Four Houston companies showed the city what they're made of at TMCx's recent Demo Day. Courtesy of TMCx

Earlier this month, 16 medical device companies wrapped up their time at the Texas Medical Center's accelerator program and pitched their companies to fellow health professionals, guests, and more. While each made important connections in the local ecosystem during the program, a quarter of the entrepreneurs had roots in Houston already.

Four of the 16 TMCx09 companies that are headquartered in Houston. They have built solutions within sepsis, surgery, and transplant spaces in health care. Here's a little more about the homegrown companies that pitched at the event.

CorInnova

Photo via corinnova.com

The standard practice for acute heart failure patients is very invasive, says William Altman, CEO of CorInnova.

"The problem with existing devices is that they have invasive blood contact," Altman says. "Problem with that is blood contact is bad. It can cause up to 15 percent rate of stroke, which could kill you, and after five to seven days it provides 10 percent rate of blood destruction and has a 47 percent rate of kidney disfunction."

CorInnova's technology features a device that can be easily inserted through a 1-inch incision, and then be used for increase blood pumping by 50 percent.

"Surgeons tell us this is less invasive than minimally invasive aortic valve replacement, which is a widely done surgery, so this promises widespread adoption for our technology as we get it approved," Altman says.

The human prototype is expected to be ready in two years, with the next year being focused on animal studies. CorInnova is raising $12 million to accomplish its goals.

Ictero Medical

Getty Images

An estimated 10 to 15 percent of the United States population will get a gallstone in their lifetime. Should one of those stones cause trouble or blockages, the only solution is to remove the gallbladder completely through surgery. However, Matthew Nojoomi, CEO and co-founder of Ictero Medical, has another idea.

Ictero Medical has created a minimally invasive treatment that uses cryoablation to defunctionize the gallbladder without having to remove it.

"The CholeSafe System not only treats the source of the disease, but it leverages existing clinical workflows that doctors use to access the gallbladder," says Nojoomi, adding that the process only uses mild station and pain control.

The company expects to get to humans in the next two years, and has launched a financing round.

PATH EX

path ex

Photo via tmc.com

Currently, sepsis is hard to identify in patience. Even if a patient is in a hospital, and that hospital knows the patient has sepsis, the individual still has a 38 percent chance of dying, says Sinead Miller, CEO of PATH EX.

"Right now the problems associated with sepsis are very clear," she says. "It's the leading cause of death in our ICUs, and it's also associated with the highest hospital cost and readmission rates."

PATH EX's technology allows medical professionals to better diagnose and treat sepsis. The PATH EX therapeutic device can be hooked up to a patient and flow his or her blood through the machine to capture bacteria, clean and recirculate the blood, and faster diagnose what sort of bacteria the patient has attracted. The device technology is similar to hemo hemodialysis, Miller explains.

The Houston company, which recently won big at the Ignite Healthcare Network's Fire Pitch Competition, was named an honoree within the Johnson and Johnson Breakthrough Medical Technologies Quickfire Challenge.

The company was recently received clearance from the Food and Drug Administration as a breakthrough device technology. PATH EX closed its $615,000 seed round — with plans for a series A next year — and has received $1 million in SBIR grant funding. The company was founded two years ago, and relocated to call Houston HQ this year.

Volumetric

Jordan Miller/Rice University

Volumetric is banking on their technology being among the inventions that will lead the medical industry into the future. The human tissue-printing technology company has created the 3D printer and the "ink" that can create whole organs for transplant.

"We can create complicated vascular architectures inside of soft water-based gels, in this case, mimicking the structure and function of human lung tissue," says Jordan Miller, CEO. "We can oxygenate red blood cells."

The company is commercializing its technology and has three streams of revenue, which as generated almost $1 million in revenue in Volumetric's second year. The company is also in the process of closing its seed round of fundraising.

Earlier this year, the startup, which works out of Rice University, was featured on the cover of Science magazine.

Ria Health took home first place at the third annual Fire Pitch Competition. Courtesy of Ignite Healthcare

Female founders win big at this Houston health tech pitch competition

pitch perfect

All it takes is a spark for something to ignite, and, at the third annual Fire Pitch Competition by the Ignite Healthcare Network, eight female founders set the stage on fire.

The Fire Pitch Competition first started in 2017 to shine a spotlight on female entrepreneurs in health care. With two successful events under her belt, Ayse McCracken says she knew she could do more to help these women with their business ideas.

