Houston research team invents cost-saving innovation for automated drug dosing

groundbreaking tech

Rice University synthetic biologists created a device to demonstrate a new method that could slash the costs of creating wearable monitors for precision, automated drug dosing of chemotherapies and other drugs. Photo by Jeff Fitlow/Rice University

A team of Rice University researchers has built a technology that uses a $20 blood-glucose sensor to potentially automate dosing of practically any drug.

In a paper recently published in Nature, researchers in Caroline Ajo-Franklin’s lab shared that they were able to modify the inexpensive piece of equipment to detect afimoxifene, an estrogen inhibitor that is naturally produced by a patient’s body after taking the chemotherapy drug tamoxifen.

“The dream is to have technology similar to what’s available today for monitoring and treating variations in blood glucose, and have that be true for basically any drug,” said Ajo-Franklin, a bioscientist, cancer researcher and director of the Rice Synthetic Biology Institute in a press release from Rice University. “Millions of people use blood-glucose monitors every day. If we can use that same basic technology to monitor other drugs and biomarkers, we could move away from the one-size-fits-all dosing regimes that we’re stuck with today.”

The lead author of the study was postdoctoral research associate Rong Cai. She and the team tested more than 400 modified versions of the electron-releasing proteins (what creates the current that glucose monitors detect) until they found a version that reacted with afimoxifene. Essentially, they built an afimoxifene sensor that could reliably detect the presence of the drug.

According to Ajo-Franklin, her team is currently at work testing ways to identify drugs other than afimoxifene.

In a press release, Cai said, “The glucometer is the part that’s so well-developed. While our target is different, it’s just a matter of engineering and changing the protein on the inside. On the outside, everything will still be the same. You can still do the test with a strip or on your arm.”

Better still, she went on to say that because the signal is electrical, it can be sent to a phone or computer to be read and stored.

“That’s the part, that marriage between electricity and biology, that is very attractive,” Cai said.

Rice University synthetic biologists (from right to left) Caroline Ajo-Franklin, Chiagoziem Ngwadom and Rong Cai worked with Rice engineer Rafael Verduzco (left) to create and demonstrate a method of universalizing blood-glucose detection technology as a way of rapidly and inexpensively creating sensors that can monitor the dosing of chemotherapies and other drugs in real time. Photo by Jeff Fitlow/Rice University

This week's roundup of Houston innovators includes Tatiana Fofanova of Koda Health, Rafael Verduzco of Rice University, and Sujata “Su” Bajaj and Dakisha Allen of Yuvo Health. Photos courtesy

4 Houston innovators to know this week

who's who

Editor's note: In this week's roundup of Houston innovators to know, I'm introducing you to four local innovators across industries — from digital health to research — recently making headlines in Houston innovation.

Tatiana Fofanova, co-founder and CEO of Koda Health

Tatiana Fofanova, co-founder and CEO of Koda, joined the Houston Innovators Podcast to discuss her company's growth. Image via LinkedIn

It's Tatiana Fofanova's goal to have Koda Health's platform — a B2B Enterprise SaaS solution that guides patients through the process of proactive healthcare planning and document authentication — active in all 50 states by the end of the first quarter of 2023. She's already halfway there.

The tech platform allows for patients and their providers to get on the same page for their care. Fofanova describes the platform as similar to TurboTax — users answer a series of questions and the program provides a care plan then shared with the patient's doctors. This greatly simplifies — and democratizes — the process for patients and providers both.

"The standard of care for advanced care planning has traditionally been left to patients to do on their own — with estate planning attorney or through a direct-to-consumer solution," Fofanova says on this week's episode of the Houston Innovators Podcast. Read more.

Rafael Verduzco, associate chair and a professor of chemical and biomolecular engineering and of materials science and nanoengineering at Rice University

Rafael Verduzco is leading the research and development. Photo by Jeff Fitlow/Rice University

A team of researchers from Rice University have received a $2 million grant to develop a unique technology that speeds up the analysis of wastewater for viruses from hours to seconds. The team is based out of Rice’s George R. Brown School of Engineering and led by Rafael Verduzco, associate chair and a professor of chemical and biomolecular engineering and of materials science and nanoengineering. The four-year grant from the National Science Foundation will support the development of the technology, which includes wastewater-testing bioelectric sensors that deliver immediate notice of presence of viruses like SARS-CoV-2, which causes COVID-19, according to a news release from Rice.

“Monitoring wastewater for COVID has been pretty effective as a way to get an idea of where we are as a population,” says Verduzco in the release. “But the way it’s done is you have to sample it, you have to do a PCR test and there’s a delay. Our selling point was to get real-time, continuous monitoring to see just how much of this virus is in the wastewater.” Read more.

