This week's innovators to know in Houston all have new and exciting things to announce. Courtesy photos

Who are Houston's innovators to know? Well this week, here's who made headlines, from a well-known Houston software entrepreneur and investor rolling out a new line of business for his company to a new podcast network with Houston roots.

Gabriella Rowe, executive director of operations at The Ion

ION Accelerator ribbon cutting event, with Mayor Sylvester Turner and business partners.

Photo by Carter Smith/Station Houston

The entrepreneurial hub dubbed the Ion that's expected to premiere in Houston's innovation district in 2021 has a new operating organization and the Rice Management Company has tapped Station Houston CEO Gabriella Rowe to run it.

"To ensure that The Ion is a catalyst for the continued growth of the innovation ecosystem, we've been collaborating with Gaby and her team as well as civic leaders, Mayor Sylvester Turner, Harris County commissioners and Midtown Houston," says Allison Thacker, president and chief investment officer of the RMC, in a news release. "We know that under Gaby's leadership The Ion will become an innovation hub for not only all Houstonians, but for anybody looking to thrive and collaborate in an entrepreneur-first, tech-forward environment." Read more.

Rakesh Agrawal, founder and CEO of SnapStream

Photo courtesy of SnapStream

Houston-based SnapStream has expanded its services, and CEO and Co-founder Rakesh Agrawal appears on the third episode of the Houston Innovators Podcast to discuss his company's growth and the role he plays in the Houston innovation ecosystem.

"A lot of people go to this question of, 'What's wrong with the Houston ecosystem?' If there's anything that's a fundamental characteristic of Houston that we need to change that would really help the startup and innovation ecosystem is that often in Houston, the left hand doesn't know what the right hand is doing," Agrawal says on the podcast. Read more.

Stephanie Wittels Wachs, co-founder of Lemonada Media

Photo via Twitter

It's safe to say that Stephanie Wittels Wachs didn't have start and run a podcast network in her life's master plan. Nonetheless, the Houstonian can check that box after she launched Lemonada Media with her business partner, Jessica Cordova Kramer. The network is about creating provoking, uncensored content about life and humanity.

"This is everything I've done in my whole life," she tells InnovationMap. "It sort of combines my writing and my education background and my artistic background and some voiceover background and my activism. It's everything." Read more.

Lemonada, founded by Houstonian Stephanie Wittels Wachs and Jessica Cordova Kramer, wants to air content that takes an unfiltered approach to life. Pexels

Houstonian launches her podcast network to talk about the tough stuff

unfiltered and on air

Even before Stephanie Wittels Wachs' Lemonada Media launched its first podcast on September 25, the network got a shout-out from none other than the New York Times, which listed its "Last Day" offering as one of seven new podcasts to listen to this fall.

The media company, which Wachs built with award-winning podcaster Jessica Cordova Kramer, takes aim at the human experience in all its messiness: addictions, the troubles of raising decent children, how we develop empathy. Its three shows will be distributed by The team has partnered with Westwood One on distribution, and upcoming guests include such star power as Jamie Lee Curtis, comedians Sarah Silverman, Tig Notaro, and Aziz Ansari, author Reza Aslan, actress Mara Wilson, activist DeRay McKesson, songwriter Justin Tranter and filmmaker Kulap Vilaysack.

None of it, however, is what Wachs set out to do in her life. But she knows it's exactly where life led her.

"This is everything I've done in my whole life," she tells InnovationMap. "It sort of combines my writing and my education background and my artistic background and some voiceover background and my activism. It's everything."

A part of that everything is her brother Harris Wittels, a creative force in his own right, known for his works on Parks and Rec, who died of a drug overdose (Wachs used her reaction to that to write Everything is Horrible and Wonderful, which not only chronicles Harris' addiction, but also how she processed her grief). He was a podcaster as well, and Wachs says this venture helps continue that legacy.

"But it's also about activism," she says. "About opioids and every other epidemic we're going through that feels so unsolvable. And that's how I roll."

Since her brother's death, Wachs has looked for ways not only to process the grief and anger she felt, but also found herself more and more drawn to finding ways to educate people and advocate for better understanding of addiction and ways to treat it. When her two young children were diagnosed with hearing disorders, she found herself advocating for having hearing aids covered by health care. So, while she may not have wanted to step into an activist role, once she found herself there, she threw herself into it with her characteristic energy and intelligence and not a little humor.

"Our goal is to make shows that help people get out of bed in the morning, that help people deal with the hardest shit in their lives," says Kramer in a press release announcing the podcast launch.

Kramer and Wachs met in 2017. Kramer had heard Wachs on another podcast, and as the two continued talking, they realized they were developing a shared mission. Lemonada takes its name from the idea of taking life's lemons and making them into lemonade – incorporating the bitter and the sweet.

To make the transition from writer and artist to media maven, Wachs drew on her already established strengths of community building and a desire to create high-quality content.

"We really wanted to bring a community flavor into the mix," she says. "And, as a women-run company, it was huge for us to have women's voices."

Houstonian Stephanie Wittels Wachs and Jessica Cordova Kramer launched Lemonada this fall. Photo via lemonadamedia.com

The result is a podcast network that brings to bear what Wachs calls incredible talent. The starting lineup includes "Last Day," which launched Sept. 25. Wachs confronts massive epidemics with humanity, wit, and a quest for progress. Starting with the opioid crisis, the show zooms in on a person's last day of life, exploring how they got there and how we, as a society, have gotten here.

