3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Joanna Nathan of Prana Thoracic, Alfredo Arvide of Cloche, and Susan Davenport of the Greater Houston Partnership. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from health tech to mobile ordering — recently making headlines in Houston innovation.

Joanna Nathan, CEO, and co-founder of Prana Thoracic

Prana Thoracic, an innovative startup in the lung cancer diagnostics space, has raised its series A round of investment. Photo via LinkedIn

Joanna Nathan has been busy. It's been just under six months since the launch of her company, Prana Thoracic, a Houston health tech startup tackling lung cancer diagnostics, and the company has already secured its next round of investment funding. A medical device company developing a tool for early interception of lung cancer, the company announced last week that it closed a $3 million series A financing round.

In August, the company received a $3 million award from the Cancer Prevention & Research Institute of Texas. All of Prana Thoracic's funding is being used to develop the unique diagnostic product and the company's path to first-in-human clinical studies.

“Our technology provides a definitive answer to patients with lung nodules and allows physicians to intervene earlier in the lung cancer patient’s journey,” says Joanna Nathan, CEO, and co-founder of Prana, in a news release. “Our team is grateful to have the support of our investors and excited to leverage this financing to accelerate our technology to the bedside.” Read more.

Alfredo Arvide, co-founder and managing director of Cloche

This new restaurant technology allows for eateries to upgrade to mobile ordering for no cost. Photo courtesy of Cloche

A new mobile software platform has launched in Houston and is currently looking for restaurants interested in utilizing their technology to upgrade their eatery with mobile ordering at no cost to the restaurant.

Alfredo Arvide, co-founder and managing director of Cloche, tells InnovationMap that the idea for the platform came after the pandemic forced restaurateurs to quickly pivot to touch-free menus. Now that the consumer has adapted to scanning QR codes to view menus, the next step is to optimize ordering — something that will also help with the labor shortages that restaurants are now facing.

"Now is the time transform this industry by creating a better meal experience for the consumers, an easier job for the restaurant staff and a more efficient, more profitable business for restaurant owners," Arvide says. Read more.Read more.

Susan Davenport, senior vice president and chief economic development officer for the Greater Houston Partnership

The Greater Houston Partnership's Susan Davenport shares details on Houston House at SXSW, HETI House at CERAWeek, and taking the city on tour to spread awareness of the ecosystem. Photo via houston.org

Every year, one of the biggest tech conferences in the world convenes right down the road from Houston in downtown Austin. That's a huge opportunity for the Greater Houston Partnership to showcase and congregate Housto's tech innovators.

Susan Davenport, senior vice president and chief economic development officer for the Greater Houston Partnership, shares on the Houston Innovators Podcast how the GHP has made an effort to increase Houston's presence at SXSW over the past few years. This year, the third year for Houston House, the GHP and the Houston Energy Transition Initiative are convening over 20 Houston innovators for two days of programming.

"We want to further the development of our ecosystem," Davenport says on the podcast. "Houston is so uniquely place for this — we have such well-developed industry sectors and a customer base. ... All entrepreneurs want to showcase their products and talk about what their doing. We'll have people there to answer questions and, most importantly, invite them to Houston." Read more and listen to the episode.

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The Greater Houston Partnership's Susan Davenport shares details on Houston House at SXSW, HETI House at CERAWeek, and taking the city on tour to spread awareness of the ecosystem. Photo via houston.org

Tapping into CERAWeek, SXSW to showcase and convene Houston tech

Houston innovators podcast episode 176

Every year, one of the biggest tech conferences in the world convenes right down the road from Houston in downtown Austin. That's a huge opportunity for the Greater Houston Partnership to showcase and congregate Housto's tech innovators.

Susan Davenport, senior vice president and chief economic development officer for the Greater Houston Partnership, shares on the Houston Innovators Podcast how the GHP has made an effort to increase Houston's presence at SXSW over the past few years. This year, the third year for Houston House, the GHP and the Houston Energy Transition Initiative are convening over 20 Houston innovators for two days of programming.

"We want to further the development of our ecosystem," Davenport says on the podcast. "Houston is so uniquely place for this — we have such well-developed industry sectors and a customer base. ... All entrepreneurs want to showcase their products and talk about what their doing. We'll have people there to answer questions and, most importantly, invite them to Houston."

