Researchers focused on finding breakthrough technologies also have to deal with some financial red tape — but this UH expert shares why it shouldn't be so daunting. Graphic byMiguel Tovar/University of Houston

Facilities and Administrative costs (F&A), also known as Indirect Costs or IDC, are at the very least misunderstood by researchers. At their worst, they smack of "Big Brother." But F&A costs truly are transparent and nothing to fear (or despise!)

Keeping the lights on

F&A are costs that cannot be uniquely associated with a particular project, but which are nonetheless incurred by the university due to the project.

"If a Principal Investigator (PI) is using on-campus lab space, there is no easy way to determine what the electricity costs or maintenance costs are for the PI's work in the lab on any particular sponsored project," states University of Berkeley's website. "The same problem exists when a piece of equipment is shared by a number of PIs or projects; there is no way to determine the cost attributable to each PI or project."

Unfunded costs

So, we know it isn't easy to calculate how much utilities or janitorial staff cost a university during a sponsored project. But the question persists: do universities "make money" on sponsored research projects?

"No," says Cris Milligan, assistant vice president for research administration at the University of Houston. "Sponsors do not cover the full costs of conducting the research that they support. The unfunded costs are subsidized through university, college, department and faculty contributions."

Where has all the money gone?

F&A costs are a relatively small percentage of the actual costs that a university spends on any given project: for instance, operations and maintenance typically includes the day-to-day activities necessary for the building and its systems and equipment to perform their intended function.

Other monies go toward departmental, sponsored program and general administration costs. Rent needs to be paid on buildings where the research takes place, equipment must be purchased and libraries are maintained.

What goes in, must come out!

Grants can be funded by federal agencies such as the National Institutes of Health, National Science Foundation and the Department of Energy. Other support from companies, foundations and state and local agencies can be pursued by development officers within the colleges.

Recovered F&A costs totaled over $22 million at the University of Houston in 2019. Salaries and benefits, maintenance and operations, travel and business expenses, scholarships and fellowships and lastly capital outlay and contracting of services all take up their fair share of the pie.

"Of course, to be successful in research, PIs need a whole ecosystem of supporting teams, from grant administrators to student services, operations and maintenance to IT. That is what indirect spend is: it relates to every purchase not directly related to the performance of the sponsored research," says Milligan.

Determining Rates

The aim of most every university is full recovery of costs associated with sponsored projects. For instance, the University of Michigan Office of Research states, "Periodically, the Department of Health and Human Services (acting on behalf of the federal government) and the University negotiate an agreement setting forth indirect cost rates for three types of sponsored activities: organized research, instruction and other sponsored activities."

The agreement specifies the rates at which the University can recover its indirect costs associated with projects sponsored by all agencies of the federal government.

Non-federal sponsors (i.e., private sponsors, whether industry or non-profit) are not bound by the terms of OMB Uniform Guidance. These monitored costs are not necessarily guided by the principle of full cost recovery for universities. Your friendly development officer will come in handy when applying for this kind of support; just be clear that the percentage of F&A may be determined on a slightly different scale.

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This article originally appeared on the University of Houston's The Big Idea. Sarah Hill, the author of this piece, is the communications manager for the UH Division of Research.

Houston-area researchers are innovating health and wellness solutions every day — even focusing on non-pandemic-related issues. Photo via Getty Images

3 research innovations in health care to know about in Houston

Research roundup

Researchers across the world are coming up with innovative breakthroughs regarding the coronavirus, but Houston research institutions are also making health and wellness discoveries outside of COVID-19.

Here are three research innovations from Houston scientists from a new cardiac medical device to artificial intelligence-driven predictive technology for cirrhosis patients.

University of Houston's new implantable cardiac device

A UH researcher has designed a flexible device that can collect key information on the human heart. Photo via UH.edu

Cardiac implants and devices like pacemakers are either made with rigid materials that don't do the moving, beating heart any favors or the devices are made with soft materials but sacrifice the quality of information collected.

Researchers led by Cunjiang Yu, a University of Houston professor of mechanical engineering, have reported in Nature Electronics a new rubbery patch designed to collect electrophysiological activity, temperature, heartbeat and other indicators, while being flexible against the heart.

