These are the Houston companies headed to MassChallenge Texas in Austin

Texas road trip

A handful of Houston startups will be bouncing back and forth to Austin for the second annual MassChallenge Texas accelerator. Getty Images

It's the second cohort for Boston-based MassChallenge Texas in Austin, and this year's 74 selected finalists are well represented by Houston.

"Coming from an extremely competitive application pool, the startups in our second Austin-based cohort represent an incredibly high bar of creativity and talent, all of who are poised to make an impact," says Mike Millard, managing director of MassChallenge Texas, in a release. "This year's program will offer the finalists innovation at scale with direct access to resources through our programs in Houston and Austin, and our community around the state. Through these channels, startups will have more opportunities to test and validate their ideas with partners while creating meaningful engagements to help them get to pilot or pivot as fast as possible."

While there is the upcoming MassChallenge Texas inaugural Houston cohort, these seven companies opted for a spot in the Austin-based cohort where the stakes are higher and cash prizes are on the line — $500,000, the largest equity-free cash prize in Texas, to be precise. (Houston's inaugural set of prizes reportedly don't included money.)

These are seven of the Houston-related companies that will be trekking back and forth to Austin from June until October.

crewcollar

 Getty Images

It's crewcollar's mission to optimize hiring for industrial and blue-collar jobs, simplifying the entire process from curated job posts to paperwork filing. The company is based just outside of Houston in Missouri City.

"We are super excited to be joining MassChallenge Texas, and know that this experience will help us take it to the next level," says M. Siler, CEO and founder, in a release.

GotSpot Inc.

Courtesy of GotSpot

Houston-based GotSpot is Reda Hicks solution to finding temporary space quickly and easily — in a way that benefits all sides of the transaction. The model is like AirBnb, but for retail, meeting, and even emergency space. The corporate lawyer has grown the platform over the past few years and the MassChallenge opportunity is another move in the right direction. Click here to read more about Hicks and GotSpot.

Grant Source

Photo via grantsourceapp.com

Grant Source is like the magic genie to help organizations find funding through grants and opportunities. The Houston startup has a database of opportunities and can help match businesses with appropriate grants to apply to — all within the Grant Source mobile app.

Guzo

Getty Images

Guzo is the tool every traveler has dreamed up. The Houston-based app connects travelers — not just in the planning phase — but throughout the travel process. The company was created by two brothers — Joshua and Gordon Taylor — and is the recreation of Croozen, formerly a long-distance carpool app.

"One of the things that got Gordan and I excited in the beginning of Croozen was just the idea of someone else in the car with you and that shared experience," Joshua Taylor tells InnovationMap in a previous interview about revamping Croozen as Guzo. "Looking past that, just being focused on the car was hindering us. Let's divorce the car and focus on travel as a whole."

Lazarus 3D

Photo via laz3d.com

Practice makes perfect, and surgeons should be as close to perfect as possible, right? Lazarus 3D uses 3D printing to make realistic body parts and organs so that surgeons can rehearse their surgeries before ever slicing into a patient. The company is conveniently located in the Texas Medical Center.

Pilot Plus

Photo via pilotplus.com

The trucking industry needs a rebrand. It's a tireless job that's go-go-go, and the unappealing nature of the career isn't ideal. Pilot Plus puts the humanity back in the process that benefits the driver and makes for bragging rights for the company employing the trucker. The logistics company allows for a system of drivers that work together for the long haul so that drivers can actually spend time resting in their own homes.

Topl

Courtesy of Topl

Topl's MassChallenge bio lists their HQ in the Netherlands, but the blockchain startup founded by three Rice University alumni has some of its operations right here in town. Topl has a goal of using blockchain technology to connect the dots and enhance transparency in various applications from retail to even being able to track the success of investments or scholarships.

"We are a generation that wants a story," Kim Raath, president at Topl, tells InnovationMap in a previous interview. "We want an origin, and don't want to be fooled. And, because you might be able to reduce the cost by having this transparency, you might be able to bring down the cost on both sides."


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Microsoft partners with Rice University's OpenStax on AI teaching tool

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Rice University’s OpenStax and Microsoft are partnering to integrate the nonprofit’s content with the tech giant’s AI innovation, known as Learning Zone.

“At OpenStax, our mission is to make an amazing education accessible to all,” Richard G. Baraniuk, founder and director of OpenStax, said in a news release. “That’s why we’re excited to integrate our trustworthy, peer-reviewed content with Microsoft’s AI technology through the Microsoft Learning Zone. Together, we aim to help more instructors and their students access engaging, effective learning experiences in new and dynamic ways. We also share a strong commitment to the thoughtful and responsible application of AI to better ensure all learners can succeed.”

OpenStax is a provider of affordable instructional technologies and is also one of the world’s largest publishers of open educational resources (OER).

Microsoft Learning Zone promises to provide educators and students with “responsible AI technology and peer-reviewed educational content to support learning” on Microsoft Copilot+ PCs. Microsoft Learning Zone works by utilizing on-device AI to generate interactive lessons for students, and its integration with OpenStax content means educators can rely on OpenStax’s digital library of 80 openly licensed titles.

The goal is for educators to create effective and engaging learning experiences safely, thereby bypassing the need to source and vet content independently. Included is a library of ready-to-use lessons, opportunity for immediate feedback and differentiated learning. Educators will maintain control of instructional content and pedagogical strategies and will be able to update or edit lessons or activities prior to sharing them with students.

Other tools included in the Microsoft Learning Zone are additional languages, reading coaching, public speaking help, math and reading progress, and a partnership with the online quiz platform Kahoot!