"What we discovered is that it's not enough. Startups get to pitch all over, and they want to invest their time wisely," McCracken says. "And it's not enough for the rest of the ecosystem — the customers — and the investors want companies that actually are investable."

So, this summer, McCracken and her team launched a mini accelerator. Thirteen companies participated in the Fire Pitch Customer-Partner Program that matched the companies with potential customers, pilot opportunities, and more. Participating customer organizations have included Humana, Houston Methodist, Memorial Hermann Health System, Gallagher, Texas Children's Hospital, Texas Children's Pediatrics, DePelchin, Next Level Urgent Care, University of Houston College of Medicine, VillageMD, and The Menninger Clinic.

Then, eight finalists of the group were selected to go on to pitch at the Fire Pitch.

Also new this year: More cash prizes. In previous years, the Fire Pitch has around $20,000 on the table. This year's awards doled out $265,000 in cash and investment prizes to six of the eight companies that pitched. The panel of five judges included: Babs Carryer, entrepreneur, and director of Big Idea Center for the University of Pittsburgh's Innovation Institute; Tom Luby, director of the Texas Medical Center Innovation Institute; Kerry Rupp, partner at True Wealth Ventures; Sarah Sossong, principal at Flare Capital Partners; and Andrew Truscott, managing director for Health and Public Service at Accenture.

Here's which companies took home prizes at the 2019 Fire Pitch Competition at the Texas Medical Center's Innovation Institute on October 17.

First place: Ria Health

Ria Health, a San Francisco-based elemental health practice that uses technology and care to provide treatment for Alcohol Use Disorder, was the big winner at the pitch event.

Jen Douglas, CFO of the company, took home first place and the $15,000 prize from Ignite Healthcare Network, but the company also snagged one of the new awards this year. The Texas Medical Center's Innovation Institute awarded Ria Health with a $50,000 investment prize. Ria Health previously participated in the TMCx08 digital health cohort, so the team is very familiar with Houston and the TMC.

Second place: SoundScouts

Sydney, Australia-based SoundScouts is on a mission to help early detection of hearing in school aged children. Carolyn Mee, founder and CEO, represented the company on the stage. She took home second place, which didn't come with an investment or cash prize.

Third place: Savonix

Savonix also didn't walk away with any money, but was recognized by the judges for founder and CEO Mylea Charvet's pitch. The San Francisco-based company is a digital cognitive assessment platform that can easily and cheaply gauge cognitive function.

Texas Halo Fund $100,000 award: PATH EX

The biggest winner of the night based on investment size was Houston-based PATH EX. Led by CEO and co-founder, Sinead Miller, PATH EX has a solution to hospitals' biggest killers: Sepsis. The current TMCx company has a unique pathogen extraction platform that can directly capture and eradicate bacteria.

Miller accepted a new award for this year's program that came with a $100,000 investment from the Texas Halo Fund.

Texas Halo Fund $50,000 award: PyrAmes 

One award wasn't enough for the Texas Halo Fund, which handed out a second new award to Cupertino, California-based PyrAmes. Presented by co-founder and CTO, Xina Quan, the company has created a wearable blood pressure monitor that is reliable and nonintrusive to patients. Quan accepted the $50,000 investment from the fund.

Houston Angel Network $50,000 award: Materna Medical 

San Francisco-base Materna Medical, which created a device to help protect and prepare expecting mothers' pelvic health ahead of childbirth, took home the last investment prize. President and CEO Tracy MacNeal presented the company and accepted the Houston Angel Network's $50,000 award.

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Local arts organizations innovate new ways to get to patrons in Houston and beyond

tech culture

With the city of Houston — and much of the rest of the state — issuing stay-at-home mandates, cultural events and institutions have closed their doors. But, thanks to a little innovation, many are now providing online options.

Arts groups all across Texas are using technology to stream concerts, opera, dance, and even museum tours for free during the coronavirus quarantine, and we're adding more here as they come in.

The Alley Theatre
Patrons can watch a taped performance of the recently canceled 1984. Current ticket holders will be sent a password protected link, and those who would like to still watch are welcome to purchase tickets to gain access to the link.

ROCO
The Houston-based music ensemble has its entire archive of audio and video recordings available online, including a number of its more than 100 world-premiere commissions (and several of which were also included in the Grammy-winning debut album Visions Take Flight).