Sujata “Su” Bajaj as CTO and Dakisha Allen as head of product of Yuvo Health

Two Houstonians have been named to the executive board of a New York startup. Photos courtesy of Yuvo Health

ANew York City-based, tech-enabled health administrative and managed care solution has announced the latest addition to its C-suite — including two executives based in Houston.

Yuvo Health, which provides community health centers a tech platform for managing care, announced the appointment of Sujata “Su” Bajaj as CTO and Dakisha Allen as head of product. Additionally, the startup named New York-based Anthony Thompson as head of development and Ishaan Jalan as chief of staff.

“It is with tremendous pride and excitement that we announce the growth of our leadership team, especially as it is less than six months since our last corporate expansion,” says Cesar Herrera, CEO and co-founder of Yuvo Health. Read more.

A team out of the engineering school at Rice University has created a technology for real-time wastewater monitoring. Photo via rice.edu

Houston research team snags $2M grant for virus sensing tech

money moves

A team of researchers from Rice University have received a $2 million grant to develop a unique technology that speeds up the analysis of wastewater for viruses from hours to seconds.

The team is based out of Rice’s George R. Brown School of Engineering and led by Rafael Verduzco, associate chair and a professor of chemical and biomolecular engineering and of materials science and nanoengineering. The four-year grant from the National Science Foundation will support the development of the technology, which includes wastewater-testing bioelectric sensors that deliver immediate notice of presence of viruses like SARS-CoV-2, which causes COVID-19, according to a news release from Rice.

The research project — with its partners at the Houston Health Department — have already developed water testing procedures and have analyzed samples from locations around the city. The current process includes taking samples and transferring them to Rice for analysis, but the new technology would be able to monitor systems onsite and instantly. The parties involved with this work are also collaborating with the Centers for Disease Control and Prevention Center of Excellence for wastewater epidemiology that was announced in August.

The grant's co-principal investigators include Jonathan Silberg, the Stewart Memorial Professor of BioSciences and director of the Systems, Synthetic and Physical Biology Ph.D. program, and Caroline Ajo-Franklin, a professor of biosciences. Co-investigators also include Lauren Stadler, an assistant professor of civil and environmental engineering, and Kirstin Matthews, a fellow at the Baker Institute for Public Policy.

“These are engineered microbes we’re putting into wastewater, and even though they’re encapsulated, we want to know if there are concerns from health authorities and the general population,” Verduzco said. “Kirstin’s role is to look at the policy side, and also gauge public reaction and educate people about what it means when we talk about engineered bacteria.”

Rafael Verduzco is leading the research and development. Photo by Jeff Fitlow/Rice University

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Here's how much money Houstonians need in case of emergency

get to saving

With nearly 40 percent of Americans living paycheck to paycheck, many Texans are scrambling to afford their basic needs. A new study on how much money you need in your emergency fund should be a wake-up call.

The report, from personal finance website GOBakingRates.com, suggests that residents living in Houston should be stockpiling a minimum of $17,461 to cover six months' worth of expenses in the event of an emergency.

The report analyzed the annual average expenditures and cost of living in the 50 most populous U.S. cities, and ranked them based on the estimated minimum emergency savings needed for three to six months to cover basic living expenses.

According to the study's findings, the average Houstonian's total expenditures add up to $34,828 per year. That includes the average cost of groceries, housing, utilities, transportation, healthcare, and other miscellaneous costs.

The minimum emergency fund estimates in Houston are:

For a 3-month emergency fund: $8,707
For a 4-month emergency fund: $11,609
For a 5-month emergency fund: $14,512
For a 6-month emergency fund: $17,414

Houston ranked No. 37 out of all 50 U.S. cities with the highest projected emergency funds, so it could be a lot worse. In San Francisco, for example, which is No. 1 on the list, you'd need to put aside $52,000-plus for a six-month emergency fund.

Since these estimates are "minimum," the actual figures for Houston could tick slightly higher. But even so-called affordable cities present a challenge.

"While the emergency savings you need will vary depending on the cost of living where you live, even in the most affordable major cities in America, $500 won’t be enough to keep you afloat for one month, let alone six," the report said.

In the event of a real emergency, Texans should search 211texas.org, the online database for Texas Health and Human Services, featuring information on food banks, electric bill assistance, domestic violence resources, and more.

Around Texas

The Texas city with the highest six-month emergency fund is, predictably, Austin (No. 13) where annual expenses average $52,052, or $17,224 more than Houston. In Austin, the minimum six-month emergency found would need to be $26,000.

Texans living in Arlington (No. 30), Dallas (No. 31), and Fort Worth (No. 32) would need nearly $19,000 saved up to cover six months of expenses.

In San Antonio (No. 38), the estimated six-month emergency fund adds up to a little more than $17,000. El Paso (No. 48) is the Texas city with the lowest amount of money needed for six months, at $15,005.

