Play it back: Looking at UH's commitment to supporting Houston innovation

Houston innovators podcast episode 242

Revisit this conversation with UH's innovation leader. Photo via UH.edu

Editor's note: On this summer holiday week, we’re revisiting a conversation with Ramanan Krishnamoorti, the vice president of energy and innovation at the University of Houston, that originally ran in May of 2023.

Last week, the University of Houston announced a new partnership with the Houston Angel Network to activate more investors with deep connections to school.

The new partnership will be based in UH's Tech Bridge, a near-campus hub that aims to support tech commercialization, industrial partnerships, and startup development.

“Investors play a vital role in the startup ecosystem and this initiative gives our alumni a rapid path to becoming angels. Our vision is to activate more investors with deep connections to UH who support world-class innovation in our community and beyond,” says Ramanan Krishnamoorti, the university’s vice president for energy and innovation, in a news release.

Last year, Krishnamoorti joined the Houston Innovators Podcast to share an overview of the university's commitment to implementing initiatives that serve Houston's innovation community, including announcing plans to develop a new central campus hub for innovation.

"What we really need at the university today is to bring innovation — which tech transfer is a piece of — and connect that to real-world challenges to deliver what the world needs, which is talented folks delivering new innovative, entrepreneurial, or intrapreneurial programs," Krishnamoorti says the episode.

For Krishnamoorti, so much of what is happening on campus is directly in line with what's happening city wide in Houston. There's a need to encourage more innovation and entrepreneurship, he says, and Houston already has what it takes to do it.

"As a city, we're known to solve problems," he says on the show. "We don't talk about things here, we get stuff done. That's been the calling card for the city."

Listen to the re-published episode of the conversation below and tune in next week for a new episode of the podcast.

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Haleh Ardebili (left) has been appointed as assistant vice president of Entrepreneurship and Startup Ecosystem, and Michael Harold as assistant vice president for Intellectual Property and Industrial Engagements at the University of Houston. Photo via UH

University of Houston names new leaders within innovation, tech

appointments made

Two professors have assumed new leadership roles in the University of Houston’s Office of Technology, Transfer, and Innovation.

Haleh Ardebili, the Kamel Salama Endowed Professor of Mechanical Engineering, has been named assistant vice president of entrepreneurship and startup ecosystem. Michael Harold, Cullen Engineering Professor of Chemical and Biomolecular Engineering, has been named assistant vice president for intellectual property and industrial engagements.

Ardebili and Harold “are both tested leaders in their respective areas —they are already contributing to our rich academic environment with their knowledge, expertise and commitment to innovation,” says Ramanan Krishnamoorti, vice president for energy and innovation at UH, in a statement. “Having them helm our growing team will help UH continue its culture of innovation and contribution to society.”

In her new role, Ardebili will oversee entrepreneurship and startup efforts at UH. She will direct the startup and entrepreneurship staff within the Office of Technology, Transfer, and Innovation (OTTI).

Ardebili, who joined the university in 2004, previously was director of the Cullen College of Engineering’s Innovation and Entrepreneurship Initiative.

In his new role, Harold will lead the university’s technology transfer activities. He will direct the OTTI licensing and IP management staff.

Harold worked at DuPont in various technical and managerial positions between 1993 and 2000. He joined UH in 2000 as chair of the Department of Chemical Engineering. He served as chair until 2008 and again from 2013 to 2020.

“Both positions will play integral roles in increasing faculty engagement, facilitating innovations from research labs to market, and enhancing collaboration with internal and external stakeholders. These appointments underscore UH’s commitment to driving innovation, economic development, and industry partnerships,” the university says in the release.

The projects are among 16 other early-stage research projects at U.S. colleges and universities to receive a total of $17.4 million from the DOE's Office of Fossil Energy and Carbon Management. Photo courtesy of University of Houston

3 UH projects land $17.4M in DOE funding for early-stage research

follow the money

Three projects from the University of Houston have been awarded funds from the U.S. Department of Energy for research on decarbonization and emissions.