Debuting on October 24, "As Me with Sinéad" explores the concept of empathy and how listening brings us closer. Academic, TED alum, and advocate Sinéad Burke leads candid conversations with diverse, notable guests who explain what it's like to be them. They challenge us to confront our biases, deepen our humanity, and feel empowered to impact and change the world around us.

And later in the year, with a debut date of November 26, comes "Good Kids: How Not to Raise an A**hole." For 15 minutes each week, a diverse set of parents, teachers, policy makers, and world shapers grab the mic and offer relevant advice, rants, and reflections. "Think of this as a quasi-manual for how to raise better humans," read the show's description in the press release.

"It feels almost non-profit in flavor," Wachs says of the endeavor. "I mean, we are a for-profit company, but it's mission driven, and that was important to both of us."

That mission, it seems, has also taken over the Wachs household. Over the summer, Wach's husband, Mike Wachs quit his job to work full-time with Lemonada, and Kramer's husband works in Lemonada's leadership, as well. That sense of family is galvanizing to Wachs, who loves that the new venture gives her time and space to watch her children grow. She's also crazy about how technology – everything from audio editing programs to conference calling to texting and FaceTime – has made Lemonada possible. Kramer took a safari as she and Wachs were planning the launch.

"I love that!" says Wachs. "We put everything on Slack and even though she was halfway around the world, it was like she was in my house."

The partnership with Westwood One gave Wachs her own tiny studio at 104 KRBE.

"It's really, truly miraculous," she says of the way the business was built. "And I know we all bring all these great gifts to the table. Mine is that I am able to talk all day," she quips."

Both she and Kramer are baking on the idea that there are a lot of people out there who feel like they do, that it's easier to survive life's challenges when you know you're not alone, who are ready to tune in and listen.

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Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”

Axiom Space wins NASA contract for fifth private mission, lands $350M in financing

ready for takeoff

Editor's note: This story has been updated to include information about Axiom's recent funding.

Axiom Space, a Houston-based space infrastructure company that’s developing the first commercial space station, has forged a deal with NASA to carry out the fifth civilian-staffed mission to the International Space Station.

Axiom Mission 5 is scheduled to launch in January 2027, at the earliest, from NASA’s Kennedy Space Center in Florida. The crew of non-government astronauts is expected to spend up to 14 days docked at the International Space Station (ISS). Various science and research activities will take place during the mission.

The crew for the upcoming mission hasn’t been announced. Previous Axiom missions were commanded by retired NASA astronauts Michael López-Alegría, the company’s chief astronaut, and Peggy Whitson, the company’s vice president of human spaceflight.

“All four previous [Axiom] missions have expanded the global community of space explorers, diversifying scientific investigations in microgravity, and providing significant insight that is benefiting the development of our next-generation space station, Axiom Station,” Jonathan Cirtain, president and CEO of Axiom, said in a news release.

As part of Axiom’s new contract with NASA, Voyager Technologies will provide payload services for Axiom’s fifth mission. Voyager, a defense, national security, and space technology company, recently announced a four-year, $24.5 million contract with NASA’s Johnson Space Center in Houston to provide mission management services for the ISS.

Axiom also announced today, Feb. 12, that it has secured $350 million in a financing round led by Type One Ventures and Qatar Investment Authority.

The company shared in a news release that the funding will support the continued development of its commercial space station, known as Axiom Station, and the production of its Axiom Extravehicular Mobility Unit (AxEMU) under its NASA spacesuit contract.

NASA awarded Axiom a contract in January 2020 to create Axiom Station. The project is currently underway.

"Axiom Space isn’t just building hardware, it’s building the backbone of humanity’s next era in orbit," Tarek Waked, Founding General Partner at Type One Ventures, said in a news release. "Their rare combination of execution, government trust, and global partnerships positions them as the clear successor-architect for life after the ISS. This is how the United States continues to lead in space.”

Houston edtech company closes oversubscribed $3M seed round

fresh funding

Houston-based edtech company TrueLeap Inc. closed an oversubscribed seed round last month.

The $3.3 million round was led by Joe Swinbank Family Limited Partnership, a venture capital firm based in Houston. Gamper Ventures, another Houston firm, also participated with additional strategic partners.

TrueLeap reports that the funding will support the large-scale rollout of its "edge AI, integrated learning systems and last-mile broadband across underserved communities."

“The last mile is where most digital transformation efforts break down,” Sandip Bordoloi, CEO and president of TrueLeap, said in a news release. “TrueLeap was built to operate where bandwidth is limited, power is unreliable, and institutions need real systems—not pilots. This round allows us to scale infrastructure that actually works on the ground.”

True Leap works to address the digital divide in education through its AI-powered education, workforce systems and digital services that are designed for underserved and low-connectivity communities.

The company has created infrastructure in Africa, India and rural America. Just this week, it announced an agreement with the City of Kinshasa in the Democratic Republic of Congo to deploy a digital twin platform for its public education system that will allow provincial leaders to manage enrollment, staffing, infrastructure and performance with live data.

“What sets TrueLeap apart is their infrastructure mindset,” Joe Swinbank, General Partner at Joe Swinbank Family Limited Partnership, added in the news release. “They are building the physical and digital rails that allow entire ecosystems to function. The convergence of edge compute, connectivity, and services makes this a compelling global infrastructure opportunity.”

TrueLeap was founded by Bordoloi and Sunny Zhang and developed out of Born Global Ventures, a Houston venture studio focused on advancing immigrant-founded technology. It closed an oversubscribed pre-seed in 2024.