OpenStax resources have been reported as used across 153 countries, and this current collaboration combines the power and potential of responsible AI usage in education with content that has been utilized by 13,569 K-12 schools and 71 percent of U.S. colleges and universities, according to Rice.

“Through our partnership with OpenStax, we’re combining the power of on-device AI in Copilot+ PCs with OpenStax’s trusted and diverse peer-reviewed content to help educators quickly create high-quality, personalized, engaging lessons,” Deirdre Quarnstrom, vice president of Microsoft Education, added in the news release. “We’re excited about how this collaboration will empower classrooms globally.”

Houston ranks among the 15 best cities in America for 2025

Ranking It

A new national report ranking the best cities in America has declared Houston is the 13th best U.S. city in 2025.

The annual "America's Best Cities" report from Resonance Consultancy, a Canada-based real estate and tourism marketing firm, ranks the relative qualities of livability, cultural "lovability," and economic prosperity in America's principal cities with metropolitan populations of 500,000 or more.

These top 100 cities "brilliantly weave local culture with economic prospects, aligning with global and domestic travel trends to create premier experiences for both residents and travelers."

Houston's new placement is three spots lower than its triumphant No. 10 rank in 2024. Though it no longer holds a prized top-10 spot, the report hails Houston as a "coveted hometown for the best and brightest on earth."

Among Houston's other shining attributes are its booming population growth – which has now grown to a staggering 7.51 million people – plus its competitive real estate market and a vibrant hospitality and culinary scene. Additionally, Houston earned a well-deserved No. 4 rank in the report's "restaurants" subcategory.

"A 221-room Home2 Suites/Tru by Hilton debuted near Toyota Center in March, while Marriott’s newly renovated Residence Inn NASA/Clear Lake keeps surging visitors happy," the report said. "West Houston’s Greenside will convert 35,000 square feet of warehouses into a park-laced retail hub by 2026, while America’s inaugural Ismaili Center, rising along Allen Parkway, remains on schedule for later this year, adding yet another cultural jewel to H-Town’s festival-fueled mosaic."

The report additionally puts a large focus on Houston's innovative energy sector and its numerous large companies that boost the local economy and create thousands of jobs. Several of these Houston-based companies are some of the best places to work, according to U.S. News and World Report.

One such company that was specifically praised in the report was the HyVelocity Hub, which aims to "ensure economic resilience and long-lasting, domestic energy production" along the Gulf Coast.

"The HyVelocity Hydrogen Hub just locked in up to $1.2 billion from the U.S. DOE, targeting 45,000 jobs and slicing 7.7 million tons of CO₂ a year," the report said.

Elsewhere in Texas

Dallas (No. 14) and Austin (No. 15) ranked right behind Houston in the top 20, while San Antonio sank into the No. 41 spot after previously ranking 32nd last year. El Paso also fell from No. 83 in 2024 to No. 100 this year.

Jason McGrath, the executive vice president and head of U.S. Corporate Reputation at Ipsos, said in the report that American cities are proving their resiliency as they are faced with "climate issues, increasing infrastructural demands, and shifting geopolitical landscapes affecting international relations and travel."

"Despite these hurdles, cities are creatively reinventing themselves to shine as examples of cultural vibrancy and innovation, keeping their competitive edge both locally and globally," McGrath said. "Our report shows that the allure of American cities remains strong, thanks to their rich diversity and vast attractions — from natural wonders to buzzing cultural hubs."

The top 10 best cities in America in 2025 are:

  • No. 1 – New York City, New York
  • No. 2 – Los Angeles, California
  • No. 3 – Chicago, Illinois
  • No. 4 – San Francisco, California
  • No. 5 – Seattle, Washington
  • No. 6 – Miami, Florida
  • No. 7 – Boston, Massachusetts
  • No. 8 – Washington, D.C.
  • No. 9 – Las Vegas, Nevada
  • No. 10 – San Diego, California
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This article originally appeared on CultureMap.com.

Houston biosciences company opens new sequencing center for drug development

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Houston-based Avance Biosciences has launched the Next-Generation Sequencing Center of Excellence, designed to enhance the company’s sequencing capabilities for drug development. Specifically, the facility at the company’s main campus in Northwest Houston will pursue breakthroughs in biologics, cell therapy and gene therapy.

In the drug industry, sequencing refers to studying nucleotides in DNA and RNA molecules. Nucleotides are the building blocks of DNA and RNA.

“This is a major milestone for Avance Biosciences as we continue to support the evolving needs of biologics and cell and gene therapy developers,” Xuening “James” Huang, co-founder, CEO and chief technology officer of Avance, said in a news release. “By consolidating state-of-the-art sequencing platforms and scientific talent, we’ve created a highly capable organization ready to solve complex genomic challenges with precision and compliance.”

In 2013, Avance rolled out next-generation sequencing (NGS) that complies with federal guidelines. Since then, Avance “has remained at the forefront of regulated sequencing services,” the company said. “The launch of the (new center) strengthens the company’s ability to deliver accurate, reproducible, and regulatory-aligned sequencing data across a wide array of therapeutic modalities.”

Cal Froberg, senior vice president of sales and marketing at Avance, said pharmaceutical and biotech clients trust the company’s technical capabilities and regulatory compliance.

“With the ever-changing global landscape and increasing scrutiny around international sample shipments, conducting advanced, cost-effective NGS testing domestically is now more feasible than ever,” Froberg said. “Our clients have confidence that their samples will remain in the U.S.”

Avance, founded in 2010, plans to hold an open house at the new facility in September to showcase its capabilities, technology, talent, and services. The company’s services include sequencing, molecular biology, cell-based testing, and bioanalytical testing.
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