“These three projects show the relevance and quality of the research at UH and our commitment to making a meaningful impact by addressing society’s needs and challenges by doing critical work that impacts the real world,” Ramanan Krishnamoorti, vice president for energy and innovation at UH, says in a statement. “The success of these project could attract investment, create jobs, produce clean energy, save costs, reduce carbon emissions, and benefit not only the greater Houston area, but the Gulf Coast and beyond.”

The projects were selected under FECM’s University Training and Research program, which aims to support "research and development opportunities for traditionally underrepresented communities and tap into the innovative and diverse thinking of student researchers," according to an announcement from the DOE.

Here are the projects from UH and their funding amounts:

A Comprehensive Roadmap for Repurposing Offshore Infrastructure for Clean Energy Projects in the Gulf of Mexico, $749,992 — Led by Ram Seetharam, UH Energy program officer, this project looks at ways to prolong the life of platforms, wells and pipelines in the Gulf Coast and will create a plan "covering technical, social, and regulatory aspects, as well as available resources," according to UH.

Houston Hydrogen Transportation Pilot, $750,000— Led by Christine Ehlig-Economides, Hugh Roy and Lillie Cranz Cullen, and managed by Joe Powell, this project will demonstrate the potential for a hydrogen refueling pilot in Houston. The first phase will create a system to optimize hydrogen and the second will create a workforce training network. The project is in collaboration with Prairie View A&M University.

Synergizing Minority-Serving Institution Partnerships for Carbon-Negative Geologic Hydrogen Production, $1.5 million — This project is in collaboration with Stanford Doerr School of Sustainability and Texas Tech. The project will create a visiting scholars program for students from UH and TTU, who will spend one month per year at Stanford for three years. While in the program, students will focus on creating carbon-negative hydrogen from rocks beneath the Earth's surface. Kyung Jae Lee, associate professor in the Department of Petroleum Engineering at UH, is working alongside colleagues at TTU and Stanford on this project.

Other projects in the group come from the University of Texas at El Paso, New Mexico Institute of Mining and Technology, Tennessee State University, North Carolina Agricultural and Technical State University, Duke University and more.

Last year the DOE also awarded $2 million to Harris and Montgomery counties for projects that improve energy efficiency and infrastructure in the region. Click here to read about those projects.

The DOE also granted more than $10 million in funding to four carbon capture projects with ties to Houston last summer.

The ultimate who's who of 2023 — these are our favorite Houston Innovators Podcast guests of last year. Photos courtesy

Editor's Picks: 7 favorite Houston Innovator Podcast episodes of 2023

year in review

Editor's note: In 2023, I recorded 50 episodes of the Houston Innovators Podcast — a weekly discussion with a Houston innovator, startup founder, investor, and more. I've rounded up seven podcast episodes that stood out for me looking back at the year of recordings. Scroll through to see whom I selected and stream their individual episodes, and tune into the last episode of the year where I explain why I enjoyed each conversation.

Episode 174 - Rolling out nationwide - Mike Francis and Carrie Horazeck of NanoTech

NanoTech's Chief Commercial Officer Carrie Horazeck and Co-Founder and CEO Mike Francis join the Houston Innovators Podcast to celebrate the nationwide launch of their roof coating product. Photo via LinkedIn

A Houston startup is celebrating its nationwide launch of its flagship product that coats roofs to reduce energy waste.

NanoTech's Nano Shield Cool Roof Coat is a unique product that can be added onto roofs to reduce energy waste on buildings. Co-founder and CEO Mike Francis and Chief Commercial Officer Carrie Horazeck joined the Houston Innovators Podcast to share more details about the product.

"It's just a coating that can go on top of existing structure — any type of commercial roof," Horazeck says on the show. "We have a pretty good amount of data from 2022 showcasing that we can reduce HVAC consumption within the building by about 30 to 40 percent.

"Our clients really see a immediate benefit in their energy bill, and, of course, if you reduce the HVAC consumption, that automatically translates to a decrease in your scope one emissions," she continues. Continue reading.

