SpaceX's Dragon capsule docked onto the ISS and will return to Earth in February. Photo via SpaceX

The two astronauts stuck at the International Space Station since June welcomed their new ride home with Sunday’s arrival of a SpaceX capsule.

SpaceX launched the rescue mission on Saturday with a downsized crew of two astronauts and two empty seats reserved for Butch Wilmore and Suni Williams, who will return next year. The Dragon capsule docked in darkness as the two craft soared 265 miles (426 kilometers) above Botswana.

NASA switched Wilmore and Williams to SpaceX following concerns over the safety of their Boeing Starliner capsule. It was the first Starliner test flight with a crew, and NASA decided the thruster failures and helium leaks that cropped up after liftoff were too serious and poorly understood to risk the test pilots’ return. So Starliner returned to Earth empty earlier this month.

The Dragon carrying NASA’s Nick Hague and the Russian Space Agency’s Alexander Gorbunov will remain at the space station until February, turning what should have been a weeklong trip for Wilmore and Williams into a mission lasting more than eight months.

Two NASA astronauts were pulled from the mission to make room for Wilmore and Williams on the return leg.

“I just want to say welcome to our new compadres,” Williams, the space station commander, said once Hague and Gorbunov floated inside and were embraced by the nine astronauts awaiting them.

Hague said it was a smooth flight up. “Coming through the hatch and seeing all the smiles, and as much as I've laughed and cried in the last 10 minutes, I know it's going to be an amazing expedition," he said.

NASA likes to replace its station crews every six months or so. SpaceX has provided the taxi service since the company’s first astronaut flight in 2020. NASA also hired Boeing for ferry flights after the space shuttles were retired, but flawed software and other Starliner issues led to years of delays and more than $1 billion in repairs.

Starliner inspections are underway at NASA’s Kennedy Space Center, with post-flight reviews of data set to begin this week.

“We’re a long way from saying, ‘Hey, we’re writing off Boeing,’” NASA’s associate administrator Jim Free said at a pre-launch briefing.

The arrival of two fresh astronauts means the four who have been up there since March can now return to Earth in their own SpaceX capsule in just over a week, bringing the station's crew size back down to the normal seven. Their stay was extended a month because of the Starliner turmoil.

Although Saturday’s liftoff went well, SpaceX said the rocket’s spent upper stage ended up outside its targeted impact zone in the Pacific because of a bad engine firing. The company has halted all Falcon launches until it figures out what went wrong.was extended a month because of the Starliner turmoil.

After almost three months, the decision finally came down from NASA’s highest ranks on Saturday. Photo via Vanessa Wyche/LinkedIn

NASA decides to keep 2 astronauts in space until February, nixes return on troubled Boeing capsule

game plan set

NASA decided Saturday it’s too risky to bring two astronauts back to Earth in Boeing’s troubled new capsule, and they'll have to wait until next year for a ride home with SpaceX. What should have been a weeklong test flight for the pair will now last more than eight months.

The seasoned pilots have been stuck at the International Space Station since the beginning of June. A cascade of vexing thruster failures and helium leaks in the new capsule marred their trip to the space station, and they ended up in a holding pattern as engineers conducted tests and debated what to do about the flight back.

After almost three months, the decision finally came down from NASA’s highest ranks on Saturday. Butch Wilmore and Suni Williams will come back in a SpaceX capsule in February. Their empty Starliner capsule will undock in early September and attempt to return on autopilot with a touchdown in the New Mexico desert.

"We are grateful to Butch and Suni for taking on new roles as International Space Station crew members and their families for supporting them in this change to mission plan. Butch and Suni will do good science, technology and STEM engagements on ISS and the entire NASA family will continue to support them during their increment," NASA's Johnson Space Center Director Vanessa Wyche wrote on LinkedIn. "I am personally proud of all of the people who support our human spaceflight endeavors all across the globe. Together, we ensure the safe exploration of space."

As Starliner’s test pilots, the pair should have overseen this critical last leg of the journey.

“A test flight by nature is neither safe nor routine,” said NASA Administrator Bill Nelson. The decision "is a result of a commitment to safety.”

Nelson said lessons learned from NASA's two space shuttle accidents played a role. This time, he noted, open dialogue was encouraged rather than crushed.

“This has not been an easy decision, but it is absolutely the right one,” added Jim Free, NASA's associate administrator.

