New initiative to bring protective equipment to underserved parts of Houston

PPE for the people

PPE For The People will donate personal protective equipment to workers in communities disproportionately affected by COVID-19. Photos via houston.impacthub.net/ppeforthepeople

Through a collaboration between a 3D printing company and a nonprofit organization, small businesses in underserved parts of town are able to apply to receive personal protective equipment donations.

Impact Hub Houston and re:3D have teamed up for an initiative called PPE For The People that will create and donate PPE to small businesses disproportionately affected by the coronavirus outbreak.

"All of the emerging data indicates that, while a coronavirus may not discriminate, disparities that already exist in society are putting communities of color at a disproportionately higher risk of infection, serious illness, and death from COVID-19," says Grace Rodriguez, CEO and executive director of Impact Hub Houston.

According to a news release, the initiative will support workers across industries — from restaurants employees and bus and delivery drivers to small businesses that seek to reopen safely, like barbershops and nail salons.

Impact Hub Houston works to prioritize inclusion in Houston, which has been recognized as the most diverse city in the nation.

"There a number of societal factors that are leading to disproportionately higher COVID-19 cases and deaths among minority communities," says Rodriguez, specifying that these factors include lack of access to health care, overrepresentation of people of color in jobs considered essential, and more.

To start, the initiative has identified the southeast, south, and southwest parts of Houston to deliver four types of 3D-printed PPE: face shields, ear savers, hands-free door opener, and splash guards.

"re:3D has extensively researched PPE production for COVID-19 throughout the crisis as well as collaborated with healthcare workers, first responders, and local businesses to identify where there are gaps in their ability to protect themselves and their customers," says re:3D's community liaison, Charlotte Craff. "We have started with these items because we are confident they fill those needs."

The campaign, which is raising money and seeking volunteers online, began Wednesday, May 6, and expects to deliver its first PPE next week. The organizations are looking into expanding the PPE offered, as well as their reach, but it depends on fundraising.

"We would like to expand the project to serve communities in the northeast and other high-risk areas of Houston, but that all depends on how much funding we can raise to keep producing and delivering PPE," Rodriguez explains.

According to the release, Impact Hub Houston is financially supporting the initiative through its Fiscal Sponsorship Program, which re:3D applied to. The H-Force network, a crisis collaboration, is also lending its support to this initiative.

"We are honored to help those who are most vulnerable," says Craff in the release. "Data from the CDC has shown minority communities are at greater risk of critical illness from COVID-19, and we want to help local small businesses protect their employees as best as possible without it being an added financial burden on already strained industries."

Boeing has started making plastic face shields at its San Antonio factory. Photo courtesy of Boeing

Aerospace giant taps Texas site to make face shields for health care workers battling the coronavirus

in need of PPE

Chicago-based Boeing, which is a major employer in Texas, began producing face shields for front-line healthcare workers at several of its facilities across the country. The company's San Antonio location is among the sites selected.

On April 10, Boeing delivered its first 2,300 face shields to the Kay Bailey Hutchison Convention Center in Dallas, which is an alternate treatment site for COVID-19 patients. The U.S. Department of Health and Human Services accepted the shipment.

In collaboration with the Federal Emergency Management Agency, Boeing is donating face shields to health care providers around the country. The company plans to make thousands of these face shields each week in San Antonio; St. Louis; Southern California; the Seattle area; Mesa, Arizona; Huntsville, Alabama; Philadelphia; Charleston, South Carolina; Salt Lake City; and Portland, Oregon.

"Boeing is proud to stand alongside many other great American companies in the fight against COVID-19, and we are dedicated to supporting our local communities, especially our front-line health care professionals, during this unprecedented time," David Calhoun, president and CEO of Boeing, says in a release.

At Port San Antonio, Boeing operates one of the world's largest military aircraft maintenance, repair, and overhaul facilities. In August 2019, Boeing said it was adding 500 jobs in San Antonio, on top of the 900 people already employed there.

Solvay, a longtime Boeing supplier, has provided clear film for the face shields. Another supplier, Trelleborg Sealing Solutions, has donated elastic for the adjustable headbands.

To date, Boeing says it has donated tens of thousands of pieces of personal protective equipment — including face masks, goggles, gloves, safety glasses, and protective bodysuits — to support U.S. health care workers fighting the pandemic.

"History has proven that Boeing is a company that rises to the toughest challenges with people who are second to none," Calhoun adds. "Today, we continue that tradition, and we stand ready to assist the federal government's response to this global pandemic."

------

This article originally ran on CultureMap.

