With Houston having the fastest growing veteran population in the country, the innovation ecosystem has plenty of veterans turned entrepreneurs. Here are five to know today. Courtesy photos

Over a quarter of a million United States military veterans call Houston home, and that number is growing.

"Houston has the second largest and fastest growing veteran population in the country," says Reda Hicks, a Houston entrepreneur and military spouse herself. "That's a very significant chunk of our city to share an affinity, and it's not something Houston has talked about."

For its large veteran population, Houston was selected in January 2018 as the third location to set up a chapter of Bunker Labs, an acceleration and incubation organization for military-affiliated entrepreneurs.

"Our whole goal is to help empower military-affiliated people to start and grow businesses," says Hicks, who is one of the Houston leads for the program, a lawyer, and the founder of GotSpot Inc.

The program provides resources for veterans, military spouses, or anyone whose lives were affected by a family member in the military. Bunker Labs provides a digital platform for early-stage ideas called Launch Lab that's used by hundreds annually, and also has face-to-face programming through its Veterans in Business program hosted through WeWork.

"It can be the case that veterans can feel siloed, and it's wonderful to have those people around you who can really understand you, but for businesses to grow, they have to really understand the ecosystem they live in," Hicks says.

In honor of Veterans Day, here are a few Houston veteran entrepreneurs to know.

Dyan Gibbens, founder and CEO of Trumbull Unmanned

Dyan Gibbons

Dyan Gibbons translated her Air Force experience with unmanned missiles into a drone services company. Courtesy of Alice

Dyan Gibbons found her dream career in the United States Air Force Academy. She served as engineering acquisitions officer managing stealth nuclear cruise missiles, and even went on to supported Air Force One and Global Hawk UAS engineering and logistics. After her years of service, she transitioned into the reserves, when she discovered she was ineligible to serve again. She went back to the drawing board to recreate herself — this time, as an entrepreneur.

She went into a doctorate program — she already had her MBA — and was close to finishing up when her drone startup took flight. Trumbull Unmanned provides drone services to the energy sector for various purposes. With her experience as a pilot and managing unmanned missiles, she knew the demand for drones was only growing — and, being from Texas, she knew what industry to focus on.

"I wanted to start a company that uses unmanned systems or drones to improve safety and improve the environment and support energy," Gibbons tells InnovationMap in a previous interview.

Nicole Baldwin, chief visionary officer and founder of Biao Skincare

Nicole Baldwin

Photo via toryburchfoundation.org

Before founding her tech-enabled, all-natural skincare line, Biao, Nicole Baldwin served in the Army Civil Affairs Units and was deployed to Bagram, Afghanistan. In honor of Veterans Day, she shared on Facebook an image of her with young girls outside the compound she lived in.

"I often tell people not to thank me for my service, because I don't feel like I should be thanked for doing something I genuinely wanted to do," she writes in the post. "I am grateful every moment of my life knowing that I did all the things in and out of uniform that was felt from the heart."

Baldwin's company, which uses a skin-scanning technology has taken off, and she's participated in Houston's Bunker Labs programming, and she has also been a Tory Burch fellow and appeared on Shark Tank.

Brett Rosenberg, founder of Semper Fi Systems

Photo via LinkedIn.com

Brett Rosenberg spent a few years in the U.S. Air Force before he took his experience from national security to a different kind of security.

Rosenberg's startup is another one utilizing the resources of Houston's Bunker Labs. Semper Fi Systems takes information security experts' knowledge and machine learning solutions to optimize cybersecurity and avoid regulatory financial exclusion.

Nathan Wilkes, CEO of Guidon Holdings

Photo via LinkedIn.com

After four years in the U.S. Army based in Georgia, Nathan Wilkes enrolled in business school at Texas A&M University. It was during the program when he founded Guidon Holdings, a Cypress-based aggregates company that — through screening, washing, separating, clarifying, and much more — can turn a natural resource that is considered waste into something of value.

Wilkes is also a West Point Academy graduate and a member of the 2019 Bunker Labs Houston cohort.

Tim Kopra, partner at Blue Bear Capital

An U.S. Army vet, Tim Kopra spent over 244 days in space, and now he's using his tech background to invest in emerging energy companies. Courtesy of Tim Kopra

Before he spent a career total of 244 days in space, Tim Kopra first served his country in the United States Army. Nowadays, he serves the Houston innovation ecosystem as an investor and adviser to startups and entrepreneurs in the energy tech industry.

As a partner at venture fund Blue Bear Capital, Kopra uses his experience in the Army and in space to do figure out if entrepreneurs have what it takes to go the distance and if their technology is worth investing in.

"On face value, it may sound like an odd match, taking someone with a tech and operational background and putting them in venture, but quite frankly it feels very familiar to me because my career has really been focused on working on complex technology and operations with very small teams," tells InnovationMap in a previous interview. "It's not just a theoretical understanding of the technology, but understanding how to use the technology and how it works."

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”