Episode 181 - Gearing up for high-speed global travel - Sassie Duggleby of Venus Aerospace

Sarah "Sassie" Duggleby of Venus Aerospace joins the Houston Innovators Podcast this week. Photo courtesy of Venus

Sarah "Sassie" Duggleby is on a mission to get people home in time for dinner — whether they are traveling around the world or working for her business. That's why she founded Venus Aerospace, which is developing hypersonic space planes. It's also why she relocated the company from the West Coast to Houston.

"We knew we had to find a location where we could test our engine and still be home for dinner," Duggleby says on this week's episode of the Houston Innovators Podcast. "Our company vision is 'home for dinner.' We want to fly you across the globe and have you home for dinner. And, if you work for us, we want you home for dinner."

Venus's technology enables this revolutionary travel through its supersonic combustion engine — more akin to a rocket's engine than an airplane's — that allows for travel at a higher elevation, she explains on the show. Jet engines rely on air outside of the aircraft to combust, and rocket engines work with a system that supplies air internally. And, as Duggleby explains, the engine can go further with the same amount of fuel, so it's a more sustainable way of traveling too. Continue reading.

Episode 182 - Stopping neurodegenerative diseases in their tracks - Howard Berman of Coya Therapeutics

For Howard Berman, CEO and co-founder of Coya Therapeutics, commercializing his company is personal. Photo courtesy of Coya

When Howard Berman sought out renowned Houston Methodist researcher and neurologist Dr. Stanley Appel, he was looking for treatment for his father, who was suffering from dementia. He wasn't looking for a job, but Dr. Appel had other ideas and asked Berman to meet with him.

"I was interested in what I could do for my dad," Berman says on the Houston Innovators Podcast, explaining how he took the meeting with Dr. Appel, who then presented him with some of his research. "By slide five my jaw had hit the ground.

"He had shown that he could stop the progression in one of his early trials of ALS," Berman says.

Not too long after that meeting, Berman, who founded digital health platform imaware, joined Dr. Appel to lead commercialization of Coya Therapeutics, a biotech startup that raised over $20 million in venture funding before going public a few months ago. Continue reading.

Episode 187 - Bridging the gap to innovation - Ramanan Krishnamoorti of University of Houston

Ramanan Krishnamoorti, vice president of energy and innovation at the University of Houston, joins the Houston Innovators Podcast to talk about the university's dedication to helping the city become an innovative force. Photo via UH.edu

Ramanan Krishnamoorti has had a varied career in academia, from an engineering professor to nanotech research. While he never made the transition from researcher to entrepreneur, he managed to snag a CEO title at the university about a decade ago: Chief energy officer.

Since then his role has expanded to include advancing UH's innovation of all kinds — from health tech to the arts — as vice president of energy and innovation at UH. In his role, he oversees the UH Technology Bridge, a lab and coworking space for tenants just a short drive away from UH's main campus, as well as future plans, like a new central campus hub for innovation that's in its early stages of development.

Episode 193 - Innovating in the East End - Erik Ibarra of Magnolia Fund and ORDRS

Erik Ibarra's latest venture is to give agency to residents in the neighborhood he grew up in. Photo courtesy

Innovation isn't always tinkering with tech or programming software, although serial entrepreneur Erik Ibarra knows that world well. Sometimes it's about rethinking how a community improves and develops without doing the residents a disservice.

That's why Ibarra started Magnolia Fund, a mission-driven investment fund dedicated to enriching the East End community and preserving the neighborhood's culture and history. Ibarra, who has lived in the area the majority of his life, says on the Houston Innovators Podcast, that he's looking to turn residents into investors.

"Our investors from the neighborhood, today they walk around and look at their house and say, 'I own that,' and that's great," Ibarra says. "In the future, our investors should be able to say that, and then point to a building and say, 'I own a portion of that building too. And I helped that small business over there.'" Continue reading.

