3 Houston innovators to know this week

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Marc Nathan, Meredith Wheeler, and Maggie Segrich are this week's Houston innovators to know. Courtesy photos

Passion is usually the motivator for starting a business, and this week's innovators to know have an undeniable passion for what they are doing.

Marc Nathan is passionate about Texas startups — it's why he started and still maintains a comprehensive newsletter of Texas innovation news. Meanwhile, Maggie Segrich and Meredith Wheeler are passionate about bringing together a community of women with Sesh Coworking.

Here's more of what you need to learn about this week's innovators to know.

Marc Nathan, vice president of client strategy at Egan Nelson and publisher of Texas Squared

Marc Nathan shares how he's seen the city of Houston's innovation world change dramatically over the past few decades. Photo courtesy of Marc Nathan

While he technically lives in Austin now, Marc Nathan is extremely proud of his Houston heritage. A third generation Houstonian, Nathan worked as an entrepreneur before getting involved with the Houston Technology Center. The University of Texas alum's current role at Egan Nelson — an Austin-based, startup-focused law firm, that brought him back to Austin a few years ago.

As much of a Houstonian at heart he is, Nathan is a major player in the entire Lone Star State's innovation world. He publishes a weekly newsletter, called Texas Squared, that he hopes can connect the dots between Texas's four innovation ecosystems — Dallas, Austin, San Antonio, and Houston, or DASH, as he likes to call them.

"I can tell you 10 years ago being an innovation person in Houston, I couldn't have told you anything about what was going on in Dallas or Austin," Nathan says on the most recent episode of the Houston Innovators Podcast. "Now, we're seeing a lot more collaboration among cities, and I think it's very important and useful."

Meredith Wheeler and Maggie Segrich, co-founders of Sesh Coworking

Meredith Wheeler and Maggie Segrich founded Sesh Coworking after years of working from home and feeling the need for a community. Photo courtesy of Sesh

Working from home can be extremely isolating, but Meredith Wheeler found the "bro culture" of coworking off putting. For years she craved a female-focused community, and now with her business partner, Maggie Segrich, she's created exactly that with Sesh Coworking.

"We come at the creation of this space and the running of this community from the female experience," Wheeler tells InnovationMap. "Most coworking spaces, when they are run only by men, it's natural that they are coming from their perspective and experience."

The coworking space in Montrose officially opened for business on Feb. 3. Sesh has memberships and day passes available for anyone who wants to cowork, but the space is designed from the female perspective.

"For me, starting Sesh is kind of like giving women that space and opportunity to let their guard down, and feel like they can be their actual selves," Segrich says.

Marc Nathan shares how he's seen the city of Houston's innovation world change dramatically over the past few decades. Photo courtesy of Marc Nathan

Lifelong Houstonian weighs in on growth within the city's innovation ecosystem over the past 20 years

HOUSTON INNOVATORS PODCAST EPISODE 17

Houston's innovation ecosystem might not have a bigger advocate based in Austin than Marc Nathan. The third generation Houstonian is one of the few people to see the city go through its highs and lows as a developing innovation ecosystem over the past few decades.

While his full-time job is working in marketing for Egan Nelson, an Austin-based, startup-focused law firm, Nathan's greatest contribution to the Texas startup scene is his weekly newsletter, Texas Squared, that gathers up the Lone Star State's innovation and startup news.

Nathan also used to work at the Houston Technology Center years before it converted into Houston Exponential and focused specifically on helping startups raise money.

"Finding money was relatively difficult, and it's not any easier now," Nathan says on this week's episode of the Houston Innovators Podcast. He notes that organizations like the Houston Angel Network and local venture capital firms like Mercury Fund have made a huge difference.

A lot has changed within Houston, Nathan says. There's more startups, money, and press around Houston innovation. He's also seeing more collaboration between the Texas cities he calls DASH —Dallas, Austin, San Antonio, and Houston.

"I can tell you 10 years ago being an innovation person in Houston, I couldn't have told you anything about what was going on in Dallas or Austin," Nathan says on the podcast. "Now, we're seeing a lot more collaboration among cities, and I think it's very important and useful."

Nathan discusses his experience in both Houston and Austin's startup scene, and where he sees this collaboration going. Plus, he weighs in on The Ion, the merge between Capital Factory and Station Houston, funding and accelerator trends, how to make the most out of SXSW and more.

Listen to the full episode below — or wherever you get your podcasts — and subscribe for weekly episodes.

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Houston researchers develop material to boost AI speed and cut energy use

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A team of researchers at the University of Houston has developed an innovative thin-film material that they believe will make AI devices faster and more energy efficient.

AI data centers consume massive amounts of electricity and use large cooling systems to operate, adding a strain on overall energy consumption.

“AI has made our energy needs explode,” Alamgir Karim, Dow Chair and Welch Foundation Professor at the William A. Brookshire Department of Chemical and Biomolecular Engineering at UH, explained in a news release. “Many AI data centers employ vast cooling systems that consume large amounts of electricity to keep the thousands of servers with integrated circuit chips running optimally at low temperatures to maintain high data processing speed, have shorter response time and extend chip lifetime.”

In a report recently published in ACS Nano, Karim and a team of researchers introduced a specialized two-dimensional thin film dielectric, or electric insulator. The film, which does not store electricity, could be used to replace traditional, heat-generating components in integrated circuit chips, which are essential hardware powering AI.

The thinner film material aims to reduce the significant energy cost and heat produced by the high-performance computing necessary for AI.

Karim and his former doctoral student, Maninderjeet Singh, used Nobel prize-winning organic framework materials to develop the film. Singh, now a postdoctoral researcher at Columbia University, developed the materials during his doctoral training at UH, along with Devin Shaffer, a UH professor of civil engineering, and doctoral student Erin Schroeder.

