4 Houston innovators to know for February 2025

Featured Innovators

Xiaoyu Yang, a graduate student at Rice, is the lead author on a study published in the journal Science on smart cell design. Photo by Jeff Fitlow/ Courtesy Rice University

Editor's note: Houston researchers and professors have been in the national spotlight as of late. For InnovationMap's February roundup of Innovators to Know, we focus on trailblazers from UH, Rice, and beyond, who have recently garnered presidential awards in STEM, revealed research breakthroughs, and more. Meet our featured innovators below.

Donna Stokes, physics professor, University of Houston

Donna Stokes. Courtesy photo

The White House recently recognized UH physics professor Donna Stokes for her outstanding mentoring in STEM disciplines with the Presidential Awards for Excellence in Science, Mathematics and Engineering Mentoring.

The National Science Foundation manages the PAESMEM awards, and the White House Office of Science and Technology Policy selects honorees.

“Spotlighting STEM educators, researchers and mentors is important to demonstrate the critical role they play in developing and encouraging students to pursue STEM degrees and careers,” Stokes said in a news release. “It is imperative to have STEM educators who can foster the next generation of scientists to address local and national scientific challenges.” Continue reading.

Allison Master, associate professor, University of Houston

Allison Master. Courtesy photo

Allison Master, an assistant professor at the University of Houston, is the first from the college to be awarded the Presidential Early Career Award for Scientists and Engineers.

Master, who works in the Department of Psychological, Health and Learning Sciences at the UH College of Education, is one of 400 scientists and engineers to receive the honor from the Biden administration. The award recognizes those who “show exceptional potential for leadership early in their research careers,” according to a statement.

Master’s research in the Identity and Academic Motivation Lab at UH involves how societal stereotypes contribute to gender gaps in motivation to pursue STEM. Her study also explored ways to counter the stereotypes through educational strategies that make students feel that they belong, what drives children’s interest in STEM and the role of social connections. Her efforts resulted in millions of dollars in grants from the U.S. Department of Education’s Institute of Education Sciences, the National Science Foundation, and other organizations, according to UH. Continue reading.

Xiaoyu Yang, graduate student, Rice University 

Xiaoyu Yang, a graduate student at Rice, is the lead author on a study published in the journal Science on smart cell design. Photo by Jeff Fitlow/ Courtesy Rice University

Bioengineers at Rice University have developed a “new construction kit” for building custom sense-and-respond circuits in human cells, representing a major breakthrough in the field of synthetic biology, which could "revolutionize" autoimmune disease and cancer therapeutics.

In a study published in the journal Science, the team focused on phosphorylation, a cellular process in the body in which a phosphate group is added to a protein, signaling a response. In multicellular organisms, phosphorylation-based signaling can involve a multistage, or a cascading-like effect. Rice’s team set out to show that each cycle in a cascade can be treated as an elementary unit, meaning that they can be reassembled in new configurations to form entirely novel pathways linking cellular inputs and outputs.

“This work brings us a whole lot closer to being able to build ‘smart cells’ that can detect signs of disease and immediately release customizable treatments in response,” said Xiaoyu Yang, graduate student in the Systems, Synthetic and Physical Biology Ph.D. program at Rice and lead author on the study. Continue reading.

Dr. Peter Hotez

Dr. Peter Hotez, pictured here with Dr. Maria Elena Bottazzi. Photo courtesy of TMC

Houston vaccine scientist Dr. Peter Hotez can add one more prize to his shelf.

Hotez — dean of the National School of Tropical Medicine and professor of Pediatrics and Molecular Virology & Microbiology at Baylor College of Medicine, co-director of the Texas Children’s Center for Vaccine Development (CVD) and Texas Children’s Hospital Endowed Chair of Tropical Pediatrics — is no stranger to impressive laurels. In 2022, he was even nominated for a Nobel Peace Prize for his low-cost COVID vaccine.

His first big win of 2025 is this year’s Hill Prize, awarded by the Texas Academy of Medicine, Engineering, Science and Technology (TAMEST).

Hotez and his team were selected to receive $500,000 from Lyda Hill Philanthropies to help fund The Texas Virosphere Project. The endeavor was born to help create a predictive disease atlas relating to climate disasters. Continue reading.

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UH physics professor Donna Stokes and Allison Master, an assistant professor in the UH College of Education, were recognized by the Biden Administration for excellence in STEM fields. Photos courtesy UH.