Yu, who is also a principal investigator with the Texas Center for Superconductivity at UH, is the author of the paper says it's the first time a device has both been flexible and accurate. The device, which generates energy from heart beats and doesn't need an external power source, can both collect information from multiple locations on the heart — also known as spatiotemporal mapping — but it can also offer therapeutic benefits such as electrical pacing and thermal ablation, according to the researchers.

"Unlike bioelectronics primarily based on rigid materials with mechanical structures that are stretchable on the macroscopic level, constructing bioelectronics out of materials with moduli matching those of the biological tissues suggests a promising route towards next-generational bioelectronics and biosensors that do not have a hard–soft interface for the heart and other organs," the researchers wrote. "Our rubbery epicardial patch is capable of multiplexed ECG mapping, strain and temperature sensing, electrical pacing, thermal ablation and energy harvesting functions."

Yu has worked on the development of fully rubbery electronics with sensing and other biological capabilities, including for use in robotic hands, skins and other devices.

Baylor College of Medicine's new tool to predict outcomes of cirrhosis

A new statistical model created from artificial intelligence can more accurately predict cirrhosis outcomes. Image via bcm.edu

Currently, the standard of care for cirrhosis patients is limited because physicians can't accurately predict long-term outcomes. But this might be changing thanks to researchers at Baylor College of Medicine, the Michael E. DeBakey Veteran's Affairs Medical Center, and the Center for Innovations in Quality, Effectiveness and Safety (IQuESt).

According to their study are published in JAMA Network Open, the researchers developed a model using a blend of artificial intelligence and traditional statistical methods to produce a score better predicting mortality in cirrhosis.

"When we see patients in the clinic we want to guide them about their long-term outcomes. We wanted to create a tool using machine learning and artificial intelligence to improve the accuracy of prognosis, while maintaining ease of use in the clinic," says Dr. Fasiha Kanwal, the author of the study and professor of medicine and section chief of gastroenterology at Baylor, in a news release.

The scientists used data collected from patients at 130 hospitals and clinics — such as demographics, comorbidities, underlying risk factors and severity of liver disease — as well as comprehensive laboratory tests and medication data to create three different statistical models to predict risk of mortality.

"Machine learning and artificial intelligence is important. It did help us find the right risk factors to use, but we didn't need to use very complex models to get there. We were able to create the CiMM score that will work easier in the clinic and is more predictive of mortality than the existing method," says Kanwal.

The Cirrhosis Mortality Model (CiMM) performed the best and most accurately and was more predictive than the current prognostic model, known as the Model for End Stage Liver Disease with sodium (MELD-Na).

"This tool could make a big difference in providing patient-centered care. The CiMM score could be reassessed every time a patient comes into the clinic," Kanwal said. "Previously, we were unable to predict anything long term. But the CiMM score could give us an idea of how to manage disease for one, two and three years out."

UTHealth's $11 million grant to study multi-drug resistant infection factors

A local multi-institutional research team has received millions to study drug resistance. Photo via Getty Images

A program at the University of Texas Health Science Center at Houston has received an $11 million grant from the National Institute of Allergy and Infectious Diseases to conduct this five-year study on why some critically ill patients develop multidrug-resistant infections.

The Dynamics of Colonization and Infection by Multidrug-Resistant Pathogens in Immunocompromised and Critically Ill Patients will enroll patients at both Memorial Hermann Hospital-Texas Medical Center and The University of Texas MD Anderson Cancer Center.

According to a news release, the research team will seek to explain the microbial, clinical, and antimicrobial resistance factors of three major multidrug-resistant pathogens: Vancomycin-resistant enterococci, Enterobacterales producing extended spectrum β-lactamases/carbapenemases, and Clostridioides difficile. Note: all three pathogens are resistant to antimicrobial treatment such as antibiotics.

"We want to learn more about how these three classes of organisms colonize the gastrointestinal tract of critically ill patients and, eventually, cause infections in these patient populations," says Dr. Cesar A. Arias, the study's principal investigator and professor of infectious disease at McGovern Medical School at UTHealth.

