Houston millionaire starts biotech accelerator for companies focusing on regenerative medicine

Stem cell-erator

The new biotech accelerator has already worked with two companies, which have relocated their operations to Houston. Getty Images

A new Houston-based startup accelerator is planning to advance companies focusing on regenerative medicine and stem cell treatment.

Houston Healthspan Innovation Group was created by founder and CEO Ed Bosarge, a local entrepreneur who's made millions of developing health care and finance technology.

"From day one, Houston Healthspan will play a significant role in shaping Houston's vibrant life sciences scene with its seasoned leadership and state-of-the-art facilities," Bosarge says in a news release. "Houston Healthspan may be a tipping point for the region's life sciences community."

The program will provide its participating startups and joint venture partners with expertise and resources in biology, clinical disease, therapeutic delivery systems, finance, and marketing, per the release.

The accelerator will be housed out of the Houston Healthspan Bio Labs —10,000 square feet of lab space just south of the Texas Medical Center. The labs will provide the scientists and researchers with cutting-edge technologies, large cleanrooms, and cGMP cell culture workstations will be used for cell manufacturing, bioprocessing, and therapeutic protocol development. The lab can even handle small-scale biologics manufacturing.

"Gaining access to lab space is a significant hurdle many start-up life sciences companies must overcome," says Dr. Steven Greco, chief science officer at Houston Healthspan. "Our Bio Labs address this need and offer a compelling and ideal setting for start-ups and joint-venture partners to conduct pre-clinical studies and obtain valuable research services."

Houston Healthspan has already started working with two regenerative medicine companies that have both relocated their operations to Houston. Rejenevie Therapeutics™, which moved from New Jersey, develops therapies for immune system restoration as well as age-related illnesses. Formerly based in Hawaii, Tissue Genesis created the Icellator X®, a technology that focuses on stem cell isolation.

"With two collaborator companies like Rejenevie and Tissue Genesis working out of our Houston Healthspan Bio Labs, we can offer significant resources and expertise for start-up and joint-venture partners to thrive and succeed," says Eric Schaeffer, chief strategy officer, in the release.

From a locally sourced meal service company to stem cell research and a balance measuring device, this week's innovators are ones to know in the health industry. Courtesy photos

3 Houston health-focused innovators to know this week

Who's who

More and more Americans are focusing on their health, from eating right to experimenting with new treatments or devices. These three Houston innovators are riding the coattails of this health-focused movement with their startups. With advances in technology and the movement only growing faster and faster, you'd better keep your eye on these Houston innovators.

Marla Murphy, founder of The Blonde Pantry

Courtesy of The Blonde Pantry

Marla Murphy didn't feel like she was doing enough to promote health and wellness with her platform, The Blonde Pantry. So, she expanded it to incorporate locally sourced produce and easy-to-make recipes she gets ready every weekend to deliver to her members by Monday.

"It's not about selling meals and moving on, I want this to be a lifestyle company that is really founded and has deep roots in Houston," says Murphy in a InnovationMap story.

Murphy tells InnovationMap that in the next year she hopes to expand into the retail space and find a bigger commercial kitchen to function as their own. She also hopes to partner with companies outside of food and continue to nourish lives in someway.

David Eller, chairman, co-founder and CEO of Celltex

Courtesy of Celltex

Stem cell treatment is personal to David Eller, chairman, co-founder and CEO of Celltex. Eller had the treatment in hopes of resolving pain from a college football injury.

"I would go to work and put four to six Advil in my pocket," Eller says in an InnovationMap story about Celltex's technology. Within months, he stopped needing those pills.

Houston-based Celltex tracks its progress with its patients. Eighty-three percent of multiple sclerosis patients have reported improvement of symptoms specific to their disease, as have 73 percent of Parkinson's sufferers. But the staggering fact is that 100 percent of 58 respondents with rheumatoid arthritis say they have benefited.