2 Houston professors earn prestigious presidential awards for excellence in STEM

Big Wins

Allison Master, an assistant professor at the University of Houston, is the first from the college to be awarded the Presidential Early Career Award for Scientists and Engineers.

Master, who works in the Department of Psychological, Health and Learning Sciences at the UH College of Education, is one of 400 scientists and engineers to receive the honor from the Biden administration. The award recognizes those who “show exceptional potential for leadership early in their research careers,” according to a statement.

“This award speaks volumes about Allison’s dedication, ingenuity and innovation in educational sciences,” Diane Z. Chase, UH senior vice president for academic affairs and provost, said in a news release. “Her groundbreaking work embodies the university’s commitment to advancing knowledge, fostering equity in education and shaping a brighter future for students and educators alike.”

Master’s research in the Identity and Academic Motivation Lab at UH involves how societal stereotypes contribute to gender gaps in motivation to pursue STEM. Her study also explored ways to counter the stereotypes through educational strategies that make students feel that they belong, what drives children’s interest in STEM and the role of social connections. Her efforts resulted in millions of dollars in grants from the U.S. Department of Education’s Institute of Education Sciences, the National Science Foundation, and other organizations, according to UH.

Established by President Bill Clinton in 1996, PECASE recognizes innovative and far-reaching developments in science and technology, expands awareness of careers in STEM fields, enhances connections between research and its impacts on society, and highlights the importance of science and technology for our nation’s future.

“This is something that was on my radar, sort of like a ‘pie in the sky’ dream that it would be amazing to win it, but I didn’t know if it could ever be possible,” Master said. “I am very grateful to the University of Houston for providing such a supportive environment for innovation, collaboration and meaningful research that made this achievement possible.”

In addition to Master’s honor, the White House also recently recognized UH physics professor Donna Stokes for outstanding mentoring in STEM disciplines with the Presidential Awards for Excellence in Science, Mathematics and Engineering Mentoring.

Stokes’ previous awards include the UH Teaching Excellence Award, the 2023 UH Honors College Outstanding Fellowship Mentorship Award, the 2011 UH Provost Academic Advising and Mentoring Award, a National Science Foundation Career Award, and a National Research Council Post-Doctoral Associateship Award. The National Science Foundation manages the PAESMEM awards, and the White House Office of Science and Technology Policy selects honorees.

PAESMEM award recipients will receive $10,000 and the opportunity to attend professional development events in Washington, D.C.

“Spotlighting STEM educators, researchers and mentors is important to demonstrate the critical role they play in developing and encouraging students to pursue STEM degrees and careers,” Stokes said in a news release. “It is imperative to have STEM educators who can foster the next generation of scientists to address local and national scientific challenges.”
Here's your latest roundup of innovation news you may have missed. Photo via Getty Images

3 Houston startups join accelerators, PE-backed biz names new execs, and more innovation news

short stories

It's been a busy month so far with plenty of Houston startup news, major ecosystem events, and more — and there might be some headlines you may have missed.

In this roundup of short stories within Houston startups and tech, three startups join three different accelerator programs, a Houston innovator publishes a book, and a PE-backed tech company makes changes to its C-suite.

Rivalry Tech snags spot in Comcast NBCUniversal SportsTech Accelerator

Rivalry Tech, the parent company for stadium mobile ordering platform sEATz, was selected for a prestigious program. Photo via rivalrytech.com

A Houston-based startup has been selected for the third cohort for the Comcast NBCUniversal SportsTech Accelerator. Rivalry Tech, a software company that provides mobile ordering technology platform sEATz to stadiums, is one of 10 startups in the program.

The new cohort was selected from over 920 applicants across 40 countries. The six-month program — expanded from its previous 12-week format — allows access to access to leaders and decision makers from across the partner consortium, including NBC Sports, Sky Sports, Comcast Spectacor, Golf, NASCAR, WWE, PGA TOUR, U.S. Ski & Snowboard, USA Swimming, and USA Cycling.

Since the first class in 2021, SportsTech startup alumni have participated in 90 pilots, partnerships, and commercial deals with consortium partners.

"Our alumni from the first two classes of the Comcast NBCUniversal SportsTech accelerator continue to display a prowess for delivering impactful technology while unlocking new revenue opportunities, and I look forward to seeing what powerful innovations and unique partnerships emerge from this year’s program,” says Jenna Kurath, vice president of Startup Partnerships and Head of Comcast NBCUniversal SportsTech, in a news release. "As we evaluated how to bring even more value to our startups and SportsTech partners, a clear need emerged - more time collaborating to tackle complex business challenges. The new six-month format creates additional space for focused testing and experimentation with a curriculum designed for business refinement while allowing the enterprise-ready startups we've selected to continue serving their existing customers.”