Currently, the GHP is also hosting its second year of involvement at CERAWeek with its HETI team. HETI House, which is open at CERAWeek showcases unique energy transition technology originating in Houston. Returning this year is HETI's startup pitch competition on March 8 from 10 am to 3 pm.

SXSW and CERAWeek are just two examples of the GHP's mission of putting Houston tech on display. Davenport shares how every year, the GHP's team embarks on a handful of domestic and international mission trips to bring Houston to other major cities — as well as bring back ideas from other ecosystems.

"We go to these conferences to provide a glimpse into what we're doing and have an opportunity to connect, but we also take that message around the globe," Davenport says. "We believe we have a great story. We believe Texas has a great backdrop, and we put all this together and take it on the road."

She shares more about these trips and on what people can expect from Houston House at SXSW on the podcast. Listen to the interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.


According to a new report, Houston has potential to lead three life science subsectors: cell and gene therapy manufacturing, molecular diagnostics, and biologics drug development and manufacturing. Photo via Getty Images

Report: Houston is primed for a boom in these life science subsectors

by the numbers

A new report found that Houston has great potential across a handful of life science subsectors.

The study by Newmark Consulting Group was commissioned by the Greater Houston Partnership and sponsored by San Jacinto College, Lone Star College, Houston Community College, and McCord Development. It looked at the region's existing resources and value proposition in the life sciences sector.

According to the report, Houston is home to industry-leading expertise in three subsectors: cell and gene therapy manufacturing, molecular diagnostics, and biologics drug development and manufacturing.

From a workforce perspective, the city has a steady flow of new talent from regional universities and "an emerging and robust commitment by community colleges to support two-year degree pathways to meet industry demands and the ability for life science companies to grow and thrive in the market," per the report. The findings led to identifying the next steps for the Houston region to capitalize on these advantages.

“The Newmark study confirms what we knew to be true about the potential for life sciences growth in Houston,” says Susan Davenport, GHP's chief economic development officer, in a news release. “The study will help us coalesce our regional partners around a cohesive strategy to grow and expand the industry in Houston.”

The report's other key findings included:

  • Houston consistently ranks as a top-15 market for life sciences employment nationwide and first in Texas with nearly 700 life science companies operating in town.
  • The Bayou City has the densest patient population in the world, which allows for transformational clinical applications.
  • The city's diverse workforce, extensive university ecosystem, education infrastructure, and research institutions sets a scene for Houston to capture extensive subsector gains.
  • Houston ranks second in the nation in clinical trial volume with more than 4,600 currently active clinical trials, which is representing 15 percent of all active U.S. trials.
  • In 2021, Houston-area institutions attracted $864.1 million in grant funding from the National Institutes of Health, which is up 16.3 percent from 2020. On average over the past five years, the region received $740.7 million per year in NIH funding for a total of $3.9 billion.
  • Houston is home to more than 26,000 non-healthcare life science employees.
  • The region's life sciences workforce ranks No. 12 in the nation, on par with numbers reported for Research Triangle Park.
In light of the report, the GHP is recommending a few action items, including "accelerating workforce development programs to produce new graduates in key life sciences occupations, refining Houston’s marketing messages to highlight the region’s existing life science assets and activities within life science R&D and manufacturing," per the report. Additionally, the GHP identified the need to develop a shared regional strategy to attract and retain leading life sciences companies.
To lead these initiatives, the GHP has assembled task forces, which will be led by the organization’s Life Sciences Committee, chaired by Ferran Prat, senior vice president of Industry Relations and Research at MD Anderson Cancer Center.
This week's roundup of Houston innovators includes Eric Rubenstein of New Climate Ventures, Susan Davenport of Greater Houston Partnership, and Zimri T. Hinshaw of Bucha Bio. Courtesy photos

3 Houston innovators to know this week

who's who

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from venture capital to sustainability — recently making headlines in Houston innovation.