Katharine Forth, founder and CEO of Zibrio

Courtesy of Zibrio

Katharine Forth has used a technology she developed with her colleague at NASA to measure balance in astronauts to create a device that any terrestrial human can now use from the comfort of their own homes.

"The machines typically used for balance measurement can be as large as a telephone booth, so we invented a new way to measure postural control using a much smaller mechanism that fit inside a moon boot," Forth says in an InnovationMap article about Zibrio, The Balance Company. Zibrio, The Balance Company.

Zibrio is now a finalist for the 2019 SXSW Pitch in the health and wearables category and will take its balance technology to the stage in March.

Celltex's stem cell technology has received positive results from its multiple sclerosis, Parkinson's, and rheumatoid arthritis patients. Courtesy of Celltex

Houston company uses stem cell technology to treat patients suffering from degenerative diseases

Regeneration nation

The medical community has former governor Rick Perry to thank for a major stride in regenerative medicine.

"He had just gotten elected for the last time and he wanted to leave a legacy. He was tired of people going to Japan or Germany when they needed stem cells," recalls David Eller, chairman, co-founder and CEO of Celltex.

That was 2011, the year that the former president of Dupont Pharmeceuticals-Europe and orthopedic surgeon Dr. Stanley Jones incorporated as Celltex. Perry got the law passed to make it legal to harvest his stem cells, and Jones implanted them while the governor was under the knife for a spinal fusion surgery.

Perry resigned from the Celltex board in 2017, but the truth is, the company no longer needed his clout. Just a year after its debut, the company had in excess of 200 clients, each paying a banking enrollment fee of $6,500. Now, there are close to 1,300.

From research to recovery
Eller is originally from Houston, and he says his hometown is the ideal home base for the company, with its access to the world's largest medical center. The Galleria-area office and lab employ 35 people, with about 50 workers worldwide.

Close to the same time that his friend Perry received his stem cells, Eller also had the treatment in hopes of resolving pain from a college football injury.

"I would go to work and put four to six Advil in my pocket," the CEO recalls.

Within months, all of them remained in his pocket.

But others have had even more dramatic results. Celltex checks in with patients three, six and nine months after their treatments to find out how they're doing. Eighty-three percent of multiple sclerosis patients have reported improvement of symptoms specific to their disease, as have 73 percent of Parkinson's sufferers. But the staggering fact is that 100 percent of 58 respondents with rheumatoid arthritis say they have benefited.

Implementation and the FDA
Celltex's chief scientific officer, Dr. Jane Young, co-authored a study of two severe juvenile rheumatoid arthritis patients whose conditions didn't respond to standard treatments. After trying stem cells, both reported marked improvement in autonomic nervous system and immune function.

Stem cells are gathered through a patient's fat, which can be extracted at any of the 80 facilities around the country that partner with Celltex. The fat is processed at the Houston lab, where processing takes 30 to 35 days.

"We have 15 billion cells in process each day," says Erik Eller, the company's vice president of operations, clarifying that some clients' cells grow faster than others'.

It takes 14 days to come out of cryostasis and leave the lab. From there, the stem cells travel to Hospital Galenia in Cancun, Mexico for implantation, since the FDA categorizes stem cells as a drug if they have expanded as they do at Celltex. That means that a patient cannot use his own stem cells in the United States without a clinical trial. To circumnavigate the red tape, Celltex has simply partnered with the luxurious Mexican hospital.

This is currently the company's biggest challenge, says David Eller, but one he expects to overcome.

"We have very good relations with the US FDA," he says. "They are very interested in what we know. Our approach is really is very progressive and we've grown every year."

Ultimately, Eller hopes to be able to implant stem cells in the United States. But the company's foreign growth is a good start. Celltex is now operating in the Bahamas and is hoping to add Australian extraction facilities sometime this year. They are also in negotiations with a team from Saudi Arabia interested in expanding Celltex to the Middle East.