Free mental health care, local COVID-19 testing, and a new great to fund an ongoing study — here's your latest roundup of research news. Image via Getty Images

These are the latest COVID-19-focused research projects happening at Houston institutions

Research roundup

As Houston heads toward the end of summer with no major vaccine or treatment confirmed for COVID-19, local research institutions are still hard at work on various coronavirus-focused innovations.

Free mental health care, local COVID-19 testing, and a new great to fund an ongoing study — here's your latest roundup of research news.

Baylor College of Medicine genomics team to partner for local COVID-19 testing

Houston millionaire to start biotech accelerator for companies focusing on regenerative medicine

Two departments at BCM are working with the county on COVID-19 testing. Getty Images

Two Baylor College of Medicine institutions have teamed up to aid in local COVID-19 testing. The Human Genome Sequencing Center and the Alkek Center for Metagenomics and Microbiome Research — under the leadership of BCM — are partnering with local public health departments to provide polymerase chain reaction testing of COVID-19 samples, according to a news release from BCM.

"We are pleased to work with the outstanding local government groups in this critical public health effort," says Dr. Richard Gibbs, director of the HGSC and Wofford Cain chair and professor of molecular and human genetics at Baylor, in the release. "We are proud of the tireless determination and expertise of our centers and college staff that enabled the rapid development of this robust testing capacity to serve the greater Houston community."

Baylor is among the testing providers for Harris County Public Health, and people can receive testing following a pre-screening questionnaire online.

"We are fortunate to have Baylor College of Medicine as a close partner during the COVID-19 pandemic," says Dr. Umair Shah, executive director of Harris County Public Health, in the release. "This is a challenging time for our community and as the need for increased testing capacity and getting results to residents faster has grown, Baylor has risen to the occasion. There are countless unsung heroes across Harris County who have stepped up to the plate during this pandemic and Baylor College of Medicine is one of them."

COVID-19 testing samples are collected from testing sites and delivered to the Alkek Center. After isolating the virus, genomic material is extracted and sent to the HGSC to quantitative reverse transcription PCR testing. Should the sample's RNA sequence match the virus, then it is positive for COVID-19. The sequencing must test positive three times to be considered overall positive.

Results are returned within 48 hours, and the lab has a capacity of more than 1,000 samples a day. Since May, the team has tested over 30,000 samples.

"We knew we had all the pieces to stand up a testing center fast – large scale clinical sequencing, experts in virology and molecular biology, and a secure way to return results to patients," says Ginger Metcalf, Human Genome Sequencing Center Director of Project Development, in the release. "We are also fortunate to have such great partners at Harris County Public Health, who have done an amazing job of gathering, tracking and delivering samples, especially for the most at-risk members of our community."

National Science Foundation renews Rice University funding amid pandemic

José Onuchic (left) and Peter Wolynes are co-directors of the Center for Theoretical Biological Physics at Rice University. Photo by Jeff Fitlow/Rice University

Rice University's Center for Theoretical Biological Physics has been granted a five-year extension from the National Science Foundation. The grant for $12.9 million will aid in continuing the CTBP's work at the intersection of biology and physics.

The center — which was founded in 2001 at the University of California, San Diego, before moving to Rice in 2011 — is led by Peter Wolynes and José Onuchic.

"We have four major areas at the center," Onuchic says in a news release. "The first is in chromatin theory and modeling, developing the underlying mathematical theory to explain the nucleus of the cell — what Peter calls the 'new nuclear physics.' The second is to test ideas based on the data being created by experimentalists. The third is to understand information processing by gene networks in general, with some applications related to metabolism in cancer. The fourth is to study the cytoskeleton and molecular motors. And the synergy between all of these areas is very important."

Onuchic adds that an upcoming donation of a supercomputer by AMDwill help the center's ongoing research into COVID-19 and four institutions — Rice, Northeastern, Baylor College of Medicine and the University of Houston — are working collaboratively on the study,

"We're all set to move on doing major COVID-related molecular simulations on day one," he says in the release. "The full functioning of a center requires a synergy of participation. Rice is the main player with people from multiple departments, but Baylor, Northeastern and Houston play critical roles."