PE-backed HungerRush names new execs

HungerRush has a handful of new execs. Photo via Getty Images

Houston-based HungerRush, a cloud software provider for the restaurant industry, announced new leaders within its C-suite. The company, recently backed by New York City-based private equity firm Corsair Capital New York City-based private equity firm Corsair Capital, announced three new executives.

  • David Tabachnick has been named CFO. He joins the company from Acoustic where he most recently served as CAO. He brings more than 20 years’ experience to his new role as CFO, including extensive private equity experience through Vista Equity Partners.
  • Patrick Hughes joins as vice president of finance. He will focus on emphasizing longstanding partnerships, reporting, automation, and environment of controls and advise on growth paths for HungerRush. With more than 15 years’ experience in both accounting and FP&A, he excels in high growth environments focused on technology advancements.
  • Jim DaBroi has been appointed COO. He has more than 25 years of experience in developing and growing customer support operations for various SaaS and payments companies. In his role at HungerRush he will be focused on leading the deployment and installations of customer success and technical support efforts.
  • Ashishh Desai has been named vice president of independent operators sales following the company's acquisition of Menufy acquisition. He was previously a co-founder of Kansas City-based Menufy, an industry-leading online food ordering platform acquired in October 2021 and will continue to build and grow HungerRush’s I/O sector.

“We are excited to attract this caliber of world-class Fintech and PE-based talent with the addition of David and Patrick, who together will be key to our rapid growth strategy. In addition, the appointments of Jim and Ashishh bring deep experience in SaaS, payments and sales to our team that is unmatched," says HungerRush CEO Perry Turbes in a news release. "With our now robust leadership team, we will continue to accelerate our commitment to elevate the restaurant technology space and meet the evolving needs of our customers to help them achieve their own goals in the restaurant industry.”

Heroshe named to nonprofit accelerator's spring cohort

The Heroshe team will participate in a hybrid accelerator program. Photo via heroshe.com

A Houston-based tech startup called Heroshe has joined Virgina-based hybrid accelerator Lighthouse Labs for their spring 2023 cohort. Heroshe, according to its website, is a purpose-driven technology company solving the problem of access to global commerce for African businesses.

"We are on a mission to bridge the commerce gap, simplify imports and empower Africans to access global markets," reads the website.

Its eleventh year, Lighthouse Labs, a nonprofit organization, named eight companies to its Batch 14, which begins March 13 in Richmond, Virginia, and ends with Demo Day on May 23.

“This cohort’s companies offer bold solutions to address current-day problems in industries ranging from logistics to cybersecurity, health/wellness to retail, and real estate to software,” says Paul Nolde, managing executive director at Lighthouse Labs, in a news release. “This group of startups represents the best of innovation and entrepreneurship across the Commonwealth and beyond.”

Around 200 companies applied and were evaluated. Of the applications, 49 moved forward to the first round of reviews, and 17 participated in interviews. All companies will receive $20,000 in equity-free funding, participate in weekly educational programming, get mentorship from Lighthouse’s extensive mentor network, and connect directly with local partners and investors.

Houston innovator publishes first book

Kara Branch's book is available on Amazon. Image via Amazon

A Houston innovator — an award-winning one at that — has published a book Kara Branch is the CEO of Black Girls Do Engineer, an organization on a mission to inspire future women in science, technology, engineering, and mathematics.She released her first book, “What is S.T.E.M.?”

"Many are familiar with the acronym S.T.E.M. but don’t necessarily understand what the term means," reads the book's description. "This book will help you understand what is S.T.E.M. and introduce you to S.T.E.M. careers that falls under each letter."

IncentiFind finds spot in growth-focused program

IncentiFind was selected for a new program. Photo courtesy of IncentiFind

IncentiFind, a Houston-based startup that helps the real estate industry find grant opportunities, has joined Chicago-based Moderne Ventures' inaugural "Passport Class," which is a six-month program providing its participants education, exposure, insight, and relationships to drive customer growth.

"Unlike a traditional accelerator, Moderne Passport is a comprehensive industry immersion program that helps companies of all stages – seed through pre-IPO – hone their go-to-market strategies in the real estate sector, build relationships with industry leaders and execute pilot programs and customer relationships with some of the largest companies in the world," says Carolyn Kwon, Moderne Passport director, in a news release.

