the group that everything she'd been teaching them was a lie.

Gerhart was stunned.

"It was confusing," she tells CultureMap. "You think to yourself, 'was I fooled? Was I indoctrinated? 'You have to understand, I had no idea there was another world out there."

Gerhart, founder of The Motherhood Center on West Alabama Street unpacks those feelings and others in her new autobiography, After The Fall, a story of growing up in Central Europe under communism and following her own wanderlust to the States, where she fell in love, got married, and built a successful business.

Click here to read more.

Rapper 50 Cent really means business. 50 Cent/Twitter

Rap star and Newstonian 50 Cent is giving back to area schools in need of help. The recently relocated rapper/producer/entrepreneur/rodeo wine bidder is teaming up with the Houston Independent School District and Horizon United Group to bolster entrepreneurship programs at Kashmere, Worthing, and Wheatley high schools.

He has funded the project with a $600,000 donation, Mayor Sylvester Turner announced on May 17.

Dubbed the G-Unity Business Lab, the new program will encourage students to engage in MBA-level lessons that represent the full lifecycle of a product or concept, from idea creation, to market branding, to even running a company, a press release notes.

Click here to read more.

Gabriela Gerhart recounts her journey from communism to American success in her new book. Photo courtesy of Gabriela Gerhart

Houston entrepreneur recounts journey from communism to U.S. success in new book

RISING FROM THE FALL

Gabriela Gerhart remembers that day, back in 1989, when her teacher walked into her classroom in Czechoslovakia and announced that communism was over. Further, she told the group that everything she'd been teaching them was a lie.

Gerhart was stunned.

"It was confusing," she tells CultureMap. "You think to yourself, 'was I fooled? Was I indoctrinated? 'You have to understand, I had no idea there was another world out there."

Gerhart, founder of The Motherhood Center on West Alabama Street unpacks those feelings and others in her new autobiography, After The Fall, a story of growing up in Central Europe under communism and following her own wanderlust to the States, where she fell in love, got married, and built a successful business.

The Houston launch for the book is Wednesday, May 19 at The Motherhood Center from 4 pm to 6 pm. The official Austin launch happens on Thursday, May 20 at Central Machine Works from 4 pm to 6 pm. Both events are free, but audiences are asked to register. After the Fall is available on Amazon, Barnes & Noble, at Brazos Bookstore, and online.

In many ways, Gerhart's journey is like many other immigrant stories of coming to a new land and rebuilding a life. For Gerhart, though, it wasn't just about building a new life, it was learning that she had choices.

Before the fall
In her homeland, she'd been involved with a communist youth group, and had plans to rise through the communist party. When communism fell, her sense of how she saw herself was battered. All of a sudden, though, there were opportunities.

"Growing up, my friends and I all wore the same clothes," she says. "But it was because you would go into a store and there might be only three kinds of winter jacket."

With the fall of communism, Gerhart could travel far beyond her Czech roots, and discover all sorts of new things: new foods, new styles, new ideas.

"I was hungry for adventures and experiences," she remembers.

After the fall
She came to the U.S. in 1998, where she became an au pair. While she didn't have a choice of where she was sent, she says that she loved that she landed in Houston. The Bayou City would open her eyes to all the possibilities of what she could do and what she could be.

Gerhart describes herself as someone who is always challenging herself, so being an entrepreneur was a natural fit. She's also always been nurturing, which is what led her to study nursing and become a pediatric nurse. Combining her love of mothers and babies with her grit and determination, she built The Motherhood Center in 2000 to provide expectant and early post-natal moms with a supportive network and educational resources to raise healthy children, while not neglecting themselves.

All of it is outlined in After the Fall, in triumph and tragedy. Gerhart outlines her inability to have children, even as she was building her business into the premier destination for moms and babies. A stepmother and grandmother now, she says she has found great happiness in her life, chasing her dreams and adventures across continents and political changes.

An American dream
"My favorite thing about America is that there are so many opportunities," she says. "I am so grateful. It's really amazing how young America is. People don't realize, the basement in my house in the Czech Republic is 300 years older than this country," she jokes.

Writing her autobiography gave her the chance to reflect on that, as well as unpack her own feelings about communism and its fall. Growing up, she says, her parents never discussed their feelings about the subject; it was far too dangerous.

"A parent might say something to their child and the child could go to school and repeat it and all of a sudden, there would be a knock on the door from the police," she says. "Writing this book meant my parents and I could speak more openly about it, and I was able to see things from their perspective."

She hopes the book will inspire others to embrace their potential and pursue their own dreams. Maybe they'll be encouraged to start their own business. Maybe they'll re-discover gratitude for being Americans. Maybe they'll set off on their own adventures.

As for Gerhart, now that the book is finished, she's looking ahead to what's next. She'll keep expanding The Motherhood Center and its programming, and she's taking on speaking engagements in the coming months.

"I have a need to share," she explains. "And I'll keep doing that.

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This article originally ran on CultureMap.

This Mother's Day, The Motherhood Center's founder is looking back on 20 years of care for Houston's new and expecting mothers. Getty Images

Houston specialist reflects on innovation and technology's effect on pregnancy care

Guest column

Mother's Day this Sunday will be a very different kind of day for mothers across the world, and I found myself reflecting on the innovation and evolution of pregnancy care and the different options women have nowadays.