University of Houston offers free mental health therapy for restaurant workers

Texas restaurant workers can get free mental health care from a UH initiative. Photo via Elle Hughes/Pexels

Through a collaboration with Southern Smoke and Mental Health America of Greater Houston, the University of Houston Clinical Psychology program launched a a free mental health care program for Texas-based food and beverage employees and their children.

"During normal times this is a high stress industry where people work very hard in environments where they are just blowing and going all the time," says John P. Vincent, professor of psychology and director of the UH Center for Forensic Psychology, in a news release.

The program has 14 graduate students who converse with a total of 30 patients and meet weekly with supervisors at UH.

"This opportunity allows our clinical program to reach people in the community who usually don't have access to mental health services," says Carla Sharp, professor of psychology and director of clinical training, in the release.

For restaurant industry workers looking for help and care, they can visit the Mental Health Services page on Southern Smoke's website.

According to Vincent, this is just the beginning.

"We're discussing it," says Vincent in the release. "But as far as I'm concerned it can just keep going and going."

Three health and tech research projects coming out of the Houston area have received grants to continue their work. Getty Images

These 3 Houston-area researchers receive millions in grants for ongoing innovation projects

Research roundup

Money makes the world go 'round, and that's certainly the case with research projects. Grants are what drives research at academic institutions across the country and fuel the next great innovations.

These three projects coming out of Houston-area universities were all granted multimillion-dollar sums in order to continue their health tech, cancer-prevention, and even electric vehicle battery research projects,

University of Houston's $3.2 million grant for its next-generation micro CT scan

Associate professor of physics Mini Das developed a better way to approach CT scans. Photo via uh.edu

In an effort to improve imaging and lower radiation, Mini Das, associate professor of physics at the University of Houston, is moving the needle on introducing the next generation of micro computed tomography (CT) imaging. Das recently received a five-year, $3.2 million grant from the National Institute of Biomedical Imaging and Bioengineering to help move along her work in this field.

"This has the potential to transform the landscape of micro-CT imaging," says Das in a news release.

Das is responsible for developing the theory, instrumentation and algorithms for spectral phase-contrast imaging (PCI) that allows for lower radiation with higher image details, according to the release.

"Current X-ray and CT systems have inherent contrast limitations and dense tissue and cancer can often look similar. Even if you increase the radiation dose, there is a limit to what you can see. In addition, image noise becomes significant when increasing resolution to see fine details, often desirable when scanning small objects," says Das.

Rice University researcher's $2.4 million grant to advance on car batteries

This company’s machine learning programs are making driving in Houston safer — and cheaper

A Rice University scientist is looking to optimize car batteries. Pexels

A Rice University scientist is working toward improving batteries for electric vehicles. Materials scientist Ming Tang and his colleagues — backed by a $2.4 million grant from the United States Advanced Battery Consortium — are working on a project led by Worcester Polytechnic Institute (WPI) in Massachusetts, which will run for 36 months and will focus on low-cost and fast-charging batteries.

"Traditional battery electrodes are prepared by the slurry casting method and usually have uniform porosity throughout the electrode thickness," says Tang, an assistant professor of materials science and nanoengineering, in a news release. "However, our earlier modeling study shows that an electrode could have better rate performance by having two or more layers with different porosities.

"Now with the Missouri University of Science and Technology and WPI developing a new dry printing method for battery electrode fabrication, such layered electrodes can be manufactured relatively easily," he said. Tang's group will use modeling to optimize the structural parameters of multilayer electrodes to guide their fabrication.

The academics will also work with a manufacturer, Microvast, that will assemble large-format pouch cells using layered electrodes and evaluate the electrochemical performance against the program goals, according to the release.

"The public/private partnership is critical to steer the research performed at universities," Tang says. "It helps us understand what matters most to commercial applications and what gaps remain between what we have and what is needed by the market. It also provides valuable feedback and gives the project access to the state-of-the-art commercial battery fabrication and testing capabilities."


Texas A&M faculty member's $5 million grant for cancer research

Tanmay Lele of Texas A&M University is looking at how cells react to mechanical forces in cancer. Photo via tamu.edu

Tanmay Lele, a new faculty member in Texas A&M University's Department of Biomedical Engineering, received a $5 million Recruitment of Established Investigators grant from the Cancer Prevention and Research Institute of Texas (CPRIT) in May to research how cancer progresses.