Eric Rubenstein, founding managing partner of New Climate Ventures

Eric Rubenstein of New Climate Ventures joins the Houston Innovators Podcast to discuss the future of Houston as a clean energy hub. Photo courtesy of NCV

Houston has a big role to play in the energy transition, says Eric Rubenstein, a climatetech investor, on last week's episode of the Houston Innovators Podcast.

"Houston's role (within the energy transition) is multifaceted," he explains. "We have a talent pool here that fits pretty well in climate tech, alternative materials, and other spaces. ...We have a customer base here that is going to adopt these new technologies."

Rubenstein founded New Climate Ventures to fund startups within the sustainability and climate tech space — which includes technologies that address circular economy, sustainably made materials, clean energy, and more. Click here to read more and stream the episode.

Susan Davenport, chief economic development officer for the Greater Houston Partnership

The Greater Houston Partnership's Susan Davenport shares details on Houston House at SXSW. Photo via houston.org

Last year, the Greater Houston Partnership created virtual content to shine a spotlight on Houston tech and innovation at SXSW. This year, the GHP is taking that same initiative in-person and in Austin. Susan Davenport, chief economic development officer at GHP, shared in a Q&A what people can expect fro Houston House at SXSW.

"Anyone who is interested in technology, commercial aerospace, life sciences, and how DEI traverses with these industries will find value in our rockstar lineup of industry leaders, investors, and startup founders," she says. "We hope to see young professionals, entrepreneurs, investors, and executives."

The activation runs Sunday, March 13, and Monday, March 14. Click here to read more.

Zimri T. Hinshaw, CEO of Bucha Bio

Bucha Bio has arrived to make an impact on the city of Houston. Image via LinkedIn

A sustainable fashion company has relocated to Houston. Bucha Bio, founded in 2019, creates in textiles and composite materials made from bacterial nanocellulose, a much more sustainable materials production, that can be used instead of animal leather, polyurethane, latex, vinyl, epoxy, and more. The company announced in a press release today that it's moving from New York City and opening a next-gen materials headquarters at the East End Maker Hub. Bucha Bio has also been accepted as a member company at Greentown Labs.

According to the release, over 20 locations were considered, and Houston stood out for its hiring potential, local universities, Texas's business-friendly regulation, and more.

“We’ve signed on senior scientists and their experiences from the oil and plastic industry are perfectly suited to biomaterials,” says Zimri T. Hinshaw, CEO of Bucha Bio, in the release. Click here to read more.

The Greater Houston Partnership's Susan Davenport shares details on Houston House at SXSW. Photo via houston.org

GHP introduces in-person Houston House for SXSW 2022

Q&A

Texas is just about two weeks away from SXSW's return to in-person activations and events since pre-pandemic times. The two-week conference includes conversations and activities within music, film, education, tech, and more. And this year, the Greater Houston Partnership is shining a spotlight on the Bayou City at the festival.

"With the return of the conference in person for the first time since 2019, we are thrilled to build on that momentum and host Houston House — a two-day activation featuring programming and networking opportunities for guests attending the conference," says Susan Davenport, chief economic development officer for the GHP.

Houston House, which first originated last year in digital form, will be held in Austin on Sunday, March 13, and Monday, March 14. Davenport shares more details on the activation in a Q&A with InnovationMap.

InnovationMap: Why did the Greater Houston Partnership decide to have a presence at SXSW this year?

Susan Davenport: As one of the premier tech conferences in the U.S., SXSW provides an incredible platform to promote Houston’s position as the most prominent emerging innovation hub in the country.

Houston was a featured partner at last year’s SXSW Online Conference, where the Partnership rallied innovative leaders from across the region for a series of virtual programming. With the return of the conference in person for the first time since 2019, we are thrilled to build on that momentum and host Houston House – a two-day activation featuring programming and networking opportunities for guests attending the conference.

With an expected attendance of 45,000 bright minds from around the globe, it’s the perfect venue to showcase Houston’s tech leadership and cultivate relationships that support the growth of our ecosystem.

IM: What can attendees expect from Houston House?

SD: This year’s activation will be held at the Line Hotel, an established SXSW venue in the heart of the action. Consistent with what attendees have come to expect from South by, Houston House will offer thought leadership programming featuring industry leaders and startup founders in a series of panel discussions on today’s most prominent topics in tech.

