This week's innovators to know in Houston all have new and exciting things to announce. Courtesy photos

Who are Houston's innovators to know? Well this week, here's who made headlines, from a well-known Houston software entrepreneur and investor rolling out a new line of business for his company to a new podcast network with Houston roots.

Gabriella Rowe, executive director of operations at The Ion

ION Accelerator ribbon cutting event, with Mayor Sylvester Turner and business partners.

Photo by Carter Smith/Station Houston

The entrepreneurial hub dubbed the Ion that's expected to premiere in Houston's innovation district in 2021 has a new operating organization and the Rice Management Company has tapped Station Houston CEO Gabriella Rowe to run it.

"To ensure that The Ion is a catalyst for the continued growth of the innovation ecosystem, we've been collaborating with Gaby and her team as well as civic leaders, Mayor Sylvester Turner, Harris County commissioners and Midtown Houston," says Allison Thacker, president and chief investment officer of the RMC, in a news release. "We know that under Gaby's leadership The Ion will become an innovation hub for not only all Houstonians, but for anybody looking to thrive and collaborate in an entrepreneur-first, tech-forward environment." Read more.

Rakesh Agrawal, founder and CEO of SnapStream

Photo courtesy of SnapStream

Houston-based SnapStream has expanded its services, and CEO and Co-founder Rakesh Agrawal appears on the third episode of the Houston Innovators Podcast to discuss his company's growth and the role he plays in the Houston innovation ecosystem.

"A lot of people go to this question of, 'What's wrong with the Houston ecosystem?' If there's anything that's a fundamental characteristic of Houston that we need to change that would really help the startup and innovation ecosystem is that often in Houston, the left hand doesn't know what the right hand is doing," Agrawal says on the podcast. Read more.

Stephanie Wittels Wachs, co-founder of Lemonada Media

Photo via Twitter

It's safe to say that Stephanie Wittels Wachs didn't have start and run a podcast network in her life's master plan. Nonetheless, the Houstonian can check that box after she launched Lemonada Media with her business partner, Jessica Cordova Kramer. The network is about creating provoking, uncensored content about life and humanity.

"This is everything I've done in my whole life," she tells InnovationMap. "It sort of combines my writing and my education background and my artistic background and some voiceover background and my activism. It's everything." Read more.

Lemonada, founded by Houstonian Stephanie Wittels Wachs and Jessica Cordova Kramer, wants to air content that takes an unfiltered approach to life. Pexels

Houstonian launches her podcast network to talk about the tough stuff

unfiltered and on air

Even before Stephanie Wittels Wachs' Lemonada Media launched its first podcast on September 25, the network got a shout-out from none other than the New York Times, which listed its "Last Day" offering as one of seven new podcasts to listen to this fall.

The media company, which Wachs built with award-winning podcaster Jessica Cordova Kramer, takes aim at the human experience in all its messiness: addictions, the troubles of raising decent children, how we develop empathy. Its three shows will be distributed by The team has partnered with Westwood One on distribution, and upcoming guests include such star power as Jamie Lee Curtis, comedians Sarah Silverman, Tig Notaro, and Aziz Ansari, author Reza Aslan, actress Mara Wilson, activist DeRay McKesson, songwriter Justin Tranter and filmmaker Kulap Vilaysack.

None of it, however, is what Wachs set out to do in her life. But she knows it's exactly where life led her.

"This is everything I've done in my whole life," she tells InnovationMap. "It sort of combines my writing and my education background and my artistic background and some voiceover background and my activism. It's everything."

A part of that everything is her brother Harris Wittels, a creative force in his own right, known for his works on Parks and Rec, who died of a drug overdose (Wachs used her reaction to that to write Everything is Horrible and Wonderful, which not only chronicles Harris' addiction, but also how she processed her grief). He was a podcaster as well, and Wachs says this venture helps continue that legacy.

"But it's also about activism," she says. "About opioids and every other epidemic we're going through that feels so unsolvable. And that's how I roll."

Since her brother's death, Wachs has looked for ways not only to process the grief and anger she felt, but also found herself more and more drawn to finding ways to educate people and advocate for better understanding of addiction and ways to treat it. When her two young children were diagnosed with hearing disorders, she found herself advocating for having hearing aids covered by health care. So, while she may not have wanted to step into an activist role, once she found herself there, she threw herself into it with her characteristic energy and intelligence and not a little humor.

"Our goal is to make shows that help people get out of bed in the morning, that help people deal with the hardest shit in their lives," says Kramer in a press release announcing the podcast launch.

Kramer and Wachs met in 2017. Kramer had heard Wachs on another podcast, and as the two continued talking, they realized they were developing a shared mission. Lemonada takes its name from the idea of taking life's lemons and making them into lemonade – incorporating the bitter and the sweet.

To make the transition from writer and artist to media maven, Wachs drew on her already established strengths of community building and a desire to create high-quality content.

"We really wanted to bring a community flavor into the mix," she says. "And, as a women-run company, it was huge for us to have women's voices."