More specifically, Lele's research focuses on mechanobiology and how cells sense external mechanical forces as well as how they generate mechanical forces, and how these mechanical forces impact cell function, according to a news release from A&M.

"The nuclei in normal tissue have smooth surfaces, but over time the surfaces of cancer nuclei become irregular in shape," Lele says in the release. "Now, why? Nobody really knows. We're still at the tip of the iceberg at trying to figure this problem out. But nuclear abnormalities are ubiquitous and occur in all kinds of cancers — breast, prostate and lung cancers."

Lele will work from two laboratories — one in College Station and one in the Texas A&M Health Science Center's Institute of Biosciences & Technology in Houston. THe will collaborate with Dr. Michael Mancini and Dr. Fabio Stossi from Baylor College of Medicine.

"Like any other basic field, we are trying to make discoveries with the hope that they will have long-term impacts on human health," Lele says.

Rice University identified 15 more pandemic-related research projects to receive support from a new research fund. Getty Images

15 more COVID-19 research projects receive funds from Houston university

coronavirus solutions

Researchers at a Houston institution have been rewarded for their work that focuses on COVID-19 and how it's affected various aspects of life.

Rice University has named its two more rounds of recipients of its COVID-19 Research Fund — an initiative created to support projects that are innovating solutions and services amid the COVID-19 crisis. In April, the COVID-19 Research Fund Oversight and Review Committee — led by engineering professor and special adviser to the provost, Marcia O'Malley — selected four projects led by Rice faculty members across industries from biomedicine to humanities that will receive the first round of funds.

The committee named another round of recipients in May and the third and final round this month. Here are the projects from the last two rounds of grants:

  • Rapid point-of-care device to detect severe cases of COVID-19 by Kevin McHugh and Peter Lillehoj of Rice and Cassian Yee of the University of Texas MD Anderson Cancer Center.
  • A mobile phone-based blood serum test for COVID-19 antibodies by Lillehoj, Wen Hsiang Chen of Baylor College of Medicine and James Le Duc of Galveston National Laboratory. The mobile test would be faster and more precise.
  • A handbook addressing pandemic response initiatives for health officials by Kirsten Ostherr and Lan Li of Rice; Thomas Cole of the McGovern Medical School at the University of Texas Health Science Center, Houston; Robert Peckham of Hong Kong University; and Sanjoy Bhattacharya of York University.
  • A look at COVID-19's effect on vehicle travel and electric power generation and air quality by Daniel Cohan and Daniel Kowal of Rice. Using both on-the-ground and satellite data, the researchers will look at various air pollutants.
  • A study on Harris County residents' compliance to stay-at-home orders by Flavio Cunha, Patricia DeLucia, Fred Oswald, Ekim Cem Muyan and E. Susan Amirian of Rice. The researchers will survey residents — particularly low-socioeconomic populations.
  • A look at how pollution and economics affect each other turing a pandemic-caused crisis by Sylvia Dee, Ted Loch-Temzelides, Caroline Masiello and Mark Torres of Rice. Thanks to stay-at-home initiatives, the study can look at which economic sectors contribute the most to carbon emissions.
  • A study on long-term effects of COVID-19 on human development by Fred Oswald of Rice, Rodica Damian and Tingshu Liu of the University of Houston and Patrick Hill of Washington University. The project looks at the pandemic's affect on social contexts including occupational, educational, community, family, lifestyle, health and financial.
  • A predictive model of Houston's COVID-19 condition by Daniel Kowal, assistant professor of statistics, and Thomas Sun, a graduate student, at Rice. The project will compare Houston to locations that are similar and further along the disease incidence curve.
  • A survey of how stay-at-home orders affected low-income families by Amelyn Ng, Wortham Fellow at Rice Architecture, and Gabriel Vergara of One Architecture and Urbanism. he survey will focus on Houston's Greater Fifth Ward.
  • Research on antibodies for disease prevention by Laura Segatori, associate professor of bioengineering and of chemical and bimolecular engineering and biosciences, and Omid Veiseh, assistant professor of bioengineering, at Rice. The two scientists plan to engineer cell lines for the rapid development of clinically translatable neutralizing antibodies for infection control.
  • An analysis of working conditions amid the pandemic by Danielle King, assistant professor of psychological sciences at Rice. King will look into both employees who can no longer go to the workplace, like teachers, and those required to, like nurses, to see what resources are most effective.
  • An oxygen sensing device by Michael Wong, department chair and a professor of chemical and biomolecular engineering, and Rafael Verduzco, associate professor of chemical and biomolecular engineering, of Rice and John Graf of NASA. The team will continue working on a NASA-designed prototype ventilator for rapid deployment based on an off-the-shelf automotive oxygen sensor.
  • A study on social distancing for musicians by Ashok Veeraraghavan, Robert Yekovich and Ashutosh Sabharwal of Rice and John Mangum of the Houston Symphony. The project will look into airflow of wind instruments using high-speed imaging.
  • Looking into public health initiatives and their use in COVID-19 by Hulya Eraslan, Rossella Calvi, Dibya Deepta Mishra and Ritika Sethi of Rice. The team will look at election data with a goal is to understand the impact of political alignment across levels of government on the effectiveness of its response.
  • Research on optimizing nursing staff schedules by Andrew Schaefer, Illya Hicks and Joseph Huchette of Rice and Nicole Fontenot of Houston Methodist Hospital. Researchers will employ data and technology to improve forecasting demand for nursing staff.
Four COVID-19-focused research projects have been selected by Rice University to receive funding. Photo courtesy of Rice University