Ars Lyrica Houston

The early music ensemble has created two new series: Musical Moments and Concerts & Conversations. All of their content will be aired on their social media platforms as well as newsletters and YouTube. They will be posting new content on Mondays and Fridays at 10 am.

Fusebox Festival
The Austin festival originally scheduled for April 15-19 will now go digital; keep an eye on the Facebook page for updates about how to watch and listen.

Black Fret
Celebrate the Austin music scene in a safe and responsible way through a livestream of Austin Love & Lightstream, a local response to the cancelation of SXSW. Closed to the public and taking place on a sterilized outdoor sound stage at Scholz Garten, Austin bands and personalities will be livestreamed six hours a day starting at 4 pm each day, beginning March 17. Viewers can access the Facebook Live stream from the Black Fret website.

Dallas Theater Center

A video was taken of the final dress rehearsal for American Mariachi, a new work by José Cruz Gonzalez about a young woman who forms the first all-female mariachi band in the 1970s, despite disapproving relatives and going against social norms. Patrons are encouraged to pay-what-you-can — starting at $15 — to receive a link and a password to access the recording within 24 hours. Purchasers will have up to two weeks to watch the video. Dallas Theater Center is allowed to sell the video up to the original close date of April 5, 2020; after that, it will be deleted. The number of videos for sale is the same as the number of seats available throughout the run, so patrons are encouraged to buy their "tickets" soon.

Avant Chamber Ballet
Watch the 360-degree world premiere video of 19th Amendment recorded on February 15, 2020, at Moody Performance Hall, spotlighting choreographer Katie Puder and composer Quinn Mason.

American Baroque Opera Company
Enjoy the full-length production of La Serva Padrona by Giovanni Battista Pergolesi.

Dallas Museum of Art
Browse more than 25,000 works of art from all cultures and time periods.

Thin Line Fest and Dallas VideoFest
The Denton-based multidisciplinary festival will be streaming its selection of documentaries online March 25-29, while Dallas VideoFest will host its Alternative Fiction festival April 3-5. Featuring a curated collection of over 50 documentary features and shorts, Thin Line Fest's film division will stream all screenings and Q&A sessions online. Attendees will be able to login at www.thinline.us and then choose which "theater" to stream live. The fest will still hold its Photography & Film Award Ceremony, which will be live-streamed on March 29.

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This article originally ran on CultureMap. Click here for latest update to the story.

If you have a virtual concert or artwork that can be enjoyed from home during this time, email lindseyw@culturemap.com and we'll add you to the ever-growing list.

Texas startup provides COVID-19 home-testing kits at no cost to medical professionals

now testing

The on-again, off-again launch of a coronavirus test from Austin startup Everlywell is on again — sort of.

On March 23, Everlywell was supposed to start shipping 30,000 test kits to U.S. consumers. But before a single test was sent, the U.S. Food and Drug Administration (FDA) blocked the distribution of at-home, self-administered tests from Everlywell and other companies.

Now, the Austin-based company is making the tests available primarily to hospitals and other healthcare providers in the U.S. to meet a "desperate need" for front-line medical professionals to be tested.

"In this evolving health crisis, our highest priority is to ensure that the people at highest risk get the accurate testing and care they need," Michelle Davey, CEO of Wheel Health, says in a March 23 release.

Everlywell says that effective March 23, its test is available only to hospitals and healthcare providers that offer it at no cost to their front-line workers, along with high-risk patients who exhibit coronavirus symptoms.

The company, which produces a variety of at-home lab tests, says its shift from testing of consumers to testing of healthcare workers and high-risk patients is "critically important" to help prevent the spread of what's known as the novel coronavirus. The virus causes the highly contagious and potentially deadly COVID-19 respiratory illness.

It's been a confusing few days since Everlywell announced it was making at-home tests for consumers. On March 20, the FDA said it hadn't authorized at-home, self-administered coronavirus tests from Everlywell or any other company. Three days later, on March 23, Dr. Deborah Birx, coronavirus coordinator for the White House, announced the federal government was clearing the way for self-swabbing coronavirus tests such as those made by Everlywell.

In a series of tweets March 23, Everlywell said it's working with the FDA on "a path forward" for at-home coronavirus tests of consumers.