Other goals for Celltex include improvements both in the realms of sales and revenue and streamlining and improving the safety and efficacy of treatment. Research collaborations with Baylor College of Medicine and Texas A&M will help with the company's medical credibility. This all may help to convince the FDA to allow the Celltex to get a biologics license, the final proof that it is not a drug company. But no matter how it's categorized, Celltex is growing exponentially as its cells.

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New sports festival reveals plans to take over downtown Houston next spring

pokatok prep

A Houston team announced their plans to bring the “world’s fair for sports” to downtown Houston in April 2024.

Pokatok, the four-day festival, will feature a sports tech expo, a film festival, speakers and panels, live music, pitch competitions, and more. The venue will be George R. Brown Convention Center, Discovery Green, and various nearby hotels, according to the release.

Gow Companies, founded by Lawson Gow (who is the son of David Gow, InnovationMap's parent company's CEO), announced that the team has secured support from Houston First, the Greater Houston Partnership, and the Harris County Houston Sports Authority to put on the event, which is slated to take place April 4-7, 2024. The company also owns Houston Exponential and a sports accelerator called Pokatok Labs.

“Pokatok will not only be the largest gathering of the entire sports tech ecosystem, it will also be a true fan festival for sports enthusiasts,” says Gow in the news release. “Everyone speaks the language of sport, it’s an incredibly powerful unifier of our society, and this festival will bring together people from around the world to experience hundreds of events revolving around the new and the next in sport.”

The festival will take place in April 2024 in downtown. Rendering courtesy of Pokatok

The festival will feature two tracks — one focused on sports innovation and the other surrounding a fan experience. Pokatok X will include an expo and showcase focused on sports innovation, bringing together startups, investors, accelerators, athletes, and industry experts to dive into sports tech.

The Pokatok Fan Festival's track will include product releases, demos for sports technology, sporting events, competitions, tournaments, and more.

Houston is no stranger to hosting major sport events, Harris County - Houston Sports Authority CEO Janis Burke points out in the news release, including the 2023 NCAA Men’s Final Four and the upcoming 2024 College Football National Championship, the 2024 Cricket World Cup, and the 2026 FIFA World Cup.

"Houston is known as one of the best sports destinations in the world," Burke continues. "As an organization, we are consistently looking for ways to innovate and grow in the sports sector. Events like Pokatok are great for advancing sports within the region and providing unique opportunities for our community!"

Tickets are expected to go on sale in the fall, and the organization is looking for potential speakers and partners. The festival's name derives from sport of pok-a-tok, which dates back thousands of years as the world’s first team sport played throughout Mesoamerica.

“The City of Houston is a sports town to its core and has been host to some of the greatest events and moments in sports,” says Mayor Sylvester Turner in the release. “Pokatok will help further Houston’s vision of being a destination city for global sporting events and innovations. The business community also supports this venture, and I thank them for their involvement and support. This project is an excellent example of local business leaders joining forces to expand the attractions the City has to offer to both residents and visitors.”

Pokatok will take place in and around the George R. Brown Convention Center. Rendering courtesy of Pokatok

Rice University team wins innovation challenge supported by Accenture

winner, winner

A team of students from Rice University may see their award-winning idea incorporated into programming from the nonprofit Smithsonian Institution — the world’s largest museum, education, and research complex.

Rice’s Team Night Owls, made up of four undergraduates, recently won Accenture’s 2023 Innovation Challenge. The team’s winning concept: a three-month, six-town mobile bus exhibit designed to expose the Smithsonian to residents of rural areas in the U.S. One of the highlights of the exhibit would be an augmented reality/virtual reality feature.

The Rice team competed against more than 1,100 applicants. Participants were asked to “envision ways to deliver the spirit and wonder of in-person visits” at the Smithsonian to rural communities nationwide.

“Our biggest takeaway from the challenge was learning how to generate innovative ideas and then combine the best aspects from each one to include into one coherent solution,” says one of the team members, Sean Bishop.

Accenture is providing pro bono support to the Smithsonian to help turn the Rice team’s “Rural Routes” concept into reality. Ideally, the Smithsonian hopes to incorporate the team’s idea into its 2026 celebration of the country’s 250th birthday.