Houston university announces first recipients of coronavirus research funding

covid heroes

Rice University has named several Houston researchers as recipients of funding as a part of a new initiative to support projects that are innovating solutions and services amid the COVID-19 crisis.

The university's COVID-19 Research Fund Oversight and Review Committee — led by engineering professor and special adviser to the provost, Marcia O'Malley — selected a few projects led by Rice faculty members across industries from biomedicine to humanities that will receive the first round of funds. However, the application window is ongoing, according to a press release, and additional awards are to be expected.

Here were the first projects and researchers to be selected by the committee.

A low-cost diagnostic tool

Rice researchers Rebecca Richards-Kortum and Kathryn Kundrod of Rice University along with Kathleen Schmeler of the University of Texas MD Anderson Cancer Center have identified a way to create a COVID-19 diagnostic device that costs less than $5,000 and less than $2 per test. It would also take fewer than 30 minutes to diagnose.

The researchers are also working with USAID and industry partners on a plan to scale the test to five countries in Africa. In the future, the device would enable broader SARS-CoV-2 testing locally and in low- and middle-income countries.

Richards-Kortum is a professor of bioengineering and electrical and computer engineering and director of Rice 360˚. Kundrod is a graduate student in bioengineering. Schmeler is a professor in the department of gynecologic oncology and reproductive medicine at MD Anderson.

A protective rubber harness to be worn over a face mask 

Jacob Robinson and Caleb Kemere, associate professors at Rice, along with Sahil Kuldip of MD Anderson, have discovered a low-cost, easy-to-manufacture rubber harness to be worn over surgical or cloth masks in order seal the masks. The seal would better prevent small airborne particles from getting around the masks.

Robinson is in Rice's electrical and computer engineering and bioengineering departments, while Kemere specializes in electrical and computer engineering. Kuldip is an assistant professor of plastic surgery at MD Anderson.

Wastewater monitoring for coronavirus contamination 

Rice researchers Lauren Stadler, Katherine Ensor and Loren Hopkins are working with the Houston Health Department and Houston Water on a plan to collect wastewater samples from local treatment plants to monitor for the presence of COVID-19.

With most people asymptomatic or experience only mild symptoms of COVID-19, the researchers are looking into the virus's presence in wastewater in order to track community infection.

Stadler, an assistant professor of civil and environmental engineering, and Ensor, the Noah G. Harding Professor of Statistics, are working with Hopkins, who is a professor in practice of statistics and chief environmental science officer for the Houston Health Department.

The identification of safe and healthy voting procedures 

Five Rice researchers — Robert Stein, Philip Kortum, Claudia Ziegler Acemyan, Daniel Wallach and Elizabeth Vann — are looking into steps Harris County can take to ensure that in-person voting is safe and keeps participants healthy. Through surveys with citizens, the team will help election officials survey both voters and poll workers on their voting preferences and concerns.

