This week's roundup of Houston innovators includes Richard Seline of the Resilience Innovation Hub, Joy Jones of Code Wiz, and Joseph Powell of the University of Houston. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from energy transition to resiliency — recently making headlines in Houston innovation.

Richard Seline, co-founder of the Resilience Innovation Hub

Richard Seline joins the Houston Innovators Podcast to explain what all Houston has accomplished within resilience innovation — as well as what's next for the city. Photo courtesy of Richard Seline

For Richard Seline, a major advocate for resilience innovation across Houston and beyond, 2022 was a year of recognizing new technologies and processes — as well as threats — to resiliency.

However, 2023 is the year to implement, he says on this week's episode of the Houston Innovators Podcast.

"What really happened in 2022 is the recognition that there are enough technologies, equipment, and data science tools that if you were to deploy all of that more efficiently and effectively, you're going to get a one-to-six better cost benefit. It's kind of a no-brainer," says Seline, co-founder of the Resilience Innovation Hub, a national organization headquartered in Houston. Read more.

Joy Jones, owner of Code Wiz Oak Forest

Joy Jones is opening her Oak Forest location of Code Wiz later this month. Screenshot via Code Wiz

A Houstonian has switched up her career to focus on inspiring and equipping children STEM-focused skills.

Joy Jones, who has worked for a decade in the corporate world, is starting the new year with a new career — this one focused on her passion of providing more STEM programming access to students. In 2021, she came across Code Wiz, a coding school franchise based in Massachusetts with 19 locations across the country, and met with Ruth Agbaji, CEO and "nerd-in-chief" of the company.

“Talking with Ruth and hearing the story of her mission to touch 1 million kids through Code Wiz, I found exactly what I’ve been looking for, a mission that aligned with mine,” says Jones, in a news release. Read more.

Joseph Powell, director of the University of Houston Energy Transition Institute

Former Shell Chief Scientist Joseph Powell has joined UH to lead its new Energy Transition Institute. Photo via uh.edu

The University of Houston has announced the first leader of its Shell-backed Energy Transition Institute.

Joseph Powell has been named the founding director of the institute, which was founded following a $10 million donation from Shell in spring of last year. Powell is the former chief scientist for Shell and member of the National Academy of Engineering, according to a news release from UH.

“What excites me about my new role is the opportunity to work with students, faculty and industry to make a difference on problems that truly matter," Powell says in the release. "Who could pass that up? Imagine the difficulties that arise when you don’t have access to energy. Read more.

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Austin company to bring AI-powered school to The Woodlands

AI education

Austin-based Alpha School, which operates AI-powered private schools, is opening its first Houston-area location in The Woodlands.

The 8,000-square-foot school, scheduled to be ready for the 2026-27 academic year, initially will serve students in kindergarten through eighth grade. Alpha says the school will offer “open workshop spaces and innovative classrooms that support personalized instruction, core academics, leadership development, and real-world life skills.”

Alpha sets aside two hours each school day for the AI-driven, self-paced study of core subjects like math, reading and science. The rest of each school day consists of life-skills workshops focusing on topics such as leadership and financial literacy.

Alpha’s school in The Woodlands has begun accepting applications for the 2026-27 school year. Annual tuition costs $40,000.

“The Woodlands is one of the most dynamic, forward-thinking communities in Texas, and Alpha is proud to bring

an innovative educational model that complements its strong academic foundation,” says Rachel Goodlad, head

of expansion for Alpha.

Founded in 2014, Alpha School combines adaptive technology-driven instruction with immersive life-skills workshops. Its model emphasizes mastery-based learning in core subjects alongside development of communication, critical thinking, financial literacy and leadership skills. It operates more than 15 schools across the country.

Elsewhere in Texas, Alpha operates schools in Austin, Brownsville, Fort Worth and Plano. Alpha also operates 12 Texas Sports Academy campuses in Texas, including locations in Houston, Pearland and Richmond, along with a NextGen Academy esports school in Austin, a school for gifted students in Georgetown, and lower-cost Nova Academy campuses in Austin and Bastrop.

Alpha has fans and critics. While supporters tout students’ high achievement rates, detractors complain about the high tuition and the AI-influenced depersonalization of education.

“Students and our country need to be in relationship with other human beings,” Randi Weingarten, president of the American Federation of Teachers, a teachers union, tells The New York Times. “When you have a school that is strictly AI, it is violating that core precept of the human endeavor and of education.”

Alpha co-founder MacKenzie Price, a podcaster and social media influencer, doesn’t share Weingarten’s views.

“Parents and teachers: We need to embrace this change,” Price wrote after President Trump signed an executive order promoting AI in schools.

The Times notes that Alpha doesn’t employ AI as a tutor or a supplement. Rather, the newspaper says, AI is “the school’s primary educational driver to move students through academic content.”

Houston researcher secures $1.7M to develop drug for aggressive form of breast cancer

cancer research

A University of Houston researcher has joined a $3.2 million effort to develop a new drug designed to attack a cancer-driving protein commonly found in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is one of the most difficult-to-treat forms of cancer and accounts for 10 percent to 15 percent of all breast cancer cases. The disease gets its name because tumors associated with it test negative for estrogen receptors, progesterone receptors and excess HER2 protein, making it difficult to target. Due to this, TNBC is often treated with general chemotherapy, which can come with negative side effects and drug resistance, according to UH.

UH College of Pharmacy research associate professor Wei Wang is developing a drug that can target the disease more specifically. The drug will target MDM2, a protein often overproduced in TNBC that also contributes to faster tumor growth.

Wang is working on a team led by Wei Li, director of the University of Tennessee Health Science Center College of Pharmacy’s Drug Discovery Center. She has received $1.7 million to support the research.

Wang and UH professor of pharmacology and toxicology Ruiwen Zhang have discovered a compound that can break down MDM2. In early laboratory models, the compound has shown the ability to shrink tumors.

Wang and Zhang will focus on understanding how the treatment works and monitoring its effectiveness in models that closely mirror human disease.

“We will study how the drug targets MDM2 and evaluate the most promising drug candidates to determine effective dosing, understand how the drug behaves in the body, compare it with existing treatments and assess early safety,” Wang said in a news release.

Li’s team at the University of Tennessee will be working on the chemistry and drug design end of the project.

“This work could lead to an entirely new class of therapies for triple-negative breast cancer,” Li added in the release. “We’re hopeful that by directly removing the MDM2 protein from cancer cells, we can help more patients respond to treatment regardless of their tumor type.”