Episode 198 - The undeniable impact of AI - Anshumali Shrivastava of ThirdAI CorpEpisode 198 - The undeniable impact of AI - Anshumali Shrivastava of ThirdAI Corp

Anshumali Shrivastava joins the Houston Innovators Podcast to share the revolutionary work ThirdAI is doing for artificial intelligence. Photo via rice.edu

Anshumali Shrivastava's career has evolved alongside the rise of artificial intelligence. Now, he believes his company represents the future of the industry's widespread implementation.

Shrivastava, who's also a professor at Rice University, founded ThirdAI, pronounced "third eye," in 2021 to democratize artificial intelligence through software innovations. As Shrivastava explains on the Houston Innovators Podcast, AI processes have historically been run on larger, less accessible computing hardware. ThirdAI's tools are able to run on a regular central processing unit, or CPU, rather than the more powerful graphics processing unit, or GPU.

"We focus on the problems that people are facing in the current AI ecosystem," Shrivastava says on the podcast. "Right now, if you are to build some of the large-language models and (linear programming) models, you need a lot of computing power, dedicated engineers to move it, and, even if you are using fully managed services, it's costly and there are a lot of privacy implications because you have to move data around." Continue reading.

Episode 212 - The 'frivolous' lawsuit over DEI funding - Carolyn Rodz and Elizabeth Gore of Hello Alice

Hello Alice Co-Founders Carolyn Rodz and Elizabeth Gore join the Houston Innovators Podcast to discuss the lawsuit they're facing. Photo courtesy Cayce Clifford/Hello Alice

For years, Hello Alice has been helping small businesses across the country get equitable access to funding and support. Now, the Houston tech company is facing its own obstacle: An affirmative action lawsuit.

"I don't think in a million years that we ever expected anything like this," Elizabeth Gore, co-founder and president of Hello Alice, says on the Houston Innovators Podcast. "There's surprise, then there's fear, and then there's anger. But now on the other side of it, we're emboldened, confident, and more passionate than ever."

America First Legal's lawsuit against Hello Alice and its partner, Progressive Insurance, alleges that their program to award10 $25,000 grants to Black-owned small businesses constitutes racial discrimination. AFL was founded by former Trump Administration adviser Stephen Miller and features a handful of other former White House officials on its board. Continue reading.

The University of Houston has teamed up with Chevron for a new fellowship program, which just announced its first class. Photo courtesy of UH.edu

University of Houston reveals inaugural cohort of energy research fellows

powered by chevron

The University of Houston has named eight graduate students to its first-ever cohort of UH-Chevron Energy Graduate Fellows.

The PhD and doctoral students will each receive a one-year $12,000 fellowship, along with mentoring from experts at UH and Chevron.

“The UH-Chevron Energy Fellowship program is an exciting opportunity for our graduate students to research the many critical areas that impact the energy industry, our communities and our global competitiveness,” Ramanan Krishnamoorti UH's Vice President for Energy and Innovation says in a statement.

“Today’s students not only recognize the importance of energy, but they are actively driving the push for affordable, reliable, sustainable and secure energy and making choices that clearly indicate that they are meaningfully contributing to the change,” he continues.

Their work focuses on energy-related research in fields ranging from public policy to geophysics and math. The fellowship is funded by Chevron.

“We love that Chevron is sponsoring this group of fellows because it’s a fantastic way for us to get involved with the students who are working on some of the biggest problems we’ll face in society,” Chevron Technology Ventures President Jim Gable adds.

The 2023 UH-Chevron Energy Graduate Fellows are:

The PhD and doctoral students will each receive a one-year $12,000 fellowship, along with mentoring from experts at UH and Chevron. Photo via UH.edu

Kripa Adhikari, a Ph.D. student in the Department of Civil and Environmental Engineering in the Cullen College of Engineering. Her work focuses on thermal regulation in enhanced geothermal systems. She currently works under the mentorship of Professor Kalyana Babu Nakshatrala and previously worked as a civil engineer with the Nepal Reconstruction Authority.

