3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Craig Ceccanti of T-Minus Solutions, Ben Jawdat of Revterra, and Sam Sabbahi of Thermocuff. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from software development to medical devices — recently making headlines in Houston innovation.

Craig Ceccanti, founder of T-Minus Solutions

Craig Ceccanti joins the Houston Innovators Podcast to share what he's learned in his time as an entrepreneur in Houston — and what he's focused on now. Photo courtesy of Craig Ceccanti

When deciding what his passion project would be, Craig Ceccanti looked back at his career. He's always been interested in tech, and grew a small business — Pinot's Palette — to a national franchise. Combining his skills and expertise, he founded T-Minus Solutions to provide entrepreneurs with software consulting and support.

"I love technology and mentoring other entrepreneurs — those were two big factors," Ceccanti says on the Houston Innovators Podcast. "So, starting a consulting agency where we could help startups and mid sized-growth companies build custom software was kind of my perfect unicorn."

He shares more about the his career — from franchising to tech startups — as well as why he's bullish on Houston's business economy on the podcast. Click here to read more and listen to the episode.

Ben Jawdat, CEO and founder of Revterra

Revterra Corp. closed a $6 million series A round led by Equinor Ventures. Photo via LinkedIn

Revterra Corp. has raised $6 million in its series A funding round to propel development of its battery for electric vehicle charging stations. Norway’s Equinor Ventures led the round, with participation from Houston-based SCF Ventures. Previously, Revterra raised nearly $500,000 through a combination of angel investments and a National Science Foundation grant.

“There is an urgent need to reduce carbon emissions globally,” physicist Ben Jawdat, founder and CEO of Revterra, says in a news release. “Our goal at Revterra is to deploy scalable energy storage solutions that facilitate the shift to renewables and EVs while hardening our electric grid. Our systems enable these ambitions while utilizing materials that are recyclable and based on a secure supply chain.” Click here to read more.

Thermocuff has several patents and expects FDA approval at the end of the year. Image via LinkedIn.com

Necessity is the mother of invention — and Sam Sabbahi needed a better way to heat and cool common joint injuries. Sabbahi, a physical therapist by trade, wanted to optimize the traditional way of using ice or heat packs.

“In the field, we were always getting people coming in trying to get us to purchase different medical devices and we wondered, ‘who knows what we need better than we do?’” he says. “A patient asked me ‘what a cold pack does’ and I was thinking in my head that a cold pack just cools the skin to three millimeters depth.”

Sabbahi then developed and invented a portable convection-based heating and cooling system device that could be used for joint injury rehabilitation – the device, dubbed Thermocuff, works much in the way that an air fryer circulates the air to get an even temperature. Click here to read more.

Thermocuff has several patents and expects FDA approval at the end of the year. Image via thermocuff.com

Houston physical therapist designs medical device to better treat joint injuries

hot and cold

A great idea can strike anytime — and for Sam Sabbahi, his concept cooked up six years ago while defrosting a chicken for his son’s dinner.

Sabbahi, a physical therapist by trade, knew there had to be a better way to heat and cool common joint injuries — elevating the traditional way of using ice or heat packs.

“It just clicked for me like a light. You know what people say,” he says. “I just got the idea and thought ‘let’s just try this out and see if it would work.”

The device uses air that goes over top of the thermoelectric unit and cycles in a closed loop system. After some proof concept testing, Sabbahi determined that Thermocuff could cool a joint more than twice as quick as the traditional water circulating system that’s currently available on the market now.

The attached tablet connects through Bluetooth to the unit, which allows the patient to increase or decrease the temperature and adjust for heating or cooling.

“You're trying to get the range of motion back,” he says. “We are addressing pain and range of motion now – trying to reduce the swelling inside of a joint to help in function.”

Because the disposable cuff kind of looks like a Chinese finger trap, Sabbahi says it’s not something that you could just make a mold of and then mass produce.

Fast forward to today, Sabbahi and his team of eight have acquired four patents in the U.S., Canada, China and Japan and are waiting on Europe and Mexico.

The team is working toward FDA approval at the end of the year. Thermocuff also has received a grant from the U.S. military. The device is part of the Southwest Pediatric Medical Device Consortium and received grants for production and research from the Medical Technology Enterprise Consortium, which helps startups in the medical field source grants.

The team is targeting business to business, physical therapy clinics, universities, and sports training associations with the hope to move into the consumer market in the coming years.

“We all have ideas is the hardest part, is trying to figure out how to turn your idea into actual product,” he says. “It's fun, actually — kind of like a big puzzle. You know, you're trying to get all, find all the pieces and put them together.”

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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