Their study shows that dielectrics with high permittivity (high-k) store more electrical energy and dissipate more energy as heat than those with low-k materials. Karim focused on low-k materials made from light elements, like carbon, that would allow chips to run cooler and faster.

The team then created new materials with carbon and other light elements, forming covalently bonded sheetlike films with highly porous crystalline structures using a process known as synthetic interfacial polymerization. Then they studied their electronic properties and applications in devices.

According to the report, the film was suitable for high-voltage, high-power devices while maintaining thermal stability at elevated operating temperatures.

“These next-generation materials are expected to boost the performance of AI and conventional electronics devices significantly,” Singh added in the release.

Houston to become 'global leader in brain health' and more innovation news

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Editor's note: The most-read Houston innovation news this month is centered around brain health, from the launch of Project Metis to Rice''s new Amyloid Mechanism and Disease Center. Here are the five most popular InnovationMap stories from December 1-15, 2025:

1. Houston institutions launch Project Metis to position region as global leader in brain health

The Rice Brain Institute, UTMB's Moody Brain Health Institute and Memorial Hermann’s comprehensive neurology care department will lead Project Metis. Photo via Unsplash.

Leaders in Houston's health care and innovation sectors have joined the Center for Houston’s Future to launch an initiative that aims to make the Greater Houston Area "the global leader of brain health." The multi-year Project Metis, named after the Greek goddess of wisdom and deep thought, will be led by the newly formed Rice Brain Institute, The University of Texas Medical Branch's Moody Brain Health Institute and Memorial Hermann’s comprehensive neurology care department. The initiative comes on the heels of Texas voters overwhelmingly approving a ballot measure to launch the $3 billion, state-funded Dementia Prevention and Research Institute of Texas (DPRIT). Continue reading.

2.Rice University researchers unveil new model that could sharpen MRI scans

New findings from a team of Rice University researchers could enhance MRI clarity. Photo via Unsplash.

Researchers at Rice University, in collaboration with Oak Ridge National Laboratory, have developed a new model that could lead to sharper imaging and safer diagnostics using magnetic resonance imaging, or MRI. In a study published in The Journal of Chemical Physics, the team of researchers showed how they used the Fokker-Planck equation to better understand how water molecules respond to contrast agents in a process known as “relaxation.” Continue reading.

3. Rice University launches new center to study roots of Alzheimer’s and Parkinson’s

The new Amyloid Mechanism and Disease Center will serve as the neuroscience branch of Rice’s Brain Institute. Photo via Unsplash.

Rice University has launched its new Amyloid Mechanism and Disease Center, which aims to uncover the molecular origins of Alzheimer’s, Parkinson’s and other amyloid-related diseases. The center will bring together Rice faculty in chemistry, biophysics, cell biology and biochemistry to study how protein aggregates called amyloids form, spread and harm brain cells. It will serve as the neuroscience branch of the Rice Brain Institute, which was also recently established. Continue reading.

4. Baylor center receives $10M NIH grant to continue rare disease research

BCM's Center for Precision Medicine Models has received funding that will allow it to study more complex diseases. Photo via Getty Images

Baylor College of Medicine’s Center for Precision Medicine Models has received a $10 million, five-year grant from the National Institutes of Health that will allow it to continue its work studying rare genetic diseases. The Center for Precision Medicine Models creates customized cell, fly and mouse models that mimic specific genetic variations found in patients, helping scientists to better understand how genetic changes cause disease and explore potential treatments. Continue reading.

5. Luxury transportation startup connects Houston with Austin and San Antonio

Shutto is a new option for Houston commuters. Photo courtesy of Shutto

Houston business and leisure travelers have a luxe new way to hop between Texas cities. Transportation startup Shutto has launched luxury van service connecting San Antonio, Austin, and Houston, offering travelers a comfortable alternative to flying or long-haul rideshare. Continue reading.

Texas falls to bottom of national list for AI-related job openings

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For all the hoopla over AI in the American workforce, Texas’ share of AI-related job openings falls short of every state except Pennsylvania and Florida.

A study by Unit4, a provider of cloud-based enterprise resource planning (ERP) software for businesses, puts Texas at No. 49 among the states with the highest share of AI-focused jobs. Just 9.39 percent of Texas job postings examined by Unit4 mentioned AI.

Behind Texas are No. 49 Pennsylvania (9.24 percent of jobs related to AI) and No. 50 Florida (9.04 percent). One spot ahead of Texas, at No. 47, is California (9.56 percent).

Unit4 notes that Texas’ and Florida’s low rankings show “AI hiring concentration isn’t necessarily tied to population size or GDP.”

“For years, California, Texas, and New York dominated tech hiring, but that’s changing fast. High living costs, remote work culture, and the democratization of AI tools mean smaller states can now compete,” Unit4 spokesperson Mark Baars said in a release.

The No. 1 state is Wyoming, where 20.38 percent of job openings were related to AI. The Cowboy State was followed by Vermont at No. 2 (20.34 percent) and Rhode Island at No. 3 (19.74 percent).

“A company in Wyoming can hire an AI engineer from anywhere, and startups in Vermont can build powerful AI systems without being based in Silicon Valley,” Baars added.

The study analyzed LinkedIn job postings across all 50 states to determine which ones were leading in AI employment. Unit4 came up with percentages by dividing the total number of job postings in a state by the total number of AI-related job postings.

Experts suggest that while states like Texas, California and Florida “have a vast number of total job postings, the sheer volume of non-AI jobs dilutes their AI concentration ratio,” according to Unit4. “Moreover, many major tech firms headquartered in California are outsourcing AI roles to smaller, more affordable markets, creating a redistribution of AI employment opportunities.”

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