3 Houston innovators to know this week

who's who

This week's roundup of Houston innovators includes Paul Cherukuri of Rice University, Berkley Luck of Milkify, and Reid Wiseman of NASA. Photos courtesy

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to three local innovators across industries — from space to molecular biology — recently making headlines in Houston innovation.


Paul Cherukuri, vice president of innovation at Rice University

This Houston innovator is set on bringing more innovation off campus and into the world

Paul Cherukuri, vice president of innovation at Rice University, joins the Houston Innovators Podcast. Photo via Rice.edu

Rice University was founded on a mission of an "unfettered pursuit of knowledge," says Paul Cherukuri, the inaugural vice president for innovation at Rice University. And that goal is specifically designed to be "for the greater good of society," — especially in Houston.

"Rice is right in the middle of one of the greatest cities in the world," Cherukuri says on this week's episode of the Houston Innovators Podcast. "Houston is special on so many levels that it's ridiculous that no one outside of Houston seems to get that. ... We have a moral responsibility as Rice to do more for this city and the country."

Among the top action items on this overarching mission Rice is on is ensuring that the Rice University's inventions and research that have the potential to make the world a better place are able to commercialize to deliver on that impact. Read more.

Berkley Luck, founder and COO of Milkify

Houston-based Milkify pitched their freeze-drying breast milk concept on Shark Tank. Photo via LinkedIn

Houston startup Milkify pitched on ABC’s “Shark Tank” on Friday, April 7. Pedro Silva, co-founder and CEO, created Milkify along with his wife, Berkley Luck, PhD, in 2019. Today, Luck is a mom, COO, and a molecular biologist, but she had the idea for the company back in grad school. A coworker was struggling with pumping breast milk “lugging the pump back to work,” as Luck puts it.

Luck was studying probiotics at the time and was using a freeze-dryer in her work. The problem inspired her to create a process of freeze-drying breast milk that is now patent pending. The trademarked process is centered around SafeDry, special freeze-drying pouches.

“The breast milk never makes contact with our equipment,” Luck explains. The powdered milk is transferred directly from the bag in which it’s freeze-dried to the final packaging under sterile conditions. The result is not only shelf-stable, but keeps for at least three years, exponentially longer than frozen milk. Read more.

Reid Wiseman, NASA's Artemis II commander

Meet Commander Reid Wiseman, the responsible for the success of the Artemis II mission once it launches. Photo courtesy of NASA

Last week, NASA announced its four-person crew for Artemis II, the first manned mission to the moon in over 50 years.

While the announcement in itself — with the first person of color and first woman to head to the moon — is history making, Commander Reid Wiseman says there's still a lot of work to be done.

"When you look at our crew, our next step is to learn about the spacecraft that will be operating in deep space. It's a very capable, very redundant, robust machine. So we have to get in the classroom, we've got to learn about all the capabilities, but we also have to get out and see the workforce," Reid says. Read more.

Meet Commander Reid Wiseman, the responsible for the success of the Artemis II mission once it launches. Photo courtesy of NASA

Meet the Houstonian commanding NASA's historic return to the moon

Q&A

The world now knows the names of the four Houston-based astronauts who will launch in the first crewed moon mission in 50 years. NASA's Artemis II will see the first woman and person of color helming a lunar voyage, a first since the agency's history.

Astronaut Christina Hammock Koch, herself part of a history-making astronaut class and first all-female spacewalk— will join Victor Glover — the first person of color heading to the moon. Rookie Canadian astronaut Jeremy Hansen rounds out the crew with Commander Reid Wiseman.

Building on the unmanned Artemis I mission to the moon that concluded in December, Artemis II is slated to launch around November 2024, per NASA. In a scene familiar to space fans, the Artemis II crew will deploy inside the cozy Orion spacecraft that will sit atop the Space Launch System (SLS) rocket from Kennedy Space Center in Florida.

Artemis II's crew will spend some 10 days in orbit and even venture farther than the 1.4 million miles logged by Artemis I, adding to the historic nature of the journey. After moon orbit, the spacecraft will return to Earth for splashdown and recovery — always a celebrated moment after the highly anticipated takeoff.

Data gathered from Artemis II will pad information from Artemis I in effort to create a permanent moon outpost. On the moon, crews will learn how to live and work away from Earth, which will pave the way for the eventual mission to Mars. A planned Artemis III mission may launch in 2025 or '26, per NASA, which picks up from the last trip, Apollo 17 in 1972. The Artemis III mission, NASA promises, will see the first woman and person of color on the moon.

