Houston startups win NASA funding for space tech projects

fresh funding

Houston startups were recently named among the nearly 300 recipients that received a portion of $44.85 million from NASA to develop space technology. Photo via NASA/Ben Smegelsky

Three Houston startups were granted awards from NASA this month to develop new technologies for the space agency.

The companies are among nearly 300 recipients that received a total agency investment of $44.85 million through the Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase I grant programs, according to NASA.

Each selected company will receive $150,000 and, based on their progress, will be eligible to submit proposals for up to $850,000 in Phase II funding to develop prototypes.

The SBIR program lasts for six months and contracts small businesses. The Houston NASA 2025 SBIR awardees include:

Solidec Inc.

  • Principal investigator: Yang Xia
  • Proposal: Highly reliable and energy-efficient electrosynthesis of high-purity hydrogen peroxide from air and water in a nanobubble facilitated porous solid electrolyte reactor

Rarefied Studios LLC

  • Principal investigator: Kyle Higdon
  • Proposal: Plume impingement module for autonomous proximity operations

The STTR program contracts small businesses in partnership with a research institution and lasts for 13 months. The Houston NASA 2025 STTR awardees include:

Affekta LLC

  • Principal investigator: Hedinn Steingrimsson
  • Proposal: Verifiable success in handling unknown unknowns in space habitat simulations and a cyber-physical system

Solidec and Affekta have ties to Rice University.

Solidec extracts molecules from water and air, then transforms them into pure chemicals and fuels that are free of carbon emissions. It was co-founded by Rice professor Haotian Wang and and was an Innovation Fellow at Rice’s Liu Idea Lab for Innovation and Entrepreneurship. It was previouslt selected for Chevron Technology Ventures’ catalyst program, a Rice One Small Step grant, a U.S. Department of Energy grant, and the first cohort of the Activate Houston program.

Affekta, an AI course, AI assistance and e-learning platform, was a part of Rice's OwlSpark in 2023.

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Together, Little Place Labs and Loft Orbital are paving the way for a new era of rapid-response capabilities in space. Photo courtesy of Little Place Labs

Houston space data startup to compute real-time insights in orbit

out of this world

A Houston space startup has announced a new partnership that will “push the boundaries of real-time data processing and insight delivery.”

Little Place Labs is collaborating with San Francisco-based Loft Orbital to pair its low-latency operations, using its space infrastructure with LittlePlace Labs’ cutting-edge analytics. This will enhance maritime domain awareness under a US Air Force Phase 2 STTR by deploying Little Place Labs software to Loft’s YAM-6 satellite as a virtual mission.

“Our on-orbit data processing solutions, paired with Loft’s satellite platform, allow us to derive and deliver insights in near real-time for time-sensitive situations,” Little Place Labs Co-founder and CEO Bosco Lai says in a news release. “These insights are critical to commercial and national security stakeholders, including those in the US government. This collaboration highlights the new space age, where companies like Little Place Labs and Loft come together, integrating our solutions into powerful capabilities.”

Loft plans to deploy Little Place Labs’ applications to its constellation of satellites. Each satellite node will be equipped with a sensing resource like visible and infrared images, and configurable software-defined radios. The satellite nodes make up Loft’s space infrastructure, which will include onboard edge compute and connectivity resources. The infrastructure will be used to build and complete complex missions. The low-latency maritime domain awareness is an example of the complex challenges that won’t involve deployment of new hardware. This aligns with both companies goals to address real-time data solutions and rapid responses in space.

"We are proud to support customers like Little Place Labs in pushing the limits of what’s possible with low latency applications and onboard edge compute,” Mitchell Scher, director of business development at Loft, adds. “While we’re providing the infrastructure to support these kinds of low-latency operations, it is only as useful as the applications our customers deploy and the operational value they produce for their end users.”

Little Place Labs will be working with another military organization, as they were recently selected by AFWERX for a STTR Phase II contract in the amount of $1.8 million dollars. The focus will be “revolutionizing space- based ISR through decentralized systems,” per a news release. This will be done in-orbit ML computing for near-real-time intelligence to address challenges in the Department of the Air Force.

Another recent collaboration sees their Orbitfy software suite on LEOcloud’s Space Edge infrastructure as a Service (IaaS). This will help facilitate “scalable real-time data processing and analysis directly on spacecraft, significantly reducing downlink costs and enabling faster mission-critical insight,” according to a news release. The Orbitfy Software suite combines data preprocessing capabilities with low-SWaP machine learning applications that is designed for deployment directly on space infrastructures and satellites.

Little Place Labs is also using its satellite real-time solutions to help address wildfires. They were one of four companies part of the completion of the first round of the XPRIZE Autonomous Wildfire Challenge by the coalition Fire Foresight.

NASA doled out funding to 12 startups — and one from Houston makes the cut. Photo courtesy of re:3D

Houston 3D printing company lands funding from NASA

funds granted

Houston-based re:3D Inc was recently one of 12 innovative companies from around the country to be granted Phase II awards from a NASA small business initiative, the space giant announced earlier this week.

