3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Joanna Nathan of Prana Thoracic, Alfredo Arvide of Cloche, and Susan Davenport of the Greater Houston Partnership. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from health tech to mobile ordering — recently making headlines in Houston innovation.

Joanna Nathan, CEO, and co-founder of Prana Thoracic

Prana Thoracic, an innovative startup in the lung cancer diagnostics space, has raised its series A round of investment. Photo via LinkedIn

Joanna Nathan has been busy. It's been just under six months since the launch of her company, Prana Thoracic, a Houston health tech startup tackling lung cancer diagnostics, and the company has already secured its next round of investment funding. A medical device company developing a tool for early interception of lung cancer, the company announced last week that it closed a $3 million series A financing round.

In August, the company received a $3 million award from the Cancer Prevention & Research Institute of Texas. All of Prana Thoracic's funding is being used to develop the unique diagnostic product and the company's path to first-in-human clinical studies.

“Our technology provides a definitive answer to patients with lung nodules and allows physicians to intervene earlier in the lung cancer patient’s journey,” says Joanna Nathan, CEO, and co-founder of Prana, in a news release. “Our team is grateful to have the support of our investors and excited to leverage this financing to accelerate our technology to the bedside.” Read more.

Alfredo Arvide, co-founder and managing director of Cloche

This new restaurant technology allows for eateries to upgrade to mobile ordering for no cost. Photo courtesy of Cloche

A new mobile software platform has launched in Houston and is currently looking for restaurants interested in utilizing their technology to upgrade their eatery with mobile ordering at no cost to the restaurant.

Alfredo Arvide, co-founder and managing director of Cloche, tells InnovationMap that the idea for the platform came after the pandemic forced restaurateurs to quickly pivot to touch-free menus. Now that the consumer has adapted to scanning QR codes to view menus, the next step is to optimize ordering — something that will also help with the labor shortages that restaurants are now facing.

"Now is the time transform this industry by creating a better meal experience for the consumers, an easier job for the restaurant staff and a more efficient, more profitable business for restaurant owners," Arvide says. Read more.Read more.

Susan Davenport, senior vice president and chief economic development officer for the Greater Houston Partnership

The Greater Houston Partnership's Susan Davenport shares details on Houston House at SXSW, HETI House at CERAWeek, and taking the city on tour to spread awareness of the ecosystem. Photo via houston.org

Every year, one of the biggest tech conferences in the world convenes right down the road from Houston in downtown Austin. That's a huge opportunity for the Greater Houston Partnership to showcase and congregate Housto's tech innovators.

Susan Davenport, senior vice president and chief economic development officer for the Greater Houston Partnership, shares on the Houston Innovators Podcast how the GHP has made an effort to increase Houston's presence at SXSW over the past few years. This year, the third year for Houston House, the GHP and the Houston Energy Transition Initiative are convening over 20 Houston innovators for two days of programming.

"We want to further the development of our ecosystem," Davenport says on the podcast. "Houston is so uniquely place for this — we have such well-developed industry sectors and a customer base. ... All entrepreneurs want to showcase their products and talk about what their doing. We'll have people there to answer questions and, most importantly, invite them to Houston." Read more and listen to the episode.

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The Greater Houston Partnership's Susan Davenport shares details on Houston House at SXSW, HETI House at CERAWeek, and taking the city on tour to spread awareness of the ecosystem. Photo via houston.org

Tapping into CERAWeek, SXSW to showcase and convene Houston tech

Houston innovators podcast episode 176

Every year, one of the biggest tech conferences in the world convenes right down the road from Houston in downtown Austin. That's a huge opportunity for the Greater Houston Partnership to showcase and congregate Housto's tech innovators.

Susan Davenport, senior vice president and chief economic development officer for the Greater Houston Partnership, shares on the Houston Innovators Podcast how the GHP has made an effort to increase Houston's presence at SXSW over the past few years. This year, the third year for Houston House, the GHP and the Houston Energy Transition Initiative are convening over 20 Houston innovators for two days of programming.