California cities dominated the top 10 with the highest annual expenses and highest emergency funds. San Francisco took the No. 1 spot, with average annual expenses at $104,729, and an emergency six-month fund of $52,365.

The top 10 U.S. cities with the highest estimated minimum six-month emergency funds are:

No. 1 – San Francisco, California ($52,365)
No. 2 – San Jose, California ($46,258)
No. 3 – Oakland, California ($38,106)
No. 4 – Los Angeles, California ($35,160)
No. 5 – Seattle, Washington ($34,455)
No. 6 – San Diego, California ($34,396)
No. 7 – New York, New York ($32,363)
No. 8 – Washington, D.C. ($32,132)
No. 9 – Long Beach, California ($31,528)
No. 10 – Boston, Massachusetts ($31,297)

GOBankingRates.com collected its data from the U.S. Census American Community Survey, cost of living indexes from Sperlings BestPlaces, and the Bureau of Labor Statistics Consumer Expenditure Survey.

The report and its methodology can be found on gobakingrates.com.

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This article originally ran on CultureMap.

Houston space tech startup reports milestone achievement in partnership with federal agency

taking flight

A Houston tech company working on an engine to enable hypersonic flights has reported its latest milestone.

Venus Aerospace announced that it's successfully ran the first long-duration engine test of their Rotating Detonation Rocket Engine in partnership with Defense Advanced Research Projects Agency, or DARPA.

The RDRE engine Venus is working on is uniquely designed and a first in the field. It has an additional 15 percent efficiency over traditional rocket engines.

"As we continue to push towards our ultimate mission of high-speed global flight, this is an important technical milestone for having a flight-ready engine," Andrew Duggleby, CTO and co-founder of Venus Aerospace, says in the news release. "I'm incredibly proud of our team as they continue to push forward on this world-changing technology."

The test results are a big win, as the RDRE had previously only been tested in a short-duration capacity. DARPA is just one of several U.S. Government agencies that has contracts with Venus.

"The successful test is a testament to our team's dedication and expertise. We're building something special here at Venus, in large part because we have the right people and the right partners," Sassie Duggleby, CEO and co-founder of Venus Aerospace, adds. "I can't say enough about our collaboration with DARPA and the role they played in helping us make this leap forward."

Last summer, Venus added a new investor to its cap table. Andrew Duggleby founded Venus Aerospace with his wife and CEO Sassie in 2020, before relocating to the Houston Spaceport in 2021. Last year, Venus raised a $20 million series A round. Sassie joined the Houston Innovators Podcast a year ago to explain her company's mission of "home for dinner."

DARPA Partnership Long-Duration Testwww.youtube.com

University of Houston receives funding to support diverse cardiovascular researchers

pumping up innovation

University of Houston professors have received a nearly $800,000 grant to create a new summer program that will support diverse future researchers.

The National Heart, Lung, and Blood Institute provided $792,900 in grant funding to Bradley McConnell, professor of pharmacology at the UH College of Pharmacy, and Tho Tran, research assistant professor of chemistry at the UH College of Natural Sciences and Mathematics.

The funding will go toward created a summer program called the University of Houston Cardiovascular Undergraduate Research Experience, or UH-CURE. Ten undergraduate students per year will be selected for five years in cardiovascular research across disciplinary lines.

"We are so grateful to be able to provide talented students across the U.S. an opportunity to experience our excellent cardiovascular research environment,” Tran says in a news release. “We want UH-CURE participants to gain confidence in their research abilities through our hands-on approach and the skillset to navigate future challenges through our professional training.”

The goal is to increase students’ interest in cardiovascular research, and students have the opportunity to receive a $6,000 stipend, travel to a globally recognized cardiovascular research conference, and take part in on-campus housing and a food allowance. The summer program will also try to develop research skills, increase awareness of transdisciplinary research, promote diversity and collaborations, cultivate transferable skills necessary for succeeding in graduate school and help facilitate undergraduate students to pursue further training in cardiovascular research.

The program will integrate students into a research lab where they will learn research skills, data analysis, and research integrity. The program will be under the mentorship of a faculty member from across UH’s colleges, and include workshop and enrichment activities.

McConnell and Tran previously formed the American Heart Association-funded UH-HEART pilot program, which focused on cardiovascular research. They expanded on that initiative with UH-CURE, which includes cardiovascular research across disciplinary lines from community engagement and population-based research to basic, translational, and applied research. UH-CURE also helps prepare for careers in cardiovascular research.

“We all know that a diverse environment leads to a much better generation of ideas and solutions,” Tran adds. “We hope to bring that strength to the future of cardiovascular research through our students.”

Tho Tran (left) and Bradley McConnell are professors at UH. Photo via UH.edu

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