The grants of up to $850,000 are awarded to early-stage, high-risk technology concepts that could be commercialized for use in space and on Earth as part of NASA's SBIR Ignite pilot, which is part of NASA’s Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs.

The program was launched to support emerging companies "whose end customers may not be only NASA but are still creating technology that NASA cares about,” Jason L. Kessler, program executive for the NASA SBIR/STTR program, says in a previous statement. And it aims to attract companies that have not yet worked with NASA.

The concepts from the cohort have applications in climate resilience, low-cost solar cells and active debris remediation. Re:3D Inc.'s project looks to develop a recycling system that uses a 3D printer to turn thermoplastic waste generated in orbit into functional and useful objects, according to the project's proposal.

SBIR Ignite made its inaugural Phase I awards in 2022, granting about $2 million in total to the 12 companies, including re:3D Inc. The Phase II grants are intended to help the companies create their prototypes.

“We are proud that all 12 of the small businesses are continuing with our program and persevering through the tough realities of early-stage research and development,” Kessler said in a statement made this month. "These awards foster a unique range of technologies that we hope will have positive impacts on the lives of everyday Americans in the future."

Re3D Inc. is the only company from Texas in the cohort. The other 11 awarded companies and their projects include:

  • Ampaire Inc.: High Efficiency Powertrain for Hybrid Aircraft
  • Canopy Aerospace Inc.: Reusable Heatshields through Additive Manufacturing
  • Cecilia Energy: Catalytic Conversion of Waste Plastic to Hydrogen
  • Crystal Sonic Inc.: Reducing Cost of Space Photovoltaics via Sound-Assisted Substrate Reuse
  • H3X Technologies Inc.: HPDM-30 – A 10 kW/kg Integrated Motor Drive for UAV and Aircraft Electric Propulsion
  • Outpost Technologies Corporation: Outpost Cargo Ferry: A Rapid Cargo Downmass Vehicle
  • Solestial, Inc.: Next Generation Silicon Based Solar Arrays for Space Stations and Other Permanent Space Infrastructure
  • StormImpact Inc.: Optimizing vegetation management to improve the resilience of the electrical power system to extreme weather
  • Terrafuse, Inc.: Wildfire Mitigation through Explainable Risk Predictions
  • Trans Astronautica Corporation: Mini Bee Capture Bag for Active Debris Remediation
  • Turion Space Corp.: Low-Cost CubeSat for Active Removal of Sizable Space Debris Utilizing a Mothership Architecture

Re:3D Inc. was founded in 2013 by NASA contractors Samantha Snabes and Matthew Fiedler and is based in Clear Lake. It's known for its GigaBot 3D printer, which uses recycled materials to create larger devices.

Since its founding it's been named to numerous accelerators and has earned national recognition, like the Tibbetts Award from the U.S. Small Business Administration, which honors small businesses that are at the forefront of technology. It was selected by the SBA to participate in its inaugural America’s Seed Fund Startup Expo last year.

Co-founder Snabes spoke on the Houston Innovators Podcast in 2020. Click here to listen to the full, in-depth interview.

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Houston researchers report promising first in-human trial for implantable cancer therapy

cancer breakthrough

When it comes to cancer remedies, the treatment can be as challenging for the body as its cause. But what if immunotherapy could be localized? That’s precisely what a Houston team may soon make a reality.

Rice University researchers, in partnership with MD Anderson Cancer Center, recently published their findings from the first in-human trial of an implantable cancer-fighting treatment in the journal Clinical Cancer Research. The paper details testing of AVB-001, encapsulated cells engineered to release interleukin-2 (IL-2)—a naturally occurring signaling protein that boosts immunity—in the peritoneal cavities of 14 patients. The goal is to avoid the toxicity usually experienced with less targeted treatments, as well as find a solution to IL-2s’ abbreviated half-lives.

“Traditional IL-2 therapy has shown potent antitumor activity, but its clinical use has been limited by severe side effects and delivery challenges,” Omid Veiseh, director of the Rice Biotech Launch Pad, professor of bioengineering at Rice and a senior author on the study, said in a press release. “This platform allows us to localize and sustain cytokine exposure directly where tumors reside while minimizing systemic toxicity.”

Serous ovarian carcinoma is especially well-suited to the use of AVB-001 because it tends to spread throughout the abdomen. After a minimally invasive laparoscopic procedure, patients implanted with the cells were noted to tolerate the treatment well. Half of the enrolled patients’ cancer was stabilized, with several among them reporting extended signs of benefit. No maximum tolerated dose was reached and there were no life-threatening events tied to the study.

If that sounds like less-than-earth-shaking results, this is only the beginning. The capsules were implanted for about one week because IL-2 activity drops off after that. The researchers now know that further testing should include either higher levels, repeated doses, or a combination thereof, in order to create stronger advances.

The team has already made early headway on this next step. Preclinical studies in nonhuman primates were not only tolerated well, but without added toxicity, the apes had consistent pharmacological effects.

“This is a foundational step,” Veiseh explained. “We now have evidence that the platform is safe, biologically active and potentially scalable. The next phase is optimizing dosing and exploring combination therapies to unlock its full clinical potential.”