When I founded The Motherhood Center in 2000, I had one simple goal, which was to provide Houston's new and expecting moms with unparalleled support and guidance. Now, 20 years later, we provide a full range of services for parents across every stage of parenthood. My team and I have held true to this mission, and, as new technologies and schools of thought emerged, so too have we evolved.

The evolution of family planning

One of the biggest changes we have witnessed over the past two decades is people's approach to family planning. We are seeing a lot more women choosing to have children later in life. With all the wonderful technological advancements — such as IVF, fertility treatments and egg freezing — we have seen women focus on their careers and start a family at an older age. One unexpected result of this is kind of funny – we are seeing a lot more twins and triplets.

We've also seen an increase in involvement from fathers. More and more dads are taking paternity leave these days – we hope to see that trend continue to grow. They are also coming to classes and getting involved in the pregnancies. Often, they are the ones who call us to learn more about our services.

New technologies and products

Technology has prompted some of the biggest changes in pregnancy. There are a lot of devices that new parents can use these days — from baby monitors, breathing and movement monitors, and much more. All this technology routes directly to parent's smartphones so they can know in real time what is always happening with their baby. While we love that parents can be more informed, we also don't want them to become so dependent on technology that they stop trusting their instincts. It is our job to encourage them to trust themselves (along with technology) so they can be the best parents they can be.

Another way technology has affected our business is that we are now able to reach our clients 24 hours a day, seven days a week through our website. We get a lot of form submissions late at night – particularly for support with breastfeeding and sleep training. We might not be able to answer the phone at 2 a.m., but our website has the resources to support new parents no matter the time of day.

For better or for worse, we have seen a huge increase in the number of products that are available for baby and mom. While there are some products that we absolutely love, many of the new products that have flooded the market are not needed. Because of this, we created a boutique at our center to help parents purchase only the items they will use. We also provide in-person support for purchasing some of the more personal products like nursing bras.

An increased access to information

Just as there are more and more products out there for new or expecting parents, there is also a wealth of information available – sometimes too much. We have seen a lot of parents using apps and reading blogs that might have inaccurate information, since many of these platforms are not regulated. For instance, these blogs don't account for the parents' medical and personal history. Because of this, we often see parents with a lot of anxiety and information overload. We find our in-person and virtual classes taught by professionals using unbiased, medically approved information brings our clients a lot of peace.

This has been a difficult year for everyone — especially expecting moms and new parents. People can't go out and attend classes and many hospitals have had to cancel their pregnancy courses. We have taken this as an opportunity to launch Motherhood Center into the next 20 years.

We now offer virtual educational courses and fitness classes. These classes are available to support parents anywhere — more information is available online. We are excited about the potential to expand our reach outside of Houston.

With The Motherhood Center celebrating its anniversary in May, we are so thankful we have been able to support Houston's mothers for 20 years, and we can't wait to see what the next 20 years hold.

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Gabriela Gerhart is the founder of The Motherhood Center.

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Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

Houston booms as No. 2 U.S. metro for new home construction

Construction Boom

Driven by population growth, more residential rooftops are popping up across Houston and the rest of Texas than anywhere else in America.

Using data from the U.S. Census Bureau and Zillow, Construction Coverage found 65,747 new residential units were authorized in greater Houston in 2024. That figure landed Houston in second place among major metro areas for the total number of housing permits, including those for single-family homes, apartments, and condos.

Just ahead of Houston was the Dallas-Fort Worth Metroplex, which took first place with 71,788 residential permits approved in 2024. In third place was the country’s largest metro, New York City (57,929 permits).Elsewhere in Texas, the Austin metro ranked sixth (32,294 permits), and the San Antonio metro ranked 20th (14,857 permits).

Construction Coverage also sorted major metro areas based on the number of new housing units authorized per 1,000 existing homes in 2024. Raleigh, North Carolina, held the No. 1 spot (28.8 permits per 1,000 existing homes), followed by Austin at No. 2 (28.6), DFW at No. 3 (22.2), Houston at No. 4 (21.6), and San Antonio at No. 13 (13.6).

A Newsweek analysis of Census Bureau data shows building permits for 225,756 new residential units were approved in 2024 in Texas — a trend fueled largely by activity in DFW, Houston, Austin, and San Antonio. That put Texas atop the list of states building the most residential units for the year.

Through the first eight months of last year, 145,901 permits for new residential units were approved in Texas, according to Census Bureau data. That’s nearly 80,000 permits shy of the 2024 total.

Among the states, Construction Coverage ranks Texas sixth for the number of residential building permits approved in 2024 per 1,000 existing homes (17.9).

Extra housing is being built in Texas to meet demand spurred by population growth. From April 2020 to July 2024, the state’s population increased 7.3 percent, the Census Bureau says.

While builders are busy constructing new housing in Texas, they’re not necessarily profiting a lot from homebuilding activity.

“Market conditions remain challenging, with two-thirds of builders reporting they are offering incentives to move buyers off the fence,” North Carolina homebuilder Buddy Hughes, chairman of the National Association of Home Builders, said in a December news release. “Meanwhile, builders are contending with rising material and labor prices, as tariffs are having serious repercussions on construction costs.”

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