Aparajita Datta, a researcher at UH Energy and a Ph.D. candidate in the Department of Political Science. Her work focuses on the federal Low-Income Home Energy Assistance Program (LIHEAP), a redistributive welfare policy designed to help households pay their energy bills. She holds a bachelor’s degree in computer science and engineering from the University of Petroleum and Energy Studies in India, and master’s degrees in energy management and public policy from UH. She also recently worked on a paper for UH about transportation emissions.

Chirag Goel, a Ph.D. student in materials science and engineering at UH. His work focuses on using High Temperature Superconductors (HTS) to optimize manufacturing processes, which he says can help achieve carbon-free economies by 2050. The work has uses in renewable energy generation, electric power transmission and advanced scientific applications.

Meghana Idamakanti, a third-year Ph.D. student in the William A. Brookshire Department of Chemical and Biomolecular Engineering. Her work focuses on using electrically heated steam methane for cleaner hydrogen production. She received her bachelor’s degree in chemical engineering from Jawaharlal Nehru Technological University in India in 2020 and previously worked as a process engineering intern at Glochem Industries in India.

Erin Picton, an environmental engineering Ph.D. student in the Shaffer Lab at UH. Her work focuses on ways to increase the sustainability of lithium processing and reducing wasted water and energy. “I love the idea of taking waste and turning it into value,” she said in a statement. She has previously worked in collaboration with MIT and Greentown Labs, as chief sustainability officer of a Houston-based desalination startup; and as a visiting graduate researcher at Argonne National Lab and at INSA in Lyon, France.

Mohamad Sarhan, a Ph.D. student and a teaching assistant in the Department of Petroleum Engineering. His work focuses on seasonal hydrogen storage and the stability of storage candidates during hydrogen cycling. He holds a bachelor’s degree and a master’s degree in petroleum engineering from Cairo University

Swapnil Sharma, a Ph.D. student in the William A. Brookshire Department of Chemical and Biomolecular Engineering. His work has been funded by the Department of Energy and focuses on thermal modeling of large-scale liquid hydrogen storage tanks. He works with Professor Vemuri Balakotaiah. He holds bachelor's and master’s degrees in chemical engineering from the Indian Institute of Technology (IIT). He also developed one of the world’s highest fiber-count optical fiber cables while working in India and founded CovRelief, which helped millions of Indians find resources about hospital beds, oxygen suppliers and more during the pandemic.

Larkin Spires, who's working on her doctoral research in the Department of Earth and Atmospheric Sciences in the College of Natural Sciences and Mathematics. Her work focuses on a semi-empirical Brown and Korringa model for fluid substitution and the ties between geophysics and mathematics. She works under Professor John Castagna and holds a bachelor’s degree in math from Louisiana State University and a master’s degree in geophysics from UH.

Earlier this month Evolve Houston also announced its first-ever cohort of 13 microgrant recipients, whose work aims to make EVs and charging infrastructure more accessible in some of the city's more underserved neighborhoods.

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This article originally ran on EnergyCapital.

A new program launched by two UH-based organizations will help early-stage startups commercialize, apply for grants, and more. Photo via UH.edu

University of Houston launches new collaborative program for startups in Houston, Gulf Coast Region

ready to grow

Two University of Houston organizations have partnered up to further support early-stage startups in the Gulf Coast Region.

The university announced this month that its UH Technology Bridge and the UH Texas Gulf Coast Small Business Development Center are now accepting applications for a new, collaborative program that will help innovators and entrepreneurs develop a pitch or commercialization plan. The program will also guide participants in applying for Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) grants and other investments.

Applications are open to those with the university and across the region.

"We are excited to partner with the University of Houston Technology Bridge to provide this valuable support to early-tech startups in the Texas Gulf Coast region," Steven Lawrence, director of the UH Texas Gulf Coast SBDC Network, says in a statement. "Our program is designed to help innovators take their ideas to the next level and prepare for success in the marketplace."