A startup and a nonprofit makerspace have rallied to create PPE, or personal protective equipment, for local hospitals. Getty Images

Houston tech community answers the call for medical equipment amid coronavirus-caused shortages

in need of PPE

In the span of one day, the founders of Houston-based Lazarus 3D received calls from emergency room directors and physicians and vice presidents of hospitals explaining a dire need for personal protective equipment — like surgical masks and face shields — for medical professionals in the front lines of the battle against COVID-19.

"We stopped everything we were doing," says Jacques Zaneveld, co-founder of Lazarus, which makes 3D-printed human organs for surgeons to practice on. "We've moved 100 percent of our focus on developing PPE."

Now, Zaneveld with his co-founder, Smriti Agrawal Zaneveld, have manufacturing orders in for 700,000 surgical masks weekly and have designed a non-FDA approved face shield, which they have ordered a few million of. The duo has taken out a short-term loan to front the cost of the medical equipment and are now looking for the right customers to buy these new PPE products. All hospitals and medical professionals in need of supplies can head to Lazarus' website to request more info.

"Our personal feeling has been to do whatever we can do to build as many as possible," Jacques tells InnovationMap. "It's very stressful because I'm borrowing money that we don't have in order to set up these production lines."

On the other side of town, 3D printing nonprofit TXRX has reprogramed 30 of its 3D printers to make PPE. The nonprofit is working Memorial Hermann to quickly prototype and test items made with materials they can get their hands on.

The Center for Disease Control has relaxed some of the requirements for PPE in light of the crisis and shortage, and Roland von Kurnatowski, president at TX/RX Labs, says that has helped speed up their efforts. But, the biggest challenge, he says, has been to quickly get together a design and prototype for Memorial Hermann to give them feedback so that they can then produce the products.

"I think there are a lot of people out there producing devices, but I think the problem is there's not a lot of clarity around materials, quality, and acceptance. People are doing what they can with what they've got," says von Kurnatowski. "Our hope working with Memorial Hermann was to make sure we are devising and testing devices that are functional and appropriate.

TXRX is also relying on Memorial Hermann and others in the medical community to indicate which PPE devices are most needed. Currently, the nonprofit is printing 10,000 face shields for Memorial Hermann, but also has designs for N95 respirators, surgical masks, a positive air pressure respirator (or PAPR), Tyvek suit, and even a portable shield for the intubation process.

Von Kurnatowski says the Houston community can get involved by donating to TXRX's GoFundMe campaign. The 3D printing process is quick and local, but expensive and out of budget for hospitals, so TXRX is taking a loss on its products it is creating. The organization is also looking for people who might have 3D printing materials or experience to volunteer — TXRX has about 20 people working on this but hopes that number ramps up to 60 to 80 people helping out.

Crisis also brings the community together in their time of need — that's what Zaneveld says he sees happening.

"Everyone who is at all involved in the medical space in engineering in Houston is trying to put stuff out," Zaneveld says. "We're sharing information and trying to work together to support each other."

Ad Placement 300x100
Ad Placement 300x600

CultureMap Emails are Awesome

Property Showcase

Houston health tech innovator collaborates on promising medical device funded by DOD

team work

The United States Department of Defense has awarded a grant that will allow the Texas Heart Institute and Rice University to continue to break ground on a novel left ventricular assist device (LVAD) that could be an alternative to current devices that prevent heart transplantation and are a long-term option in end-stage heart failure.

The grant is part of the DOD’s Congressionally Directed Medical Research Programs (CDMRP). It was awarded to Georgia Institute of Technology, one of four collaborators on the project that will be designed and evaluated by the co-investigator Yaxin Wang. Wang is part of O.H. “Bud” Frazier’s team at Texas Heart Institute, where she is director of Innovative Device & Engineering Applications Lab. The other institution working on the new LVAD is North Carolina State University.

The project is funded by a four-year, $7.8 million grant. THI will use about $2.94 million of that to fund its part of the research. As Wang explained to us last year, an LVAD is a minimally invasive device that mechanically pumps a person’s own heart. Frazier claims to have performed more than 900 LVAD implantations, but the devices are far from perfect.

The team working on this new research seeks to minimize near-eventualities like blood clot formation, blood damage, and driveline complications such as infection and limitations in mobility. The four institutions will try to innovate with a device featuring new engineering designs, antithrombotic slippery hydrophilic coatings (SLIC), wireless power transfer systems, and magnetically levitated driving systems.

Wang and her team believe that the non-contact-bearing technology will help to decrease the risk of blood clotting and damage when implanting an LVAD. The IDEA Lab will test the efficacy and safety of the SLIC LVAD developed by the multi-institutional team with a lab-bench-based blood flow loop, but also in preclinical models.

“The Texas Heart Institute continues to be a leading center for innovation in mechanical circulatory support systems,” said Joseph G. Rogers, MD, the president and CEO of THI, in a press release.

“This award will further the development and testing of the SLIC LVAD, a device intended to provide an option for a vulnerable patient population and another tool in the armamentarium of the heart failure teams worldwide.”