In addition to main stage programming, Houston House will also offer a lounge space that will serve as a landing pad for stakeholders and attendees to cultivate relationships. Each day of programming will conclude with a networking reception.

IM: The programming is geared around a few topics — what are some of these themes and how do they pertain to Houston innovation?

SD: On Sunday, March 13, our programming will be focus on topics like commercial aerospace, medical device innovation, cell therapy, and investment for diverse entrepreneurs. These panel sessions will showcase Houston’s leadership through the incredible work taking place at the Ion, Houston Spaceport, Johnson Space Center, and the Texas Medical Center.

On Monday, March 14, our programming will kick off the start of the SXSW Climate Change track and focus primarily on how Houston is leveraging its energy leadership to accelerate solutions for a low-carbon future. Topics will include VC investment in climate tech, corporate and startup partnerships, emerging low-carbon energy technologies, and ensuring an equitable energy transition.

Our full lineup of Houston House programming and speakers can be found online, along with an overview of the 2022 SXSW Conference.

IM: Who should stop by Houston House at SXSW?

SD: Anyone who is interested in technology, commercial aerospace, life sciences, and how DEI traverses with these industries will find value in our rockstar lineup of industry leaders, investors, and startup founders. We hope to see young professionals, entrepreneurs, investors, and executives.

For fellow Houstonians attending the conference, Houston House will serve as a home base to kick off your SXSW experience. For those who are not currently involved in our tech ecosystem, this will be the perfect opportunity to dive in and learn more about the amazing things taking place in our great region.

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This conversation has been edited for brevity and clarity.

A new report from the Greater Houston Partnership analyzes the city's startup ecosystem's banner year of VC activity. Photo via Getty Images

New analysis puts Houston's leap in venture capital investment in perspective

by the numbers

Houston-area startups raked in the cash last year, setting a record for the region’s annual tally of venture capital.

In 2021, Houston startups collected $2.02 billion in VC funding, according to a Greater Houston Partnership analysis of data from PitchBook. That’s up 175 percent from the $734.2 million raised in 2020.

Three startups (Solugen, HighRadius, and Lancium) accounted for more than $800 million of last year’s VC haul.

“This record year in venture capital funding for Houston companies is another important example of the positive momentum building around our innovation ecosystem,” says Susan Davenport, chief economic development officer for the Greater Houston Partnership.

“In just the last year alone, we saw the opening of The Ion, East End Maker Hub, Greentown Labs as well as the growth of other startup development organizations,” Davenport adds. “We also witnessed two of our startups — Solugen and Axiom Space — grow into unicorns, achieving a valuation of more than $1 billion. Add to this the expanded local presence of tech giants such as Microsoft, Amazon Web Services and Google Cloud, and it’s clear that Houston is rapidly building on its reputation as an innovation and technology hub.”

Here’s a breakdown of last year’s record-shattering year for VC in Houston.

Funding

  • $188.5 million in angel and seed funding, up 92.6 percent from $97.9 million in 2020.
  • $687.4 million in early-stage funding, up 361 percent from $149.1 million in 2020.
  • $1,144.3 billion in late-stage funding, up 134.9 percent from $487.3 million in 2020.

Deal volume

  • 219 deals, up 26.6 percent from up from 173 deals in 2020.
  • 122 angel and seed deals, up 9.9 percent from up from 111 deals in 2020.
  • 49 early-stage deals, up 58.1 percent from 31 deals in 2020.
  • 48 late-stage deals, up 54.8 percent from 31 deals in 2020.

Average deal size

$11.6 million average deal size, up 110.3 percent from $5.5 million in 2020.

Industries receiving the most VC in 2021

  • Information technology, $632.1 million.
  • Health care, $518.4 million.
  • Materials and resources, $426.5 million.

Serafina Lalany, executive director of Houston Exponential, told InnovationMap in January that tracking VC data offers her organization a metric for growth of the local innovation ecosystem.

“It gives us insights into the rate of capital that is deployed and how that’s growing over time and where it’s getting deployed. [It also] gives us the signal as to what our strengths are and the areas that we need to continue to build out infrastructure,” Lalany said.

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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

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