"We want to further the development of our ecosystem," Davenport says on the podcast. "Houston is so uniquely place for this — we have such well-developed industry sectors and a customer base. ... All entrepreneurs want to showcase their products and talk about what their doing. We'll have people there to answer questions and, most importantly, invite them to Houston."

Currently, the GHP is also hosting its second year of involvement at CERAWeek with its HETI team. HETI House, which is open at CERAWeek showcases unique energy transition technology originating in Houston. Returning this year is HETI's startup pitch competition on March 8 from 10 am to 3 pm.

SXSW and CERAWeek are just two examples of the GHP's mission of putting Houston tech on display. Davenport shares how every year, the GHP's team embarks on a handful of domestic and international mission trips to bring Houston to other major cities — as well as bring back ideas from other ecosystems.

"We go to these conferences to provide a glimpse into what we're doing and have an opportunity to connect, but we also take that message around the globe," Davenport says. "We believe we have a great story. We believe Texas has a great backdrop, and we put all this together and take it on the road."

She shares more about these trips and on what people can expect from Houston House at SXSW on the podcast. Listen to the interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


According to a new report, Houston has potential to lead three life science subsectors: cell and gene therapy manufacturing, molecular diagnostics, and biologics drug development and manufacturing. Photo via Getty Images

Report: Houston is primed for a boom in these life science subsectors

by the numbers

A new report found that Houston has great potential across a handful of life science subsectors.

The study by Newmark Consulting Group was commissioned by the Greater Houston Partnership and sponsored by San Jacinto College, Lone Star College, Houston Community College, and McCord Development. It looked at the region's existing resources and value proposition in the life sciences sector.

According to the report, Houston is home to industry-leading expertise in three subsectors: cell and gene therapy manufacturing, molecular diagnostics, and biologics drug development and manufacturing.

From a workforce perspective, the city has a steady flow of new talent from regional universities and "an emerging and robust commitment by community colleges to support two-year degree pathways to meet industry demands and the ability for life science companies to grow and thrive in the market," per the report. The findings led to identifying the next steps for the Houston region to capitalize on these advantages.

“The Newmark study confirms what we knew to be true about the potential for life sciences growth in Houston,” says Susan Davenport, GHP's chief economic development officer, in a news release. “The study will help us coalesce our regional partners around a cohesive strategy to grow and expand the industry in Houston.”

The report's other key findings included:

  • Houston consistently ranks as a top-15 market for life sciences employment nationwide and first in Texas with nearly 700 life science companies operating in town.
  • The Bayou City has the densest patient population in the world, which allows for transformational clinical applications.
  • The city's diverse workforce, extensive university ecosystem, education infrastructure, and research institutions sets a scene for Houston to capture extensive subsector gains.
  • Houston ranks second in the nation in clinical trial volume with more than 4,600 currently active clinical trials, which is representing 15 percent of all active U.S. trials.
  • In 2021, Houston-area institutions attracted $864.1 million in grant funding from the National Institutes of Health, which is up 16.3 percent from 2020. On average over the past five years, the region received $740.7 million per year in NIH funding for a total of $3.9 billion.
  • Houston is home to more than 26,000 non-healthcare life science employees.
  • The region's life sciences workforce ranks No. 12 in the nation, on par with numbers reported for Research Triangle Park.
In light of the report, the GHP is recommending a few action items, including "accelerating workforce development programs to produce new graduates in key life sciences occupations, refining Houston’s marketing messages to highlight the region’s existing life science assets and activities within life science R&D and manufacturing," per the report. Additionally, the GHP identified the need to develop a shared regional strategy to attract and retain leading life sciences companies.
To lead these initiatives, the GHP has assembled task forces, which will be led by the organization’s Life Sciences Committee, chaired by Ferran Prat, senior vice president of Industry Relations and Research at MD Anderson Cancer Center.
This week's roundup of Houston innovators includes Eric Rubenstein of New Climate Ventures, Susan Davenport of Greater Houston Partnership, and Zimri T. Hinshaw of Bucha Bio. Courtesy photos

3 Houston innovators to know this week

who's who

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from venture capital to sustainability — recently making headlines in Houston innovation.