The research team spans campus departments: Stein is the Lena Gohlman Fox Professor of Political Science, Kortum is an associate professor of psychological sciences, Acemyan is an adjunct assistant professor of psychological sciences, Wallach is a professor of computer science and of electrical and computer engineering, and Vann is the director of programs and partnerships at the Center for Civic Leadership

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Houston family's $20M donation drives neurodegeneration research

big impact

Neurodegeneration is one of the cruelest ways to age, but one Houston family is sharing its wealth to invigorate research with the goal of eradicating diseases like Alzheimer’s.

This month, Laurence Belfer announced that his family, led by oil tycoon Robert Belfer, had donated an additional $20 million to the Belfer Neurodegeneration Consortium, a multi-institutional initiative that targets the study and treatment of Alzheimer’s disease.

This latest sum brings the family’s donations to BNDC to $53.5 million over a little more than a decade. The Belfer family’s recent donation will be matched by institutional philanthropic efforts, meaning BNDC will actually be $40 million richer.

BNDC was formed in 2012 to help scientists gain stronger awareness of neurodegenerative disease biology and its potential treatments. It incorporates not only The University of Texas MD Anderson Cancer Center, but also Baylor College of Medicine, Massachusetts Institute of Technology (MIT) and Icahn School of Medicine at Mount Sinai.

It is the BNDC’s lofty objective to develop five new drugs for Alzheimer’s disease and related disorders over the next 10 years, with two treatments to demonstrate clinical efficacy.

“Our goal is ambitious, but having access to the vast clinical trial expertise at MD Anderson ensures our therapeutics can improve the lives of patients everywhere,” BNDC Executive Director Jim Ray says in a press release. “The key elements for success are in place: a powerful research model, a winning collaborative team and a robust translational pipeline, all in the right place at the right time.”

It may seem out of place that this research is happening at MD Anderson, but scientists are delving into the intersection between cancer and neurological disease through the hospital’s Cancer Neuroscience Program.

“Since the consortium was formed, we have made tremendous progress in our understanding of the molecular and genetic basis of neurodegenerative diseases and in translating those findings into effective targeted drugs and diagnostics for patients,” Ray continues. “Yet, we still have more work to do. Alzheimer's disease is already the most expensive disease in the United States. As our population continues to age, addressing quality-of-life issues and other challenges of treating and living with age-associated diseases must become a priority.”

And for the magnanimous Belfer family, it already is.

3 Houston innovators to know this week

who's who

Editor's note: Every week, I introduce you to a handful of Houston innovators to know recently making headlines with news of innovative technology, investment activity, and more. This week's batch includes a podcast with the founder of a new venture firm, a former astronaut and recent award recipient, and a health care innovator with fresh funding.

Zach Ellis, founder and managing partner of South Loop Ventures

Zach Ellis explains on the Houston Innovators Podcast that South Loop Ventures plans to invest in promising companies from across the country and bring them into Houston's ecosystem to grow and scale. Photo via LinkedIn

Houston has a lot of the right ingredients for commercialization and scaling up companies, so when Zach Ellis moved to town to stand up a venture capital firm that made investments in diverse founders, he decided to go about it in an innovative way.

South Loop Ventures, which Ellis launched two years ago, invests in pre-seed and seed-stage startups across health care, climatetech, aerospace, sports, and fintech. While the first handful of investments, which have already been made, are into Houston-based companies, Ellis explains on the Houston Innovators Podcast that the firm plans to invest in promising companies from across the country and bring them into Houston's ecosystem to grow and scale.

"Any investor wants to feel like they are looking at the best possible investment opportunities in which to deploy capital," Ellis says on the show. "So that's reason No. 1 to cast your net as widely as possible.

"At the same time, you want to give any investment that you make greatest chances of success," he continues. "The biggest factor of success outside of the team and the capital you give them, is the customers that they can call upon. In bringing targeted companies to Houston or connecting them with Houston, you introduce the opportunity for them to achieve rapid scale and work with world-class partners very efficiently." Read more.