CultureMap caught up with a very busy Wiseman, who is now responsible for the success of the Artemis II mission once it launches. Hailing from Baltimore, Maryland, the 47-year-old earned his master's degree from Johns Hopkins University and is a decorated naval aviator, serving in the Middle East as a fighter pilot. The Artemis II mission commander completed a 165-day trip to the International Space Station in 2014 and was most recently chief of the astronaut office, per his bio. He has two sons with wife Carol, who passed away from cancer in May 2020.

The Artemis II crew was announced earlier this week. Photo courtesy of NASA

CultureMap: Congratulations, Commander. As Artemis II's leader, you are joining lunar mission commander names like the first man on the moon, Neil Armstrong, and Apollo 13's Jim Lovell. Do you allow yourself to think like that?

Reid Wiseman: Thank you. I do not allow myself to think like that. I think if you get to meet this crew — Victor Glover, Christina Koch, Jeremy Hanson — I really think we would say we want this to be so routine. We want Artemis II to be so successful and so long term that people completely forget about us. We're just that initial little stepping stone. I really hope that's the case. I am flying with an incredible group of heroes and I can't wait to go get this job done.

CM: What does it mean, as mission commander, to have the safety — and the lives — of these amazing and history-making astronauts in your hands once you launch?

RW: It means everything to me.

CM: You and the crew are so incredibly accomplished in your own individual spaces. Yet when you get to NASA — as Christina Koch once told me — you're kind of learning anew. What are you learning now?

RW: When you look at our crew, our next step is to learn about the spacecraft that will be operating in deep space. It's a very capable, very redundant, robust machine. So we have to get in the classroom, we've got to learn about all the capabilities, but we also have to get out and see the workforce.

We'll be the first humans to ever ride on this vehicle. And there's a lot of unknowns. We have a lot of systems to test. Uh One was very successful.

We need to hit the books and then we need to get in the sim [simulator], we need to practice simulations, learn how we all operate together as a team and then learn about the failure modes of the vehicle, how we can work around to keep ourselves safe and keep the mission going. And then after that, I think we'll be ready to look at Florida — and head out to the moon.

CM: Do prior lunar flight commanders and icons — like Armstrong and Lovell — serve as role models? How about the astronaut network in general?

RW: I think we look at those legends as their heroes, but they are also friends. Those folks really gave their lives to our nation and when they landed on the moon for the first time. But the amazing part for us as younger astronauts is they're still heavily engaged in everything we do right now.

I talked to Jack [Harrrison] Schmitt just a few months ago. Dave Scott still comes by every time he can to talk about geologic processes on the moon. Like these guys are our friends. It's really, really neat.

Neil Armstrong was amazing. John Young was incredible — he led our office for a number of years. Those guys are heroes to us for sure. When you look at who has taught me the most about being an astronaut, it's the folks I flew with on my first mission. It's the folks that I've worked with in the astronaut office. Now, I've seen some exceptional examples of leadership and followership and both skills are critical to be an astronaut.

CM: You learned you'll be headed to the moon — the dream adventure of billions all over the world— in the most office kind of way, we hear.

RW: Uh yeah, we all goofed up [laughs]. We missed the meeting. The chief astronaut put a placeholder on my schedule for a different topic. I was actually at a doctor's office and the doctor just walked in. So, I missed the first part of the meeting and I was able to use Microsoft Teams and dial in towards the end.

When the camera popped up, I saw the chief astronaut — who I expected to see for my meeting. But then, I also saw Norm Knight, our director of flight operations. I also saw Victor Glover and Christina Koch. And I was like, ‘oh boy, I think I just missed something big here.’

CM: Well, we've all missed meetings. But this was big — like headed to the moon big.

RW: Right [laughs]. It turned out that both Christina and Victor also missed the beginning of the meeting. So, we all showed up in perfect harmony.

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This article originally ran on CultureMap.

The history-making team was announced at Ellington Field near Johnson Space Center in Houston. Photo via LinkedIn

NASA names four astronauts heading to the moon at Houston event

ready for liftoff

NASA and the Canadian Space Agency announced the four astronauts who will be onboard the Artemis II mission around the moon yesterday at an event at Ellington Field near NASA’s Johnson Space Center in Houston.

The 10-day mission is slated to put the first woman and the first person of color on the moon.