IncentiFind, founded by Natalie Goodman, is one of six companies selected for the first batch of startups. Moderne Ventures is a venture capital firm focused on the industries of real estate, finance, insurance, ESG, and home services.

"Moderne most often looks outside its industries to find technologies that can be applicable within them," says Constance Freedman, founder and managing partner at Moderne Ventures. "This latest Passport cohort was curated to include innovative solutions that are highly applicable to some of our industry's most pressing challenges. We look forward to helping these companies optimize their products and services and connect with partners in the Moderne Network who can benefit most from them."

Joy Jones is opening her Oak Forest location of Code Wiz later this month. Screenshot via Code Wiz

Houston business woman brings STEM-focused programming to town

stemming education

A Houstonian has switched up her career to focus on inspiring and equipping children STEM-focused skills.

Joy Jones, who has worked for a decade in the corporate world, is starting the new year with a new career — this one focused on her passion of providing more STEM programming access to students. In 2021, she came across Code Wiz, a coding school franchise based in Massachusetts with 19 locations across the country, and met with Ruth Agbaji, CEO and "nerd-in-chief" of the company.

“Talking with Ruth and hearing the story of her mission to touch 1 million kids through Code Wiz, I found exactly what I’ve been looking for, a mission that aligned with mine,” says Jones, in a news release.

Code Wiz features a Montessori-style approach, according to the release, and classes are project-based so that students are able to explore at their own pace while building confidence and interest. Here are some of the things Code Wiz students engage with:

  • Build multi-level video games
  • Create animation
  • Introduction to Python
  • Website development in HTML, CSS, and Javascript
  • Enroll in classes for Roblox, Minecraft and Unity
  • Enter robotics competitions
  • Celebrate birthday parties and programs for local Girl Scout troops

The Houston area is already home to two Code Wiz locations — one in Cypress and the other in Katy — and Jones is bringing the third oneto Houston proper in Oak Forest on the northside of Houston later this month.

"We have a chance to teach young learners in Oak Forest and the surrounding central Houston area, the language of the future – coding – in a language they already understand in games and robotics,” she continues.

Classes at Code Wiz Oak Forest begin next week, and the location is celebrating its grand opening on Saturday, January 14, from 10 am to 1 pm. with classes starting the week before. Per the release, Founding Family memberships are currently available to the first 50 families who sign up to receive 31.4 percent off a lifetime membership.

A new program at UH is providing Houston students with access to research tools and mentorship. Photo via UH.edu

Houston high school students step into STEM thanks to UH program

science friction

A group of Houston high schoolers aren't taking a break this summer. Instead, they are researching the human body thanks to a new program from the University of Houston.

The STEM Research Inquiry Summer Experience was launched to encourage future STEM leaders and combat the underrepresentation of people of color working in science, technology, engineering and math. Students from Jack Yates High School in Houston's Third Ward are researching hypertension, breast cancer, the spleen, and more during the summer program, according to a news release.

“STEM RISE was inspired by the goal to broaden participation in STEM teaching and learning, and to inspire students from our neighborhood community of Third Ward to envision themselves with futures at UH and ultimately in promising STEM careers,” says Mariam Manuel, director of STEM RISE student success, in the release.

UH students from across STEM fields and departments — science, math, medical, etc. — serve as mentors for the program, which received funding from the National Science Foundation.

“This unique opportunity also gives the young visitors a glimpse into college life,” says Jacqueline Ekeoba, director of STEM RISE instruction, in the release.

In collaboration with UH’s College of Natural Sciences and Mathematics, teachHOUSTON, the Tilman J. Fertitta Family College of Medicine, and Jack Yates High School, the program provides the students with hands-on experience and access to research equipment and lab space.

“Creating safe and supportive learning experiences for the next generation of scientists and doctors is crucial for ensuring diversity in science and medicine," says Thomas Thesen, director of STEM RISE research experience and associate professor of neuroscience at the Fertitta Family College of Medicine. "Not only is this a valuable experience for our high school participants, but our UH students receive training in culturally responsive pedagogy by acting as near-peer mentors."

From left to right, the UH STEM RISE team includes Jacqueline Ekeoba, Mariam Manuel, and Thomas Thesen. Photo via UH.edu

Over 450 student teams competed in an annual international robotics competition in Houston last weekend. Photo by Argenis Apolinario/FIRST

International robotics competition brings STEM students to Houston

automation nation

Adolescents from 40-plus countries convened in Houston to put their robotic skills to test at the annual FIRST Championship last week.