It was a blow to Boeing, adding to the safety concerns plaguing the company on its airplane side. Boeing had counted on Starliner’s first crew trip to revive the troubled spacecraft program after years of delays and ballooning costs. The company had insisted Starliner was safe based on all the recent thruster tests both in space and on the ground.

Boeing did not participate in Saturday's news conference by NASA, but released a statement.

“Boeing continues to focus, first and foremost, on the safety of the crew and spacecraft," reads the statement. The company said it is preparing the spacecraft “for a safe and successful return.”

Rand Corp.'s Jan Osburg, a senior engineer who specializes in aerospace and defense, said NASA made the right choice. “But the U.S. is still left with egg on its face due to the Starliner design issues that should have been caught earlier."

Wilmore, 61, and Williams, 58, are both retired Navy captains with previous long-duration spaceflight experience. Before their June 5 launch from Cape Canaveral, Wilmore and Williams said their families bought into the uncertainty and stress of their professional careers decades ago.

During their lone orbital news conference last month, the astronauts said they had trust in the thruster testing being conducted. They had no complaints, they added, and enjoyed pitching in with space station work.

Wilmore's wife, Deanna, said she and their daughters, along with family and friends, “were praying for a safe return on whatever spacecraft that may be." While they are disappointed that he will be away longer, “we know that it's the Lord's plan,” she said via text.

Flight operations director Norm Knight said he talked to the astronauts Saturday and they fully support the decision to postpone their return.

There were few options.

The SpaceX capsule currently parked at the space station is reserved for the four residents who have been there since March. They will return in late September, their routine six-month stay extended a month by the Starliner dilemma. NASA said it would be unsafe to squeeze two more into the capsule, except in an emergency.

The docked Russian Soyuz capsule is even tighter, capable of flying only three — two of them Russians wrapping up a yearlong stint.

So Wilmore and Williams will wait for SpaceX's next taxi flight. It’s due to launch in late September with two astronauts instead of the usual four. NASA is yanking two to make room for Wilmore and Williams on the return flight in late February.

NASA said no serious consideration was given to asking SpaceX for a quick stand-alone rescue. Last year, the Russian Space Agency had to rush up a replacement Soyuz capsule for three men whose original craft was damaged by space junk. The switch pushed their six-month mission to just over a year.

Former Canadian astronaut Chris Hadfield, applauded the decision via X: “Good to err on the side of caution for astronaut lives.” Long missions are “what astronauts work their entire career for. I’d take it in a heartbeat!”

Starliner’s woes began long before its latest flight.

Bad software fouled the first test flight without a crew in 2019, prompting a do-over in 2022. Then parachute and other issues cropped up, including a helium leak in the capsule’s propellant system that nixed a launch attempt in May. The leak eventually was deemed to be isolated and small enough to pose no concern. But more leaks sprouted following liftoff, and five thrusters also failed.

All but one of those small thrusters restarted in flight. But engineers were perplexed by ground testing that showed a thruster seal swelling and obstructing a propellant line. They theorized the seals in orbit may have expanded and then reverted to their normal size. Officials said the results marked the turning point, as their concerns grew.

With all the uncertainty about how the thrusters might perform, “There was too much risk for the crew," Steve Stich, NASA's commercial crew program manager, told reporters.

These 28 thrusters are vital. Besides needed for space station rendezvous, they keep the capsule pointed in the right direction at flight’s end as bigger engines steer the craft out of orbit. Coming in crooked could result in catastrophe.

With the Columbia disaster still fresh in many minds — the shuttle broke apart during reentry in 2003, killing all seven aboard — NASA made an extra effort to embrace open debate over Starliner's return capability.

Despite Saturday's decision, NASA isn’t giving up on Boeing. Nelson said he is “100%” certain that Starliner will fly again.

NASA went into its commercial crew program a decade ago wanting two competing U.S. companies ferrying astronauts in the post-shuttle era. Boeing won the bigger contract: more than $4 billion, compared with SpaceX’s $2.6 billion.

With station supply runs already under its belt, SpaceX aced its first of now nine astronaut flights in 2020, while Boeing got bogged down in design flaws that set the company back more than $1 billion. NASA officials still hold out hope that Starliner’s problems can be corrected in time for another crew flight in another year or so.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."