These three entrepreneurs didn't see their careers coming. Courtesy photos

The career paths of startup or innovation leaders isn't usually a direct path. All three of this week's innovators to know took a roundabout way to their current gigs, which included a leap of faith or two for each of them. If their winding careers are any indication, they've got more exciting leadership ahead.

Youngro Lee, CEO and co-founder of NextSeed

Courtesy of NextSeed

Starting off on Wall Street as a private equity lawyer, Youngro Lee knows money. And he knew when the Jobs Act went into effect several years ago, there was a huge opportunity for companies to raise money from non-accredited individual investors, rather than just the super wealthy private investors. He left his legal career to leverage this new law to start NextSeed, which is a platform for businesses to raise capital for from anybody. Read more here.

Jane Henry, founder and CEO of SeeHerWork

Courtesy of SeeHerWork

Jane Henry watched as her glove flew right off her hand when she was cleaning up after Hurricane Harvey — her house got three feet of mud, and she got the idea for her company. SeeHerWork goes above and beyond the normal "pink it and shrink it" approach to women's workwear. Henry wants to see female workers with better fitting safety gear. Read more here.

Erik Halvorsen, director of the TMC Innovation Institute

Courtesy of TMC

As a kid, Erik Halvorsen wanted to be a doctor — he even took the MCAT and was on track for med school. He decided to look into other avenues that combined his passion for medicine and his entrepreneurial spirit. As director of TMCx, he helps innovative medical technologies become standard practice in hospitals. Read more here.

Editor's note: Halvorsen reportedly left his position at TMC on December 13, 2018.

SeeHerWork launched its line of female-gear in September. Courtesy of SeeHerWork

Houston company aims to equally equip female workers

If the glove doesn't fit

When Jane Henry was working on her home right after Hurricane Harvey — her house got three feet of mud in it — she went to throw a board into the dumpster, and her glove went with it.

Henry says the industry standard is to recommend small and extra-small sizes for women's workwear, but as a ladies large in athletic gloves, Henry still had a good inch or so of glove at her fingertips in her workwear gloves.

"I went upstairs to my sewing room, and I ripped that glove apart and I resewed it to fit my hand," Henry says.

Other women stopped her in hardware stores to ask her about her shoddily sewn glove, and she realized this was the idea for next company. She incorporated SeeHerWork a few months later in January of 2018, and she launched her line of clothing in September, just a year after she had the idea. Based in Houston, SeeHerWork rents warehouse space in Kingwood and has its corporate office in Midtown.

Doing the legwork
Henry is no stranger to the startup game. She created her own consulting company, Xcution Inc., over 16 years ago, but she downsized the company in 2016 when oil prices took a turn. Instead, she went into Rice University's MBA program, where, ultimately, she created a network of associates that would eventually help SeeHerWork grow.

"I've been a serial entrepreneur — been trying to avoid calling myself that," says Henry. "I have two entrepreneurial parents, and I told myself I'd never be an entrepreneur, yet that's what I keep doing."

Through her business expertise and education, she knew she had to start with a one-page business plan for the company. She then took her idea to over 50 focus groups made up of 10 to 20 female workers, safety managers, and procurement managers across industries — transportation, military oil and gas, engineering, and more.

"The response was eerily similar despite the industry," Henry says.

The focus group participants were tired of the "pink it and shrink it" approach to women's workwear and equipment. They felt like if their supplies don't fit, they don't fit. Mentorship opportunities and performance are then subsequently hindered, creating a spiral effect of deterring women from entering the skilled labor workforce. This is a huge problem, considering there's the recent labor shortage with these types of jobs.

She took this information and her first prototypes to a national pitch competition to great success — and a standing ovation. Henry also connected with the Rice Angel Network, Station Houston, The Cannon, and other local innovation-focused entities.

Roadwork ahead
Henry has big plans for SeeHerWork, and is in talks with a few large entities — like the Houston Airport System, Fluor Corp., and Toyota — that have expressed interest in using her gear for their workforce. Henry also wants to expand her products and reach female workers through retail — online and in store.

"Ultimately, SeeHerWork is the Lululemon of workwear," Henry says.

SeeHerWork is focused on keeping women safe, firstly, but also encouraging more women to enter the skilled labor workforce and then work their way up the ladder.

"I don't want people to think of us as a workwear company," Henry says. "I want them to think of us as an inclusion company. Mostly because just like professional sports team, the first step is the right clothing and equipment and the second step is working to be a team and working together."

At your fingertips

Courtesy of SeeHerWork

SeeHerWork has a full line of products, from gloves and bags to safety vests and long-sleeves shirts. She's launching more products — like coveralls, pants, and footwear — soon.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."