"The FDA sees the public health value in expanding the availability of COVID-19 testing through safe and accurate tests that may include home collection," the federal agency says, "and we are actively working with test developers in this space."

Everlywell unveiled a $1 million program design to spur labs to speed up development of an at-home coronavirus diagnostic test. Many labs answered the call, allowing Everlywell to set up a coronavirus testing and diagnosis system in a matter of days. For consumers, each test will cost $135. Some providers of health savings accounts and flexible spending accounts will cover these tests.

Eventually, Everlywell wants to ship 250,000 tests per week.

At the same time, another Austin startup, Wheel Health, and Houston-based Microdrop have unveiled a partnership that will provide at-home coronavirus testing administered by licensed healthcare professionals, rather than consumers themselves, and supported by telemedicine technology. The federally approved product is geared toward people at high risk of the coronavirus or people with limited access to testing. For now, it's available only in Texas.

The test from Wheel, a telehealth provider, and Microdrop, a producer of at-home health tests, also costs $135. At the outset, the companies will roll out 5,000 test kits in Texas. After that, they plan to sell 10,000 test kits per week. Nationwide, the companies hope to offer 100,000 test kits per week by the end of April.

"Providing accurate medical guidance to people who are concerned about, or may have been exposed to, COVID-19 will determine the way this pandemic plays out in our country — and collaboration is essential to mobilizing toward this common goal rapidly and efficiently," says Dr. Rafid Fadul, chief medical officer of Wheel.

5 most popular innovation stories in Houston this week

WHAT'S TRENDING

Editor's note: The Houston innovation ecosystem is joining together — virtually — to provide health and resources to those affected by coronavirus — from fashion entrepreneurs designing face masks to 3D printers making personal protective equipment. Both non-COVID-19 news, like Houston's fastest-growing companies and three female innovators to know, and virus-related articles, like a coronavirus tracking tool and resources for startups, trended this week.

3 female Houston innovators to know this week

This week's innovators to know are Allie Danziger, Sylvia Kampshoff, and Brittany Barreto. Courtesy photos

This one's for the ladies. InnovationMap's weekly roundup of innovators to know features three female founders — one is offering her advice on crisis communications, one is innovating the at-home workout, and one is planning on making Houston a city for femtech. Continue reading.

Houston startups turn to digital pitches during coronavirus shutdown

Three Houston-based startups logged on to pitch digitally this week since SXSW was canceled. Getty Images

When SXSW canceled a couple weeks ago, event organizers were sent into a frantic scramble of how to salvage some aspect of their plans while also balancing lost deposits, canceled travel, and so much more.

Three pitch events associated with SXSW and featuring Houston startups went on in a digital capacity, and the social distancing has only just began. Michele Price who leads Startup Grind Houston says the Google-backed organization with locations everywhere is aware of the need for digital networking options. Continue reading.

Houston startup creates COVID-19 tracking tool

A Houston startup has created a web tool for tracking the coronavirus. Pexels

AHouston tech startup has created a web application to give the residents of Harris County all the local information on COVID-19 in the palm of their hand.

Predictive Solutions uses a map tool to indicate the county's nearby testing locations as well as cases that have been self reported in the area through the tool. While not trying to be comprehensive, the website is trying to track trends with the disease. Continue reading.

These are the 5 fastest-growing companies in Houston, according to a recent report

Inc. magazine has identified the fastest-growing companies in Houston. Nick Bee/Pexels

Bellaire-based startup Instafuel is pumping up its revenue in a big way.

Among the 250 fastest-growing companies in Texas identified by Inc. magazine, Instafuel tops the group of businesses based in the Houston metro area and ranks fifth statewide. Houston-based companies make up 68 of the state's fast-growing companies — eight Houston companies make up the top 25 list. Continue reading.

4 resources for Houston startups and small businesses during COVID-19 shutdown

Small businesses and startups are likely to hurt — and hurt bad — from COVID-19's affect on the economy. Here are some resources to get support. Photo by Hero Images

It's a trying time for the world, and Houston small businesses and startups have been put in a difficult spot. From having to work remotely or being forced to close or scale back operations due to mandates from the government, entrepreneurs are having to figure out their new normals.

However, organizations have leapt at the chance to help their fellow Houstonians, and a number of resources have appeared to provide aid to startups, from advice and resources to grants. Continue reading.