Here are three of the latest updates on new hires and promotions from these Houston organizations. Photos courtesy

It's been a busy year so far for Houston organizations — three of which have made new appointments to their leadership.

In this round up of movers and shakers in Houston innovation, a venture capital firm names its newest principal, an astronaut gets a leadership role here at ground control, and a VR studio snags a leader to steer its growth.

Joe Acaba, chief of NASA's Astronaut Office at Johnson Space Center

Joe Acaba was promoted to a new role and will be responsible for crew assignments for future spaceflight missions. Photo via NASA

NASA tapped Joe Acaba as its chief of the Astronaut Office based in Johnson Space Center in Houston. He's served on multiple spaceflights and is a former U.S. Marine and former educator. According to NASA, he's the first person of Hispanic heritage selected to lead the office.

Acaba replaces Drew Feustel, who spent two years as deputy chief and has been acting chief of the office since NASA astronaut Reid Wiseman left the post late last year.

"Joe is an experienced space flyer and a proven leader, and he will undoubtedly inspire the next generation of NASA astronauts," says NASA Administrator Bill Nelson in a news release. " As we build on the International Space Station’s unparalleled success in low-Earth orbit with our eyes on the Moon and then Mars, Joe will play an integral role in ensuring our NASA astronauts are prepared for the challenges ahead."

Acaba, who spent a total of 306 days in space, has already supported the astronaut office in a few of roles, including director of operations in Russia and chief of the Vehicle Integration Test Office. In this new role, he will be oversee astronaut resources and operations and help develop astronaut flight crew operation concepts. Additionally, Acaba will make crew assignments for future spaceflight missions, including astronauts assigned to fly on Artemis missions.

“Our Johnson Space Center team congratulates Joe Acaba on his selection to chief of the Astronaut Office. We wish him well as he takes on this new and exciting leadership role,” says NASA Johnson Space Center Director Vanessa Wyche.

Samantha Lewis, partner at Mercury Fund

Samantha Lewis was promoted to partner at Mercury Fund. Photo courtesy of Mercury Fund

Samantha Lewis was promoted to partner from principal at Houston-based venture capital firm Mercury, per her LinkedIn. She previously was the investment director of investor network GOOSE Capital before joining the Mercury team just over two years ago.

Last year, Lewis — who also served on the board of two Houston-founded startups, Syzygy and Topl — was named a member of the Class 27 of the Kauffman Fellows Program, a group of global innovation investors.

Lewis is focused on what she calls the "power theme" at Mercury, which includes fintech, blockchain, web3, and more. She told InnovationMap on a recent episode of the Houston Innovators Podcast that these industries have been hit in particular within market uncertainty.

Bob Kleinhample, senior vice president of growth at HTX Labs

Bob Kleinhample joins HTX Labs at a time of strategic growth. Photo courtesy of HTX Labs

Virtual reality studio HTX Labs has named Bob Kleinhample as the company’s senior vice president of growth. He has more than 15 years leading business efforts in the tech space. A 20-year Army veteran, Kleinhample will oversee all aspects of HTX Labs' growth — including business development, product strategy, and marketing.

“Bob brings the right balance of market knowledge and product strategy, in combination with the commitment to bring immersive training and simulation to the warfighter, to really drive our EMPACT offering into the market,” says Scott Schneider, CEO and co-founder of HTX Labs. "We’re very excited to be adding this incredibly important role to our organization and having Bob lead these efforts as we expand the usage and adoption of EMPACT across the Department of Defense."

The appointment comes after the startup raised $3.2 million in its first outside capital round.

“Last year we secured funding from Cypress Growth Capital for the sole purpose of accelerating the growth of our EMPACT platform and our customer base, and we immediately began a search for the right person to lead these growth efforts," Schneider continues. "After performing an extensive search, we are fortunate to have connected with Bob Kleinhample who is coming on board to lead our company’s growth efforts“.

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Houston doctor wins NIH grant to test virtual reality for ICU delirium

Virtual healing

Think of it like a reverse version of The Matrix. A person wakes up in a hospital bed and gets plugged into a virtual reality game world in order to heal.

While it may sound far-fetched, Dr. Hina Faisal, a Houston Methodist critical care specialist in the Department of Surgery, was recently awarded a $242,000 grant from the National Institute of Health to test the effects of VR games on patients coming out of major surgery in the intensive care unit (ICU).