Houstonian Stephanie Wittels Wachs and Jessica Cordova Kramer launched Lemonada this fall. Photo via lemonadamedia.com

The result is a podcast network that brings to bear what Wachs calls incredible talent. The starting lineup includes "Last Day," which launched Sept. 25. Wachs confronts massive epidemics with humanity, wit, and a quest for progress. Starting with the opioid crisis, the show zooms in on a person's last day of life, exploring how they got there and how we, as a society, have gotten here.

Debuting on October 24, "As Me with Sinéad" explores the concept of empathy and how listening brings us closer. Academic, TED alum, and advocate Sinéad Burke leads candid conversations with diverse, notable guests who explain what it's like to be them. They challenge us to confront our biases, deepen our humanity, and feel empowered to impact and change the world around us.

And later in the year, with a debut date of November 26, comes "Good Kids: How Not to Raise an A**hole." For 15 minutes each week, a diverse set of parents, teachers, policy makers, and world shapers grab the mic and offer relevant advice, rants, and reflections. "Think of this as a quasi-manual for how to raise better humans," read the show's description in the press release.

"It feels almost non-profit in flavor," Wachs says of the endeavor. "I mean, we are a for-profit company, but it's mission driven, and that was important to both of us."

That mission, it seems, has also taken over the Wachs household. Over the summer, Wach's husband, Mike Wachs quit his job to work full-time with Lemonada, and Kramer's husband works in Lemonada's leadership, as well. That sense of family is galvanizing to Wachs, who loves that the new venture gives her time and space to watch her children grow. She's also crazy about how technology – everything from audio editing programs to conference calling to texting and FaceTime – has made Lemonada possible. Kramer took a safari as she and Wachs were planning the launch.

"I love that!" says Wachs. "We put everything on Slack and even though she was halfway around the world, it was like she was in my house."

The partnership with Westwood One gave Wachs her own tiny studio at 104 KRBE.

"It's really, truly miraculous," she says of the way the business was built. "And I know we all bring all these great gifts to the table. Mine is that I am able to talk all day," she quips."

Both she and Kramer are baking on the idea that there are a lot of people out there who feel like they do, that it's easier to survive life's challenges when you know you're not alone, who are ready to tune in and listen.

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Axiom Space-tested cancer drug advances to clinical trials

mission critical

A cancer-fighting drug tested aboard several Axiom Space missions is moving forward to clinical trials.

Rebecsinib, which targets a cancer cloning and immune evasion gene, ADAR1, has received FDA approval to enter clinical trials under active Investigational New Drug (IND) status, according to a news release. The drug was tested aboard Axiom Mission 2 (Ax-2) and Axiom Mission 3 (Ax-3). It was developed by Aspera Biomedicine, led by Dr. Catriona Jamieson, director of the UC San Diego Sanford Stem Cell Institute (SSCI).

The San Diego-based Aspera team and Houston-based Axiom partnered to allow Rebecsinib to be tested in microgravity. Tumors have been shown to grow more rapidly in microgravity and even mimic how aggressive cancers can develop in patients.

“In terms of tumor growth, we see a doubling in growth of these little mini-tumors in just 10 days,” Jamieson explained in the release.

Rebecsinib took part in the patient-derived tumor organoid testing aboard the International Space Station. Similar testing is planned to continue on Axiom Station, the company's commercial space station that's currently under development.

Additionally, the drug will be tested aboard Ax-4 under its active IND status, which was targeted to launch June 25.

“We anticipate that this monumental mission will inform the expanded development of the first ADAR1 inhibitory cancer stem cell targeting drug for a broad array of cancers," Jamieson added.

According to Axiom, the milestone represents the potential for commercial space collaborations.

“We’re proud to work with Aspera Biomedicines and the UC San Diego Sanford Stem Cell Institute, as together we have achieved a historic milestone, and we’re even more excited for what’s to come,” Tejpaul Bhatia, the new CEO of Axiom Space, said in the release. “This is how we crack the code of the space economy – uniting public and private partners to turn microgravity into a launchpad for breakthroughs.”

Chevron enters the lithium market with major Texas land acquisition

to market

Chevron U.S.A., a subsidiary of Houston-based energy company Chevron, has taken its first big step toward establishing a commercial-scale lithium business.

Chevron acquired leaseholds totaling about 125,000 acres in Northeast Texas and southwest Arkansas from TerraVolta Resources and East Texas Natural Resources. The acreage contains a high amount of lithium, which Chevron plans to extract from brines produced from the subsurface.

Lithium-ion batteries are used in an array of technologies, such as smartwatches, e-bikes, pacemakers, and batteries for electric vehicles, according to Chevron. The International Energy Agency estimates lithium demand could grow more than 400 percent by 2040.

“This acquisition represents a strategic investment to support energy manufacturing and expand U.S.-based critical mineral supplies,” Jeff Gustavson, president of Chevron New Energies, said in a news release. “Establishing domestic and resilient lithium supply chains is essential not only to maintaining U.S. energy leadership but also to meeting the growing demand from customers.”

Rania Yacoub, corporate business development manager at Chevron New Energies, said that amid heightening demand, lithium is “one of the world’s most sought-after natural resources.”

“Chevron is looking to help meet that demand and drive U.S. energy competitiveness by sourcing lithium domestically,” Yacoub said.

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This article originally appeared on EnergyCapital.