Eric Rubenstein, founding managing partner of New Climate Ventures

Eric Rubenstein of New Climate Ventures joins the Houston Innovators Podcast to discuss the future of Houston as a clean energy hub. Photo courtesy of NCV

Houston has a big role to play in the energy transition, says Eric Rubenstein, a climatetech investor, on last week's episode of the Houston Innovators Podcast.

"Houston's role (within the energy transition) is multifaceted," he explains. "We have a talent pool here that fits pretty well in climate tech, alternative materials, and other spaces. ...We have a customer base here that is going to adopt these new technologies."

Rubenstein founded New Climate Ventures to fund startups within the sustainability and climate tech space — which includes technologies that address circular economy, sustainably made materials, clean energy, and more. Click here to read more and stream the episode.

Susan Davenport, chief economic development officer for the Greater Houston Partnership

The Greater Houston Partnership's Susan Davenport shares details on Houston House at SXSW. Photo via houston.org

Last year, the Greater Houston Partnership created virtual content to shine a spotlight on Houston tech and innovation at SXSW. This year, the GHP is taking that same initiative in-person and in Austin. Susan Davenport, chief economic development officer at GHP, shared in a Q&A what people can expect fro Houston House at SXSW.

"Anyone who is interested in technology, commercial aerospace, life sciences, and how DEI traverses with these industries will find value in our rockstar lineup of industry leaders, investors, and startup founders," she says. "We hope to see young professionals, entrepreneurs, investors, and executives."

The activation runs Sunday, March 13, and Monday, March 14. Click here to read more.

Zimri T. Hinshaw, CEO of Bucha Bio

Bucha Bio has arrived to make an impact on the city of Houston. Image via LinkedIn

A sustainable fashion company has relocated to Houston. Bucha Bio, founded in 2019, creates in textiles and composite materials made from bacterial nanocellulose, a much more sustainable materials production, that can be used instead of animal leather, polyurethane, latex, vinyl, epoxy, and more. The company announced in a press release today that it's moving from New York City and opening a next-gen materials headquarters at the East End Maker Hub. Bucha Bio has also been accepted as a member company at Greentown Labs.

According to the release, over 20 locations were considered, and Houston stood out for its hiring potential, local universities, Texas's business-friendly regulation, and more.

“We’ve signed on senior scientists and their experiences from the oil and plastic industry are perfectly suited to biomaterials,” says Zimri T. Hinshaw, CEO of Bucha Bio, in the release. Click here to read more.

The Greater Houston Partnership's Susan Davenport shares details on Houston House at SXSW. Photo via houston.org

GHP introduces in-person Houston House for SXSW 2022

Q&A

Texas is just about two weeks away from SXSW's return to in-person activations and events since pre-pandemic times. The two-week conference includes conversations and activities within music, film, education, tech, and more. And this year, the Greater Houston Partnership is shining a spotlight on the Bayou City at the festival.

"With the return of the conference in person for the first time since 2019, we are thrilled to build on that momentum and host Houston House — a two-day activation featuring programming and networking opportunities for guests attending the conference," says Susan Davenport, chief economic development officer for the GHP.

Houston House, which first originated last year in digital form, will be held in Austin on Sunday, March 13, and Monday, March 14. Davenport shares more details on the activation in a Q&A with InnovationMap.

InnovationMap: Why did the Greater Houston Partnership decide to have a presence at SXSW this year?

Susan Davenport: As one of the premier tech conferences in the U.S., SXSW provides an incredible platform to promote Houston’s position as the most prominent emerging innovation hub in the country.

Houston was a featured partner at last year’s SXSW Online Conference, where the Partnership rallied innovative leaders from across the region for a series of virtual programming. With the return of the conference in person for the first time since 2019, we are thrilled to build on that momentum and host Houston House – a two-day activation featuring programming and networking opportunities for guests attending the conference.

With an expected attendance of 45,000 bright minds from around the globe, it’s the perfect venue to showcase Houston’s tech leadership and cultivate relationships that support the growth of our ecosystem.