"Our goal is to help innovators turn their ideas into successful businesses, and this partnership will help us achieve that goal," Tanu Chatterji, Associate Director of Startup Development at UH, echoes in the news release.

The UH Texas Gulf Coast SBDC Network is one of 14 SBDCs in the Texas Gulf Coast Region that's part of UH's C.T. Bauer College of Business and funded in part by the U.S. Small Business Administration. The centers provide no-cost and affordable business training and advising.

The UH Tech Bridge focuses on providing research and development space to UH-affiliated startups and entrepreneurs. The 15-building complex and its 31,000 square feet of incubator space houses more than 20 small companies and startups that provide internship and learning opportunities for UH students, along with several federally funded research centers and institutes.

Earlier this year, the Tech Bridge received a $2.875 million grant from the U.S. Department of Housing and Urban Development. The grant is slated to benefit the UH Industry & International Innovation Hub and will establish The Deck Innovation & Coworking Center.

Ramanan Krishnamoorti, the vice president of energy and innovation at the University of Houston who oversees the UH Technology Bridge, spoke with the Houston Innovators Podcast earlier this summer about UH's plans to build a central campus hub for innovation and the need to encourage more innovation and entrepreneurship.

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Rice launches 'brain economy' initiative at World Economic Forum

brain health

Rice University has launched an initiative that will position “brain capital” as a key asset in the 21st century.

Rice rolled out the Global Brain Economy Initiative on Jan. 21 at the World Economic Forum in Davos, Switzerland.

“This initiative positions brain capital, or brain health and brain skills, at the forefront of global economic development, particularly in the age of artificial intelligence,” the university said in a news release.

The Rice-based initiative, whose partners are the University of Texas Medical Branch in Galveston and the Davos Alzheimer’s Collaborative, aligns with a recent World Economic Forum and McKinsey Health Institute report titled “The Human Advantage: Stronger Brains in the Age of AI,” co-authored by Rice researcher Harris Eyre. Eyre is leading the initiative.

“With an aging population and the rapid transformation of work and society driven by AI, the urgency has never been greater to focus on brain health and build adaptable human skills—both to support people and communities and to ensure long-term economic stability,” says Amy Dittmar, a Rice provost and executive vice president for academic affairs.

This initiative works closely with the recently launched Rice Brain Institute.

In its first year, the initiative will establish a global brain research agenda, piloting brain economy strategies in certain regions, and introducing a framework to guide financial backers and leaders. It will also advocate for public policies tied to the brain economy.

The report from the McKinsey Health Institute and World Economic Forum estimates that advancements in brain health could generate $6.2 trillion in economic gains by 2050.

“Stronger brains build stronger societies,” Eyre says. “When we invest in brain health and brain skills, we contribute to long-term growth, resilience, and shared prosperity.”

Rice Alliance and the Ion leader Brad Burke to retire this summer

lasting legacy

Brad Burke—a Rice University associate vice president who leads the Ion District’s Rice Alliance for Technology and Entrepreneurship and is a prominent figure in Houston’s startup community—is retiring this summer after a 25-year career at the university.

Burke will remain at the Rice Alliance as an adviser until his retirement on June 30.

“Brad’s impact on Rice extends far beyond any single program or initiative. He grew the Rice Alliance from a promising campus initiative into one of the most respected university-based entrepreneurship platforms,” Rice President Reginald DesRoches said in a news release.

During Burke’s tenure, the Rice Business School went from unranked in entrepreneurship to The Princeton Review’s No. 1 graduate entrepreneurship program for the past seven years and a top 20 entrepreneurship program in U.S. News & World Report’s rankings for the past 14 years.

“Brad didn’t just build programs — he built an ecosystem, a culture, and a reputation for Rice that now resonates around the world,” said Peter Rodriguez, dean of the business school. “Through his vision and steady leadership, Rice became a place where founders are taken seriously, ideas are rigorously supported, and entrepreneurship is embedded in the fabric of the university.”