If it works as hypothesized, the SLIC LVAD will improve upon current LVAD technology, which will boost quality of life for countless heart patients. But the innovation won’t stop there. Technologies that IDEA Lab is testing include wireless power transfer for medical devices and coatings to reduce blood clotting could find applications in many other technologies that could help patients live longer, healthier lives.

Houston investor on SaaS investing and cracking product-market fit

Houston innovators podcast episode 230

Aziz Gilani's career in tech dates back to when he'd ride his bike from Clear Lake High School to a local tech organization that was digitizing manuals from mission control. After years working on every side of the equation of software technology, he's in the driver's seat at a local venture capital firm deploying funding into innovative software businesses.

As managing director at Mercury, the firm he's been at since 2008, Gilani looks for promising startups within the software-as-a-service space — everything from cloud computing and data science and beyond.

"Once a year at Mercury, we sit down with our partners and talk about the next investment cycle and the focuses we have for what makes companies stand out," Gilani says on the Houston Innovators Podcast. "The current software investment cycle is very focused on companies that have truly achieved product-market fit and are showing large customer adoption."



An example of this type of company is Houston-based RepeatMD, which raised a $50 million series A round last November. Mercury's Fund V, which closed at an oversubscribed $160 million, contributed to RepeatMD's round.

"While looking at that investment, it really made me re-calibrate a lot of my thoughts in terms what product-market fit meant," Gilani says. "At RepeatMD, we had customers that were so eager for the service that they were literally buying into products while we were still making them."

Gilani says he's focused on finding more of these high-growth companies to add to Mercury's portfolio amidst what, admittedly, has been a tough time for venture capital. But 2024 has been looking better for those fundraising.

"We've some potential for improvement," Gilani says. "But overall, the environment is constrained, interest rates haven't budged, and we've seen some potential for IPO activity."

Gilani shares more insight into his investment thesis, what areas of tech he's been focused on recently, and how Houston has developed as an ecosystem on the podcast.

Houston startup scores $12M grant to support clinical evaluation of cancer-fighting drug

fresh funding

Allterum Therapeutics, a Houston biopharmaceutical company, has been awarded a $12 million product development grant from the Cancer Prevention and Research Institute of Texas (CPRIT).

The funds will support the clinical evaluation of a therapeutic antibody that targets acute lymphoblastic leukemia (ALL), one of the most common childhood cancers.

However, CEO and President Atul Varadhachary, who's also the managing director of Fannin Innovation, tells InnovationMap, “Our mission has grown much beyond ALL.”

The antibody, called 4A10, was invented by Scott Durum PhD and his team at the National Cancer Institute (NCI). Licensed exclusively by Allterum, a company launched by Fannin, 4A10 is a novel immunotherapy that utilizes a patient’s own immune system to locate and kill cancer cells.

Varadhachary explained that while about 80 percent of patients afflicted with ALL have the B-cell version, the other 20 percent suffer from T-cell ALL.

“Because the TLL population is so small, there are really no approved, effective drugs for it. The last drug that was approved was 18 or 19 years ago,” the CEO-scientist said. 4A10 addresses this unmet need, but also goes beyond it.

Because 4A10 targets CD127, also known as the interleukin-7 receptor, it could be useful in the treatment of myriad cancers. In fact, the receptor is expressed not just in hematological cancers like ALL, but also solid tumors like breast, lung, and colorectal cancers. There’s also “robust data,” according to Varadhachary for the antibody’s success against B-cell ALL, as well as many other cancers.

“Now what we're doing in parallel with doing the development for ALL is that we're continuing to do additional preclinical work in these other indications, and then at some point, we will raise a series A financing that will allow us to expand markets into things which are much more commercially attractive,” Varadhachary explains.

Why did they go for the less commercially viable application first? As Varadhachary put it, “The Fannin model is to allow us to go after areas which are major unmet medical needs, even if they are not necessarily as attractive on a commercial basis.”

But betting on a less common malady could have a bigger payoff than the Allterum team originally expected.

Before the new CPRIT grant, Allterum’s funding included a previous seed grant from CPRIT of $3 million. Other funds included an SBIR grant from NCI, as well as another NCI program called NExT, which deals specifically with experimental therapies.

“To get an antibody from research into clinical testing takes about $10 million,” Varadhachary says. “It's an expensive proposition.”

With this, and other nontraditional financing, the company was able to take what Varadhachary called “a huge unmet medical need but a really tiny commercial market” and potentially help combat a raft of other childhood cancers.

“That's our vision. It's not economically hugely attractive, but we think it's important,” says Varadhachary.

Atul Varadhachary is the managing director of Fannin Innovation. Photo via LinkedIn

View All Listings