“For the first time in more than 50 years, these individuals – the Artemis II crew – will be the first humans to fly to the vicinity of the Moon. Among the crew are the first woman, first person of color, and first Canadian on a lunar mission, and all four astronauts will represent the best of humanity as they explore for the benefit of all,” says JSC Director Vanessa Wyche. “This mission paves the way for the expansion of human deep space exploration and presents new opportunities for scientific discoveries, commercial, industry and academic partnerships and the Artemis Generation.”

The crew assignments include:

  • Commander Reid Wiseman, who has logged more than 165 days in space in two trips. He previously served as a flight engineer aboard the International Station and most recently served as chief of the Astronaut Office from December 2020 until November 2022.
  • Pilot Victor Glover, who served as pilot on NASA’s SpaceX Crew-1 mission in 2021. This will be his second trip to space.
  • Mission Specialist 1 Christina Hammock Koch, who set the record for longest single spaceflight by a woman with a total of 328 days in space and participated in the first all-female spacewalks. This will be her second flight into space.
  • Mission Specialist 2 Jeremy Hansen, representing Canada. Hansen is a colonel in the Canadian Armed Forces and former fighter pilot and has served as Capcom in NASA's Mission Control Center at Johnson Space Center. He was the first Canadian to lead a NASA astronaut class. This will be his first flight into space.

Meet the four astronauts who will return humans to the moon. Photo courtesy of NASA

“NASA astronauts Reid Wiseman, Victor Glover, and Christina Hammock Koch, and CSA astronaut Jeremy Hansen, each has their own story, but, together, they represent our creed: E pluribus unum – out of many, one," NASA Administrator Bill Nelson said. "Together, we are ushering in a new era of exploration for a new generation of star sailors and dreamers–the Artemis Generation.”

Artemis II is slated to build upon the uncrewed Artemis I mission that was completed in December. The crew will be NASA's first to aboard the agency's deep space rocket, the Space Launch System, and Orion spacecraft. They will test the spacecrafts' systems to ensure they operate as planned for humans in deep space before setting course for the moon.

NASA's Artemis program collaborates with commercial and international partners with the goal of establishing a long-term presence on the moon. Lessons learned from the missions are planned to be used to send the first astronauts to Mars.

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Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

Houston booms as No. 2 U.S. metro for new home construction

Construction Boom

Driven by population growth, more residential rooftops are popping up across Houston and the rest of Texas than anywhere else in America.

Using data from the U.S. Census Bureau and Zillow, Construction Coverage found 65,747 new residential units were authorized in greater Houston in 2024. That figure landed Houston in second place among major metro areas for the total number of housing permits, including those for single-family homes, apartments, and condos.

Just ahead of Houston was the Dallas-Fort Worth Metroplex, which took first place with 71,788 residential permits approved in 2024. In third place was the country’s largest metro, New York City (57,929 permits).Elsewhere in Texas, the Austin metro ranked sixth (32,294 permits), and the San Antonio metro ranked 20th (14,857 permits).

Construction Coverage also sorted major metro areas based on the number of new housing units authorized per 1,000 existing homes in 2024. Raleigh, North Carolina, held the No. 1 spot (28.8 permits per 1,000 existing homes), followed by Austin at No. 2 (28.6), DFW at No. 3 (22.2), Houston at No. 4 (21.6), and San Antonio at No. 13 (13.6).

A Newsweek analysis of Census Bureau data shows building permits for 225,756 new residential units were approved in 2024 in Texas — a trend fueled largely by activity in DFW, Houston, Austin, and San Antonio. That put Texas atop the list of states building the most residential units for the year.

Through the first eight months of last year, 145,901 permits for new residential units were approved in Texas, according to Census Bureau data. That’s nearly 80,000 permits shy of the 2024 total.

Among the states, Construction Coverage ranks Texas sixth for the number of residential building permits approved in 2024 per 1,000 existing homes (17.9).

Extra housing is being built in Texas to meet demand spurred by population growth. From April 2020 to July 2024, the state’s population increased 7.3 percent, the Census Bureau says.

While builders are busy constructing new housing in Texas, they’re not necessarily profiting a lot from homebuilding activity.

“Market conditions remain challenging, with two-thirds of builders reporting they are offering incentives to move buyers off the fence,” North Carolina homebuilder Buddy Hughes, chairman of the National Association of Home Builders, said in a December news release. “Meanwhile, builders are contending with rising material and labor prices, as tariffs are having serious repercussions on construction costs.”

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