The five-year study will focus on older patients using mental stimulation techniques to reduce incidences of delirium. The award comes courtesy of the National Institute on Aging K76 Paul B. Beeson Emerging Leaders Career Development Award in Aging.

“As the population of older adults continues to grow, the need for effective, scalable interventions to prevent postoperative complications like delirium is more important than ever,” Faisal said in a news release.

ICU delirium is a serious condition that can lead to major complications and even death. Roughly 87 percent of patients who undergo major surgery involving intubation will experience some form of delirium coming out of anesthesia. Causes can range from infection to drug reactions. While many cases are mild, prolonged ICU delirium may prevent a patient from following medical advice or even cause them to hurt themselves.

Using VR games to treat delirium is a rapidly emerging and exciting branch of medicine. Studies show that VR games can help promote mental activity, memory and cognitive function. However, the full benefits are currently unknown as studies have been hampered by small patient populations.

Faisal believes that half of all ICU delirium cases are preventable through VR treatment. Currently, a general lack of knowledge and resources has been holding back the advancement of the treatment.

Hopefully, the work of Faisal in one of the busiest medical cities in the world can alleviate that problem as she spends the next half-decade plugging patients into games to aid in their healing.

Houston scientists develop breakthrough AI-driven process to design, decode genetic circuits

biotech breakthrough

Researchers at Rice University have developed an innovative process that uses artificial intelligence to better understand complex genetic circuits.

A study, published in the journal Nature, shows how the new technique, known as “Combining Long- and Short-range Sequencing to Investigate Genetic Complexity,” or CLASSIC, can generate and test millions of DNA designs at the same time, which, according to Rice.

The work was led by Rice’s Caleb Bashor, deputy director for the Rice Synthetic Biology Institute and member of the Ken Kennedy Institute. Bashor has been working with Kshitij Rai and Ronan O’Connell, co-first authors on the study, on the CLASSIC for over four years, according to a news release.

“Our work is the first demonstration that you can use AI for designing these circuits,” Bashor said in the release.

Genetic circuits program cells to perform specific functions. Finding the circuit that matches a desired function or performance "can be like looking for a needle in a haystack," Bashor explained. This work looked to find a solution to this long-standing challenge in synthetic biology.

First, the team developed a library of proof-of-concept genetic circuits. It then pooled the circuits and inserted them into human cells. Next, they used long-read and short-read DNA sequencing to create "a master map" that linked each circuit to how it performed.

The data was then used to train AI and machine learning models to analyze circuits and make accurate predictions for how untested circuits might perform.

“We end up with measurements for a lot of the possible designs but not all of them, and that is where building the (machine learning) model comes in,” O’Connell explained in the release. “We use the data to train a model that can understand this landscape and predict things we were not able to generate data on.”

Ultimately, the researchers believe the circuit characterization and AI-driven understanding can speed up synthetic biology, lead to faster development of biotechnology and potentially support more cell-based therapy breakthroughs by shedding new light on how gene circuits behave, according to Rice.

“We think AI/ML-driven design is the future of synthetic biology,” Bashor added in the release. “As we collect more data using CLASSIC, we can train more complex models to make predictions for how to design even more sophisticated and useful cellular biotechnology.”

The team at Rice also worked with Pankaj Mehta’s group in the department of physics at Boston University and Todd Treangen’s group in Rice’s computer science department. Research was supported by the National Institutes of Health, Office of Naval Research, the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, the American Heart Association, National Library of Medicine, the National Science Foundation, Rice’s Ken Kennedy Institute and the Rice Institute of Synthetic Biology.

James Collins, a biomedical engineer at MIT who helped establish synthetic biology as a field, added that CLASSIC is a new, defining milestone.

“Twenty-five years ago, those early circuits showed that we could program living cells, but they were built one at a time, each requiring months of tuning,” said Collins, who was one of the inventors of the toggle switch. “Bashor and colleagues have now delivered a transformative leap: CLASSIC brings high-throughput engineering to gene circuit design, allowing exploration of combinatorial spaces that were previously out of reach. Their platform doesn’t just accelerate the design-build-test-learn cycle; it redefines its scale, marking a new era of data-driven synthetic biology.”