One of Burke’s notable achievements at Rice is the creation of the Rice Business Plan Competition. During his tenure, the competition has grown from nine student teams competing for $10,000 into the world’s largest intercollegiate competition for student-led startups. Today, the annual competition welcomes 42 student-led startups that vie for more than $1 million in prizes.

Away from Rice, Burke has played a key role in cultivating entrepreneurship in the energy sector: He helped establish the Energy Tech Venture Forum along with Houston Energy and Climate Startup Week.

Furthermore, Burke co-founded the Texas University Network for Innovation and Entrepreneurship in 2008 to bolster the entrepreneurship programs at every university in Texas. In 2016, the Rice Alliance assumed leadership of the Global Consortium of Entrepreneurship Centers.

In 2023, Burke received the Trailblazer Award at the 2023 Houston Innovation Awards and was recognized by the Deshpande Foundation for his contributions to innovation and entrepreneurship in higher education.

“Working with an amazing team to build the entrepreneurial ecosystem at Rice, in Houston, and beyond has been the privilege of my career,” Burke said in the release. “It has been extremely gratifying to hear entrepreneurs say our efforts changed their lives, while bringing new innovations to market. The organization is well-positioned to help drive exponential growth across startups, investors, and the entrepreneurial ecosystem.”

Starting April 15, John “JR” Reale Jr. will serve as interim associate vice president at Rice and executive director of the Rice Alliance. He is managing director of the alliance and co-founder of Station Houston, beginning April 15. Reale is co-founder of the Station Houston startup hub and a startup investor and was also recently named director for startups and investor engagement for the Ion.

“The Rice Alliance has always been about helping founders gain advantages to realize their visions,” Reale said. “Under Brad’s leadership, the Rice Alliance has become a globally recognized platform that is grounded in trust and drives transformational founder outcomes. My commitment is to honor what Brad has built and led while continuing to serve our team and community, deepen relationships and deliver impact.”

Burke joined the Houston Innovators Podcast back in 2022. Listen to the full interview here.

Houston team uses CPRIT funding to develop nanodrug for cancer immunotherapy

cancer research

With a relative five-year survival rate of 50 percent, pancreatic cancer is a diagnosis nobody wants. At 60 percent, the prognosis for lung cancer isn’t much rosier. That’s because both cancers contain regulatory B cells (Bregs), which block the body’s natural immunity, making it harder to fight the enemies within.

Newly popular immunotherapies in a category known as STING agonists may stimulate natural cancer defenses. However, they can also increase Bregs while simultaneously causing significant side effects. But Wei Gao, assistant professor of pharmacology at the University of Houston College of Pharmacy, may have a solution to that conundrum.

Gao and her team have developed Nano-273, a dual-function drug, packaged in an albumin-based particle, that boosts the immune system to help it better fight pancreatic and lung cancers. Gao’s lab recently received a $900,000 grant from the Cancer Prevention and Research Institute of Texas (CPRIT) to aid in fueling her research into the nanodrug.

“Nano-273 both activates STING and blocks PI3Kγ—a pathway that drives Breg expansion, while albumin nanoparticles help deliver the drug directly to immune cells, reducing unwanted side effects,” Gao said in a press release. “This approach reduces harmful Bregs while boosting immune cells that attack cancer, leading to stronger and more targeted anti-tumor responses.”

In studies using models of both pancreatic and lung cancers, Nano-273 has shown great promise with low toxicity. Its best results thus far have involved using the drug in combination with immunotherapy or chemotherapy.

With the CPRIT funds, Gao and her team will be able to charge closer to clinical use with a series of important steps. Those include continuing to test Nano-273 alongside other drugs, including immune checkpoint inhibitors. Safety studies will follow, but with future patients in mind, Gao will also work toward improving her drug’s production, making sure that it’s safe and high-quality every time, so that it is eventually ready for trials.

Gao added: “If successful, this project could lead to a new type of immunotherapy that offers lasting tumor control and improved survival for patients with pancreatic and lung cancers, two diseases that urgently need better treatments."

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