The massive robotics championship returned this year to the George R. Brown to conclude the 2021-22 season of the international program, which is aimed at preparing youth ages 12 to 18 for the future through various robotics challenges and competitions.

The theme of this year’s season was FIRST FORWARD, in which students were challenged to think of new ways to overcome transportation challenges, “from the shipment of packages in rural and urban areas, to disaster relief delivery and high-tech space transit,” according to a release from the STEM organization.

The season was sponsored by California-based semiconductor company Qualcomm and was inspired in part by the UN Sustainable Development Goal of building resilient infrastructure, promoting inclusive and sustainable industrialization, and fostering innovation, according to the statement.

“I have met so many great students, volunteers, mentors, alumni, and sponsors who truly embody the FIRST mission and core Values," FIRST CEO Chris Moore says in a statement after the event. "People who strive to be gracious professionals who innovate, compete, and collaborate with equal energy. People who share our common passion for science and technology as a force for good with the world. The rewards of your efforts don’t stop at this event.”

Teams competed in final matches for FIRST's two major competitions.

In the FIRST Robotics Competition, which featured the RAPID REACT Game presented by Boeing, students were required to reimagine the future of his-speed transport with strict rules, limited resources, and time limits and using autonomous and driver-operated skills.

More than 3,200 teams competed during this game throughout the 2002 FIRST season and 454 teams advanced to the championship at the GRB. Team 1629 from Accident, Maryland, took home the top prize in this competition. Other teams from Austin, New York, Hawaii, Mexico, and Turkey were finalists.

In the FIRST Tech Challenge, teams were asked to think like engineers, building robots from reusables kits in the game FREIGHT FRENZY presented by Raytheon Technologies. Thousands of teams competed in this event throughout the season with 160 teams advancing to Houston. Team 8565 (the TechnicBots) from Plano won the top award.

A FIRST LEGO League challenge was also open to younger students, ages 4 to 16, and the championship. Also during the event, actress and director Gillian Jacobs accepted an award for the film "More Than Robots," which follows four teams as they prepare for the 2020 FIRST competition. The film premiered at SXSW last month and is featured on Disney+.

“I named this documentary ‘More Than Robots’ because as you all well know better than anyone, FIRST is about so much more than robots. I learned that it's about teamwork, compassion, friendship, learning new skills, and challenging yourself to do things you never dreamed you were capable of," Jacobs said at the event.

FIRST's 2022-23 season, dubbed FIRST ENERGIZE, will focus on innovative energy solutions. The season opens in May. Learn more here.

The theme of this year’s season was FIRST FORWARD, in which students were challenged to think of new ways to overcome transportation challenges. Photo by Argenis Apolinario/FIRST

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Texas tops ranking of best state for investors in new report

by the numbers

Texas ranks third on a new list of the best states for investors and startups.

Investment platform BrokerChooser weighed five factors to come up with its ranking:

  • 2024 Google search volume for terms related to investing
  • Number of investors
  • Number of businesses receiving investments in 2024
  • Total amount of capital invested in businesses in 2024
  • Percentage change in amount of investment from 2019 to 2024

Based on those figures, provided mostly by Crunchbase, Texas sits at No. 3 on the list, behind No. 1 California and No. 2 New York.

Especially noteworthy for Texas is its investment total for 2024: more than $164.5 billion. From 2019 to 2024, the state saw a 440 percent jump in business investments, according to BrokerChooser. The same percentages are 204 percent for California and 396 percent for New York.

“There is definitely development and diversification in the American investment landscape, with impressive growth in areas that used to fly under the radar,” says Adam Nasli, head analyst at BrokerChooser.

According to Crunchbase, funding for Texas startups is off to a strong start in 2025. In the first three months of this year, venture capital investors poured nearly $2.9 billion into Lone Star State companies, Crunchbase data shows. Crunchbase attributes that healthy dollar amount to “enthusiasm around cybersecurity, defense tech, robotics, and de-extincting mammoths.”

During the first quarter of this year, roughly two-thirds of VC funding in Texas went to just five companies, says Crunchbase. Those companies are Austin-based Apptronik, Austin-based Colossal Biosciences, Dallas-based Island, Austin-based NinjaOne, and Austin-based Saronic.

Autonomous truck company rolls out driverless Houston-Dallas route

up and running

Houston is helping drive the evolution of self-driving freight trucks.

