These three entrepreneurs didn't see their careers coming. Courtesy photos

The career paths of startup or innovation leaders isn't usually a direct path. All three of this week's innovators to know took a roundabout way to their current gigs, which included a leap of faith or two for each of them. If their winding careers are any indication, they've got more exciting leadership ahead.

Youngro Lee, CEO and co-founder of NextSeed

Courtesy of NextSeed

Starting off on Wall Street as a private equity lawyer, Youngro Lee knows money. And he knew when the Jobs Act went into effect several years ago, there was a huge opportunity for companies to raise money from non-accredited individual investors, rather than just the super wealthy private investors. He left his legal career to leverage this new law to start NextSeed, which is a platform for businesses to raise capital for from anybody. Read more here.

Jane Henry, founder and CEO of SeeHerWork

Courtesy of SeeHerWork

Jane Henry watched as her glove flew right off her hand when she was cleaning up after Hurricane Harvey — her house got three feet of mud, and she got the idea for her company. SeeHerWork goes above and beyond the normal "pink it and shrink it" approach to women's workwear. Henry wants to see female workers with better fitting safety gear. Read more here.

Erik Halvorsen, director of the TMC Innovation Institute

Courtesy of TMC

As a kid, Erik Halvorsen wanted to be a doctor — he even took the MCAT and was on track for med school. He decided to look into other avenues that combined his passion for medicine and his entrepreneurial spirit. As director of TMCx, he helps innovative medical technologies become standard practice in hospitals. Read more here.

Editor's note: Halvorsen reportedly left his position at TMC on December 13, 2018.

SeeHerWork launched its line of female-gear in September. Courtesy of SeeHerWork

Houston company aims to equally equip female workers

If the glove doesn't fit

When Jane Henry was working on her home right after Hurricane Harvey — her house got three feet of mud in it — she went to throw a board into the dumpster, and her glove went with it.

Henry says the industry standard is to recommend small and extra-small sizes for women's workwear, but as a ladies large in athletic gloves, Henry still had a good inch or so of glove at her fingertips in her workwear gloves.

"I went upstairs to my sewing room, and I ripped that glove apart and I resewed it to fit my hand," Henry says.

Other women stopped her in hardware stores to ask her about her shoddily sewn glove, and she realized this was the idea for next company. She incorporated SeeHerWork a few months later in January of 2018, and she launched her line of clothing in September, just a year after she had the idea. Based in Houston, SeeHerWork rents warehouse space in Kingwood and has its corporate office in Midtown.

Doing the legwork
Henry is no stranger to the startup game. She created her own consulting company, Xcution Inc., over 16 years ago, but she downsized the company in 2016 when oil prices took a turn. Instead, she went into Rice University's MBA program, where, ultimately, she created a network of associates that would eventually help SeeHerWork grow.

"I've been a serial entrepreneur — been trying to avoid calling myself that," says Henry. "I have two entrepreneurial parents, and I told myself I'd never be an entrepreneur, yet that's what I keep doing."

Through her business expertise and education, she knew she had to start with a one-page business plan for the company. She then took her idea to over 50 focus groups made up of 10 to 20 female workers, safety managers, and procurement managers across industries — transportation, military oil and gas, engineering, and more.

"The response was eerily similar despite the industry," Henry says.

The focus group participants were tired of the "pink it and shrink it" approach to women's workwear and equipment. They felt like if their supplies don't fit, they don't fit. Mentorship opportunities and performance are then subsequently hindered, creating a spiral effect of deterring women from entering the skilled labor workforce. This is a huge problem, considering there's the recent labor shortage with these types of jobs.

She took this information and her first prototypes to a national pitch competition to great success — and a standing ovation. Henry also connected with the Rice Angel Network, Station Houston, The Cannon, and other local innovation-focused entities.

Roadwork ahead
Henry has big plans for SeeHerWork, and is in talks with a few large entities — like the Houston Airport System, Fluor Corp., and Toyota — that have expressed interest in using her gear for their workforce. Henry also wants to expand her products and reach female workers through retail — online and in store.

"Ultimately, SeeHerWork is the Lululemon of workwear," Henry says.

SeeHerWork is focused on keeping women safe, firstly, but also encouraging more women to enter the skilled labor workforce and then work their way up the ladder.

"I don't want people to think of us as a workwear company," Henry says. "I want them to think of us as an inclusion company. Mostly because just like professional sports team, the first step is the right clothing and equipment and the second step is working to be a team and working together."

At your fingertips

Courtesy of SeeHerWork

SeeHerWork has a full line of products, from gloves and bags to safety vests and long-sleeves shirts. She's launching more products — like coveralls, pants, and footwear — soon.

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”