Toby R. Hamilton, founder and CEO of Hamilton Health Box

Dr. Toby Hamilton has secured $10 million to grow his company. Photo via tmc.edu

A Houston company that is working on a value-based model for primary care has fresh funding to support its mission.

Hamilton Health Box announced the completion of a $10 million series A funding round led by 1588 Ventures with participation from Memorial Hermann Health System, Impact Ventures by Johnson & Johnson Foundation, Texas Medical Center Venture Fund, and the Sullivan Brothers.

The company, founded in 2019 by Dr. Toby R. Hamilton, will use the funding to fuel its expansion into rural areas to help assist those living in Health Professional Shortage Areas, or HPSAs. Read more.

Ellen Ochoa, former astronaut and center director at the NASA's Johnson Space Center

Ellen Ochoa was recognized for her leadership at NASA Johnson and for being the first Hispanic woman in space. Photo via NASA

Two astronauts recently received Presidential Medals of Freedom from President Joe Biden for their leadership in space.

Ellen Ochoa, the former center director and astronaut at the NASA's Johnson Space Center in Houston, and Jane Rigby, senior project scientist for NASA’s James Webb Space Telescope, were honored at the White House on May 3.

Ochoa spent 30 years with NASA, which included being the 11th director of JSC, deputy center director of JSC, and director of Flight Crew Operations. She served on the nine-day STS-56 mission aboard the space shuttle Discovery in 1993, and became the first Hispanic woman in space. She flew four more times to space with STS-66, STS-96, STS-110, and more.

“I’m so grateful for all my amazing NASA colleagues who shared my career journey with me,” Ochoa says in a NASA news release. Read more.

Houston health care institutions receive $22M to attract top recruits

coming to Hou

Houston’s Baylor College of Medicine has received a total of $12 million in grants from the Cancer Prevention & Research Institute of Texas to attract two prominent researchers.

The two grants, which are $6 million each, are earmarked for recruitment of Thomas Milner and Radek Skoda. The Cancer Prevention & Research Institute of Texas (CPRIT) announced the grants May 14.

Milner, an expert in photomedicine for surgery and diagnostics, is a professor of surgery and biomedical engineering at the Beckman Laser Institute & Medical Clinic at the University of California, Irvine and the university’s Chao Family Comprehensive Cancer Center

In 2013, Milner was named Inventor of the Year by the University of Texas at Austin. At the time, he was a professor of biomedical engineering at UT. One of his major achievements is co-development of the MasSpec Pen, a handheld device that identifies cancerous tissue within 10 seconds during surgical procedures.

Skoda is a professor of molecular medicine in the Department of Biomedicine at the University of Basel and the University Hospital Basel, both in Switzerland. He specializes in developing treatments for myeloproliferative neoplasms, which are a group of blood diseases including leukemia.

Other recruitment grants provided by the institute to Houston-area organizations are:

  • $4 million for recruitment of Susan Bullman to the University of Texas M.D. Anderson Cancer Center. She was an assistant professor at Seattle’s Fred Hutchinson Cancer Center, where she studied the connection between microbes and cancer.
  • $4 million for recruitment of Oren Rom to the University of Texas M.D. Anderson Cancer Center. Rom is an assistant professor of pathology and translational pathobiology at Louisiana State University Shreveport.
  • Nearly $2 million for recruitment of Lauren Hagler to conduct RNA cancer biology at Texas A&M University. She is a postdoctoral scholar in biochemistry at Stanford University.

The institute also awarded grants to five companies in the Houston area:

  • $4.7 million to 7 Hills Pharma for development of immunotherapies to treat cancer and prevent infectious diseases.
  • $4.5 million to Indapta Therapeutics for the Phase 1 trial of a cell therapy for treatment of multiple myeloma and non-Hodgkin’s lymphoma.
  • $2.75 million to Bectas Therapeutics for development of antibodies and biomarkers to overcome a type of resistance T-cell checkpoint therapy.
  • $2.69 million to MS Pen Technologies for development of technology that differentiates between normal tissue and cancerous tissue during surgery.
  • $2.58 million to Crossbridge Bio for development of an antibody-drug combination to treat certain solid tumors.