In October, Aurora opened a more than 90,000-square-foot terminal at a Fallbrook Drive logistics hub in northwest Houston to support the launch of its first “lane” for driverless trucks—a Houston-to-Dallas route on the Interstate 45 corridor. Aurora opened its Dallas-area terminal in April and the company began regular driverless customer deliveries between the two Texas cities on April 27.

Close to half of all truck freight in Texas moves along I-45 between Houston and Dallas.

“Now, we are the first company to successfully and safely operate a commercial driverless trucking service on public roads. Riding in the back seat for our inaugural trip was an honor of a lifetime – the Aurora Driver performed perfectly and it’s a moment I’ll never forget,” Chris Urmson, CEO and co-founder of Pittsburgh-based Aurora, said in a news release.

Aurora produces software that controls autonomous vehicles and is known for its flagship product, the Aurora Driver. The software is installed in Volvo and Paccar trucks, the latter of which includes brands like Kenworth and Peterbilt.

Aurora previously hauled more than 75 loads per week under the supervision of vehicle operators from Houston to Dallas and Fort Worth to El Paso for customers in its pilot project, including FedEx, Uber Freight and Werner. To date, it has completed over 1,200 miles without a driver.

The company launched its new Houston to Dallas route with customers Uber Freight and Hirschbach Motor Lines, which ran supervised commercial pilots with Aurora.

“Transforming an old school industry like trucking is never easy, but we can’t ignore the safety and efficiency benefits this technology can deliver. Autonomous trucks aren’t just going to help grow our business – they’re also going to give our drivers better lives by handling the lengthier and less desirable routes,” Richard Stocking, CEO of Hirschbach Motor Lines, added in the statement.

The company plans to expand its service to El Paso and Phoenix by the end of 2025.

“These new, autonomous semis on the I-45 corridor will efficiently move products, create jobs, and help make our roadways safer,” Gov. Greg Abbott added in the release. “Texas offers businesses the freedom to succeed, and the Aurora Driver will further spur economic growth and job creation in Texas. Together through innovation, we will build a stronger, more prosperous Texas for generations.”

In July, Aurora said it raised $820 million in capital to fuel its growth—growth that’s being accompanied by scrutiny.

In light of recent controversies surrounding self-driving vehicles, the International Brotherhood of Teamsters, whose union members include over-the-road truckers, recently sent a letter to Lt. Gov. Dan Patrick calling for a ban on autonomous vehicles in Texas.

“The Teamsters believe that a human operator is needed in every vehicle—and that goes beyond partisan politics,” the letter states. “State legislators have a solemn duty in this matter to keep dangerous autonomous vehicles off our streets and keep Texans safe. Autonomous vehicles are not ready for prime time, and we urge you to act before someone in our community gets killed.”

Houston cell therapy company launches second-phase clinical trial

fighting cancer

A Houston cell therapy company has dosed its first patient in a Phase 2 clinical trial. March Biosciences is testing the efficacy of MB-105, a CD5-targeted CAR-T cell therapy for patients with relapsed or refractory CD5-positive T-cell lymphoma.

Last year, InnovationMap reported that March Biosciences had closed its series A with a $28.4 million raise. Now, the company, co-founded by Sarah Hein, Max Mamonkin and Malcolm Brenner, is ready to enroll a total of 46 patients in its study of people with difficult-to-treat cancer.

The trial will be conducted at cancer centers around the United States, but the first dose took place locally, at The University of Texas MD Anderson Cancer Center. Dr. Swaminathan P. Iyer, a professor in the department of lymphoma/myeloma at MD Anderson, is leading the trial.

“This represents a significant milestone in advancing MB-105 as a potential treatment option for patients with T-cell lymphoma who currently face extremely limited therapeutic choices,” Hein, who serves as CEO, says. “CAR-T therapies have revolutionized the treatment of B-cell lymphomas and leukemias but have not successfully addressed the rarer T-cell lymphomas and leukemias. We are optimistic that this larger trial will further validate MB-105's potential to address the critical unmet needs of these patients and look forward to reporting our first clinical readouts.”

The Phase 1 trial showed promise for MB-105 in terms of both safety and efficacy. That means that potentially concerning side effects, including neurological events and cytokine release above grade 3, were not observed. Those results were published last year, noting lasting remissions.

In January 2025, MB-105 won an orphan drug designation from the FDA. That results in seven years of market exclusivity if the drug is approved, as well as development incentives along the way.

The trial is enrolling its single-arm, two-stage study on ClinicalTrials.gov. For patients with stubborn blood cancers, the drug is providing new hope.

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