Officials say they liked the Rice team’s proposal because it would be a way for the organization to familiarize rural America with the Smithsonian while also collecting and displaying the stories of rural residents.

“We hope to amplify the voices of rural Americans and raise the visibility of their cultural stories,” the Smithsonian says in a statement provided to InnovationMap.

Nico Motta, a rising junior studying business and data science at Rice, says his team’s idea was born out of a desire to bring the Smithsonian to people and bring people to the Smithsonian.

“From there, two different ideas emerged that we eventually brought together. First, we connected the idea of campaign buses that allow political candidates to travel to smaller communities,” Motta tells InnovationMap. “Second, we researched existing Smithsonian initiatives and were intrigued by the Crossroads program, a stationary exhibit shipped out to community centers.”

The team then brainstormed ways to marry the two ideas. The result: the Rural Routes project.

Aside from Motta and Bishop, members of the Rice team are Eva Moughan, a rising junior studying math and operations research at Rice, and Austin Tran, a rising junior studying business and statistics.

Bishop, a rising senior studying chemical and biomolecular engineering at Rice, says the Rural Routes entry stood out partly because the team:

  • Dug into how to finance the exhibit.
  • Supplied examples of similar projects that have achieved success.
  • Folded augmented reality/virtual reality into the project.

Organizers believe the Rice team’s winning entry embodies the competition’s goal this year to generate “bold ideas and innovative thinking” about introducing more Americans to the Smithsonian.

“The Accenture Innovation Challenge invites students seeking to do well and do good to collaborate on solving real and real-time business challenges for leading nonprofits. The students’ innovative ideas make the nonprofit better able to achieve its mission, and together we work to implement the winning solution,” says Marty Rodgers, senior managing director of Accenture’s U.S. south region and executive sponsor of the Accenture Innovation Challenge.

Houston innovator on the importance of commercial missions for the future of space health research

HOUSTON INNOVATORS PODCAST EPISODE 189

With the rise of commercial space flight, researchers have increased access to space health data that's key to the future of the industry as a whole. The organization that's conducting this valuable research is based right in Houston's Texas Medical Center.

TRISH, or the Translational Research Institute for Space Health, is an organization based out of Baylor College of Medicine and partnered with NASA's Human Spaceflight group. As commercial space companies have emerged, TRISH has strategically aligned with these businesses to bring back health data from the civilian trips.

“Most of the research that’s done at NASA and other government agencies usually takes decades to get something that could be implemented in space or terrestrially," Dr. Emmanuel Urquieta, chief medical officer for TRISH, says on the Houston Innovators Podcast. "What we do at TRISH is something different.

"On the one hand, we look at really new technologies that are just an idea, but could be really game changing," he continues. "Then on the other hand, we look at technologies already in the market that could be tweaked to work in spaceflight.”

Since 2021, TRISH has conducted its research on four missions — Inspiration4, the first all-civilian mission to space; Axiom Mission 1, the first all civilian mission to the International Space Station; MS20, which flew two Japanese civilians to ISS; and, most recently, Axiom Mission 2, which included the first all-private crew commanded by a woman and two members of the Kingdom of Saudi Arabia's national astronaut program.

“We really saw the value of implementing research in civilians because they are different from your traditional government astronaut,” Urquieta says. “In civilians, you see a more diverse population.”

Urquieta says TRISH's experiments on these missions all fall within a few pillars of space health, including space's effects on sensory motor skills, like balance and motion sickness, as well as mental health, environmental data from the vehicles, vital monitoring, and more.

“We’ve developed a capability to collect high-priority, high-value data from these space flight participants without having to train them for long periods of time — which is a challenge, because they don’t train for years like traditional astronauts,” he explains.

The plan, Urquieta says, is to be able to share TRISH's space health data in order to more safely send humans into space. He shares more about TRISH's program and the challenges the organization faces on the show. Listen to the interview below — or wherever you stream your podcasts — and subscribe for weekly episodes.

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