IM: What can attendees expect from Houston House?

SD: This year’s activation will be held at the Line Hotel, an established SXSW venue in the heart of the action. Consistent with what attendees have come to expect from South by, Houston House will offer thought leadership programming featuring industry leaders and startup founders in a series of panel discussions on today’s most prominent topics in tech.

In addition to main stage programming, Houston House will also offer a lounge space that will serve as a landing pad for stakeholders and attendees to cultivate relationships. Each day of programming will conclude with a networking reception.

IM: The programming is geared around a few topics — what are some of these themes and how do they pertain to Houston innovation?

SD: On Sunday, March 13, our programming will be focus on topics like commercial aerospace, medical device innovation, cell therapy, and investment for diverse entrepreneurs. These panel sessions will showcase Houston’s leadership through the incredible work taking place at the Ion, Houston Spaceport, Johnson Space Center, and the Texas Medical Center.

On Monday, March 14, our programming will kick off the start of the SXSW Climate Change track and focus primarily on how Houston is leveraging its energy leadership to accelerate solutions for a low-carbon future. Topics will include VC investment in climate tech, corporate and startup partnerships, emerging low-carbon energy technologies, and ensuring an equitable energy transition.

Our full lineup of Houston House programming and speakers can be found online, along with an overview of the 2022 SXSW Conference.

IM: Who should stop by Houston House at SXSW?

SD: Anyone who is interested in technology, commercial aerospace, life sciences, and how DEI traverses with these industries will find value in our rockstar lineup of industry leaders, investors, and startup founders. We hope to see young professionals, entrepreneurs, investors, and executives.

For fellow Houstonians attending the conference, Houston House will serve as a home base to kick off your SXSW experience. For those who are not currently involved in our tech ecosystem, this will be the perfect opportunity to dive in and learn more about the amazing things taking place in our great region.

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This conversation has been edited for brevity and clarity.

A new report from the Greater Houston Partnership analyzes the city's startup ecosystem's banner year of VC activity. Photo via Getty Images

New analysis puts Houston's leap in venture capital investment in perspective

by the numbers

Houston-area startups raked in the cash last year, setting a record for the region’s annual tally of venture capital.

In 2021, Houston startups collected $2.02 billion in VC funding, according to a Greater Houston Partnership analysis of data from PitchBook. That’s up 175 percent from the $734.2 million raised in 2020.

Three startups (Solugen, HighRadius, and Lancium) accounted for more than $800 million of last year’s VC haul.

“This record year in venture capital funding for Houston companies is another important example of the positive momentum building around our innovation ecosystem,” says Susan Davenport, chief economic development officer for the Greater Houston Partnership.

“In just the last year alone, we saw the opening of The Ion, East End Maker Hub, Greentown Labs as well as the growth of other startup development organizations,” Davenport adds. “We also witnessed two of our startups — Solugen and Axiom Space — grow into unicorns, achieving a valuation of more than $1 billion. Add to this the expanded local presence of tech giants such as Microsoft, Amazon Web Services and Google Cloud, and it’s clear that Houston is rapidly building on its reputation as an innovation and technology hub.”

Here’s a breakdown of last year’s record-shattering year for VC in Houston.

Funding

  • $188.5 million in angel and seed funding, up 92.6 percent from $97.9 million in 2020.
  • $687.4 million in early-stage funding, up 361 percent from $149.1 million in 2020.
  • $1,144.3 billion in late-stage funding, up 134.9 percent from $487.3 million in 2020.

Deal volume

  • 219 deals, up 26.6 percent from up from 173 deals in 2020.
  • 122 angel and seed deals, up 9.9 percent from up from 111 deals in 2020.
  • 49 early-stage deals, up 58.1 percent from 31 deals in 2020.
  • 48 late-stage deals, up 54.8 percent from 31 deals in 2020.

Average deal size

$11.6 million average deal size, up 110.3 percent from $5.5 million in 2020.

Industries receiving the most VC in 2021

  • Information technology, $632.1 million.
  • Health care, $518.4 million.
  • Materials and resources, $426.5 million.