The combination would also include a checkpoint inhibitor, which might improve AVB-001’s tumor-fighting power. “What is exciting is that we are not just delivering a drug, we are programming a microenvironment,” added Dr. Amir Jazaeri, professor of gynecologic oncology at MD Anderson, member of the Rice Biotech Launch Pad’s clinical advisory board and a senior author on the study. “This opens the door to combination strategies that could amplify immune responses in ways that have not been feasible before.”

5 must-read innovation headlines: Pharma giant considers Houston hub + more

Trending news

Editor's note: With May coming to a close, it's time to look back at the biggest innovation headlines for the second half of the month. Major moves were made in May, with NuScale Power entering the market, Persona AI inking a deal with Under Armour, and a pharma giant considering Houston for its next manufacturing hub. Here are the most-read InnovationMap stories published May 15-29, 2026:

1. Pharma giant considers Houston for $1 billion manufacturing campus

Another pharmaceutical giant is considering Houston’s Generation Park for a manufacturing hub. According to a recent filing with the Texas Jobs, Energy, Technology and Innovation (JETI) program, Bristol Myers Squibb Co. is considering the northeast Houston management district for a new $1 billion multi-modal pharmaceutical manufacturing campus.

2. Modular nuclear reactor co. NuScale Power moves into Houston market

The nuclear energy renaissance continues in Texas with an announcement by NuScale Power. The Oregon-based provider of proprietary and innovative advanced small modular reactor (SMR) nuclear technology announced in April it would be opening office space in Houston’s CityCentre.

3. Persona AI teams with Under Armour to protect next-gen robots

Houston-based Persona AI has cemented a partnership with sportswear manufacturer Under Armour to provide materials to protect future robots operating in dangerous conditions. Through the partnership, Persona AI and Under Armour will launch a research initiative to explore whether advanced performance textiles can improve the durability and resilience of humanoid robots operating in harsh industrial environments.

4. Houston quantum energy chip startup emerges from stealth with $12M round

Houston-based Casimir has emerged from stealth with a $12 million seed round to commercialize its quantum energy chip. The round was led by Austin-based Scout Ventures. Lavrock Ventures, Cottonwood Technology, Capital Factory, American Deep Tech, and Tim Draper of Draper Associates also participated in the round. The oversubscribed round exceeded the company’s original $8 million target.

5. Global summit spotlights Houston's growing role in brain health, innovation

The Center for Houston’s Future and UTMB are bringing the Texas Brain Economy Summit back to Houston this summer to continue to position the region as a global leader in brain health. The summit, held June 9-10 at the Texas Medical Center's Helix Park, will bring together more than 500 executives, researchers, policymakers and innovators from around the world to discuss the global brain economy.

Houston startup raises $6M to scale home-based healthcare platform

fresh funding

As healthcare systems race to expand care beyond hospitals and into the home, investors are placing bigger bets on the infrastructure needed to make that shift possible.

This month, Rosarium Health announced it has raised $6 million in seed funding led by Kalos Ventures, with participation from ResilienceVC, Rock Health Capital, Symphonic Capital, Black Tech Nations Ventures and others.

The investment will help the Houston-based startup continue to build its platform, which features a national network of 800-plus clinicians and 3,000-plus contractors to coordinate home accessibility upgrades and modifications for seniors and people living with disabilities.

For founder and CEO Cameron Carter, the company’s mission grew out of firsthand caregiving experiences.

“From my own personal caregiving experiences, I realized that the benefits exist on paper, but not in reality,” Carter said in a news release. “Families are being left to figure out the paperwork and installations all on their own, which shouldn’t be how this works.”

While Medicare Advantage and Medicaid plans have expanded coverage for home-based services and accessibility modifications, the logistics behind delivering those services often remain fragmented.

Rosarium’s platform coordinates the entire process, from clinical assessments and referrals to contractor management, documentation, reimbursement and installation.

“A clinician can document that a home isn’t safe and a plan can approve a benefit, but there’s no one that’s responsible for making sure the work actually gets done,” Carter says. “We built the missing piece.”

The company was founded in 2021 as Rose Health and was a 2023 participant in the Texas Medical Center’s Accelerator for HealthTech program. It has scaled quickly, building a network of more than 800 clinicians and 3,000 contractors across 34 states.

Rosarium is currently in-network for 1.2 million Medicare and Medicaid lives, with projected coverage expected to reach nearly 4 million by the end of the year, according to the release.

“We’re excited to back Cameron because he and the team at Rosarium are building the infrastructure healthcare needs right now to make the home a safe and comfortable place of care,” Kate Ballinger, investor at Kalos Ventures, added in the release.

As part of the recent investment, Ballinger will join Rosarium’s board of directors.

With eyes on the future, Rosarium plans to grow its partnerships with Medicaid and Medicare Advantage plans, including CalViva and Community Health Plan of Imperial Valley, strengthening its presence in California while expanding access to underserved communities.

Additionally, Carter predicts that home-based healthcare will be part of a broader transformation happening across the industry.

“There’s a growing recognition that health outcomes are shaped by what happens in the home,” he said in the release. “The future of healthcare isn’t just treating people after something goes wrong. It’s creating environments that help prevent those problems in the first place.”

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