Serafina Lalany, executive director of Houston Exponential, told InnovationMap in January that tracking VC data offers her organization a metric for growth of the local innovation ecosystem.

“It gives us insights into the rate of capital that is deployed and how that’s growing over time and where it’s getting deployed. [It also] gives us the signal as to what our strengths are and the areas that we need to continue to build out infrastructure,” Lalany said.

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Rice University professor earns $550k NSF award for wearable imaging tech​

science supported

Another Houston scientist has won one of the highly competitive National Science Foundation (NSF) CAREER Awards.

Lei Li, an assistant professor of electrical and computer engineering at Rice University, has received a $550,000, five-year grant to develop wearable, hospital-grade medical imaging technology capable of visualizing deep tissue function in real-time, according to the NSF. The CAREER grants are given to "early career faculty members who demonstrate the potential to serve as academic models and leaders in research and education."

“This is about giving people access to powerful diagnostic tools that were once confined to hospitals,” Li said in a news release from Rice. “If we can make imaging affordable, wearable and continuous, we can catch disease earlier and treat it more effectively.”

Li’s research focuses on photoacoustic imaging, which merges light and sound to produce high-resolution images of structures deep inside the body. It relies on pulses of laser light that are absorbed by tissue, leading to a rapid temperature rise. During this process, the heat causes the tissue to expand by a fraction, generating ultrasound waves that travel back to the surface and are detected and converted into an image. The process is known to yield more detailed images without dyes or contrast agents used in some traditional ultrasounds.

However, current photoacoustic systems tend to use a variety of sensors, making them bulky, expensive and impractical. Li and his team are taking a different approach.

Instead of using hundreds of separate sensors, Li and his researchers are developing a method that allows a single sensor to capture the same information via a specially designed encoder. The encoder assigns a unique spatiotemporal signature to each incoming sound wave. A reconstruction algorithm then interprets and decodes the signals.

These advances have the potential to lower the size, cost and power consumption of imaging systems. The researchers believe the device could be used in telemedicine, remote diagnostics and real-time disease monitoring. Li’s lab will also collaborate with clinicians to explore how the miniaturized technology could help monitor cancer treatment and other conditions.

“Reducing the number of detection channels from hundreds to one could shrink these devices from bench-top systems into compact, energy-efficient wearables,” Li said in the release. “That opens the door to continuous health monitoring in daily life—not just in hospitals.”

Amanda Marciel, the William Marsh Rice Trustee Chair of chemical and biomolecular engineering and an assistant professor at Rice, received an NSF CAREER Award last year. Read more here.

Houston Spaceport launches $12M expansion for leading space tech co.

to the moon

Houston will get one step closer to the moon, as the Houston Spaceport at Ellington Airport (EFD) has announced an expansion of the lease for Intuitive Machines, the Houston space tech leader dedicated to furthering lunar exploration.

On July 15, the City of Houston announced passage of Amendment 1, which would add three acres of commercial space for Intuitive Machines at the spaceport and a $12 million infrastructure expansion. Approved by the city council and Mayor John Whitmire, the expansion will include new production, testing and support facilities. The amendment extends the current lease for Intuitive Machines from 20 years to 25 years.

"I want to shout out to Intuitive Machines about everything they’re doing at the Houston Spaceport. It’s exciting to see them expand. We’re starting to reach a critical mass out there — more and more aerospace companies want to be at the Spaceport because that’s where innovation is happening,” said Fred Flinkinger, who represents District E on the Houston City Council. “It’s a great sign of momentum, and we’re proud to have them here in Houston."

Intuitive Machines was the first commercial tenant for the Houston Spaceport when it moved into the facility in August 2016. Founded by Stephen Altemus, Kam Ghaffarian, and Tim Crain in 2013, the company holds three contracts with the National Aeronautics and Space Administration (NASA) to deliver payloads to the lunar surface. In 2023, the company opened its doors in Houston with a 105,572-square-foot Lunar Production and Operations Center that contains research and development labs, clean rooms, mission control centers, and a spacecraft assembly floor.


Intuitive Machines landed Odysseus on the moon in February 2024, the first privately owned soft lunar landing ever and the first soft landing since 1972.

The Houston Spaceport is owned and operated by the City of Houston and Houston Airports, who have an eye of keeping the city a prime name in space exploration. As "Houston" was the first word spoken on the moon when Apollo 11 landed in 1969, lunar exploration in particular has a soft place in the heart of the metropolis formerly known as Space City.

“This agreement reinforces Houston’s leadership in space innovation,” said Jim Szczesniak, director of aviation for Houston Airports. “We’re building infrastructure and supporting the next era of lunar and deep space exploration, right here at Houston Spaceport. This partnership represents the forward-thinking development that fuels job creation and drives long-term economic growth.”

Houston hardtech accelerator names 8 scientists to 2025 cohort

ready, set, activate

National hardtech-focused organization Activate has named its 2025 cohort of scientists, which includes new members to Activate Houston.

The Houston hub was introduced last year, and joins others in Boston, New York, and Berkley, California—where Activate is headquartered. The organization also offers a virtual and remote cohort, known as Activate Anywhere. Collectively, the 2025 Activate Fellowship consists of 47 scientists and engineers from nine U.S. states.

This year's cohort comprises subject matter experts across various fields, including quantum, robotics, biology, agriculture, energy and direct air capture.

Activate aims to support scientists at "the outset of their entrepreneurial journey." It partners with U.S.-based funders and research institutions to support its fellows in developing high-impact technology. The fellows receive a living stipend, connections from Activate's robust network of mentors and access to a curriculum specific to the program for two years.

“Science entrepreneurship is the origin story of tomorrow’s industries,” Cyrus Wadia, CEO of Activate, said in an announcement. “The U.S. has long been a world center for science leadership and technological advancement. When it comes to solving the world’s biggest challenges, hard-tech innovation is how we unlock the best solutions. From infrastructure to energy to agriculture, these Activate Fellows are the bold thinkers who are building the next generation of science-focused companies to lead us into the future.”

The Houston fellows selected for the 2025 class include:

  • Jonathan Bessette, founder and CEO of KIRA, which uses its adaptive electrodialysis system to treat diverse water sources and reduce CO2 emissions
  • Victoria Coll Araoz, co-founder and chief science officer of Florida-based SEMION, an agricultural technology company developing pest control strategies by restoring crops' natural defenses
  • Eugene Chung, co-founder and CEO of Lift Biolabs, a biomanufacturing company developing low-cost, nanobubble-based purification reagents. Chung is completing his Ph.D. in bioengineering at Rice University.
  • Isaac Ju, co-founder of EarthFlow AI, which has developed an AI-powered platform for subsurface modeling, enabling the rapid scaling of carbon storage, geothermal energy and lithium extraction
  • Junho Lee, principal geotechnical engineer of Houston-based Deep Anchor Solutions, a startup developing innovative anchoring systems for floating renewables and offshore infrastructure
  • Sotiria (Iria) Mostrou, principal inventor at Houston-based Biosimo Chemicals, a chemical engineering startup that develops and operates processes to produce bio-based platform chemicals
  • Becca Segel, CEO and founder of Pittsburgh-based FlowCellutions, which prevents power outages for critical infrastructure such as hospitals, data centers and the grid through predictive battery diagnostics
  • Joshua Yang, CEO and co‑founder of Cambridge, Massachusetts-based Brightlight Photonics, which develops chip-scale titanium: sapphire lasers to bring cost-effective, lab-grade performance to quantum technologies, diagnostics and advanced manufacturing

The program, led locally by Houston Managing Director Jeremy Pitts, has supported 296 Activate fellows since the organization was founded in 2015. Members have gone on to raise roughly $4 billion in follow-on funding, according to Activate's website.

Activate officially named its Houston office in the Ion last year.

Charlie Childs, co-founder and CEO of Intero Biosystems, which won both the top-place finish and the largest total investment at this year's Rice Business Plan Competition, was named to the Activate Anywhere cohort. Read more about the Boston, New York, Berkley and Activate Anywhere cohorts here.

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